OG_ID	cog_best	cog_best_name	cog_best_gene	cog_best_letter	cog_best_description	cog_support	n_genes	cog_rate
OG0000000	COG1132	ABC-type multidrug and LPS transport system, ATPase and permease component MsbA	MdlB	M	Cell wall/membrane/envelope biogenesis	21	1797	0.011686143572621035
OG0000000	COG1134	ABC-type polysaccharide/polyol phosphate transport system, ATPase component	TagH	G	Carbohydrate transport and metabolism	1	1797	5.564830272676684e-4
OG0000000	COG1135	ABC-type methionine transport system, ATPase component	AbcC	E	Amino acid transport and metabolism	1	1797	5.564830272676684e-4
OG0000000	COG1136	ABC-type lipoprotein targeting system ATPase component LolD	LolD	M	Cell wall/membrane/envelope biogenesis	828	1797	0.4607679465776294
OG0000000	COG2274	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain	SunT	V	Defense mechanisms	18	1797	0.01001669449081803
OG0000000	COG3638	ABC-type phosphate/phosphonate transport system, ATPase component	PhnC	P	Inorganic ion transport and metabolism	72	1797	0.04006677796327212
OG0000000	COG4133	ABC-type transport system involved in cytochrome c biogenesis, ATPase component	CcmA	O	Posttranslational modification, protein turnover, chaperones	2	1797	0.0011129660545353367
OG0000000	COG4175	ABC-type proline/glycine betaine transport system, ATPase component	ProV	E	Amino acid transport and metabolism	850	1797	0.4730105731775181
OG0000000	COG4988	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components	CydD	C	Energy production and conversion	3	1797	0.001669449081803005
OG0000001	COG1116	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component	TauB	P	Inorganic ion transport and metabolism	149	1548	0.0962532299741602
OG0000001	COG3839	ABC-type sugar transport system, ATPase component MalK	MalK	G	Carbohydrate transport and metabolism	1096	1548	0.7080103359173127
OG0000001	COG3842	ABC-type Fe3+/spermidine/putrescine transport systems, ATPase component	PotA	E	Amino acid transport and metabolism	18	1548	0.011627906976744186
OG0000001	COG4525	ABC-type taurine transport system, ATPase component	TauB	P	Inorganic ion transport and metabolism	283	1548	0.18281653746770027
OG0000002	COG0395	ABC-type glycerol-3-phosphate transport system, permease component	UgpE	G	Carbohydrate transport and metabolism	1037	1520	0.6822368421052631
OG0000002	COG1176	ABC-type spermidine/putrescine transport system, permease component I	PotB	E	Amino acid transport and metabolism	1	1520	6.578947368421052e-4
OG0000002	COG1177	ABC-type spermidine/putrescine transport system, permease component II	PotC	E	Amino acid transport and metabolism	482	1520	0.3171052631578947
OG0000003	COG0697	Amino acid export permease, drug/metabolite transporter (DMT) superfamily	EamA	E	Amino acid transport and metabolism	1222	1224	0.9983660130718954
OG0000004	COG0665	Glycine/D-amino acid oxidase (deaminating)	DadA	E	Amino acid transport and metabolism	1177	1180	0.997457627118644
OG0000005	COG0362	6-phosphogluconate dehydrogenase	Gnd	G	Carbohydrate transport and metabolism	3	1174	0.002555366269165247
OG0000005	COG2084	3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase	MmsB	I	Lipid transport and metabolism	1167	1174	0.9940374787052811
OG0000006	COG2165	Type II secretion system/type IV prepilin peptidase GspO/PulO/PilD	GspO/PilD	N	Cell motility	103	1150	0.08956521739130435
OG0000006	COG4537	Competence protein ComGC	ComGC	X	Mobilome: prophages, transposons	1	1150	8.695652173913044e-4
OG0000006	COG4538	Uncharacterized conserved protein, contains SnoaL-like domain	SnoaL	S	Function unknown	1	1150	8.695652173913044e-4
OG0000006	COG4968	Type IV pilus minor pilin/pseudopilin PilE	PilE	N	Cell motility	670	1150	0.5826086956521739
OG0000006	COG4969	Type IV pilus major pilin PilA	PilA	N	Cell motility	123	1150	0.10695652173913044
OG0000006	COG4970	Type IV pilus assembly protein FimT or FimU	FimT	N	Cell motility	191	1150	0.16608695652173913
OG0000007	COG0300	Short-chain dehydrogenase	YqjQ	R	General function prediction only	72	1138	0.0632688927943761
OG0000007	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	FabG	I	Lipid transport and metabolism	1041	1138	0.9147627416520211
OG0000007	COG1091	dTDP-4-dehydrorhamnose reductase	RfbD	M	Cell wall/membrane/envelope biogenesis	1	1138	8.787346221441124e-4
OG0000007	COG3967	Short-chain dehydrogenase involved in D-alanine esterification of teichoic acids	DltE	M	Cell wall/membrane/envelope biogenesis	1	1138	8.787346221441124e-4
OG0000007	COG4221	NADP-dependent 3-hydroxy acid dehydrogenase YdfG	YdfG	C	Energy production and conversion	16	1138	0.014059753954305799
OG0000008	COG0457	Tetratricopeptide (TPR) repeat	TPR	R	General function prediction only	1	1109	9.017132551848512e-4
OG0000008	COG0500	SAM-dependent methyltransferase SmtA (CmoB moved to COG2228)	SmtA	Q	Secondary metabolites biosynthesis, transport and catabolism	11	1109	0.009918845807033363
OG0000008	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9	UbiE	H	Coenzyme transport and metabolism	108	1109	0.09738503155996393
OG0000008	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	951	1109	0.8575293056807936
OG0000008	COG2230	Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases	Cfa	I	Lipid transport and metabolism	1	1109	9.017132551848512e-4
OG0000008	COG3914	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family	Spy	O	Posttranslational modification, protein turnover, chaperones	1	1109	9.017132551848512e-4
OG0000008	COG4106	Trans-aconitate methyltransferase	Tam	C	Energy production and conversion	2	1109	0.0018034265103697023
OG0000008	COG4123	tRNA1(Val) A37 N6-methylase TrmN6	TrmN6	J	Translation, ribosomal structure and biogenesis	1	1109	9.017132551848512e-4
OG0000008	COG4976	Predicted methyltransferase, contains TPR repeat	NA	R	General function prediction only	8	1109	0.007213706041478809
OG0000009	COG0604	NADPH:quinone reductase or related Zn-dependent oxidoreductase	Qor	C	Energy production and conversion	555	1053	0.5270655270655271
OG0000009	COG1062	Zn-dependent alcohol/formaldehyde dehydrogenase	FrmA	C	Energy production and conversion	23	1053	0.02184235517568851
OG0000009	COG1063	Threonine dehydrogenase or related Zn-dependent dehydrogenase	Tdh	E	Amino acid transport and metabolism	191	1053	0.18138651471984804
OG0000009	COG1064	D-arabinose 1-dehydrogenase, Zn-dependent alcohol dehydrogenase family	AdhP	G	Carbohydrate transport and metabolism	193	1053	0.18328584995251662
OG0000009	COG2130	NADPH-dependent curcumin reductase CurA	CurA	Q	Secondary metabolites biosynthesis, transport and catabolism	90	1053	0.08547008547008547
OG0000010	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	1016	1049	0.9685414680648237
OG0000010	COG1922	UDP-N-acetyl-D-mannosaminuronic acid transferase, WecB/TagA/CpsF family	WecG	M	Cell wall/membrane/envelope biogenesis	1	1049	9.532888465204957e-4
OG0000011	COG0111	Phosphoglycerate dehydrogenase or related dehydrogenase	SerA	H	Coenzyme transport and metabolism	1001	1043	0.959731543624161
OG0000011	COG1052	Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase	LdhA	C	Energy production and conversion	41	1043	0.039309683604985615
OG0000012	COG0119	Isopropylmalate/homocitrate/citramalate synthases	LeuA	E	Amino acid transport and metabolism	1001	1002	0.999001996007984
OG0000013	COG0673	Predicted dehydrogenase	MviM	R	General function prediction only	948	986	0.9614604462474645
OG0000013	COG1063	Threonine dehydrogenase or related Zn-dependent dehydrogenase	Tdh	E	Amino acid transport and metabolism	1	986	0.0010141987829614604
OG0000013	COG1086	NDP-sugar epimerase, includes UDP-N-acetylglucosamine 4,6-dehydratase EpsC	EpsC	M	Cell wall/membrane/envelope biogenesis	2	986	0.002028397565922921
OG0000013	COG1648	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)	CysG2	H	Coenzyme transport and metabolism	1	986	0.0010141987829614604
OG0000014	COG0028	Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme	IlvB	E	Amino acid transport and metabolism	693	982	0.7057026476578412
OG0000014	COG3962	TPP-dependent trihydroxycyclohexane-1,2-dione (THcHDO) dehydratase, myo-inositol metabolism	IolD	G	Carbohydrate transport and metabolism	284	982	0.2892057026476578
OG0000015	COG5470	Uncharacterized conserved protein, DUF1330 family	NA	S	Function unknown	965	965	1
OG0000016	COG1175	ABC-type sugar transport system, permease component	UgpA	G	Carbohydrate transport and metabolism	959	959	1
OG0000017	COG0600	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component	TauC	P	Inorganic ion transport and metabolism	4	956	0.0041841004184100415
OG0000017	COG1174	ABC-type proline/glycine betaine transport system, permease component	OpuBB	E	Amino acid transport and metabolism	2	956	0.0020920502092050207
OG0000017	COG4176	ABC-type proline/glycine betaine transport system, permease component	ProW	E	Amino acid transport and metabolism	950	956	0.9937238493723849
OG0000018	COG0034	Glutamine phosphoribosylpyrophosphate amidotransferase	PurF	F	Nucleotide transport and metabolism	351	939	0.3738019169329074
OG0000018	COG0367	Asparagine synthetase B (glutamine-hydrolyzing)	AsnB	E	Amino acid transport and metabolism	1	939	0.0010649627263045794
OG0000018	COG0449	Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains	GlmS	M	Cell wall/membrane/envelope biogenesis	584	939	0.6219382321618744
OG0000019	COG0472	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase/archaeal AglH	Rfe	M	Cell wall/membrane/envelope biogenesis	860	868	0.9907834101382489
OG0000020	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	641	843	0.7603795966785291
OG0000020	COG1088	dTDP-D-glucose 4,6-dehydratase	RfbB	M	Cell wall/membrane/envelope biogenesis	196	843	0.232502965599051
OG0000020	COG1091	dTDP-4-dehydrorhamnose reductase	RfbD	M	Cell wall/membrane/envelope biogenesis	4	843	0.004744958481613286
OG0000021	COG0410	ABC-type branched-chain amino acid transport system, ATPase component LivF	LivF	E	Amino acid transport and metabolism	1	833	0.0012004801920768306
OG0000021	COG0559	Branched-chain amino acid ABC-type transport system, permease component	LivH	E	Amino acid transport and metabolism	411	833	0.49339735894357745
OG0000021	COG1172	Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component	AraH	G	Carbohydrate transport and metabolism	421	833	0.5054021608643458
OG0000022	COG0404	Glycine cleavage system protein T (aminomethyltransferase)	GcvT	E	Amino acid transport and metabolism	825	833	0.9903961584633854
OG0000022	COG0492	Thioredoxin reductase	TrxB	O	Posttranslational modification, protein turnover, chaperones	4	833	0.004801920768307323
OG0000022	COG1148	Heterodisulfide reductase, subunit A (polyferredoxin)	HdrA	C	Energy production and conversion	2	833	0.0024009603841536613
OG0000023	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	125	831	0.15042117930204574
OG0000023	COG1086	NDP-sugar epimerase, includes UDP-N-acetylglucosamine 4,6-dehydratase EpsC	EpsC	M	Cell wall/membrane/envelope biogenesis	1	831	0.0012033694344163659
OG0000023	COG1087	UDP-glucose 4-epimerase	GalE	M	Cell wall/membrane/envelope biogenesis	183	831	0.22021660649819494
OG0000023	COG1088	dTDP-D-glucose 4,6-dehydratase	RfbB	M	Cell wall/membrane/envelope biogenesis	5	831	0.006016847172081829
OG0000023	COG1089	GDP-D-mannose dehydratase	Gmd	M	Cell wall/membrane/envelope biogenesis	498	831	0.5992779783393501
OG0000024	COG4311	Sarcosine oxidase delta subunit	SoxD	E	Amino acid transport and metabolism	815	815	1
OG0000025	COG0111	Phosphoglycerate dehydrogenase or related dehydrogenase	SerA	H	Coenzyme transport and metabolism	166	804	0.2064676616915423
OG0000025	COG1052	Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase	LdhA	C	Energy production and conversion	634	804	0.7885572139303483
OG0000026	COG2055	Malate/lactate/ureidoglycolate dehydrogenase, LDH2 family	AllD	C	Energy production and conversion	801	803	0.9975093399750934
OG0000027	COG0004	Ammonia channel protein AmtB	AmtB	P	Inorganic ion transport and metabolism	798	800	0.9975
OG0000027	COG2208	Phosphoserine phosphatase RsbU, regulator of sigma subunit	RsbU	T	Signal transduction mechanisms	2	800	0.0025
OG0000028	COG0275	16S rRNA C1402 N4-methylase RsmH	RmsH	J	Translation, ribosomal structure and biogenesis	1	786	0.001272264631043257
OG0000028	COG0293	23S rRNA U2552 or 16S rRNA-U1369 or eukaryotic tRNA-C32/G34 (ribose-2'-O)-methylase RlmE/FtsJ/TRM7	RlmE	J	Translation, ribosomal structure and biogenesis	1	786	0.001272264631043257
OG0000028	COG0500	SAM-dependent methyltransferase SmtA (CmoB moved to COG2228)	SmtA	Q	Secondary metabolites biosynthesis, transport and catabolism	8	786	0.010178117048346057
OG0000028	COG0526	Thiol-disulfide isomerase or thioredoxin	TrxA	O	Posttranslational modification, protein turnover, chaperones	3	786	0.003816793893129771
OG0000028	COG1221	Transcriptional regulators containing sigma54-interacting ATPase domain	PspF	K	Transcription	1	786	0.001272264631043257
OG0000028	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9	UbiE	H	Coenzyme transport and metabolism	10	786	0.01272264631043257
OG0000028	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	13	786	0.01653944020356234
OG0000028	COG2890	Methylase of polypeptide chain release factors	HemK	J	Translation, ribosomal structure and biogenesis	1	786	0.001272264631043257
OG0000028	COG2956	Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain	LapB	M	Cell wall/membrane/envelope biogenesis	1	786	0.001272264631043257
OG0000028	COG3510	Rhamnose/hydroxycephalosporin O-methyltransferase, CmcI/Rv2959c family	CmcI	M	Cell wall/membrane/envelope biogenesis	1	786	0.001272264631043257
OG0000028	COG4106	Trans-aconitate methyltransferase	Tam	C	Energy production and conversion	1	786	0.001272264631043257
OG0000028	COG4122	tRNA 5-hydroxyU34 O-methylase TrmR/YrrM	TrmR	J	Translation, ribosomal structure and biogenesis	363	786	0.4618320610687023
OG0000028	COG4974	Site-specific tyrosine recombinase XerD	XerD	L	Replication, recombination and repair	1	786	0.001272264631043257
OG0000029	COG0174	Glutamine synthetase	GlnA	E	Amino acid transport and metabolism	782	784	0.9974489795918368
OG0000030	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	14	781	0.01792573623559539
OG0000030	COG0702	Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains	YbjT	R	General function prediction only	743	781	0.9513444302176697
OG0000030	COG1091	dTDP-4-dehydrorhamnose reductase	RfbD	M	Cell wall/membrane/envelope biogenesis	4	781	0.005121638924455826
OG0000031	COG0677	UDP-N-acetyl-D-mannosaminuronate dehydrogenase	WecC	M	Cell wall/membrane/envelope biogenesis	210	775	0.2709677419354839
OG0000031	COG1004	UDP-glucose 6-dehydrogenase	Ugd	M	Cell wall/membrane/envelope biogenesis	564	775	0.727741935483871
OG0000031	COG2084	3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase	MmsB	I	Lipid transport and metabolism	1	775	0.0012903225806451613
OG0000032	COG0500	SAM-dependent methyltransferase SmtA (CmoB moved to COG2228)	SmtA	Q	Secondary metabolites biosynthesis, transport and catabolism	8	773	0.01034928848641656
OG0000032	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9	UbiE	H	Coenzyme transport and metabolism	738	773	0.9547218628719275
OG0000032	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	23	773	0.029754204398447608
OG0000032	COG4627	Predicted SAM-depedendent methyltransferase	NA	R	General function prediction only	1	773	0.00129366106080207
OG0000033	COG3090	TRAP-type C4-dicarboxylate transport system, small permease component YiaM	DctM	G	Carbohydrate transport and metabolism	7	743	0.009421265141318977
OG0000033	COG4665	TRAP-type mannitol/chloroaromatic compound transport system, small permease component	FcbT2	Q	Secondary metabolites biosynthesis, transport and catabolism	735	743	0.9892328398384926
OG0000034	COG0436	Aspartate/methionine/tyrosine aminotransferase	AspB	E	Amino acid transport and metabolism	736	738	0.997289972899729
OG0000035	COG0223	Methionyl-tRNA formyltransferase	Fmt	J	Translation, ribosomal structure and biogenesis	216	738	0.2926829268292683
OG0000035	COG0299	Folate-dependent phosphoribosylglycinamide formyltransferase PurN	PurN	F	Nucleotide transport and metabolism	512	738	0.6937669376693767
OG0000035	COG1208	NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis protein s	GCD1	J	Translation, ribosomal structure and biogenesis	1	738	0.0013550135501355014
OG0000036	COG0524	Sugar or nucleoside kinase, ribokinase family	RbsK	G	Carbohydrate transport and metabolism	733	734	0.9986376021798365
OG0000037	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	425	729	0.5829903978052127
OG0000037	COG0662	Mannose-6-phosphate isomerase, cupin superfamily	ManC	G	Carbohydrate transport and metabolism	1	729	0.0013717421124828531
OG0000037	COG1087	UDP-glucose 4-epimerase	GalE	M	Cell wall/membrane/envelope biogenesis	6	729	0.00823045267489712
OG0000037	COG1088	dTDP-D-glucose 4,6-dehydratase	RfbB	M	Cell wall/membrane/envelope biogenesis	1	729	0.0013717421124828531
OG0000037	COG1091	dTDP-4-dehydrorhamnose reductase	RfbD	M	Cell wall/membrane/envelope biogenesis	256	729	0.3511659807956104
OG0000037	COG2910	Putative NADH-flavin reductase	YwnB	R	General function prediction only	1	729	0.0013717421124828531
OG0000038	COG0516	IMP dehydrogenase/GMP reductase	GuaB	F	Nucleotide transport and metabolism	689	723	0.9529737206085753
OG0000038	COG2070	NAD(P)H-dependent flavin oxidoreductase YrpB, nitropropane dioxygenase family	YrpB	R	General function prediction only	32	723	0.04426002766251729
OG0000039	COG0667	Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family	PdxI	H	Coenzyme transport and metabolism	721	721	1
OG0000040	COG0473	Isocitrate/isopropylmalate dehydrogenase	LeuB	C	Energy production and conversion	721	721	1
OG0000041	COG0022	Pyruvate/2-oxoglutarate/acetoin dehydrogenase complex, dehydrogenase (E1) component, beta subunit	AcoB	C	Energy production and conversion	48	710	0.0676056338028169
OG0000041	COG1154	Deoxyxylulose-5-phosphate synthase	Dxs	H	Coenzyme transport and metabolism	489	710	0.6887323943661972
OG0000041	COG3958	Transketolase, C-terminal subunit	TktA2	G	Carbohydrate transport and metabolism	136	710	0.19154929577464788
OG0000041	COG4972	Type II secretion system/type IV pilus alignment protein GspL/PulL/PilM	GspL/PilM	N	Cell motility	1	710	0.0014084507042253522
OG0000042	COG2076	Multidrug transporter EmrE and related cation transporters	EmrE	V	Defense mechanisms	705	706	0.9985835694050992
OG0000043	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	690	695	0.9928057553956835
OG0000044	COG1995	4-hydroxy-L-threonine phosphate dehydrogenase PdxA	PdxA	H	Coenzyme transport and metabolism	690	695	0.9928057553956835
OG0000045	COG0532	Translation initiation factor IF-2, a GTPase	InfB	J	Translation, ribosomal structure and biogenesis	1	687	0.001455604075691412
OG0000045	COG1423	ATP-dependent RNA circularization protein, DNA/RNA ligase (PAB1020)  family	NA	L	Replication, recombination and repair	1	687	0.001455604075691412
OG0000045	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9	UbiE	H	Coenzyme transport and metabolism	3	687	0.004366812227074236
OG0000045	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	9	687	0.013100436681222707
OG0000045	COG2242	Precorrin-6Y C5,15-methylase subunit CbiT	CbiT	H	Coenzyme transport and metabolism	5	687	0.00727802037845706
OG0000045	COG2265	tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family	TrmA	J	Translation, ribosomal structure and biogenesis	4	687	0.005822416302765648
OG0000045	COG2519	tRNA A57/A58 N1-methylase Trm61	Gcd14	J	Translation, ribosomal structure and biogenesis	4	687	0.005822416302765648
OG0000045	COG2520	tRNA G37 N1-methylase Trm5	Trm5	J	Translation, ribosomal structure and biogenesis	15	687	0.021834061135371178
OG0000045	COG2813	16S rRNA G1207 or 23S rRNA G1835 methylase RsmC/RlmG	RsmC	J	Translation, ribosomal structure and biogenesis	6	687	0.008733624454148471
OG0000045	COG3434	c-di-GMP phosphodiesterase YuxH/PdeH, contains EAL and HDOD domains	YuxH	T	Signal transduction mechanisms	2	687	0.002911208151382824
OG0000045	COG4076	Predicted RNA methylase	NA	R	General function prediction only	12	687	0.017467248908296942
OG0000045	COG4106	Trans-aconitate methyltransferase	Tam	C	Energy production and conversion	12	687	0.017467248908296942
OG0000045	COG4123	tRNA1(Val) A37 N6-methylase TrmN6	TrmN6	J	Translation, ribosomal structure and biogenesis	26	687	0.03784570596797671
OG0000046	COG0300	Short-chain dehydrogenase	YqjQ	R	General function prediction only	1	686	0.0014577259475218659
OG0000046	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	FabG	I	Lipid transport and metabolism	682	686	0.9941690962099126
OG0000046	COG4221	NADP-dependent 3-hydroxy acid dehydrogenase YdfG	YdfG	C	Energy production and conversion	1	686	0.0014577259475218659
OG0000047	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	AdhE	I	Lipid transport and metabolism	681	681	1
OG0000048	COG0031	Cysteine synthase	CysK	E	Amino acid transport and metabolism	4	681	0.005873715124816446
OG0000048	COG0457	Tetratricopeptide (TPR) repeat	TPR	R	General function prediction only	13	681	0.01908957415565345
OG0000048	COG1917	Cupin domain protein related to quercetin dioxygenase	QdoI	R	General function prediction only	2	681	0.002936857562408223
OG0000048	COG3181	Tripartite-type tricarboxylate transporter, extracytoplasmic receptor component TctC	TctC	C	Energy production and conversion	7	681	0.010279001468428781
OG0000048	COG5285	Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family	PhyH	Q	Secondary metabolites biosynthesis, transport and catabolism	91	681	0.13362701908957417
OG0000049	COG0243	Anaerobic selenocysteine-containing dehydrogenase	BisC	C	Energy production and conversion	3	680	0.004411764705882353
OG0000049	COG1034	NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G)	NuoG	C	Energy production and conversion	484	680	0.711764705882353
OG0000049	COG3383	Mo-containing formate dehydrogenase ForCE, catalytic subunit	ForC	C	Energy production and conversion	188	680	0.27647058823529413
OG0000050	COG1894	NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit (chain F)	NuoF	C	Energy production and conversion	679	680	0.9985294117647059
OG0000050	COG1905	NADH:ubiquinone oxidoreductase 24 kD subunit (chain E)	NuoE	C	Energy production and conversion	1	680	0.0014705882352941176
OG0000051	COG0596	2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH/undecaprenyl monophosphate-sugar esterase UshA/YqjL	MenH	H	Coenzyme transport and metabolism	677	678	0.9985250737463127
OG0000052	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component	DctQ	G	Carbohydrate transport and metabolism	672	675	0.9955555555555555
OG0000052	COG4664	TRAP-type mannitol/chloroaromatic compound transport system, large permease component	FcbT3	Q	Secondary metabolites biosynthesis, transport and catabolism	1	675	0.0014814814814814814
OG0000053	COG0607	Rhodanese-related sulfurtransferase	PspE	P	Inorganic ion transport and metabolism	675	675	1
OG0000054	COG2303	Choline dehydrogenase or related flavoprotein	BetA	I	Lipid transport and metabolism	674	675	0.9985185185185185
OG0000055	COG0001	Glutamate-1-semialdehyde aminotransferase	HemL	H	Coenzyme transport and metabolism	106	672	0.15773809523809523
OG0000055	COG0160	Acetylornithine aminotransferase/4-aminobutyrate aminotransferase/amino acid racemase	ArgD	E	Amino acid transport and metabolism	16	672	0.023809523809523808
OG0000055	COG1861	Spore coat polysaccharide biosynthesis protein SpsF, cytidylyltransferase family	SpsF	M	Cell wall/membrane/envelope biogenesis	30	672	0.044642857142857144
OG0000055	COG4992	Acetylornithine/succinyldiaminopimelate/putrescine aminotransferase	ArgD	E	Amino acid transport and metabolism	519	672	0.7723214285714286
OG0000056	COG0488	ABC cassette proteins with duplicated ATPase domains, Uup/ABCF family	Uup	J	Translation, ribosomal structure and biogenesis	1	672	0.001488095238095238
OG0000056	COG1082	Sugar phosphate isomerase/epimerase	YcjR	G	Carbohydrate transport and metabolism	1	672	0.001488095238095238
OG0000056	COG1861	Spore coat polysaccharide biosynthesis protein SpsF, cytidylyltransferase family	SpsF	M	Cell wall/membrane/envelope biogenesis	3	672	0.004464285714285714
OG0000056	COG2089	Sialic acid synthase SpsE, contains C-terminal SAF domain	SpsE	M	Cell wall/membrane/envelope biogenesis	658	672	0.9791666666666666
OG0000057	COG5285	Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family	PhyH	Q	Secondary metabolites biosynthesis, transport and catabolism	661	667	0.9910044977511244
OG0000058	COG0106	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase	HisA	E	Amino acid transport and metabolism	514	664	0.7740963855421686
OG0000058	COG0107	Imidazole glycerol phosphate synthase subunit HisF	HisF	E	Amino acid transport and metabolism	150	664	0.22590361445783133
OG0000059	COG0673	Predicted dehydrogenase	MviM	R	General function prediction only	656	663	0.9894419306184012
OG0000060	COG0118	Imidazoleglycerol phosphate synthase glutamine amidotransferase subunit HisH	HisH	E	Amino acid transport and metabolism	662	663	0.9984917043740573
OG0000060	COG2071	Gamma-glutamyl-gamma-aminobutyrate hydrolase PuuD (putrescine degradation), contains GATase1-like domain	PuuD	E	Amino acid transport and metabolism	1	663	0.0015082956259426848
OG0000061	COG0447	1,4-Dihydroxy-2-naphthoyl-CoA synthase	MenB	H	Coenzyme transport and metabolism	20	650	0.03076923076923077
OG0000061	COG1024	Enoyl-CoA hydratase/carnithine racemase	CaiD	I	Lipid transport and metabolism	630	650	0.9692307692307692
OG0000062	COG1083	CMP-N-acetylneuraminic acid synthetase, NeuA/PseF family	NeuA	M	Cell wall/membrane/envelope biogenesis	3	647	0.00463678516228748
OG0000062	COG1212	CMP-2-keto-3-deoxyoctulosonic acid synthetase	KdsB	M	Cell wall/membrane/envelope biogenesis	622	647	0.9613601236476044
OG0000062	COG1861	Spore coat polysaccharide biosynthesis protein SpsF, cytidylyltransferase family	SpsF	M	Cell wall/membrane/envelope biogenesis	21	647	0.03245749613601236
OG0000063	COG0129	Dihydroxyacid dehydratase/phosphogluconate dehydratase	IlvD	E	Amino acid transport and metabolism	647	647	1
OG0000064	COG0154	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase	GatA	J	Translation, ribosomal structure and biogenesis	639	642	0.9953271028037384
OG0000065	COG0410	ABC-type branched-chain amino acid transport system, ATPase component LivF	LivF	E	Amino acid transport and metabolism	612	642	0.9532710280373832
OG0000065	COG1137	ABC-type lipopolysaccharide export system, ATPase component	LptB	M	Cell wall/membrane/envelope biogenesis	30	642	0.04672897196261682
OG0000066	COG0697	Amino acid export permease, drug/metabolite transporter (DMT) superfamily	EamA	E	Amino acid transport and metabolism	639	641	0.9968798751950078
OG0000066	COG2510	Riboflavin transporter RibN, EamA domain	RibN	H	Coenzyme transport and metabolism	1	641	0.0015600624024961
OG0000067	COG0265	Periplasmic serine protease DegP/DegQ, contain C-terminal PDZ domain	DegQ	O	Posttranslational modification, protein turnover, chaperones	628	636	0.9874213836477987
OG0000067	COG4642	Uncharacterized conserved protein, contains MORN repeats	NA	R	General function prediction only	3	636	0.0047169811320754715
OG0000068	COG3333	TctA family transporter	NA	R	General function prediction only	633	633	1
OG0000069	COG0021	Transketolase	TktA	G	Carbohydrate transport and metabolism	511	627	0.8149920255183413
OG0000069	COG1154	Deoxyxylulose-5-phosphate synthase	Dxs	H	Coenzyme transport and metabolism	1	627	0.001594896331738437
OG0000069	COG3959	Transketolase, N-terminal subunit	TktA1	G	Carbohydrate transport and metabolism	114	627	0.18181818181818182
OG0000070	COG2319	WD40 repeat	WD40	R	General function prediction only	2	627	0.003189792663476874
OG0000070	COG3210	Large exoprotein involved in heme utilization or adhesion	FhaB	U	Intracellular trafficking, secretion, and vesicular transport	69	627	0.11004784688995216
OG0000070	COG3391	DNA-binding beta-propeller fold protein YncE	YncE	R	General function prediction only	31	627	0.049441786283891544
OG0000070	COG3468	Autotransporter adhesin AidA	AidA	M	Cell wall/membrane/envelope biogenesis	2	627	0.003189792663476874
OG0000070	COG4625	Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain	NA	S	Function unknown	475	627	0.7575757575757576
OG0000070	COG4946	Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats	NA	S	Function unknown	1	627	0.001594896331738437
OG0000070	COG5571	Secreted esterase EstA, contains T5SS autotransporter beta-barrel domain	EstA	U	Intracellular trafficking, secretion, and vesicular transport	26	627	0.04146730462519936
OG0000071	COG0643	Chemotaxis protein histidine kinase CheA	CheA	T	Signal transduction mechanisms	1	622	0.001607717041800643
OG0000071	COG1024	Enoyl-CoA hydratase/carnithine racemase	CaiD	I	Lipid transport and metabolism	6	622	0.00964630225080386
OG0000071	COG1250	3-hydroxyacyl-CoA dehydrogenase	FadB	I	Lipid transport and metabolism	611	622	0.9823151125401929
OG0000072	COG1638	TRAP-type C4-dicarboxylate transport system, periplasmic component	DctP	G	Carbohydrate transport and metabolism	158	620	0.25483870967741934
OG0000072	COG4663	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component	FcbT1	Q	Secondary metabolites biosynthesis, transport and catabolism	460	620	0.7419354838709677
OG0000073	COG0413	Ketopantoate hydroxymethyltransferase	PanB	H	Coenzyme transport and metabolism	618	618	1
OG0000074	COG0318	O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming)	MenE	I	Lipid transport and metabolism	612	617	0.9918962722852512
OG0000074	COG1020	EntF, seryl-AMP synthase component  of non-ribosomal peptide synthetase	EntF	Q	Secondary metabolites biosynthesis, transport and catabolism	4	617	0.006482982171799027
OG0000075	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	556	614	0.9055374592833876
OG0000075	COG1088	dTDP-D-glucose 4,6-dehydratase	RfbB	M	Cell wall/membrane/envelope biogenesis	57	614	0.09283387622149837
OG0000076	COG1280	Threonine/homoserine/homoserine lactone efflux protein	RhtB	E	Amino acid transport and metabolism	607	609	0.9967159277504105
OG0000077	COG1775	Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB	HgdB	E	Amino acid transport and metabolism	4	608	0.006578947368421052
OG0000077	COG4424	LPS sulfotransferase NodH	LpsS	M	Cell wall/membrane/envelope biogenesis	1	608	0.001644736842105263
OG0000077	COG5891	Spore coat protein YheC/YheD, ATP-grasp superfamily	YheC	D	Cell cycle control, cell division, chromosome partitioning	3	608	0.004934210526315789
OG0000078	COG1454	Alcohol dehydrogenase, class IV	EutG	C	Energy production and conversion	601	605	0.9933884297520661
OG0000078	COG2907	Predicted flavin-containing amine oxidase	Ppro0129	R	General function prediction only	1	605	0.001652892561983471
OG0000079	COG0247	Fe-S cluster-containing oxidoreductase, includes glycolate oxidase subunit GlcF	GlpC	C	Energy production and conversion	2	605	0.003305785123966942
OG0000079	COG0277	FAD/FMN-containing lactate dehydrogenase/glycolate oxidase	GlcD	C	Energy production and conversion	603	605	0.996694214876033
OG0000080	COG0404	Glycine cleavage system protein T (aminomethyltransferase)	GcvT	E	Amino acid transport and metabolism	594	599	0.991652754590985
OG0000080	COG0665	Glycine/D-amino acid oxidase (deaminating)	DadA	E	Amino acid transport and metabolism	5	599	0.008347245409015025
OG0000081	COG0115	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase	IlvE	E	Amino acid transport and metabolism	598	598	1
OG0000082	COG0697	Amino acid export permease, drug/metabolite transporter (DMT) superfamily	EamA	E	Amino acid transport and metabolism	595	595	1
OG0000083	COG0486	tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE	MnmE	J	Translation, ribosomal structure and biogenesis	502	591	0.8494077834179357
OG0000083	COG1159	GTPase Era, involved in 16S rRNA processing	Era	J	Translation, ribosomal structure and biogenesis	46	591	0.077834179357022
OG0000083	COG1160	Double Era-like domain GTPase Der	Der	J	Translation, ribosomal structure and biogenesis	43	591	0.0727580372250423
OG0000084	COG0664	cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases	Crp	T	Signal transduction mechanisms	4	591	0.00676818950930626
OG0000084	COG1221	Transcriptional regulators containing sigma54-interacting ATPase domain	PspF	K	Transcription	2	591	0.00338409475465313
OG0000084	COG1321	Mn-dependent transcriptional regulator MntR, DtxR family	MntR	K	Transcription	6	591	0.01015228426395939
OG0000084	COG1349	DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family	GlpR	K	Transcription	52	591	0.08798646362098139
OG0000084	COG1378	Sugar-specific transcriptional regulator TrmB	YrhO	K	Transcription	5	591	0.008460236886632826
OG0000084	COG1414	DNA-binding transcriptional regulator, IclR family	IclR	K	Transcription	47	591	0.07952622673434856
OG0000084	COG1522	DNA-binding transcriptional regulator, Lrp family	Lrp	K	Transcription	32	591	0.05414551607445008
OG0000084	COG1580	Flagellar basal body-associated protein FliL	FliL	N	Cell motility	3	591	0.005076142131979695
OG0000084	COG1846	DNA-binding transcriptional regulator, MarR family	MarR	K	Transcription	1	591	0.001692047377326565
OG0000084	COG2512	Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain	NA	R	General function prediction only	48	591	0.08121827411167512
OG0000084	COG3177	Fic family protein	NA	K	Transcription	4	591	0.00676818950930626
OG0000084	COG3355	Transcriptional regulator of archaellar biosynthesis and archaeal biofilm formation AfbR	AbfR1	K	Transcription	49	591	0.0829103214890017
OG0000084	COG4189	Predicted transcriptional regulator, ArsR family	NA	K	Transcription	2	591	0.00338409475465313
OG0000084	COG4648	Uncharacterized membrane protein	NA	S	Function unknown	5	591	0.008460236886632826
OG0000084	COG4742	Transcriptional regulator of archaellar expression ArnR	ArnR	K	Transcription	3	591	0.005076142131979695
OG0000085	COG0028	Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme	IlvB	E	Amino acid transport and metabolism	1	590	0.001694915254237288
OG0000085	COG2721	Altronate dehydratase	UxaA	G	Carbohydrate transport and metabolism	589	590	0.9983050847457627
OG0000086	COG1638	TRAP-type C4-dicarboxylate transport system, periplasmic component	DctP	G	Carbohydrate transport and metabolism	589	589	1
OG0000087	COG0235	5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation)	AraD	E	Amino acid transport and metabolism	585	587	0.9965928449744463
OG0000088	COG0726	Peptidoglycan/xylan/chitin deacetylase, PgdA/NodB/CDA1 family	PgaB	G	Carbohydrate transport and metabolism	577	586	0.984641638225256
OG0000088	COG1506	Dipeptidyl aminopeptidase/acylaminoacyl peptidase	DAP2	E	Amino acid transport and metabolism	1	586	0.0017064846416382253
OG0000089	COG0730	Sulfite exporter TauE/SafE/YfcA and related permeases, UPF0721 family	TauE	P	Inorganic ion transport and metabolism	580	581	0.9982788296041308
OG0000090	COG0074	Succinyl-CoA synthetase, alpha subunit	SucD	C	Energy production and conversion	579	580	0.9982758620689656
OG0000090	COG0673	Predicted dehydrogenase	MviM	R	General function prediction only	1	580	0.0017241379310344827
OG0000091	COG0306	Phosphate/sulfate permease	PitA	P	Inorganic ion transport and metabolism	5	578	0.00865051903114187
OG0000091	COG0612	Predicted Zn-dependent peptidase, M16 family	PqqL	R	General function prediction only	61	578	0.10553633217993079
OG0000091	COG0744	Penicillin-binding protein 1B/1F, peptidoglycan  transglycosylase/transpeptidase	MrcB	M	Cell wall/membrane/envelope biogenesis	3	578	0.005190311418685121
OG0000091	COG1368	Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily	MdoB	M	Cell wall/membrane/envelope biogenesis	1	578	0.0017301038062283738
OG0000091	COG1566	Multidrug resistance efflux pump EmrA	EmrA	V	Defense mechanisms	4	578	0.006920415224913495
OG0000091	COG3206	Tyrosine-protein kinase Wzc involved in exopolysaccharide export, GumC/Wzc1 domain	GumC	M	Cell wall/membrane/envelope biogenesis	3	578	0.005190311418685121
OG0000091	COG3462	Uncharacterized protein, contains short C-terminal (SHOCT) domain	TM0315	S	Function unknown	4	578	0.006920415224913495
OG0000091	COG3469	Chitinase	Chi1	G	Carbohydrate transport and metabolism	1	578	0.0017301038062283738
OG0000091	COG3883	Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO	CwlO1	S	Function unknown	2	578	0.0034602076124567475
OG0000091	COG4766	Ethanolamine utilization protein EutQ, cupin superfamily (function unknown)	EutQ	E	Amino acid transport and metabolism	1	578	0.0017301038062283738
OG0000091	COG4961	Flp/Tad pilus assembly protein TadE/TadG (TadG includes C-terminal von Willebrand factor A (vWFA) domain)	TadE/TadG	W	Extracellular structures	2	578	0.0034602076124567475
OG0000092	COG0045	Succinyl-CoA synthetase, beta subunit	SucC	C	Energy production and conversion	577	577	1
OG0000093	COG0399	dTDP-4-amino-4,6-dideoxygalactose transaminase	WecE	M	Cell wall/membrane/envelope biogenesis	558	574	0.9721254355400697
OG0000093	COG1670	Protein N-acetyltransferase, RimJ/RimL family	RimL	J	Translation, ribosomal structure and biogenesis	1	574	0.0017421602787456446
OG0000094	COG0436	Aspartate/methionine/tyrosine aminotransferase	AspB	E	Amino acid transport and metabolism	570	570	1
OG0000095	COG0494	8-oxo-dGTP pyrophosphatase MutT and related house-cleaning NTP pyrophosphohydrolases, NUDIX family	MutT	V	Defense mechanisms	511	569	0.8980667838312829
OG0000095	COG1051	ADP-ribose pyrophosphatase YjhB, NUDIX family	YjhB	F	Nucleotide transport and metabolism	57	569	0.10017574692442882
OG0000096	COG0626	Cystathionine beta-lyase/cystathionine gamma-synthase	MetC	E	Amino acid transport and metabolism	32	568	0.056338028169014086
OG0000096	COG2873	O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent	MET17	E	Amino acid transport and metabolism	536	568	0.9436619718309859
OG0000097	COG0404	Glycine cleavage system protein T (aminomethyltransferase)	GcvT	E	Amino acid transport and metabolism	563	565	0.9964601769911504
OG0000098	COG0245	2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	IspF	I	Lipid transport and metabolism	462	564	0.8191489361702128
OG0000098	COG1207	Bifunctional protein GlmU, N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase	GlmU	M	Cell wall/membrane/envelope biogenesis	2	564	0.0035460992907801418
OG0000098	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	IspD	I	Lipid transport and metabolism	15	564	0.026595744680851064
OG0000098	COG1213	Choline kinase	NA	I	Lipid transport and metabolism	8	564	0.014184397163120567
OG0000098	COG2068	CTP:molybdopterin cytidylyltransferase MocA	MocA	H	Coenzyme transport and metabolism	70	564	0.12411347517730496
OG0000099	COG0183	Acetyl-CoA acetyltransferase	PaaJ	I	Lipid transport and metabolism	563	563	1
OG0000100	COG0583	DNA-binding transcriptional regulator, LysR family	LysR	K	Transcription	563	563	1
OG0000101	COG0765	ABC-type amino acid transport system, permease component	HisM	E	Amino acid transport and metabolism	135	562	0.2402135231316726
OG0000101	COG4160	ABC-type arginine/histidine transport system, permease component	ArtM	E	Amino acid transport and metabolism	427	562	0.7597864768683275
OG0000102	COG0225	Peptide methionine sulfoxide reductase MsrA	MsrA	O	Posttranslational modification, protein turnover, chaperones	562	562	1
OG0000103	COG0187	DNA gyrase/topoisomerase IV, subunit B	GyrB	L	Replication, recombination and repair	561	561	1
OG0000104	COG1131	Ribosome-associated ATPase or ATPase component of an ABC-type multidrug transport system	RbbA	J	Translation, ribosomal structure and biogenesis	547	559	0.97853309481216455
OG0000104	COG1132	ABC-type multidrug and LPS transport system, ATPase and permease component MsbA	MdlB	M	Cell wall/membrane/envelope biogenesis	7	559	0.012522361359570662
OG0000104	COG2274	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain	SunT	V	Defense mechanisms	5	559	0.008944543828264758
OG0000105	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	4	559	0.007155635062611807
OG0000105	COG0500	SAM-dependent methyltransferase SmtA (CmoB moved to COG2228)	SmtA	Q	Secondary metabolites biosynthesis, transport and catabolism	4	559	0.007155635062611807
OG0000105	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9	UbiE	H	Coenzyme transport and metabolism	143	559	0.2558139534883721
OG0000105	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	404	559	0.7227191413237924
OG0000105	COG4627	Predicted SAM-depedendent methyltransferase	NA	R	General function prediction only	1	559	0.0017889087656529517
OG0000106	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	FabG	I	Lipid transport and metabolism	557	557	1
OG0000107	COG2223	Nitrate/nitrite transporter NarK	NarK	P	Inorganic ion transport and metabolism	552	557	0.9910233393177738
OG0000107	COG2271	Sugar phosphate permease	UhpC	G	Carbohydrate transport and metabolism	2	557	0.003590664272890485
OG0000107	COG2814	Predicted arabinose efflux permease AraJ, MFS family	AraJ	G	Carbohydrate transport and metabolism	1	557	0.0017953321364452424
OG0000108	COG0028	Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme	IlvB	E	Amino acid transport and metabolism	552	554	0.9963898916967509
OG0000109	COG3842	ABC-type Fe3+/spermidine/putrescine transport systems, ATPase component	PotA	E	Amino acid transport and metabolism	553	553	1
OG0000110	COG1129	ABC-type sugar transport system, ATPase component	MglA	G	Carbohydrate transport and metabolism	427	553	0.7721518987341772
OG0000110	COG3845	ABC-type guanosine uptake system NupNOPQ, ATPase component NupO	NupO	F	Nucleotide transport and metabolism	126	553	0.22784810126582278
OG0000111	COG0842	ABC-type multidrug transport system, permease component	YadH	V	Defense mechanisms	552	552	1
OG0000112	COG1126	ABC-type polar amino acid transport system, ATPase component	GlnQ	E	Amino acid transport and metabolism	551	551	1
OG0000113	COG0608	ssDNA-specific exonuclease RecJ, DHH superfamily, may be involved in archaeal DNA replication intiation	RecJ	L	Replication, recombination and repair	2	551	0.003629764065335753
OG0000113	COG1221	Transcriptional regulators containing sigma54-interacting ATPase domain	PspF	K	Transcription	1	551	0.0018148820326678765
OG0000113	COG4166	ABC-type oligopeptide transport system, periplasmic component	OppA	E	Amino acid transport and metabolism	1	551	0.0018148820326678765
OG0000113	COG5635	Predicted NTPase, NACHT family domain	NACHT	T	Signal transduction mechanisms	1	551	0.0018148820326678765
OG0000114	COG0029	Aspartate oxidase	NadB	H	Coenzyme transport and metabolism	539	551	0.9782214156079855
OG0000114	COG1053	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit	SdhA	C	Energy production and conversion	11	551	0.019963702359346643
OG0000115	COG0300	Short-chain dehydrogenase	YqjQ	R	General function prediction only	538	548	0.9817518248175182
OG0000115	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	FabG	I	Lipid transport and metabolism	3	548	0.005474452554744526
OG0000115	COG4221	NADP-dependent 3-hydroxy acid dehydrogenase YdfG	YdfG	C	Energy production and conversion	4	548	0.0072992700729927005
OG0000116	COG4663	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component	FcbT1	Q	Secondary metabolites biosynthesis, transport and catabolism	547	547	1
OG0000117	COG0520	Selenocysteine lyase/Cysteine desulfurase	CsdA	E	Amino acid transport and metabolism	526	546	0.9633699633699634
OG0000117	COG1104	Cysteine desulfurase/Cysteine sulfinate desulfinase IscS or related enzyme, NifS family	NifS	E	Amino acid transport and metabolism	20	546	0.03663003663003663
OG0000118	COG0424	7-methyl-GTP pyrophosphatase and related NTP pyrophosphatases, Maf/HAM1 superfamily	Maf	Q	Secondary metabolites biosynthesis, transport and catabolism	546	546	1
OG0000119	COG0161	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	BioA	H	Coenzyme transport and metabolism	544	544	1
OG0000120	COG0110	O-acetyltransferase, isoleucine patch superfamily, LacA/YvoF/WbbJ family	WbbJ	R	General function prediction only	89	544	0.1636029411764706
OG0000120	COG0450	Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin)	AhpC	V	Defense mechanisms	1	544	0.001838235294117647
OG0000120	COG0663	Carbonic anhydrase or acetyltransferase, isoleucine patch superfamily	PaaY	R	General function prediction only	1	544	0.001838235294117647
OG0000120	COG1044	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase	LpxD	M	Cell wall/membrane/envelope biogenesis	2	544	0.003676470588235294
OG0000120	COG1045	Serine acetyltransferase	CysE	E	Amino acid transport and metabolism	448	544	0.8235294117647058
OG0000121	COG0841	Multidrug efflux pump subunit AcrB	AcrB	V	Defense mechanisms	544	544	1
OG0000122	COG0349	Ribonuclease D, nanoRNase NrnC or deoxydinuclease (diDNase)	Rnd	A	RNA processing and modification	544	544	1
OG0000123	COG0646	Methionine synthase I (cobalamin-dependent), methyltransferase domain	MetH1	E	Amino acid transport and metabolism	4	543	0.007366482504604052
OG0000123	COG2040	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent)	MHT1	E	Amino acid transport and metabolism	538	543	0.990791896869245
OG0000124	COG1732	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)	OsmF	M	Cell wall/membrane/envelope biogenesis	2	543	0.003683241252302026
OG0000124	COG2113	ABC-type proline/glycine betaine transport system, periplasmic component	ProX	E	Amino acid transport and metabolism	540	543	0.994475138121547
OG0000125	COG0769	UDP-N-acetylmuramyl tripeptide synthase	MurE	M	Cell wall/membrane/envelope biogenesis	466	543	0.858195211786372
OG0000125	COG0770	UDP-N-acetylmuramyl pentapeptide synthase	MurF	M	Cell wall/membrane/envelope biogenesis	76	543	0.13996316758747698
OG0000126	COG1038	Pyruvate carboxylase	PycA	C	Energy production and conversion	1	542	0.0018450184501845018
OG0000126	COG4770	Acetyl/propionyl-CoA carboxylase, alpha subunit	PccA	I	Lipid transport and metabolism	541	542	0.9981549815498155
OG0000127	COG0404	Glycine cleavage system protein T (aminomethyltransferase)	GcvT	E	Amino acid transport and metabolism	541	541	1
OG0000128	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	538	541	0.9944547134935305
OG0000128	COG1807	PMT family glycosyltransferase ArnT/Agl22, involved in glycosylation of proteins and lipid IVA	ArnT	M	Cell wall/membrane/envelope biogenesis	1	541	0.0018484288354898336
OG0000129	COG0188	DNA gyrase/topoisomerase IV, subunit A	GyrA	L	Replication, recombination and repair	541	541	1
OG0000130	COG1033	Predicted exporter protein, RND superfamily	MMPL	R	General function prediction only	1	541	0.0018484288354898336
OG0000130	COG1326	Uncharacterized archaeal Zn-finger protein	NA	R	General function prediction only	42	541	0.07763401109057301
OG0000130	COG1333	Cytochrome c biogenesis protein ResB	ResB	C	Energy production and conversion	1	541	0.0018484288354898336
OG0000130	COG1459	Type II secretion system/type IV pilus membrane platform protein GspF/PulF/PilC	GspF/PilC	N	Cell motility	2	541	0.0036968576709796672
OG0000130	COG1996	DNA-directed RNA polymerase, subunit RPC12/RpoP, contains C4-type Zn-finger	RPC10	K	Transcription	5	541	0.009242144177449169
OG0000130	COG2433	Possible nuclease of RNase H fold, RuvC/YqgF family	NA	R	General function prediction only	1	541	0.0018484288354898336
OG0000130	COG2995	Intermembrane transporter PqiABC subunit PqiA	PqiA	M	Cell wall/membrane/envelope biogenesis	2	541	0.0036968576709796672
OG0000130	COG3883	Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO	CwlO1	S	Function unknown	4	541	0.0073937153419593345
OG0000130	COG4487	Uncharacterized conserved protein, contains DUF2130 domain	NA	S	Function unknown	12	541	0.022181146025878003
OG0000130	COG4942	Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB	EnvC	D	Cell cycle control, cell division, chromosome partitioning	1	541	0.0018484288354898336
OG0000131	COG0450	Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin)	AhpC	V	Defense mechanisms	160	541	0.2957486136783734
OG0000131	COG1225	Peroxiredoxin	Bcp	O	Posttranslational modification, protein turnover, chaperones	380	541	0.7024029574861368
OG0000132	COG0443	Molecular chaperone DnaK (HSP70)	DnaK	O	Posttranslational modification, protein turnover, chaperones	534	538	0.9925650557620818
OG0000133	COG0304	3-oxoacyl-(acyl-carrier-protein) synthase	FabB	I	Lipid transport and metabolism	538	538	1
OG0000134	COG0568	DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32)	RpoD	K	Transcription	537	537	1
OG0000135	COG1622	Heme/copper-type cytochrome/quinol oxidase, subunit 2	CyoA	C	Energy production and conversion	534	535	0.9981308411214953
OG0000136	COG1233	Phytoene dehydrogenase-related protein	NA	Q	Secondary metabolites biosynthesis, transport and catabolism	534	534	1
OG0000137	COG0223	Methionyl-tRNA formyltransferase	Fmt	J	Translation, ribosomal structure and biogenesis	530	533	0.9943714821763602
OG0000138	COG1033	Predicted exporter protein, RND superfamily	MMPL	R	General function prediction only	533	533	1
OG0000139	COG0843	Heme/copper-type cytochrome/quinol oxidase, subunit 1	CyoB	C	Energy production and conversion	533	533	1
OG0000140	COG2021	Homoserine O-acetyltransferase	MET2	E	Amino acid transport and metabolism	531	532	0.9981203007518797
OG0000141	COG0863	DNA modification adenine methylase	YhdJ	L	Replication, recombination and repair	515	531	0.9698681732580038
OG0000141	COG1041	tRNA G10 N-methylase Trm11	Trm11	J	Translation, ribosomal structure and biogenesis	1	531	0.0018832391713747645
OG0000141	COG1743	Adenine-specific DNA methylase, contains a Zn-ribbon domain	NA	L	Replication, recombination and repair	1	531	0.0018832391713747645
OG0000141	COG2189	Adenine specific DNA methylase Mod	Mod	L	Replication, recombination and repair	11	531	0.02071563088512241
OG0000142	COG2050	Acyl-CoA thioesterase PaaI, contains HGG motif	PaaI	Q	Secondary metabolites biosynthesis, transport and catabolism	531	531	1
OG0000143	COG0411	ABC-type branched-chain amino acid transport system, ATPase component LivG	LivG	E	Amino acid transport and metabolism	514	530	0.969811320754717
OG0000143	COG1137	ABC-type lipopolysaccharide export system, ATPase component	LptB	M	Cell wall/membrane/envelope biogenesis	8	530	0.01509433962264151
OG0000143	COG4674	ABC-type uncharacterized transport system, ATPase component	NA	R	General function prediction only	8	530	0.01509433962264151
OG0000144	COG0079	Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase	HisC	E	Amino acid transport and metabolism	527	530	0.9943396226415094
OG0000145	COG0169	Shikimate 5-dehydrogenase	AroE	E	Amino acid transport and metabolism	529	530	0.9981132075471698
OG0000146	COG0194	Guanylate kinase	Gmk	F	Nucleotide transport and metabolism	483	530	0.9113207547169812
OG0000146	COG3709	Ribose 1,5-bisphosphate kinase PhnN	PhnN	G	Carbohydrate transport and metabolism	47	530	0.08867924528301886
OG0000147	COG2236	Hypoxanthine phosphoribosyltransferase	Hpt1	H	Coenzyme transport and metabolism	530	530	1
OG0000148	COG0678	Peroxiredoxin	AHP1	O	Posttranslational modification, protein turnover, chaperones	524	528	0.9924242424242424
OG0000149	COG0558	Phosphatidylglycerophosphate synthase	PgsA	I	Lipid transport and metabolism	528	528	1
OG0000150	COG2885	Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins	OmpA	M	Cell wall/membrane/envelope biogenesis	527	528	0.9981060606060606
OG0000151	COG0372	Citrate synthase	GltA	C	Energy production and conversion	527	527	1
OG0000152	COG0190	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase	FolD	H	Coenzyme transport and metabolism	527	527	1
OG0000153	COG0810	Periplasmic protein TonB, links inner and outer membranes	TonB	M	Cell wall/membrane/envelope biogenesis	381	526	0.7243346007604563
OG0000153	COG1579	Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain	DR0291	R	General function prediction only	1	526	0.0019011406844106464
OG0000154	COG0621	tRNA A37 methylthiotransferase MiaB	MiaB	J	Translation, ribosomal structure and biogenesis	524	526	0.9961977186311787
OG0000155	COG0241	Histidinol phosphatase/D-glycero-mannoheptose bisphosphatephosphatase, HAD superfamily	HisB1/GmhB	E	Amino acid transport and metabolism	6	525	0.011428571428571429
OG0000155	COG0546	Phosphoglycolate phosphatase, HAD superfamily	Gph	C	Energy production and conversion	518	525	0.9866666666666667
OG0000155	COG0637	Beta-phosphoglucomutase, HAD superfamily	YcjU	G	Carbohydrate transport and metabolism	1	525	0.0019047619047619048
OG0000156	COG0398	Uncharacterized membrane protein YdjX, related to fungal oxalate transporter, TVP38/TMEM64 family	TVP38	S	Function unknown	523	525	0.9961904761904762
OG0000157	COG0242	Peptide deformylase	Def	J	Translation, ribosomal structure and biogenesis	525	525	1
OG0000158	COG0123	Acetoin utilization deacetylase AcuC or a related deacetylase	AcuC	Q	Secondary metabolites biosynthesis, transport and catabolism	524	524	1
OG0000159	COG0511	Biotin carboxyl carrier protein	AccB	I	Lipid transport and metabolism	514	524	0.9809160305343512
OG0000159	COG1038	Pyruvate carboxylase	PycA	C	Energy production and conversion	10	524	0.019083969465648856
OG0000160	COG0550	DNA topoisomerase IA	TopA	L	Replication, recombination and repair	505	524	0.9637404580152672
OG0000160	COG1754	Uncharacterized C-terminal domain of topoisomerase IA	NA	S	Function unknown	19	524	0.03625954198473282
OG0000161	COG3474	Cytochrome c2	Cyc7	C	Energy production and conversion	524	524	1
OG0000162	COG0653	Preprotein translocase subunit SecA	SecA	U	Intracellular trafficking, secretion, and vesicular transport	521	524	0.9942748091603053
OG0000163	COG0847	DNA polymerase III, epsilon subunit or related 3'-5' exonuclease	DnaQ	L	Replication, recombination and repair	502	524	0.9580152671755725
OG0000163	COG2176	DNA polymerase III, alpha subunit (gram-positive type)	PolC	L	Replication, recombination and repair	22	524	0.04198473282442748
OG0000164	COG0101	tRNA U38,U39,U40 pseudouridine synthase TruA	TruA	J	Translation, ribosomal structure and biogenesis	524	524	1
OG0000165	COG5342	Invasion protein IalB, involved in pathogenesis	IalB	R	General function prediction only	516	524	0.9847328244274809
OG0000166	COG0318	O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming)	MenE	I	Lipid transport and metabolism	2	523	0.0038240917782026767
OG0000166	COG0365	Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase	Acs	I	Lipid transport and metabolism	521	523	0.9961759082217974
OG0000167	COG0535	Radical SAM superfamily maturase, SkfB/NifB/PqqE family	SkfB	D	Cell cycle control, cell division, chromosome partitioning	280	523	0.5353728489483748
OG0000167	COG0641	Sulfatase maturation enzyme AslB, radical SAM superfamily	AslB	O	Posttranslational modification, protein turnover, chaperones	20	523	0.03824091778202677
OG0000167	COG2896	GTP 3',8-cyclase (molybdenum cofactor biosynthesis protein MoaA)	MoaA	H	Coenzyme transport and metabolism	213	523	0.4072657743785851
OG0000168	COG1845	Heme/copper-type cytochrome/quinol oxidase, subunit 3	CyoC	C	Energy production and conversion	523	523	1
OG0000169	COG3118	Chaperedoxin CnoX, contains thioredoxin-like and TPR-like domains, YbbN/TrxSC family	CnoX	O	Posttranslational modification, protein turnover, chaperones	523	523	1
OG0000170	COG1846	DNA-binding transcriptional regulator, MarR family	MarR	K	Transcription	123	523	0.23518164435946462
OG0000170	COG3888	Predicted transcriptional regulator	NA	K	Transcription	1	523	0.0019120458891013384
OG0000171	COG0353	Recombinational DNA repair protein RecR	RecR	L	Replication, recombination and repair	523	523	1
OG0000172	COG0107	Imidazole glycerol phosphate synthase subunit HisF	HisF	E	Amino acid transport and metabolism	522	522	1
OG0000173	COG0591	Na+/proline symporter	PutP	E	Amino acid transport and metabolism	28	522	0.05363984674329502
OG0000173	COG4147	Na+(or H+)/acetate symporter ActP	ActP	C	Energy production and conversion	494	522	0.946360153256705
OG0000174	COG1403	HNH family endonuclease, includes 5-methylcytosine-specific restriction endonuclease McrA	McrA	V	Defense mechanisms	522	522	1
OG0000175	COG0624	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase	ArgE	E	Amino acid transport and metabolism	522	522	1
OG0000176	COG0458	Carbamoylphosphate synthase large subunit	CarB	E	Amino acid transport and metabolism	521	522	0.9980842911877394
OG0000177	COG0718	DNA-binding nucleoid-associated protein YbaB/EfbC	YbaB	K	Transcription	522	522	1
OG0000178	COG0661	Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family	AarF	H	Coenzyme transport and metabolism	520	522	0.9961685823754789
OG0000179	COG1238	Membrane protein YqaA involved in indium extrusion, DedA family, contains VTT domain	YgaA	P	Inorganic ion transport and metabolism	522	522	1
OG0000180	COG2171	Tetrahydrodipicolinate N-succinyltransferase	DapD	E	Amino acid transport and metabolism	522	522	1
OG0000181	COG0285	Folylpolyglutamate synthase/Dihydropteroate synthase	FolC	H	Coenzyme transport and metabolism	505	521	0.9692898272552783
OG0000181	COG0770	UDP-N-acetylmuramyl pentapeptide synthase	MurF	M	Cell wall/membrane/envelope biogenesis	1	521	0.0019193857965451055
OG0000182	COG3292	Periplasmic ligand-binding sensor domain	NA	T	Signal transduction mechanisms	7	521	0.013435700575815739
OG0000182	COG3933	Transcriptional regulator of LevR family, contains sigma54-interacting AAA domain, PTS regulation domain (PRD), and EIIA-type domain	LevR	K	Transcription	2	521	0.003838771593090211
OG0000183	COG0305	Replicative DNA helicase	DnaB	L	Replication, recombination and repair	1	521	0.0019193857965451055
OG0000183	COG0847	DNA polymerase III, epsilon subunit or related 3'-5' exonuclease	DnaQ	L	Replication, recombination and repair	1	521	0.0019193857965451055
OG0000183	COG2176	DNA polymerase III, alpha subunit (gram-positive type)	PolC	L	Replication, recombination and repair	1	521	0.0019193857965451055
OG0000183	COG2925	Exonuclease I (degrades ssDNA)	SbcB	L	Replication, recombination and repair	509	521	0.9769673704414588
OG0000183	COG3359	Uncharacterized conserved protein YprB, contains RNaseH-like and TPR domains	YprB	R	General function prediction only	1	521	0.0019193857965451055
OG0000183	COG5018	3'-5' exonuclease KapD, inhibitor of KinA-controlled sporulation	KapD	T	Signal transduction mechanisms	2	521	0.003838771593090211
OG0000184	COG0177	Endonuclease III	Nth	L	Replication, recombination and repair	521	521	1
OG0000185	COG0365	Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase	Acs	I	Lipid transport and metabolism	520	520	1
OG0000186	COG0604	NADPH:quinone reductase or related Zn-dependent oxidoreductase	Qor	C	Energy production and conversion	518	520	0.9961538461538462
OG0000186	COG1062	Zn-dependent alcohol/formaldehyde dehydrogenase	FrmA	C	Energy production and conversion	1	520	0.0019230769230769232
OG0000186	COG4221	NADP-dependent 3-hydroxy acid dehydrogenase YdfG	YdfG	C	Energy production and conversion	1	520	0.0019230769230769232
OG0000187	COG0548	N-acetylglutamate kinase	ArgB	E	Amino acid transport and metabolism	520	520	1
OG0000188	COG0533	tRNA A37 threonylcarbamoyltransferase TsaD	TsaD	J	Translation, ribosomal structure and biogenesis	520	520	1
OG0000189	COG0173	Aspartyl-tRNA synthetase	AspS	J	Translation, ribosomal structure and biogenesis	520	520	1
OG0000190	COG0459	Chaperonin GroEL (HSP60 family)	GroEL	O	Posttranslational modification, protein turnover, chaperones	520	520	1
OG0000191	COG0217	Transcriptional and/or translational regulatory protein YebC/TACO1	TACO1	K	Transcription	520	520	1
OG0000192	COG0400	Palmitoyl-CoA esterase	YpfH	R	General function prediction only	520	520	1
OG0000193	COG4547	Cobalamin biosynthesis cobaltochelatase CobT subunit	CobT2	H	Coenzyme transport and metabolism	520	520	1
OG0000194	COG0505	Carbamoylphosphate synthase small subunit	CarA	E	Amino acid transport and metabolism	519	519	1
OG0000195	COG0272	NAD-dependent DNA ligase	Lig	L	Replication, recombination and repair	519	519	1
OG0000196	COG0159	Tryptophan synthase alpha chain	TrpA	E	Amino acid transport and metabolism	519	519	1
OG0000197	COG1692	2',3'- and 3',5'-cNMP phosphodiesterase YmdB, calcineurin family	YmdB	T	Signal transduction mechanisms	519	519	1
OG0000198	COG0811	Biopolymer transport protein ExbB/TolQ	TolQ	U	Intracellular trafficking, secretion, and vesicular transport	519	519	1
OG0000199	COG0210	Superfamily I DNA or RNA helicase	UvrD	L	Replication, recombination and repair	517	518	0.9980694980694981
OG0000200	COG2941	Demethoxyubiquinone hydroxylase, CLK1/Coq7/Cat5 family (ubiquinone biosynthesis)	Coq7	H	Coenzyme transport and metabolism	518	518	1
OG0000201	COG0137	Argininosuccinate synthase	ArgG	E	Amino acid transport and metabolism	518	518	1
OG0000202	COG0723	Rieske Fe-S protein	QcrA/PetC	C	Energy production and conversion	517	517	1
OG0000203	COG0493	NADPH-dependent glutamate synthase beta chain or related oxidoreductase	GltD	E	Amino acid transport and metabolism	515	517	0.9961315280464217
OG0000203	COG1232	Protoporphyrinogen oxidase HemY/PPOX	HemY	H	Coenzyme transport and metabolism	1	517	0.0019342359767891683
OG0000203	COG2907	Predicted flavin-containing amine oxidase	Ppro0129	R	General function prediction only	1	517	0.0019342359767891683
OG0000204	COG0133	Tryptophan synthase beta chain	TrpB	E	Amino acid transport and metabolism	510	517	0.9864603481624759
OG0000204	COG1171	Threonine deaminase	IlvA	E	Amino acid transport and metabolism	1	517	0.0019342359767891683
OG0000205	COG0823	Periplasmic component TolB of the Tol biopolymer transport system	TolB	U	Intracellular trafficking, secretion, and vesicular transport	517	517	1
OG0000206	COG0445	tRNA U34 5-carboxymethylaminomethyl modifying enzyme MnmG/GidA	MnmG	J	Translation, ribosomal structure and biogenesis	517	517	1
OG0000207	COG0706	Membrane protein insertase Oxa1/YidC/SpoIIIJ	YidC	M	Cell wall/membrane/envelope biogenesis	515	517	0.9961315280464217
OG0000208	COG0122	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase	AlkA	L	Replication, recombination and repair	517	517	1
OG0000209	COG0006	Xaa-Pro aminopeptidase	PepP	E	Amino acid transport and metabolism	511	517	0.988394584139265
OG0000210	COG0717	dCTP deaminase	Dcd	F	Nucleotide transport and metabolism	517	517	1
OG0000211	COG0078	Ornithine carbamoyltransferase	ArgF	E	Amino acid transport and metabolism	514	517	0.9941972920696325
OG0000212	COG0077	Prephenate dehydratase (decarboxylase)	PheA2	E	Amino acid transport and metabolism	517	517	1
OG0000213	COG0104	Adenylosuccinate synthase	PurA	F	Nucleotide transport and metabolism	516	517	0.9980657640232108
OG0000214	COG0140	Phosphoribosyl-ATP pyrophosphohydrolase	HisI2	E	Amino acid transport and metabolism	517	517	1
OG0000215	COG0016	Phenylalanyl-tRNA synthetase alpha subunit	PheS	J	Translation, ribosomal structure and biogenesis	517	517	1
OG0000216	COG0060	Isoleucyl-tRNA synthetase	IleS	J	Translation, ribosomal structure and biogenesis	516	516	1
OG0000217	COG0764	3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase	FabA	I	Lipid transport and metabolism	516	516	1
OG0000218	COG2876	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase	AroGA	E	Amino acid transport and metabolism	12	516	0.023255813953488372
OG0000218	COG2877	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase	KdsA	M	Cell wall/membrane/envelope biogenesis	504	516	0.9767441860465116
OG0000219	COG0457	Tetratricopeptide (TPR) repeat	TPR	R	General function prediction only	30	516	0.05813953488372093
OG0000219	COG2956	Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain	LapB	M	Cell wall/membrane/envelope biogenesis	2	516	0.003875968992248062
OG0000219	COG3914	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family	Spy	O	Posttranslational modification, protein turnover, chaperones	2	516	0.003875968992248062
OG0000219	COG4235	Cytochrome c-type biogenesis protein CcmH/NrfG	NrfG	C	Energy production and conversion	86	516	0.16666666666666666
OG0000219	COG4783	Periplasmic chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains	BepA	M	Cell wall/membrane/envelope biogenesis	325	516	0.6298449612403101
OG0000219	COG5010	Flp/Tad pilus assembly pilotin TadD, contains TPR repeats	TadD	W	Extracellular structures	68	516	0.13178294573643412
OG0000220	COG0289	4-hydroxy-tetrahydrodipicolinate reductase	DapB	E	Amino acid transport and metabolism	516	516	1
OG0000221	COG0848	Biopolymer transport protein ExbD	ExbD	U	Intracellular trafficking, secretion, and vesicular transport	516	516	1
OG0000222	COG0537	Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family	HinT	F	Nucleotide transport and metabolism	516	516	1
OG0000223	COG0592	DNA polymerase III sliding clamp (beta) subunit, PCNA homolog	DnaN	L	Replication, recombination and repair	516	516	1
OG0000224	COG0204	1-acyl-sn-glycerol-3-phosphate acyltransferase	PlsC	I	Lipid transport and metabolism	515	516	0.998062015503876
OG0000225	COG1495	Disulfide bond formation protein DsbB	DsbB	O	Posttranslational modification, protein turnover, chaperones	501	516	0.9709302325581395
OG0000226	COG0181	Porphobilinogen deaminase	HemC	H	Coenzyme transport and metabolism	516	516	1
OG0000227	COG0019	Diaminopimelate decarboxylase	LysA	E	Amino acid transport and metabolism	515	515	1
OG0000228	COG1290	Cytochrome b subunit of the bc complex	QcrB/PetB	C	Energy production and conversion	515	515	1
OG0000229	COG0042	tRNA-dihydrouridine synthase	DusA	J	Translation, ribosomal structure and biogenesis	514	515	0.9980582524271845
OG0000230	COG0793	C-terminal processing protease CtpA/Prc, contains a PDZ domain	CtpA	O	Posttranslational modification, protein turnover, chaperones	514	515	0.9980582524271845
OG0000231	COG0234	Co-chaperonin GroES (HSP10)	GroES	O	Posttranslational modification, protein turnover, chaperones	515	515	1
OG0000232	COG0280	Phosphotransacetylase (includes Pta, EutD and phosphobutyryltransferase)	Pta	C	Energy production and conversion	9	515	0.017475728155339806
OG0000232	COG0281	Malic enzyme	SfcA	C	Energy production and conversion	506	515	0.9825242718446602
OG0000233	COG0072	Phenylalanyl-tRNA synthetase beta subunit	PheT	J	Translation, ribosomal structure and biogenesis	514	515	0.9980582524271845
OG0000233	COG0073	tRNA-binding EMAP/Myf domain	EMAP	J	Translation, ribosomal structure and biogenesis	1	515	0.001941747572815534
OG0000234	COG0642	Signal transduction histidine kinase	BaeS	T	Signal transduction mechanisms	477	515	0.9262135922330097
OG0000234	COG2205	K+-sensing histidine kinase KdpD	KdpD	T	Signal transduction mechanisms	37	515	0.07184466019417475
OG0000234	COG4191	Signal transduction histidine kinase regulating C4-dicarboxylate transport system	NA	T	Signal transduction mechanisms	1	515	0.001941747572815534
OG0000235	COG0174	Glutamine synthetase	GlnA	E	Amino acid transport and metabolism	514	514	1
OG0000236	COG5524	Bacteriorhodopsin	NA	C	Energy production and conversion	514	514	1
OG0000237	COG0623	Enoyl-[acyl-carrier-protein] reductase FabI	FabI	I	Lipid transport and metabolism	514	514	1
OG0000238	COG0044	Dihydroorotase or related cyclic amidohydrolase	AllB	F	Nucleotide transport and metabolism	514	514	1
OG0000239	COG0777	Acetyl-CoA carboxylase beta subunit	AccD	I	Lipid transport and metabolism	514	514	1
OG0000240	COG0730	Sulfite exporter TauE/SafE/YfcA and related permeases, UPF0721 family	TauE	P	Inorganic ion transport and metabolism	513	514	0.9980544747081712
OG0000241	COG0258	5'-3' exonuclease Xni/ExoIX (flap endonuclease)	ExoIX	L	Replication, recombination and repair	8	514	0.01556420233463035
OG0000241	COG0749	DNA polymerase I, 3'-5' exonuclease and polymerase domains	PolA	L	Replication, recombination and repair	506	514	0.9844357976653697
OG0000242	COG0014	Gamma-glutamyl phosphate reductase	ProA	E	Amino acid transport and metabolism	512	514	0.9961089494163424
OG0000243	COG1109	Phosphomannomutase	ManB	G	Carbohydrate transport and metabolism	514	514	1
OG0000244	COG0452	Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC	CoaBC	H	Coenzyme transport and metabolism	514	514	1
OG0000245	COG0441	Threonyl-tRNA synthetase	ThrS	J	Translation, ribosomal structure and biogenesis	514	514	1
OG0000246	COG0404	Glycine cleavage system protein T (aminomethyltransferase)	GcvT	E	Amino acid transport and metabolism	510	513	0.9941520467836257
OG0000246	COG0665	Glycine/D-amino acid oxidase (deaminating)	DadA	E	Amino acid transport and metabolism	2	513	0.003898635477582846
OG0000247	COG0012	Ribosome-binding ATPase YchF, GTP1/OBG family	GTP1	J	Translation, ribosomal structure and biogenesis	513	513	1
OG0000248	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	FabG	I	Lipid transport and metabolism	513	513	1
OG0000249	COG0552	Signal recognition particle GTPase FtsY	FtsY	U	Intracellular trafficking, secretion, and vesicular transport	512	513	0.9980506822612085
OG0000250	COG3088	Cytochrome c-type biogenesis protein CcmH/NrfF	NrfF	C	Energy production and conversion	1	513	0.001949317738791423
OG0000250	COG4771	Outer membrane receptor for ferrienterochelin and colicins	FepA	P	Inorganic ion transport and metabolism	1	513	0.001949317738791423
OG0000251	COG2857	Cytochrome c1	CYT1	C	Energy production and conversion	513	513	1
OG0000252	COG2812	DNA polymerase III, gamma/tau subunits	DnaX	L	Replication, recombination and repair	502	513	0.9785575048732943
OG0000253	COG1193	Bacterial ribosome collision sensor RqcU, MutS2 ATPase family	RqcU	J	Translation, ribosomal structure and biogenesis	1	513	0.001949317738791423
OG0000253	COG2840	Stalled ribosome-rescuing mRNA endonuclease or DNA-nicking endonuclease, Smr domain	SmrA	J	Translation, ribosomal structure and biogenesis	490	513	0.9551656920077972
OG0000254	COG0365	Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase	Acs	I	Lipid transport and metabolism	1	513	0.001949317738791423
OG0000254	COG0668	Small-conductance mechanosensitive channel	MscS	M	Cell wall/membrane/envelope biogenesis	509	513	0.9922027290448343
OG0000254	COG3264	Small-conductance mechanosensitive channel MscK	MscK	M	Cell wall/membrane/envelope biogenesis	1	513	0.001949317738791423
OG0000255	COG0625	Glutathione S-transferase or stringent starvation protein SspA	GstA	O	Posttranslational modification, protein turnover, chaperones	513	513	1
OG0000256	COG1351	Thymidylate synthase ThyX, FAD-dependent family	ThyX	F	Nucleotide transport and metabolism	511	513	0.9961013645224172
OG0000257	COG0131	Imidazoleglycerol phosphate dehydratase HisB	HisB2	E	Amino acid transport and metabolism	513	513	1
OG0000258	COG1185	Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase)	Pnp	J	Translation, ribosomal structure and biogenesis	513	513	1
OG0000259	COG0593	Chromosomal replication initiation ATPase DnaA	DnaA	L	Replication, recombination and repair	513	513	1
OG0000260	COG2609	Pyruvate dehydrogenase complex, dehydrogenase (E1) component	AceE	C	Energy production and conversion	513	513	1
OG0000261	COG0176	Transaldolase/fructose-6-phosphate aldolase	TalA	G	Carbohydrate transport and metabolism	511	512	0.998046875
OG0000262	COG1048	Aconitase A	AcnA	C	Energy production and conversion	512	512	1
OG0000263	COG1197	Transcription-repair coupling factor (superfamily II helicase)	Mfd	L	Replication, recombination and repair	20	512	0.0390625
OG0000263	COG1200	RecG-like helicase	RecG	L	Replication, recombination and repair	492	512	0.9609375
OG0000264	COG4764	Predicted transglycosylase, contains SLT domain	SLT	R	General function prediction only	510	512	0.99609375
OG0000265	COG0773	UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family	MurC	M	Cell wall/membrane/envelope biogenesis	512	512	1
OG0000266	COG0328	Ribonuclease HI	RnhA	L	Replication, recombination and repair	512	512	1
OG0000267	COG0251	Enamine deaminase RidA/Endoribonuclease Rid7C, YjgF/YER057c/UK114 family	RidA	V	Defense mechanisms	512	512	1
OG0000268	COG1384	Lysyl-tRNA synthetase, class I	LysS	J	Translation, ribosomal structure and biogenesis	512	512	1
OG0000269	COG0757	3-dehydroquinate dehydratase, type II	AroQ	E	Amino acid transport and metabolism	512	512	1
OG0000270	COG2823	Phospholipid-binding membrane integrity protein DolP/YraP/OsmY, contains BON domain	OsmY	M	Cell wall/membrane/envelope biogenesis	511	512	0.998046875
OG0000271	COG3807	SH3-like domain	SH3	S	Function unknown	512	512	1
OG0000272	COG0290	Translation initiation factor IF-3	InfC	J	Translation, ribosomal structure and biogenesis	512	512	1
OG0000273	COG0755	ABC-type transport system involved in cytochrome c biogenesis, permease component	CcmC	O	Posttranslational modification, protein turnover, chaperones	511	512	0.998046875
OG0000274	COG0241	Histidinol phosphatase/D-glycero-mannoheptose bisphosphatephosphatase, HAD superfamily	HisB1/GmhB	E	Amino acid transport and metabolism	94	511	0.18395303326810175
OG0000274	COG1208	NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis protein s	GCD1	J	Translation, ribosomal structure and biogenesis	415	511	0.812133072407045
OG0000275	COG0484	DnaJ molecular chaperone, contains DnaJ and DnaJ_C  domains	DnaJ	O	Posttranslational modification, protein turnover, chaperones	511	511	1
OG0000276	COG0111	Phosphoglycerate dehydrogenase or related dehydrogenase	SerA	H	Coenzyme transport and metabolism	2	511	0.003913894324853229
OG0000276	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	1	511	0.0019569471624266144
OG0000276	COG0499	S-adenosylhomocysteine hydrolase	SAM1	H	Coenzyme transport and metabolism	503	511	0.9843444227005871
OG0000276	COG1893	Ketopantoate reductase	PanE	H	Coenzyme transport and metabolism	1	511	0.0019569471624266144
OG0000276	COG5495	Predicted oxidoreductase, contains short-chain dehydrogenase (SDR) and DUF2520 domains	NA	R	General function prediction only	2	511	0.003913894324853229
OG0000277	COG0355	FoF1-type ATP synthase, epsilon subunit	AtpC	C	Energy production and conversion	511	511	1
OG0000278	COG0055	FoF1-type ATP synthase, beta subunit	AtpD	C	Energy production and conversion	511	511	1
OG0000279	COG0082	Chorismate synthase	AroC	E	Amino acid transport and metabolism	511	511	1
OG0000280	COG0670	Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family	YbhL	P	Inorganic ion transport and metabolism	511	511	1
OG0000281	COG1758	DNA-directed RNA polymerase, subunit K/omega	RpoZ	K	Transcription	510	511	0.9980430528375733
OG0000282	COG0227	Ribosomal protein L28	RpmB	J	Translation, ribosomal structure and biogenesis	511	511	1
OG0000283	COG0167	Dihydroorotate dehydrogenase	PyrD	F	Nucleotide transport and metabolism	509	511	0.9960861056751468
OG0000284	COG0209	Ribonucleotide reductase alpha subunit	NrdA	F	Nucleotide transport and metabolism	23	511	0.04500978473581213
OG0000284	COG1601	Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain	GCD7	J	Translation, ribosomal structure and biogenesis	1	511	0.0019569471624266144
OG0000285	COG1530	Ribonuclease G or E	CafA	J	Translation, ribosomal structure and biogenesis	506	511	0.9902152641878669
OG0000286	COG0498	Threonine synthase	ThrC	E	Amino acid transport and metabolism	511	511	1
OG0000287	COG0825	Acetyl-CoA carboxylase alpha subunit	AccA	I	Lipid transport and metabolism	510	511	0.9980430528375733
OG0000287	COG3206	Tyrosine-protein kinase Wzc involved in exopolysaccharide export, GumC/Wzc1 domain	GumC	M	Cell wall/membrane/envelope biogenesis	1	511	0.0019569471624266144
OG0000288	COG1729	Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction	CpoB	D	Cell cycle control, cell division, chromosome partitioning	509	511	0.9960861056751468
OG0000288	COG4942	Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB	EnvC	D	Cell cycle control, cell division, chromosome partitioning	1	511	0.0019569471624266144
OG0000289	COG0564	Pseudouridine synthase RluA, 23S rRNA- or tRNA-specific	RluA	J	Translation, ribosomal structure and biogenesis	511	511	1
OG0000290	COG4395	Predicted lipid-binding transport protein, Tim44 family	Tim44	I	Lipid transport and metabolism	511	511	1
OG0000291	COG0567	2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes	SucA	C	Energy production and conversion	1	511	0.0019569471624266144
OG0000291	COG1221	Transcriptional regulators containing sigma54-interacting ATPase domain	PspF	K	Transcription	1	511	0.0019569471624266144
OG0000291	COG1333	Cytochrome c biogenesis protein ResB	ResB	C	Energy production and conversion	1	511	0.0019569471624266144
OG0000291	COG2848	Uncharacterized conserved protein, UPF0210 family	NA	D	Cell cycle control, cell division, chromosome partitioning	1	511	0.0019569471624266144
OG0000291	COG3317	Outer membrane protein assembly factor BamC	BamC	M	Cell wall/membrane/envelope biogenesis	4	511	0.007827788649706457
OG0000291	COG4105	Outer membrane protein assembly factor BamD, BamD/ComL family	BamD	M	Cell wall/membrane/envelope biogenesis	7	511	0.0136986301369863
OG0000291	COG4826	Serine protease inhibitor	SERPIN	O	Posttranslational modification, protein turnover, chaperones	8	511	0.015655577299412915
OG0000292	COG0764	3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase	FabA	I	Lipid transport and metabolism	509	511	0.9960861056751468
OG0000292	COG2239	Mg/Co/Ni transporter MgtE (contains CBS domain)	MgtE	P	Inorganic ion transport and metabolism	1	511	0.0019569471624266144
OG0000293	COG0291	Ribosomal protein L35	RpmI	J	Translation, ribosomal structure and biogenesis	511	511	1
OG0000294	COG0481	Translation elongation factor EF-4, membrane-bound GTPase	LepA	J	Translation, ribosomal structure and biogenesis	511	511	1
OG0000295	COG0541	Signal recognition particle GTPase Srp/Ffh	Srp	U	Intracellular trafficking, secretion, and vesicular transport	511	511	1
OG0000296	COG1192	ParA-like ATPase involved in chromosome/plasmid partitioning or cellulose biosynthesis protein BcsQ	ParA	D	Cell cycle control, cell division, chromosome partitioning	509	510	0.9980392156862745
OG0000297	COG2897	3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains	SseA	P	Inorganic ion transport and metabolism	510	510	1
OG0000298	COG0224	FoF1-type ATP synthase, gamma subunit	AtpG	C	Energy production and conversion	509	510	0.9980392156862745
OG0000298	COG0263	Glutamate 5-kinase	ProB	E	Amino acid transport and metabolism	1	510	0.00196078431372549
OG0000299	COG0492	Thioredoxin reductase	TrxB	O	Posttranslational modification, protein turnover, chaperones	510	510	1
OG0000300	COG0774	UDP-3-O-acyl-N-acetylglucosamine deacetylase	LpxC	M	Cell wall/membrane/envelope biogenesis	510	510	1
OG0000301	COG0492	Thioredoxin reductase	TrxB	O	Posttranslational modification, protein turnover, chaperones	510	510	1
OG0000302	COG1573	Uracil-DNA glycosylase	Udg4	L	Replication, recombination and repair	510	510	1
OG0000303	COG0294	Dihydropteroate synthase	FolP	H	Coenzyme transport and metabolism	508	510	0.996078431372549
OG0000304	COG0259	Pyridoxine/pyridoxamine 5'-phosphate oxidase	PdxH	H	Coenzyme transport and metabolism	1	510	0.00196078431372549
OG0000304	COG5135	Uncharacterized conserved protein	NA	S	Function unknown	508	510	0.996078431372549
OG0000305	COG0713	NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K)	NuoK	C	Energy production and conversion	510	510	1
OG0000306	COG0162	Tyrosyl-tRNA synthetase	TyrS	J	Translation, ribosomal structure and biogenesis	1	510	0.00196078431372549
OG0000306	COG4946	Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats	NA	S	Function unknown	1	510	0.00196078431372549
OG0000307	COG0465	ATP-dependent Zn proteases	HflB	O	Posttranslational modification, protein turnover, chaperones	510	510	1
OG0000308	COG0165	Argininosuccinate lyase	ArgH	E	Amino acid transport and metabolism	510	510	1
OG0000309	COG0292	Ribosomal protein L20	RplT	J	Translation, ribosomal structure and biogenesis	510	510	1
OG0000310	COG0645	Predicted kinase, contains AAA domain	AAA	R	General function prediction only	294	510	0.5764705882352941
OG0000310	COG0714	MoxR-like ATPase, includes components of a predicted archaeal secretion system	MMP0363	R	General function prediction only	202	510	0.396078431372549
OG0000310	COG1763	Molybdopterin-guanine dinucleotide biosynthesis protein	MobB	H	Coenzyme transport and metabolism	2	510	0.00392156862745098
OG0000310	COG2086	Electron transfer flavoprotein, alpha and beta subunits	FixA	C	Energy production and conversion	5	510	0.00980392156862745
OG0000310	COG4547	Cobalamin biosynthesis cobaltochelatase CobT subunit	CobT2	H	Coenzyme transport and metabolism	1	510	0.00196078431372549
OG0000311	COG0484	DnaJ molecular chaperone, contains DnaJ and DnaJ_C  domains	DnaJ	O	Posttranslational modification, protein turnover, chaperones	509	510	0.9980392156862745
OG0000312	COG0253	Diaminopimelate epimerase	DapF	E	Amino acid transport and metabolism	510	510	1
OG0000313	COG3785	Heat shock protein HspQ	HspQ	O	Posttranslational modification, protein turnover, chaperones	510	510	1
OG0000314	COG0491	Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II	GloB	R	General function prediction only	506	509	0.9941060903732809
OG0000315	COG0633	Ferredoxin	Fdx	C	Energy production and conversion	509	509	1
OG0000316	COG0379	Quinolinate synthase	NadA	H	Coenzyme transport and metabolism	505	509	0.9921414538310412
OG0000317	COG0358	DNA primase (bacterial type)	DnaG	L	Replication, recombination and repair	496	509	0.9744597249508841
OG0000318	COG0013	Alanyl-tRNA synthetase	AlaS	J	Translation, ribosomal structure and biogenesis	490	509	0.962671905697446
OG0000318	COG2872	Ser-tRNA(Ala) deacylase AlaX (editing enzyme)	AlaX	J	Translation, ribosomal structure and biogenesis	19	509	0.03732809430255403
OG0000319	COG1109	Phosphomannomutase	ManB	G	Carbohydrate transport and metabolism	507	509	0.9960707269155207
OG0000320	COG0597	Lipoprotein signal peptidase	LspA	M	Cell wall/membrane/envelope biogenesis	509	509	1
OG0000321	COG0766	UDP-N-acetylglucosamine enolpyruvyl transferase	MurA	M	Cell wall/membrane/envelope biogenesis	509	509	1
OG0000322	COG0201	Preprotein translocase subunit SecY	SecY	U	Intracellular trafficking, secretion, and vesicular transport	509	509	1
OG0000323	COG0322	Excinuclease UvrABC, nuclease subunit	UvrC	L	Replication, recombination and repair	1	509	0.0019646365422396855
OG0000323	COG1221	Transcriptional regulators containing sigma54-interacting ATPase domain	PspF	K	Transcription	3	509	0.005893909626719057
OG0000323	COG2911	Autotransporter translocation and assembly protein TamB	TamB	U	Intracellular trafficking, secretion, and vesicular transport	18	509	0.03536345776031434
OG0000323	COG2982	Outer membrane assembly factor AsmA	AsmA	M	Cell wall/membrane/envelope biogenesis	11	509	0.021611001964636542
OG0000323	COG3164	Phospholipid transporter to the outer membrane, contains AsmA2 domain	YhdP	M	Cell wall/membrane/envelope biogenesis	228	509	0.44793713163064836
OG0000323	COG3292	Periplasmic ligand-binding sensor domain	NA	T	Signal transduction mechanisms	75	509	0.14734774066797643
OG0000323	COG3933	Transcriptional regulator of LevR family, contains sigma54-interacting AAA domain, PTS regulation domain (PRD), and EIIA-type domain	LevR	K	Transcription	2	509	0.003929273084479371
OG0000324	COG1143	Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)	NuoI	C	Energy production and conversion	508	509	0.9980353634577603
OG0000325	COG2001	MraZ, DNA-binding transcriptional regulator and inhibitor of RsmH methyltransferase activity	MraZ	J	Translation, ribosomal structure and biogenesis	509	509	1
OG0000326	COG3660	Mitochondrial fission protein ELM1	ELM1	D	Cell cycle control, cell division, chromosome partitioning	508	509	0.9980353634577603
OG0000327	COG1674	DNA segregation ATPase FtsK/SpoIIIE or related protein	FtsK	D	Cell cycle control, cell division, chromosome partitioning	507	509	0.9960707269155207
OG0000328	COG0540	Aspartate carbamoyltransferase, catalytic subunit	PyrB	F	Nucleotide transport and metabolism	509	509	1
OG0000329	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	AdhE	I	Lipid transport and metabolism	508	508	1
OG0000330	COG0812	UDP-N-acetylenolpyruvoylglucosamine reductase	MurB	M	Cell wall/membrane/envelope biogenesis	507	508	0.9980314960629921
OG0000331	COG0138	AICAR transformylase/IMP cyclohydrolase PurH	PurH	F	Nucleotide transport and metabolism	508	508	1
OG0000332	COG1158	Transcription termination factor Rho	Rho	K	Transcription	508	508	1
OG0000333	COG0762	Cytochrome b6 maturation protein CCB3/Ycf19 and related maturases, YggT family	Ycf19	O	Posttranslational modification, protein turnover, chaperones	508	508	1
OG0000334	COG0839	NADH:ubiquinone oxidoreductase subunit 6 (chain J)	NuoJ	C	Energy production and conversion	508	508	1
OG0000335	COG0504	CTP synthase (UTP-ammonia lyase)	PyrG	F	Nucleotide transport and metabolism	508	508	1
OG0000336	COG0178	Excinuclease UvrABC ATPase subunit	UvrA	L	Replication, recombination and repair	508	508	1
OG0000337	COG1947	4-diphosphocytidyl-2C-methyl-D-erythritol kinase	IspE	I	Lipid transport and metabolism	507	508	0.9980314960629921
OG0000338	COG0407	Uroporphyrinogen-III decarboxylase HemE	HemE	H	Coenzyme transport and metabolism	507	508	0.9980314960629921
OG0000338	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	FabG	I	Lipid transport and metabolism	1	508	0.001968503937007874
OG0000339	COG0532	Translation initiation factor IF-2, a GTPase	InfB	J	Translation, ribosomal structure and biogenesis	506	508	0.9960629921259843
OG0000340	COG2151	Metal-sulfur cluster biosynthetic enzyme, includes PaaD subunit of phenylacetate degradation complex	PaaD	O	Posttranslational modification, protein turnover, chaperones	508	508	1
OG0000341	COG2947	Predicted RNA-binding protein, contains EVE domain	EVE	R	General function prediction only	507	508	0.9980314960629921
OG0000342	COG0154	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase	GatA	J	Translation, ribosomal structure and biogenesis	507	507	1
OG0000343	COG0483	Archaeal fructose-1,6-bisphosphatase or related enzyme, inositol monophosphatase family	SuhB	G	Carbohydrate transport and metabolism	506	507	0.9980276134122288
OG0000344	COG0009	tRNA A37 threonylcarbamoyladenosine synthetase subunit TsaC/SUA5/YrdC	TsaC	J	Translation, ribosomal structure and biogenesis	1	507	0.0019723865877712033
OG0000344	COG0142	Geranylgeranyl pyrophosphate synthase	IspA	H	Coenzyme transport and metabolism	505	507	0.9960552268244576
OG0000345	COG0329	4-hydroxy-tetrahydrodipicolinate synthase/N-acetylneuraminate lyase	DapA	E	Amino acid transport and metabolism	507	507	1
OG0000346	COG0195	Transcription antitermination factor NusA, contains S1 and KH domains	NusA	K	Transcription	503	507	0.9921104536489151
OG0000346	COG0272	NAD-dependent DNA ligase	Lig	L	Replication, recombination and repair	1	507	0.0019723865877712033
OG0000347	COG0202	DNA-directed RNA polymerase, alpha subunit/40 kD subunit	RpoA	K	Transcription	507	507	1
OG0000348	COG2917	Intracellular septation protein A	YciB	D	Cell cycle control, cell division, chromosome partitioning	507	507	1
OG0000349	COG0056	FoF1-type ATP synthase, alpha subunit	AtpA	C	Energy production and conversion	506	507	0.9980276134122288
OG0000350	COG0462	Phosphoribosylpyrophosphate synthetase	PrsA	E	Amino acid transport and metabolism	507	507	1
OG0000351	COG0527	Aspartate kinase	MetL1	E	Amino acid transport and metabolism	484	507	0.9546351084812623
OG0000351	COG0528	Uridylate kinase	PyrH	F	Nucleotide transport and metabolism	22	507	0.04339250493096647
OG0000351	COG0622	Mn2+-dependent phosphodiesterase, calcineurin family	YfcE	R	General function prediction only	1	507	0.0019723865877712033
OG0000352	COG3288	NAD/NADP transhydrogenase alpha subunit	PntA	C	Energy production and conversion	507	507	1
OG0000353	COG0576	Molecular chaperone GrpE (heat shock protein HSP-70)	GrpE	O	Posttranslational modification, protein turnover, chaperones	506	507	0.9980276134122288
OG0000354	COG1138	Cytochrome c biogenesis protein CcmF	CcmF	C	Energy production and conversion	507	507	1
OG0000355	COG2332	Cytochrome c biogenesis protein CcmE	CcmE	C	Energy production and conversion	507	507	1
OG0000356	COG0065	Homoaconitase/3-isopropylmalate dehydratase large subunit	LeuC	E	Amino acid transport and metabolism	507	507	1
OG0000357	COG0069	Glutamate synthase domain 2	GltB2	E	Amino acid transport and metabolism	1	506	0.001976284584980237
OG0000357	COG0159	Tryptophan synthase alpha chain	TrpA	E	Amino acid transport and metabolism	1	506	0.001976284584980237
OG0000359	COG0647	Ribonucleotide monophosphatase NagD, HAD superfamily	NagD	F	Nucleotide transport and metabolism	506	506	1
OG0000360	COG5352	Transcription factor GcrA interacting with sigma70	GcrA	K	Transcription	506	506	1
OG0000361	COG0455	MinD-like ATPase FlhG/YlxH, activator of the FlhF-type GTPase	FlhG	D	Cell cycle control, cell division, chromosome partitioning	3	506	0.005928853754940711
OG0000361	COG0489	Fe-S cluster carrier ATPase, Mrp/ApbC/NBP35 family	Mrp	D	Cell cycle control, cell division, chromosome partitioning	503	506	0.9940711462450593
OG0000362	COG0276	Protoheme ferro-lyase (ferrochelatase)	HemH	H	Coenzyme transport and metabolism	506	506	1
OG0000363	COG0067	Glutamate synthase domain 1	GltB1	E	Amino acid transport and metabolism	6	506	0.011857707509881422
OG0000363	COG0070	Glutamate synthase domain 3	GltB3	E	Amino acid transport and metabolism	500	506	0.9881422924901185
OG0000364	COG0738	Fucose permease	FucP	G	Carbohydrate transport and metabolism	3	506	0.005928853754940711
OG0000364	COG2211	Na+/melibiose symporter or related transporter	MelB	G	Carbohydrate transport and metabolism	165	506	0.32608695652173914
OG0000364	COG2223	Nitrate/nitrite transporter NarK	NarK	P	Inorganic ion transport and metabolism	213	506	0.4209486166007905
OG0000364	COG2271	Sugar phosphate permease	UhpC	G	Carbohydrate transport and metabolism	34	506	0.06719367588932806
OG0000364	COG2814	Predicted arabinose efflux permease AraJ, MFS family	AraJ	G	Carbohydrate transport and metabolism	14	506	0.02766798418972332
OG0000365	COG0179	Oxaloacetate decarboxylase and tautomerase, fumarylacetoacetate (FAA) hydrolase family	FAHD1	C	Energy production and conversion	506	506	1
OG0000366	COG1734	RNA polymerase-binding transcription factor DksA	DksA	K	Transcription	506	506	1
OG0000367	COG0595	mRNA degradation ribonuclease J1/J2	RnjA	J	Translation, ribosomal structure and biogenesis	506	506	1
OG0000368	COG0320	Lipoate synthase	LipA	H	Coenzyme transport and metabolism	506	506	1
OG0000369	COG3761	NADH:ubiquinone oxidoreductase NDUFA12 subunit (Leigh syndrome)	NDUFA12	C	Energy production and conversion	506	506	1
OG0000370	COG0157	Nicotinate-nucleotide pyrophosphorylase	NadC	H	Coenzyme transport and metabolism	506	506	1
OG0000371	COG1610	Uncharacterized conserved protein YqeY, may have tRNA amino acid amidase activity	YqeY	R	General function prediction only	506	506	1
OG0000372	COG0151	Phosphoribosylamine-glycine ligase	PurD	F	Nucleotide transport and metabolism	506	506	1
OG0000373	COG0166	Glucose-6-phosphate isomerase	Pgi	G	Carbohydrate transport and metabolism	504	506	0.9960474308300395
OG0000374	COG0124	Histidyl-tRNA synthetase	HisS	J	Translation, ribosomal structure and biogenesis	10	506	0.019762845849802372
OG0000374	COG3705	ATP phosphoribosyltransferase regulatory subunit HisZ	HisZ	E	Amino acid transport and metabolism	493	506	0.974308300395257
OG0000376	COG0322	Excinuclease UvrABC, nuclease subunit	UvrC	L	Replication, recombination and repair	505	505	1
OG0000377	COG0539	Ribosomal protein S1	RpsA	J	Translation, ribosomal structure and biogenesis	502	505	0.994059405940594
OG0000378	COG1249	Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase	Lpd	C	Energy production and conversion	505	505	1
OG0000379	COG0034	Glutamine phosphoribosylpyrophosphate amidotransferase	PurF	F	Nucleotide transport and metabolism	505	505	1
OG0000380	COG0510	Thiamine kinase or a related kinase	CotS	H	Coenzyme transport and metabolism	1	505	0.0019801980198019802
OG0000380	COG2334	Ser/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist	SrkA	T	Signal transduction mechanisms	503	505	0.996039603960396
OG0000381	COG0822	Fe-S cluster assembly scaffold protein IscU, NifU family	IscU	O	Posttranslational modification, protein turnover, chaperones	505	505	1
OG0000382	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	OmpR	T	Signal transduction mechanisms	1	505	0.0019801980198019802
OG0000382	COG4567	DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains	NA	T	Signal transduction mechanisms	504	505	0.998019801980198
OG0000383	COG0791	Cell wall-associated hydrolase, NlpC_P60 family	NlpC	M	Cell wall/membrane/envelope biogenesis	499	505	0.9881188118811881
OG0000383	COG3103	Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family	YgiM	R	General function prediction only	4	505	0.007920792079207921
OG0000384	COG0211	Ribosomal protein L27	RpmA	J	Translation, ribosomal structure and biogenesis	505	505	1
OG0000385	COG0799	Ribosomal silencing factor RsfS, regulates association of 30S and 50S subunits	RsfS	J	Translation, ribosomal structure and biogenesis	505	505	1
OG0000386	COG0341	Preprotein translocase subunit SecF	SecF	U	Intracellular trafficking, secretion, and vesicular transport	505	505	1
OG0000387	COG0330	Regulator of protease activity HflC, stomatin/prohibitin superfamily	HflC	O	Posttranslational modification, protein turnover, chaperones	504	505	0.998019801980198
OG0000388	COG0193	Peptidyl-tRNA hydrolase	Pth	J	Translation, ribosomal structure and biogenesis	505	505	1
OG0000389	COG0164	Ribonuclease HII	RnhB	L	Replication, recombination and repair	505	505	1
OG0000390	COG1196	Chromosome segregation ATPase Smc	Smc	D	Cell cycle control, cell division, chromosome partitioning	505	505	1
OG0000391	COG0711	FoF1-type ATP synthase, membrane subunit b or b'	AtpF	C	Energy production and conversion	504	505	0.998019801980198
OG0000392	COG2220	L-ascorbate lactonase UlaG, metallo-beta-lactamase superfamily	UlaG	G	Carbohydrate transport and metabolism	503	505	0.996039603960396
OG0000393	COG0126	3-phosphoglycerate kinase	Pgk	G	Carbohydrate transport and metabolism	504	505	0.998019801980198
OG0000393	COG5441	ATP-binding helicase-inhibiting domain, Tm-1/UPF0261 family	Tm-1N	V	Defense mechanisms	1	505	0.0019801980198019802
OG0000394	COG0330	Regulator of protease activity HflC, stomatin/prohibitin superfamily	HflC	O	Posttranslational modification, protein turnover, chaperones	505	505	1
OG0000395	COG5405	ATP-dependent protease HslVU (ClpYQ), peptidase subunit	HslV	O	Posttranslational modification, protein turnover, chaperones	505	505	1
OG0000396	COG1952	Preprotein translocase subunit SecB	SecB	U	Intracellular trafficking, secretion, and vesicular transport	393	505	0.7782178217821782
OG0000397	COG0313	16S rRNA C1402 (ribose-2'-O) methylase RsmI	RsmI	J	Translation, ribosomal structure and biogenesis	494	505	0.9782178217821782
OG0000398	COG0192	S-adenosylmethionine synthetase	MetK	H	Coenzyme transport and metabolism	505	505	1
OG0000399	COG0816	YqgF/RuvX protein, pre-16S rRNA maturation RNase/Holliday junction resolvase/anti-termination factor	YqgF	J	Translation, ribosomal structure and biogenesis	505	505	1
OG0000400	COG3088	Cytochrome c-type biogenesis protein CcmH/NrfF	NrfF	C	Energy production and conversion	504	505	0.998019801980198
OG0000401	COG0318	O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming)	MenE	I	Lipid transport and metabolism	16	504	0.031746031746031744
OG0000401	COG1022	Long-chain acyl-CoA synthetase (AMP-forming)	FAA1	I	Lipid transport and metabolism	486	504	0.9642857142857143
OG0000402	COG0036	Pentose-5-phosphate-3-epimerase	Rpe	G	Carbohydrate transport and metabolism	504	504	1
OG0000403	COG0040	ATP phosphoribosyltransferase	HisG	E	Amino acid transport and metabolism	504	504	1
OG0000404	COG0128	5-enolpyruvylshikimate-3-phosphate synthase	AroA	E	Amino acid transport and metabolism	504	504	1
OG0000405	COG0260	Leucyl aminopeptidase	PepB	E	Amino acid transport and metabolism	503	504	0.998015873015873
OG0000406	COG0203	Ribosomal protein L17	RplQ	J	Translation, ribosomal structure and biogenesis	502	504	0.996031746031746
OG0000407	COG0663	Carbonic anhydrase or acetyltransferase, isoleucine patch superfamily	PaaY	R	General function prediction only	504	504	1
OG0000408	COG0263	Glutamate 5-kinase	ProB	E	Amino acid transport and metabolism	503	504	0.998015873015873
OG0000409	COG0526	Thiol-disulfide isomerase or thioredoxin	TrxA	O	Posttranslational modification, protein turnover, chaperones	504	504	1
OG0000410	COG1505	Prolyl endopeptidase PreP, S9A serine peptidase family	PreP	E	Amino acid transport and metabolism	1	504	0.001984126984126984
OG0000410	COG1770	Protease II	PtrB	E	Amino acid transport and metabolism	503	504	0.998015873015873
OG0000411	COG1225	Peroxiredoxin	Bcp	O	Posttranslational modification, protein turnover, chaperones	504	504	1
OG0000412	COG0206	Cell division GTPase FtsZ	FtsZ	D	Cell cycle control, cell division, chromosome partitioning	500	504	0.9920634920634921
OG0000413	COG2853	Outer membrane channel MlaA of the intermembrane phospholipid transporter MlaABCDEF complex	MlaA	M	Cell wall/membrane/envelope biogenesis	502	504	0.996031746031746
OG0000414	COG2854	Periplasmic subunit MlaC of the ABC-type intermembrane phospholipid transporter Mla	MlaC	M	Cell wall/membrane/envelope biogenesis	504	504	1
OG0000415	COG1825	Ribosomal protein L25 (general stress protein Ctc)	RplY	J	Translation, ribosomal structure and biogenesis	504	504	1
OG0000416	COG1385	16S rRNA U1498 N3-methylase RsmE	RsmE	J	Translation, ribosomal structure and biogenesis	504	504	1
OG0000417	COG0100	Ribosomal protein S11	RpsK	J	Translation, ribosomal structure and biogenesis	504	504	1
OG0000418	COG3114	Heme exporter protein D	CcmD	U	Intracellular trafficking, secretion, and vesicular transport	348	504	0.6904761904761905
OG0000419	COG0479	Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit	SdhB	C	Energy production and conversion	504	504	1
OG0000420	COG1220	ATP-dependent protease HslVU (ClpYQ), ATPase subunit HslU	HslU	O	Posttranslational modification, protein turnover, chaperones	503	503	1
OG0000421	COG0642	Signal transduction histidine kinase	BaeS	T	Signal transduction mechanisms	228	503	0.4532803180914513
OG0000421	COG2205	K+-sensing histidine kinase KdpD	KdpD	T	Signal transduction mechanisms	264	503	0.5248508946322068
OG0000421	COG5002	Sensor histidine kinase WalK	WalK	T	Signal transduction mechanisms	9	503	0.017892644135188866
OG0000422	COG0046	Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain	PurL1	F	Nucleotide transport and metabolism	503	503	1
OG0000423	COG0415	Deoxyribodipyrimidine photolyase	PhrB	L	Replication, recombination and repair	503	503	1
OG0000424	COG0859	ADP-heptose:LPS heptosyltransferase	RfaF	M	Cell wall/membrane/envelope biogenesis	503	503	1
OG0000425	COG0261	Ribosomal protein L21	RplU	J	Translation, ribosomal structure and biogenesis	501	503	0.9960238568588469
OG0000426	COG1043	Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase	LpxA	M	Cell wall/membrane/envelope biogenesis	503	503	1
OG0000427	COG1974	SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase)	LexA	K	Transcription	502	503	0.9980119284294234
OG0000427	COG4775	Outer membrane protein assembly factor BamA	BamA	M	Cell wall/membrane/envelope biogenesis	1	503	0.0019880715705765406
OG0000428	COG4974	Site-specific tyrosine recombinase XerD	XerD	L	Replication, recombination and repair	503	503	1
OG0000429	COG0782	Transcription elongation factor, GreA/GreB family	GreA	K	Transcription	503	503	1
OG0000430	COG1738	Queuosine precursor transporter YhhQ, DUF165 family	YhhQ	J	Translation, ribosomal structure and biogenesis	503	503	1
OG0000431	COG0389	Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair	DinP	L	Replication, recombination and repair	502	503	0.9980119284294234
OG0000432	COG1005	NADH:ubiquinone oxidoreductase subunit 1 (chain H)	NuoH	C	Energy production and conversion	503	503	1
OG0000433	COG0008	Glutamyl- or glutaminyl-tRNA synthetase	GlnS	J	Translation, ribosomal structure and biogenesis	503	503	1
OG0000434	COG0134	Indole-3-glycerol phosphate synthase	TrpC	E	Amino acid transport and metabolism	501	503	0.9960238568588469
OG0000434	COG0147	Anthranilate/para-aminobenzoate synthases component I	TrpE	E	Amino acid transport and metabolism	1	503	0.0019880715705765406
OG0000435	COG0711	FoF1-type ATP synthase, membrane subunit b or b'	AtpF	C	Energy production and conversion	502	503	0.9980119284294234
OG0000436	COG1282	NAD/NADP transhydrogenase beta subunit	PntB	C	Energy production and conversion	502	503	0.9980119284294234
OG0000437	COG3030	FxsA protein affecting phage T7 exclusion by the F plasmid, UPF0716 family	FxsA	R	General function prediction only	503	503	1
OG0000438	COG3203	Outer membrane porin OmpC/OmpF/PhoE	OmpC	M	Cell wall/membrane/envelope biogenesis	278	503	0.5526838966202783
OG0000438	COG3210	Large exoprotein involved in heme utilization or adhesion	FhaB	U	Intracellular trafficking, secretion, and vesicular transport	3	503	0.005964214711729622
OG0000438	COG3468	Autotransporter adhesin AidA	AidA	M	Cell wall/membrane/envelope biogenesis	2	503	0.003976143141153081
OG0000439	COG0030	rRNA adenine N6-methylase, includes 16S rRNA A1518 and A1519 N6-dimethyltransferase  RsmA/KsgA/DIM  and 23S rRNA A2058 N6-methylase ErmO/TlrD (may also have DNA glycosylase/AP lyase activity)	RsmA	J	Translation, ribosomal structure and biogenesis	483	502	0.9621513944223108
OG0000439	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	2	502	0.00398406374501992
OG0000439	COG3963	Phosphatidylethanolamine N-methyltransferase	NA	I	Lipid transport and metabolism	11	502	0.021912350597609563
OG0000439	COG4076	Predicted RNA methylase	NA	R	General function prediction only	3	502	0.00597609561752988
OG0000440	COG0517	CBS domain	CBS	T	Signal transduction mechanisms	1	502	0.00199203187250996
OG0000440	COG0794	D-arabinose 5-phosphate isomerase GutQ	GutQ	G	Carbohydrate transport and metabolism	495	502	0.9860557768924303
OG0000440	COG2905	Signal-transduction protein containing cAMP-binding, CBS, and nucleotidyltransferase domains	NA	T	Signal transduction mechanisms	6	502	0.01195219123505976
OG0000441	COG1280	Threonine/homoserine/homoserine lactone efflux protein	RhtB	E	Amino acid transport and metabolism	499	502	0.9940239043824701
OG0000442	COG0112	Glycine/serine hydroxymethyltransferase	GlyA	E	Amino acid transport and metabolism	502	502	1
OG0000443	COG0408	Coproporphyrinogen-III oxidase HemH, oxygen-dependent	HemF	H	Coenzyme transport and metabolism	502	502	1
OG0000444	COG0284	Orotidine-5'-phosphate decarboxylase	PyrF	F	Nucleotide transport and metabolism	501	502	0.99800796812749
OG0000445	COG0254	Ribosomal protein L31	RpmE	J	Translation, ribosomal structure and biogenesis	502	502	1
OG0000446	COG0343	Queuine/archaeosine tRNA-ribosyltransferase	Tgt	J	Translation, ribosomal structure and biogenesis	502	502	1
OG0000447	COG0114	Fumarate hydratase class II	FumC	C	Energy production and conversion	502	502	1
OG0000448	COG0231	Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A)	Efp	J	Translation, ribosomal structure and biogenesis	502	502	1
OG0000449	COG0858	Ribosome-binding factor RbfA	RbfA	J	Translation, ribosomal structure and biogenesis	502	502	1
OG0000450	COG0099	Ribosomal protein S13	RpsM	J	Translation, ribosomal structure and biogenesis	502	502	1
OG0000451	COG0719	Fe-S cluster assembly scaffold protein SufB	SufB	O	Posttranslational modification, protein turnover, chaperones	502	502	1
OG0000452	COG0064	Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit	GatB	J	Translation, ribosomal structure and biogenesis	502	502	1
OG0000453	COG3820	Cell cycle regulator TrcR, DUF1013 family	TrcR	K	Transcription	499	501	0.9960079840319361
OG0000454	COG3288	NAD/NADP transhydrogenase alpha subunit	PntA	C	Energy production and conversion	500	501	0.998003992015968
OG0000455	COG1329	RNA polymerase-interacting regulator, CarD/CdnL/TRCF family	CdnL	K	Transcription	501	501	1
OG0000456	COG2377	1,6-Anhydro-N-acetylmuramate kinase	AnmK	M	Cell wall/membrane/envelope biogenesis	501	501	1
OG0000457	COG0336	tRNA G37 N-methylase TrmD	TrmD	J	Translation, ribosomal structure and biogenesis	501	501	1
OG0000458	COG1587	Uroporphyrinogen-III synthase	HemD	H	Coenzyme transport and metabolism	496	501	0.9900199600798403
OG0000459	COG0342	Preprotein translocase subunit SecD	SecD	U	Intracellular trafficking, secretion, and vesicular transport	501	501	1
OG0000460	COG0636	FoF1-type ATP synthase, membrane subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K	AtpE	C	Energy production and conversion	501	501	1
OG0000461	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	OmpR	T	Signal transduction mechanisms	382	501	0.7624750499001997
OG0000461	COG2771	DNA-binding transcriptional regulator, CsgD family	CsgD	K	Transcription	1	501	0.001996007984031936
OG0000461	COG3710	DNA-binding winged helix-turn-helix (wHTH) domain	CadC1	K	Transcription	118	501	0.23552894211576847
OG0000462	COG0694	Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain	NifU	O	Posttranslational modification, protein turnover, chaperones	500	501	0.998003992015968
OG0000463	COG0184	Ribosomal protein S15P/S13E	RpsO	J	Translation, ribosomal structure and biogenesis	500	501	0.998003992015968
OG0000464	COG5009	Membrane carboxypeptidase/penicillin-binding protein	MrcA	M	Cell wall/membrane/envelope biogenesis	500	501	0.998003992015968
OG0000465	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	AdhE	I	Lipid transport and metabolism	500	500	1
OG0000466	COG0287	Prephenate dehydrogenase	TyrA	E	Amino acid transport and metabolism	499	500	0.998
OG0000467	COG0216	Protein chain release factor RF1	PrfA	J	Translation, ribosomal structure and biogenesis	498	500	0.996
OG0000468	COG0009	tRNA A37 threonylcarbamoyladenosine synthetase subunit TsaC/SUA5/YrdC	TsaC	J	Translation, ribosomal structure and biogenesis	493	500	0.986
OG0000469	COG1327	Transcriptional regulator NrdR, contains Zn-ribbon and ATP-cone domains	NrdR	K	Transcription	497	500	0.994
OG0000470	COG4105	Outer membrane protein assembly factor BamD, BamD/ComL family	BamD	M	Cell wall/membrane/envelope biogenesis	500	500	1
OG0000471	COG1286	Colicin V production accessory protein CvpA, regulator of purF expression and biofilm formation	CvpA	F	Nucleotide transport and metabolism	496	500	0.992
OG0000472	COG4765	Uncharacterized conserved protein, DUF2155 domain	NA	S	Function unknown	500	500	1
OG0000473	COG0219	tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain	TrmL	J	Translation, ribosomal structure and biogenesis	500	500	1
OG0000474	COG0356	FoF1-type ATP synthase, membrane subunit a	AtpB	C	Energy production and conversion	500	500	1
OG0000475	COG0761	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH	IspH	I	Lipid transport and metabolism	500	500	1
OG0000476	COG0643	Chemotaxis protein histidine kinase CheA	CheA	T	Signal transduction mechanisms	3	500	0.006
OG0000476	COG0724	RNA recognition motif (RRM) domain	RRM	J	Translation, ribosomal structure and biogenesis	1	500	0.002
OG0000476	COG0817	Holliday junction resolvasome RuvABC endonuclease subunit RuvC	RuvC	L	Replication, recombination and repair	308	500	0.616
OG0000476	COG2433	Possible nuclease of RNase H fold, RuvC/YqgF family	NA	R	General function prediction only	14	500	0.028
OG0000476	COG2441	Predicted butyrate kinase, DUF1464 family	NA	R	General function prediction only	1	500	0.002
OG0000477	COG0037	tRNA-C32 2-thiocytidine or tRNA(Ile)-C34 C2-lysylcytidine synthase TtcA/TilS/MesJ	TtcA	J	Translation, ribosomal structure and biogenesis	495	500	0.99
OG0000478	COG0180	Tryptophanyl-tRNA synthetase	TrpS	J	Translation, ribosomal structure and biogenesis	500	500	1
OG0000479	COG0268	Ribosomal protein S20	RpsT	J	Translation, ribosomal structure and biogenesis	497	500	0.994
OG0000480	COG0105	Nucleoside diphosphate kinase	Ndk	F	Nucleotide transport and metabolism	500	500	1
OG0000481	COG1968	Undecaprenyl pyrophosphate phosphatase	UppP	I	Lipid transport and metabolism	498	500	0.996
OG0000482	COG0480	Translation elongation factor EF-G, a GTPase	FusA	J	Translation, ribosomal structure and biogenesis	500	500	1
OG0000483	COG0162	Tyrosyl-tRNA synthetase	TyrS	J	Translation, ribosomal structure and biogenesis	499	500	0.998
OG0000484	COG2945	Alpha/beta superfamily hydrolase	NA	R	General function prediction only	499	500	0.998
OG0000485	COG0049	Ribosomal protein S7	RpsG	J	Translation, ribosomal structure and biogenesis	500	500	1
OG0000486	COG0772	Peptodoglycan polymerase FtsW/RodA/SpoVE	FtsW	D	Cell cycle control, cell division, chromosome partitioning	498	499	0.9979959919839679
OG0000487	COG0503	Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein	Apt	F	Nucleotide transport and metabolism	476	499	0.9539078156312625
OG0000487	COG2236	Hypoxanthine phosphoribosyltransferase	Hpt1	H	Coenzyme transport and metabolism	22	499	0.04408817635270541
OG0000488	COG0240	Glycerol-3-phosphate dehydrogenase	GpsA	C	Energy production and conversion	495	499	0.9919839679358717
OG0000489	COG0707	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase	MurG	M	Cell wall/membrane/envelope biogenesis	497	499	0.9959919839679359
OG0000490	COG4274	Uncharacterized conserved protein, contains GYD domain	NA	S	Function unknown	456	499	0.9138276553106213
OG0000491	COG0050	Translation elongation factor EF-Tu, a GTPase	TufA	J	Translation, ribosomal structure and biogenesis	492	499	0.9859719438877755
OG0000491	COG2895	Sulfate adenylyltransferase subunit 1, EFTu-like GTPase family	CysN	P	Inorganic ion transport and metabolism	7	499	0.014028056112224449
OG0000492	COG1057	Nicotinate-nucleotide adenylyltransferase NadD	NadD	H	Coenzyme transport and metabolism	499	499	1
OG0000493	COG0629	Single-stranded DNA-binding protein	Ssb	L	Replication, recombination and repair	498	499	0.9979959919839679
OG0000494	COG0698	Ribose 5-phosphate isomerase RpiB	RpiB	G	Carbohydrate transport and metabolism	499	499	1
OG0000495	COG1560	Palmitoleoyl-ACP: Kdo2-lipid-IV acyltransferase (lipid A biosynthesis)	LpxP	I	Lipid transport and metabolism	497	499	0.9959919839679359
OG0000496	COG3588	Fructose-bisphosphate aldolase class 1	Fba1	G	Carbohydrate transport and metabolism	499	499	1
OG0000497	COG2834	Periplasmic chaperone for outer membrane lipoprotein sorting	LolA	M	Cell wall/membrane/envelope biogenesis	486	499	0.9739478957915831
OG0000498	COG0739	Murein endopeptidase or hydrolase activator MepM/NlpD, contains LysM domain	NlpD	M	Cell wall/membrane/envelope biogenesis	496	499	0.9939879759519038
OG0000499	COG0066	3-isopropylmalate dehydratase small subunit	LeuD	E	Amino acid transport and metabolism	499	499	1
OG0000500	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	OmpR	T	Signal transduction mechanisms	495	499	0.9919839679358717
OG0000500	COG2204	DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains	AtoC	T	Signal transduction mechanisms	2	499	0.004008016032064128
OG0000500	COG3710	DNA-binding winged helix-turn-helix (wHTH) domain	CadC1	K	Transcription	2	499	0.004008016032064128
OG0000501	COG0649	NADH:ubiquinone oxidoreductase 49 kD subunit (chain D)	NuoD	C	Energy production and conversion	499	499	1
OG0000502	COG0768	Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2)	FtsI	D	Cell cycle control, cell division, chromosome partitioning	498	499	0.9979959919839679
OG0000503	COG0579	L-2-hydroxyglutarate oxidase LhgO	LhgO	G	Carbohydrate transport and metabolism	2	499	0.004008016032064128
OG0000503	COG0644	Dehydrogenase (flavoprotein)	FixC	C	Energy production and conversion	1	499	0.002004008016032064
OG0000503	COG0654	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	UbiH	H	Coenzyme transport and metabolism	466	499	0.9338677354709419
OG0000503	COG1232	Protoporphyrinogen oxidase HemY/PPOX	HemY	H	Coenzyme transport and metabolism	21	499	0.04208416833667335
OG0000503	COG2907	Predicted flavin-containing amine oxidase	Ppro0129	R	General function prediction only	1	499	0.002004008016032064
OG0000504	COG3908	Uncharacterized conserved protein, DUF2093 domain	NA	S	Function unknown	477	499	0.9559118236472945
OG0000505	COG0057	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase	GapA	G	Carbohydrate transport and metabolism	499	499	1
OG0000506	COG0212	5-formyltetrahydrofolate cyclo-ligase	FAU1	H	Coenzyme transport and metabolism	499	499	1
OG0000507	COG0325	Pyridoxal 5'-phosphate homeostasis protein YggS, UPF0001 family	YggS	H	Coenzyme transport and metabolism	499	499	1
OG0000508	COG2940	Histone-lysine N-methyltransferase, H3-specific, SET domain	SET	O	Posttranslational modification, protein turnover, chaperones	499	499	1
OG0000509	COG0563	Adenylate kinase or related kinase	Adk	F	Nucleotide transport and metabolism	499	499	1
OG0000510	COG0344	Phospholipid biosynthesis protein PlsY, probable glycerol-3-phosphate acyltransferase	PlsY	I	Lipid transport and metabolism	499	499	1
OG0000511	COG0086	DNA-directed RNA polymerase, beta' subunit/160 kD subunit	RpoC	K	Transcription	499	499	1
OG0000512	COG0526	Thiol-disulfide isomerase or thioredoxin	TrxA	O	Posttranslational modification, protein turnover, chaperones	499	499	1
OG0000513	COG3223	Phosphate starvation-inducible membrane PsiE (function unknown)	PsiE	R	General function prediction only	455	499	0.9118236472945892
OG0000513	COG3431	Uncharacterized membrane protein, DUF373 family	NA	S	Function unknown	1	499	0.002004008016032064
OG0000514	COG0741	Soluble lytic murein transglycosylase or regulatory protein ( may contain LysM/invasin domain), , includes type III secretion system proteins IagB/IpgF/YsaH	MltE	M	Cell wall/membrane/envelope biogenesis	492	499	0.9859719438877755
OG0000515	COG0776	DNA-binding chromatin protein HU or IHF, alpha or beta variants	HupA	B	Chromatin structure and dynamics	498	498	1
OG0000516	COG1219	ATP-dependent protease Clp, ATPase subunit ClpX	ClpX	O	Posttranslational modification, protein turnover, chaperones	498	498	1
OG0000517	COG1044	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase	LpxD	M	Cell wall/membrane/envelope biogenesis	498	498	1
OG0000518	COG0564	Pseudouridine synthase RluA, 23S rRNA- or tRNA-specific	RluA	J	Translation, ribosomal structure and biogenesis	496	498	0.9959839357429718
OG0000519	COG0305	Replicative DNA helicase	DnaB	L	Replication, recombination and repair	498	498	1
OG0000520	COG0556	Excinuclease UvrABC helicase subunit UvrB	UvrB	L	Replication, recombination and repair	498	498	1
OG0000521	COG0196	FAD synthase	RibF	H	Coenzyme transport and metabolism	498	498	1
OG0000522	COG0259	Pyridoxine/pyridoxamine 5'-phosphate oxidase	PdxH	H	Coenzyme transport and metabolism	498	498	1
OG0000523	COG0096	Ribosomal protein S8	RpsH	J	Translation, ribosomal structure and biogenesis	498	498	1
OG0000524	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	AcrA	M	Cell wall/membrane/envelope biogenesis	498	498	1
OG0000525	COG0588	Phosphoglycerate mutase (BPG-dependent)	GpmA	G	Carbohydrate transport and metabolism	498	498	1
OG0000526	COG0763	Lipid A disaccharide synthetase	LpxB	M	Cell wall/membrane/envelope biogenesis	497	498	0.9979919678714859
OG0000527	COG0768	Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2)	FtsI	D	Cell cycle control, cell division, chromosome partitioning	497	498	0.9979919678714859
OG0000528	COG0756	dUTP pyrophosphatase (dUTPase)	Dut	F	Nucleotide transport and metabolism	498	498	1
OG0000529	COG0200	Ribosomal protein L15	RplO	J	Translation, ribosomal structure and biogenesis	498	498	1
OG0000530	COG0098	Ribosomal protein S5	RpsE	J	Translation, ribosomal structure and biogenesis	498	498	1
OG0000531	COG0097	Ribosomal protein L6P/L9E	RplF	J	Translation, ribosomal structure and biogenesis	498	498	1
OG0000532	COG0092	Ribosomal protein S3	RpsC	J	Translation, ribosomal structure and biogenesis	498	498	1
OG0000533	COG0091	Ribosomal protein L22	RplV	J	Translation, ribosomal structure and biogenesis	498	498	1
OG0000534	COG0721	Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit	GatC	J	Translation, ribosomal structure and biogenesis	498	498	1
OG0000535	COG0501	Zn-dependent protease with chaperone function	HtpX	O	Posttranslational modification, protein turnover, chaperones	2	497	0.004024144869215292
OG0000535	COG0750	Membrane-associated protease RseP, regulator of RpoE activity	RseP	O	Posttranslational modification, protein turnover, chaperones	3	497	0.006036217303822937
OG0000535	COG0793	C-terminal processing protease CtpA/Prc, contains a PDZ domain	CtpA	O	Posttranslational modification, protein turnover, chaperones	3	497	0.006036217303822937
OG0000535	COG4784	Putative Zn-dependent protease	NA	R	General function prediction only	488	497	0.9818913480885312
OG0000536	COG1146	NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit	PreA	F	Nucleotide transport and metabolism	489	497	0.9839034205231388
OG0000536	COG4231	TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit	IorA	C	Energy production and conversion	8	497	0.01609657947686117
OG0000537	COG0849	Cell division ATPase FtsA	FtsA	D	Cell cycle control, cell division, chromosome partitioning	236	497	0.47484909456740443
OG0000537	COG1221	Transcriptional regulators containing sigma54-interacting ATPase domain	PspF	K	Transcription	1	497	0.002012072434607646
OG0000537	COG1234	Ribonuclease BN, tRNA processing enzyme	ElaC	J	Translation, ribosomal structure and biogenesis	1	497	0.002012072434607646
OG0000537	COG1867	tRNA G26 N,N-dimethylase Trm1	TRM1	J	Translation, ribosomal structure and biogenesis	1	497	0.002012072434607646
OG0000538	COG1011	FMN and 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YigB, HAD superfamily (riboflavin biosynthesis)	YigB	H	Coenzyme transport and metabolism	497	497	1
OG0000539	COG0278	Glutaredoxin-related protein	GrxD	O	Posttranslational modification, protein turnover, chaperones	497	497	1
OG0000540	COG0148	Enolase	Eno	G	Carbohydrate transport and metabolism	497	497	1
OG0000541	COG0103	Ribosomal protein S9	RpsI	J	Translation, ribosomal structure and biogenesis	497	497	1
OG0000542	COG0102	Ribosomal protein L13	RplM	J	Translation, ribosomal structure and biogenesis	497	497	1
OG0000543	COG0457	Tetratricopeptide (TPR) repeat	TPR	R	General function prediction only	352	497	0.7082494969818913
OG0000543	COG2956	Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain	LapB	M	Cell wall/membrane/envelope biogenesis	7	497	0.014084507042253521
OG0000543	COG4783	Periplasmic chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains	BepA	M	Cell wall/membrane/envelope biogenesis	134	497	0.26961770623742454
OG0000543	COG4785	Lipoprotein NlpI, contains TPR repeats	NlpI	M	Cell wall/membrane/envelope biogenesis	1	497	0.002012072434607646
OG0000544	COG0109	Polyprenyltransferase (heme O synthase)	CyoE	H	Coenzyme transport and metabolism	496	497	0.9979879275653923
OG0000545	COG0654	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	UbiH	H	Coenzyme transport and metabolism	483	497	0.971830985915493
OG0000545	COG1232	Protoporphyrinogen oxidase HemY/PPOX	HemY	H	Coenzyme transport and metabolism	2	497	0.004024144869215292
OG0000546	COG0199	Ribosomal protein S14	RpsN	J	Translation, ribosomal structure and biogenesis	497	497	1
OG0000547	COG1054	tRNA U34 5'-hydroxylase TrhO, rhodanese family	TrhO	J	Translation, ribosomal structure and biogenesis	496	497	0.9979879275653923
OG0000548	COG0335	Ribosomal protein L19	RplS	J	Translation, ribosomal structure and biogenesis	497	497	1
OG0000550	COG0208	Ribonucleotide reductase beta subunit, ferritin-like domain	NrdB	F	Nucleotide transport and metabolism	496	496	1
OG0000551	COG0168	Trk-type K+ transport system, membrane component	TrkG	P	Inorganic ion transport and metabolism	496	496	1
OG0000552	COG0386	Thioredoxin/glutathione peroxidase BtuE, reduces lipid peroxides	BtuE	V	Defense mechanisms	496	496	1
OG0000553	COG5336	FoF1-type ATP synthase AtpZ/Atp1/AtpQ subunit, putative Ca2+/Mg2+ transporter	AtpZ	C	Energy production and conversion	496	496	1
OG0000554	COG0742	16S rRNA G966 N2-methylase RsmD	RsmD	J	Translation, ribosomal structure and biogenesis	496	496	1
OG0000555	COG0495	Leucyl-tRNA synthetase	LeuS	J	Translation, ribosomal structure and biogenesis	1	496	0.0020161290322580645
OG0000555	COG1466	DNA polymerase III, delta subunit	HolA	L	Replication, recombination and repair	490	496	0.9879032258064516
OG0000556	COG0728	Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis)	MurJ	M	Cell wall/membrane/envelope biogenesis	495	496	0.9979838709677419
OG0000557	COG0090	Ribosomal protein L2	RplB	J	Translation, ribosomal structure and biogenesis	496	496	1
OG0000558	COG0512	Anthranilate/para-aminobenzoate synthase component II (glutamine amidotransferase)	PabA	E	Amino acid transport and metabolism	494	495	0.997979797979798
OG0000559	COG0085	DNA-directed RNA polymerase, beta subunit/140 kD subunit	RpoB	K	Transcription	493	495	0.9959595959595959
OG0000560	COG0500	SAM-dependent methyltransferase SmtA (CmoB moved to COG2228)	SmtA	Q	Secondary metabolites biosynthesis, transport and catabolism	4	495	0.00808080808080808
OG0000560	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	3	495	0.006060606060606061
OG0000560	COG2813	16S rRNA G1207 or 23S rRNA G1835 methylase RsmC/RlmG	RsmC	J	Translation, ribosomal structure and biogenesis	8	495	0.01616161616161616
OG0000560	COG2890	Methylase of polypeptide chain release factors	HemK	J	Translation, ribosomal structure and biogenesis	475	495	0.9595959595959596
OG0000560	COG4106	Trans-aconitate methyltransferase	Tam	C	Energy production and conversion	1	495	0.00202020202020202
OG0000561	COG4122	tRNA 5-hydroxyU34 O-methylase TrmR/YrrM	TrmR	J	Translation, ribosomal structure and biogenesis	494	495	0.997979797979798
OG0000562	COG1009	NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Na+/H+ antiporter, MnhA subunit/Na+:bicarbonate transporter, MpsA subunit	NuoL	C	Energy production and conversion	495	495	1
OG0000563	COG0759	Membrane-anchored protein YidD, putatitve component of membrane protein insertase Oxa1/YidC/SpoIIIJ	YidD	M	Cell wall/membrane/envelope biogenesis	495	495	1
OG0000564	COG0317	(p)ppGpp synthase/hydrolase, HD superfamily	SpoT	T	Signal transduction mechanisms	1	495	0.00202020202020202
OG0000564	COG0460	Homoserine dehydrogenase	ThrA	E	Amino acid transport and metabolism	490	495	0.98989898989899
OG0000564	COG0673	Predicted dehydrogenase	MviM	R	General function prediction only	2	495	0.00404040404040404
OG0000564	COG3830	ACT domain, binds amino acids and other small ligands	ACT	T	Signal transduction mechanisms	1	495	0.00202020202020202
OG0000565	COG0321	Lipoate-protein ligase B (lipoyltransferase)	LipB	H	Coenzyme transport and metabolism	495	495	1
OG0000566	COG1538	Outer membrane protein TolC	TolC	M	Cell wall/membrane/envelope biogenesis	495	495	1
OG0000567	COG0039	Malate/lactate dehydrogenase	Mdh	C	Energy production and conversion	494	495	0.997979797979798
OG0000568	COG3494	UDP-2,3-diacylglucosamine hydrolase LpxI, combines lipid X-binding and nucleotide phosphodiesterase domains	LpxI	M	Cell wall/membrane/envelope biogenesis	489	495	0.9878787878787879
OG0000569	COG2867	Ribosome association toxin PasT (RatA) of the RatAB toxin-antitoxin module	PasT	J	Translation, ribosomal structure and biogenesis	494	495	0.997979797979798
OG0000570	COG0708	Exonuclease III	XthA	L	Replication, recombination and repair	494	495	0.997979797979798
OG0000570	COG3568	Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family	ElsH	R	General function prediction only	1	495	0.00202020202020202
OG0000571	COG0059	Ketol-acid reductoisomerase	IlvC	E	Amino acid transport and metabolism	495	495	1
OG0000572	COG1651	Protein thiol-disulfide isomerase DsbC	DsbG	O	Posttranslational modification, protein turnover, chaperones	495	495	1
OG0000573	COG0815	Apolipoprotein N-acyltransferase	Lnt	M	Cell wall/membrane/envelope biogenesis	493	495	0.9959595959595959
OG0000574	COG0150	Phosphoribosylaminoimidazole (AIR) synthetase	PurM	F	Nucleotide transport and metabolism	494	495	0.997979797979798
OG0000575	COG0051	Ribosomal protein S10	RpsJ	J	Translation, ribosomal structure and biogenesis	495	495	1
OG0000576	COG0136	Aspartate-semialdehyde dehydrogenase	Asd	E	Amino acid transport and metabolism	495	495	1
OG0000577	COG0110	O-acetyltransferase, isoleucine patch superfamily, LacA/YvoF/WbbJ family	WbbJ	R	General function prediction only	3	494	0.006072874493927126
OG0000577	COG1207	Bifunctional protein GlmU, N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase	GlmU	M	Cell wall/membrane/envelope biogenesis	491	494	0.9939271255060729
OG0000578	COG2239	Mg/Co/Ni transporter MgtE (contains CBS domain)	MgtE	P	Inorganic ion transport and metabolism	494	494	1
OG0000579	COG2992	Uncharacterized FlgJ-related protein	Bax	R	General function prediction only	494	494	1
OG0000580	COG1181	D-alanine-D-alanine ligase or related ATP-grasp enzyme	DdlA	M	Cell wall/membrane/envelope biogenesis	494	494	1
OG0000581	COG0482	tRNA U34 2-thiouridine synthase MnmA/TrmU, contains the PP-loop ATPase domain	MnmA	J	Translation, ribosomal structure and biogenesis	493	494	0.9979757085020243
OG0000582	COG0518	GMP synthase, glutamine amidotransferase domain/subunit	GuaA1	F	Nucleotide transport and metabolism	4	494	0.008097165991902834
OG0000582	COG0519	GMP synthase, PP-ATPase domain/subunit	GuaA2	F	Nucleotide transport and metabolism	489	494	0.9898785425101214
OG0000583	COG0236	Acyl carrier protein	AcpP	I	Lipid transport and metabolism	494	494	1
OG0000584	COG0215	Cysteinyl-tRNA synthetase	CysS	J	Translation, ribosomal structure and biogenesis	494	494	1
OG0000585	COG0536	GTPase involved in cell partioning and DNA repair	Obg	D	Cell cycle control, cell division, chromosome partitioning	494	494	1
OG0000586	COG1198	Primosomal protein N' (replication factor Y) - superfamily II helicase	PriA	L	Replication, recombination and repair	494	494	1
OG0000587	COG1546	Nicotinamide mononucleotide (NMN) deamidase PncC	PncC	H	Coenzyme transport and metabolism	494	494	1
OG0000588	COG1741	Redox-sensitive bicupin YhaK, pirin superfamily	YhaK	R	General function prediction only	494	494	1
OG0000589	COG2225	Malate synthase	AceB	C	Energy production and conversion	472	494	0.9554655870445344
OG0000590	COG0351	Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase	ThiD	H	Coenzyme transport and metabolism	494	494	1
OG0000591	COG0497	DNA repair ATPase RecN	RecN	L	Replication, recombination and repair	5	494	0.010121457489878543
OG0000591	COG1722	Exonuclease VII small subunit	XseB	L	Replication, recombination and repair	62	494	0.12550607287449392
OG0000591	COG3883	Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO	CwlO1	S	Function unknown	2	494	0.004048582995951417
OG0000592	COG0357	16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B)	RsmG	J	Translation, ribosomal structure and biogenesis	493	494	0.9979757085020243
OG0000593	COG0256	Ribosomal protein L18	RplR	J	Translation, ribosomal structure and biogenesis	494	494	1
OG0000594	COG2223	Nitrate/nitrite transporter NarK	NarK	P	Inorganic ion transport and metabolism	113	493	0.22920892494929007
OG0000594	COG2271	Sugar phosphate permease	UhpC	G	Carbohydrate transport and metabolism	365	493	0.7403651115618661
OG0000594	COG2814	Predicted arabinose efflux permease AraJ, MFS family	AraJ	G	Carbohydrate transport and metabolism	6	493	0.012170385395537525
OG0000595	COG0466	ATP-dependent Lon protease, bacterial type	Lon	O	Posttranslational modification, protein turnover, chaperones	492	493	0.9979716024340771
OG0000596	COG3808	Na+ or H+-translocating membrane pyrophosphatase	OVP1	C	Energy production and conversion	493	493	1
OG0000597	COG1073	Fermentation-respiration switch esterase FrsA, DUF1100 family	FrsA	T	Signal transduction mechanisms	18	493	0.036511156186612576
OG0000597	COG1647	Esterase/lipase	YvaK	Q	Secondary metabolites biosynthesis, transport and catabolism	470	493	0.9533468559837728
OG0000597	COG2267	Lysophospholipase, alpha-beta hydrolase superfamily	PldB	I	Lipid transport and metabolism	3	493	0.006085192697768763
OG0000598	COG0594	RNase P protein component	RnpA	A	RNA processing and modification	489	493	0.9918864097363083
OG0000599	COG1333	Cytochrome c biogenesis protein ResB	ResB	C	Energy production and conversion	4	493	0.008113590263691683
OG0000599	COG2913	Outer membrane protein assembly factor BamE	BamE	M	Cell wall/membrane/envelope biogenesis	84	493	0.17038539553752535
OG0000599	COG3017	Outer membrane lipoprotein LolB, involved in outer membrane biogenesis	LolB	M	Cell wall/membrane/envelope biogenesis	5	493	0.010141987829614604
OG0000599	COG3417	Outer membrane lipoprotein LpoB, binds and activates PBP1b	LpoB	M	Cell wall/membrane/envelope biogenesis	1	493	0.002028397565922921
OG0000599	COG4105	Outer membrane protein assembly factor BamD, BamD/ComL family	BamD	M	Cell wall/membrane/envelope biogenesis	6	493	0.012170385395537525
OG0000599	COG4380	Uncharacterized conserved protein, DUF799 domain	NA	S	Function unknown	5	493	0.010141987829614604
OG0000599	COG4851	Uncharacterized conserved protein involved in sex pheromone biosynthesis	CamS	R	General function prediction only	4	493	0.008113590263691683
OG0000599	COG5510	Entericidin EcnA/EcnB	EcnA	V	Defense mechanisms	7	493	0.014198782961460446
OG0000599	COG5904	Spore germination receptor GerD	GerD	D	Cell cycle control, cell division, chromosome partitioning	1	493	0.002028397565922921
OG0000599	COG5912	Spore cortex protein CoxA (YrbB), YhcN/YlaJ family	CoxA	D	Cell cycle control, cell division, chromosome partitioning	11	493	0.02231237322515213
OG0000600	COG0567	2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes	SucA	C	Energy production and conversion	493	493	1
OG0000601	COG0250	Transcription termination/antitermination protein NusG	NusG	K	Transcription	493	493	1
OG0000602	COG0324	tRNA A37 N6-isopentenylltransferase MiaA	MiaA	J	Translation, ribosomal structure and biogenesis	493	493	1
OG0000603	COG1475	Chromosome segregation protein Spo0J, contains ParB-like CTPase domain	Spo0J	D	Cell cycle control, cell division, chromosome partitioning	493	493	1
OG0000604	COG0127	Inosine/xanthosine triphosphate pyrophosphatase, all-alpha NTP-PPase family	RdgB	F	Nucleotide transport and metabolism	493	493	1
OG0000605	COG0185	Ribosomal protein S19	RpsS	J	Translation, ribosomal structure and biogenesis	493	493	1
OG0000606	COG0719	Fe-S cluster assembly scaffold protein SufB	SufB	O	Posttranslational modification, protein turnover, chaperones	492	493	0.9979716024340771
OG0000607	COG0048	Ribosomal protein S12	RpsL	J	Translation, ribosomal structure and biogenesis	493	493	1
OG0000608	COG2009	Succinate dehydrogenase/fumarate reductase, cytochrome b subunit	SdhC	C	Energy production and conversion	493	493	1
OG0000609	COG1210	UTP-glucose-1-phosphate uridylyltransferase	GalU	M	Cell wall/membrane/envelope biogenesis	492	492	1
OG0000610	COG0776	DNA-binding chromatin protein HU or IHF, alpha or beta variants	HupA	B	Chromatin structure and dynamics	492	492	1
OG0000611	COG0508	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component	AceF	C	Energy production and conversion	487	492	0.9898373983739838
OG0000612	COG4341	Predicted HD phosphohydrolase	NA	R	General function prediction only	491	492	0.9979674796747967
OG0000613	COG0522	Ribosomal protein S4 or related protein	RpsD	J	Translation, ribosomal structure and biogenesis	492	492	1
OG0000614	COG0683	ABC-type branched-chain amino acid transport system, periplasmic component	LivK	E	Amino acid transport and metabolism	491	492	0.9979674796747967
OG0000615	COG0772	Peptodoglycan polymerase FtsW/RodA/SpoVE	FtsW	D	Cell cycle control, cell division, chromosome partitioning	491	492	0.9979674796747967
OG0000616	COG3200	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase, class II	AroG2	E	Amino acid transport and metabolism	492	492	1
OG0000617	COG0019	Diaminopimelate decarboxylase	LysA	E	Amino acid transport and metabolism	492	492	1
OG0000618	COG1899	Deoxyhypusine synthase	DYS1	O	Posttranslational modification, protein turnover, chaperones	490	492	0.9959349593495935
OG0000619	COG0080	Ribosomal protein L11	RplK	J	Translation, ribosomal structure and biogenesis	492	492	1
OG0000620	COG0691	tmRNA-binding protein	SmpB	O	Posttranslational modification, protein turnover, chaperones	492	492	1
OG0000621	COG1077	Cell shape-determining ATPase MreB, actin-like superfamily	MreB	D	Cell cycle control, cell division, chromosome partitioning	492	492	1
OG0000622	COG0275	16S rRNA C1402 N4-methylase RsmH	RmsH	J	Translation, ribosomal structure and biogenesis	492	492	1
OG0000623	COG0616	Periplasmic serine protease, ClpP class	SppA	O	Posttranslational modification, protein turnover, chaperones	491	492	0.9979674796747967
OG0000624	COG2154	Pterin-4a-carbinolamine dehydratase	PhhB	H	Coenzyme transport and metabolism	490	492	0.9959349593495935
OG0000625	COG3786	L,D-peptidoglycan transpeptidase YkuD, ErfK/YbiS/YcfS/YnhG family	NA	M	Cell wall/membrane/envelope biogenesis	492	492	1
OG0000626	COG0266	Formamidopyrimidine-DNA glycosylase	Nei	L	Replication, recombination and repair	492	492	1
OG0000627	COG4103	Tellurite/oxyanion resistance protein, TerB superfamily	TerB2	P	Inorganic ion transport and metabolism	492	492	1
OG0000628	COG0197	Ribosomal protein L16/L10AE	RplP	J	Translation, ribosomal structure and biogenesis	492	492	1
OG0000629	COG1974	SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase)	LexA	K	Transcription	492	492	1
OG0000630	COG1213	Choline kinase	NA	I	Lipid transport and metabolism	1	491	0.002036659877800407
OG0000630	COG3178	N-acetylmuramate/N-acetylglucosamine kinase, aminoglycoside/choline kinase (APH/ChoK) family	AmgK	R	General function prediction only	481	491	0.9796334012219959
OG0000631	COG0052	Ribosomal protein S2	RpsB	J	Translation, ribosomal structure and biogenesis	491	491	1
OG0000632	COG0547	Anthranilate phosphoribosyltransferase, glycosyltransferase domain	TrpD	E	Amino acid transport and metabolism	491	491	1
OG0000633	COG0642	Signal transduction histidine kinase	BaeS	T	Signal transduction mechanisms	353	491	0.7189409368635438
OG0000633	COG2205	K+-sensing histidine kinase KdpD	KdpD	T	Signal transduction mechanisms	4	491	0.008146639511201629
OG0000633	COG2770	HAMP domain	HAMP	T	Signal transduction mechanisms	2	491	0.004073319755600814
OG0000633	COG5002	Sensor histidine kinase WalK	WalK	T	Signal transduction mechanisms	132	491	0.26883910386965376
OG0000634	COG0538	Isocitrate dehydrogenase	Icd	C	Energy production and conversion	491	491	1
OG0000635	COG0302	GTP cyclohydrolase I	FolE	H	Coenzyme transport and metabolism	491	491	1
OG0000636	COG1905	NADH:ubiquinone oxidoreductase 24 kD subunit (chain E)	NuoE	C	Energy production and conversion	491	491	1
OG0000637	COG0442	Prolyl-tRNA synthetase	ProS	J	Translation, ribosomal structure and biogenesis	490	491	0.9979633401221996
OG0000638	COG0735	Fe2+ or Zn2+ uptake regulation protein Fur/Zur	Fur	P	Inorganic ion transport and metabolism	491	491	1
OG0000639	COG1133	Peptide antibiotic transporter SbmA/BacA, ABC-type permease family	SbmA	V	Defense mechanisms	476	491	0.9694501018329938
OG0000639	COG4178	ABC-type uncharacterized transport system, permease and ATPase components	YddA	R	General function prediction only	15	491	0.03054989816700611
OG0000640	COG3023	N-acetyl-anhydromuramyl-L-alanine amidase AmpD	AmpD	M	Cell wall/membrane/envelope biogenesis	490	491	0.9979633401221996
OG0000641	COG0142	Geranylgeranyl pyrophosphate synthase	IspA	H	Coenzyme transport and metabolism	490	491	0.9979633401221996
OG0000642	COG2802	Uncharacterized conserved protein, LON_N-like domain, ASCH/PUA-like superfamily	LON/PUA	S	Function unknown	491	491	1
OG0000643	COG0094	Ribosomal protein L5	RplE	J	Translation, ribosomal structure and biogenesis	491	491	1
OG0000644	COG0186	Ribosomal protein S17	RpsQ	J	Translation, ribosomal structure and biogenesis	491	491	1
OG0000645	COG0255	Ribosomal protein L29	RpmC	J	Translation, ribosomal structure and biogenesis	491	491	1
OG0000646	COG3046	Uncharacterized conserved protein related to deoxyribodipyrimidine photolyase	NA	R	General function prediction only	491	491	1
OG0000647	COG0740	ATP-dependent protease ClpP, protease subunit	ClpP	O	Posttranslational modification, protein turnover, chaperones	491	491	1
OG0000648	COG0440	Acetolactate synthase, small subunit	IlvH	E	Amino acid transport and metabolism	490	490	1
OG0000649	COG2079	2-methylcitrate dehydratase PrpD	PrpD	G	Carbohydrate transport and metabolism	490	490	1
OG0000650	COG0172	Seryl-tRNA synthetase	SerS	J	Translation, ribosomal structure and biogenesis	490	490	1
OG0000651	COG2022	Thiazole synthase ThiGH, ThiG subunit (thiamin biosynthesis)	ThiG	H	Coenzyme transport and metabolism	490	490	1
OG0000652	COG1565	SAM-dependent methyltransferase, MidA family	MidA	R	General function prediction only	490	490	1
OG0000653	COG1496	UDP-MurNAc-monopeptide hydrolase/purine nucleoside phosphorylase YfiH, contains laccase domain	YfiH	F	Nucleotide transport and metabolism	489	490	0.9979591836734694
OG0000654	COG0495	Leucyl-tRNA synthetase	LeuS	J	Translation, ribosomal structure and biogenesis	490	490	1
OG0000655	COG0703	Shikimate kinase	AroK	E	Amino acid transport and metabolism	490	490	1
OG0000656	COG0093	Ribosomal protein L14	RplN	J	Translation, ribosomal structure and biogenesis	490	490	1
OG0000657	COG1218	3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase	CysQ	P	Inorganic ion transport and metabolism	489	489	1
OG0000658	COG0697	Amino acid export permease, drug/metabolite transporter (DMT) superfamily	EamA	E	Amino acid transport and metabolism	488	489	0.9979550102249489
OG0000659	COG1494	Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase or related protein	GlpX	G	Carbohydrate transport and metabolism	486	489	0.9938650306748467
OG0000660	COG0354	Folate-binding protein YgfZ, synthesis and repair of Fe-S clusters, tRNA thiomethylation	YgfZ	J	Translation, ribosomal structure and biogenesis	484	489	0.9897750511247444
OG0000661	COG0316	Fe-S cluster assembly iron-binding protein IscA	IscA	O	Posttranslational modification, protein turnover, chaperones	489	489	1
OG0000662	COG0171	NH3-dependent NAD+ synthetase	NadE	H	Coenzyme transport and metabolism	488	489	0.9979550102249489
OG0000663	COG3011	Predicted thiol-disulfide oxidoreductase YuxK, DCC family	YuxK	R	General function prediction only	225	489	0.4601226993865031
OG0000664	COG0852	NADH:ubiquinone oxidoreductase 27 kD subunit (chain C)	NuoC	C	Energy production and conversion	489	489	1
OG0000665	COG1314	Protein translocase subunit SecG	SecG	U	Intracellular trafficking, secretion, and vesicular transport	465	489	0.950920245398773
OG0000666	COG1612	Heme A synthase	CtaA	H	Coenzyme transport and metabolism	489	489	1
OG0000667	COG1539	Dihydroneopterin aldolase	FolB	H	Coenzyme transport and metabolism	489	489	1
OG0000668	COG1364	Bifunctional glutamate N-acetyltransferase (ornithine transacetylase) ArgJ	ArgJ	E	Amino acid transport and metabolism	488	489	0.9979550102249489
OG0000669	COG0396	Fe-S cluster assembly ATPase SufC	SufC	O	Posttranslational modification, protein turnover, chaperones	489	489	1
OG0000670	COG2142	Succinate dehydrogenase, hydrophobic anchor subunit	SdhD	C	Energy production and conversion	470	489	0.9611451942740287
OG0000671	COG0147	Anthranilate/para-aminobenzoate synthases component I	TrpE	E	Amino acid transport and metabolism	487	488	0.9979508196721312
OG0000672	COG0468	RecA/RadA recombinase	RecA	L	Replication, recombination and repair	487	488	0.9979508196721312
OG0000673	COG1702	Phosphate starvation-inducible protein PhoH, predicted ATPase	PhoH	T	Signal transduction mechanisms	485	488	0.9938524590163934
OG0000673	COG1875	Predicted ribonuclease YlaK, contains NYN-type RNase and PhoH-family ATPase domains	YlaK	R	General function prediction only	1	488	0.0020491803278688526
OG0000674	COG0293	23S rRNA U2552 or 16S rRNA-U1369 or eukaryotic tRNA-C32/G34 (ribose-2'-O)-methylase RlmE/FtsJ/TRM7	RlmE	J	Translation, ribosomal structure and biogenesis	488	488	1
OG0000675	COG0209	Ribonucleotide reductase alpha subunit	NrdA	F	Nucleotide transport and metabolism	488	488	1
OG0000676	COG0345	Pyrroline-5-carboxylate reductase	ProC	E	Amino acid transport and metabolism	476	488	0.9754098360655737
OG0000677	COG0821	4-hydroxy-3-methylbut-2-enyl diphosphate synthase IspG/GcpE	IspG	I	Lipid transport and metabolism	488	488	1
OG0000678	COG1806	Regulator of PEP synthase PpsR, kinase-PPPase family (combines ADP:protein kinase and phosphorylase activities)	PpsR	T	Signal transduction mechanisms	488	488	1
OG0000679	COG0087	Ribosomal protein L3	RplC	J	Translation, ribosomal structure and biogenesis	488	488	1
OG0000680	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	OmpR	T	Signal transduction mechanisms	486	487	0.997946611909651
OG0000680	COG3710	DNA-binding winged helix-turn-helix (wHTH) domain	CadC1	K	Transcription	1	487	0.002053388090349076
OG0000681	COG0264	Translation elongation factor EF-Ts	Tsf	J	Translation, ribosomal structure and biogenesis	487	487	1
OG0000682	COG0317	(p)ppGpp synthase/hydrolase, HD superfamily	SpoT	T	Signal transduction mechanisms	487	487	1
OG0000683	COG0331	Malonyl CoA-acyl carrier protein transacylase	FabD	I	Lipid transport and metabolism	487	487	1
OG0000684	COG0047	Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain	PurL2	F	Nucleotide transport and metabolism	487	487	1
OG0000685	COG0565	tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase	TrmJ	J	Translation, ribosomal structure and biogenesis	484	487	0.9938398357289527
OG0000686	COG1268	Biotin transporter BioY	BioY	H	Coenzyme transport and metabolism	487	487	1
OG0000687	COG0488	ABC cassette proteins with duplicated ATPase domains, Uup/ABCF family	Uup	J	Translation, ribosomal structure and biogenesis	1	487	0.002053388090349076
OG0000687	COG0542	ATP-dependent Clp protease, ATP-binding subunit ClpA	ClpA	O	Posttranslational modification, protein turnover, chaperones	1	487	0.002053388090349076
OG0000687	COG1196	Chromosome segregation ATPase Smc	Smc	D	Cell cycle control, cell division, chromosome partitioning	405	487	0.8316221765913757
OG0000687	COG1754	Uncharacterized C-terminal domain of topoisomerase IA	NA	S	Function unknown	2	487	0.004106776180698152
OG0000687	COG3096	Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB	MukB	D	Cell cycle control, cell division, chromosome partitioning	21	487	0.043121149897330596
OG0000687	COG3206	Tyrosine-protein kinase Wzc involved in exopolysaccharide export, GumC/Wzc1 domain	GumC	M	Cell wall/membrane/envelope biogenesis	2	487	0.004106776180698152
OG0000687	COG3883	Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO	CwlO1	S	Function unknown	3	487	0.006160164271047228
OG0000687	COG4913	Uncharacterized conserved protein, contains a C-terminal ATPase domain	NA	S	Function unknown	2	487	0.004106776180698152
OG0000687	COG4942	Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB	EnvC	D	Cell cycle control, cell division, chromosome partitioning	1	487	0.002053388090349076
OG0000688	COG3651	Uncharacterized conserved protein, DUF2237 family	NA	S	Function unknown	487	487	1
OG0000689	COG0695	Glutaredoxin	GrxC	O	Posttranslational modification, protein turnover, chaperones	487	487	1
OG0000690	COG0593	Chromosomal replication initiation ATPase DnaA	DnaA	L	Replication, recombination and repair	486	487	0.997946611909651
OG0000691	COG1846	DNA-binding transcriptional regulator, MarR family	MarR	K	Transcription	487	487	1
OG0000692	COG1519	3-deoxy-D-manno-octulosonic-acid transferase	KdtA	M	Cell wall/membrane/envelope biogenesis	486	487	0.997946611909651
OG0000693	COG0476	Molybdopterin or thiamine biosynthesis adenylyltransferase	ThiF	H	Coenzyme transport and metabolism	487	487	1
OG0000694	COG4581	Superfamily II RNA helicase	Dob1	L	Replication, recombination and repair	477	487	0.9794661190965093
OG0000695	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	485	486	0.9979423868312757
OG0000696	COG0587	DNA polymerase III, alpha subunit	DnaE	L	Replication, recombination and repair	482	486	0.9917695473251029
OG0000697	COG0113	Delta-aminolevulinic acid dehydratase, porphobilinogen synthase	HemB	H	Coenzyme transport and metabolism	486	486	1
OG0000698	COG2137	SOS response regulatory protein OraA/RecX, interacts with RecA	RecX	O	Posttranslational modification, protein turnover, chaperones	481	486	0.9897119341563786
OG0000699	COG0139	Phosphoribosyl-AMP cyclohydrolase	HisI1	E	Amino acid transport and metabolism	485	486	0.9979423868312757
OG0000700	COG0377	NADH:ubiquinone oxidoreductase 20 kD subunit (chain B) or related Fe-S oxidoreductase	NuoB	C	Energy production and conversion	486	486	1
OG0000701	COG0577	ABC-type antimicrobial peptide transport system, permease component	SalY	V	Defense mechanisms	3	486	0.006172839506172839
OG0000701	COG4591	ABC-type lipoprotein targeting system transmembrane component LolC/LolE	LolC	M	Cell wall/membrane/envelope biogenesis	480	486	0.9876543209876543
OG0000702	COG2919	Cell division protein FtsB	FtsB	D	Cell cycle control, cell division, chromosome partitioning	460	486	0.9465020576131687
OG0000703	COG1267	Phosphatidylglycerophosphatase A	PgpA	I	Lipid transport and metabolism	486	486	1
OG0000704	COG1862	Protein translocase subunit YajC	YajC	U	Intracellular trafficking, secretion, and vesicular transport	486	486	1
OG0000705	COG5389	Uncharacterized conserved protein, DUF721 domain	NA	S	Function unknown	444	486	0.9135802469135802
OG0000706	COG0382	4-hydroxybenzoate polyprenyltransferase	UbiA	H	Coenzyme transport and metabolism	486	486	1
OG0000707	COG0249	DNA mismatch repair ATPase MutS	MutS	L	Replication, recombination and repair	7	486	0.01440329218106996
OG0000708	COG0735	Fe2+ or Zn2+ uptake regulation protein Fur/Zur	Fur	P	Inorganic ion transport and metabolism	486	486	1
OG0000709	COG0198	Ribosomal protein L24	RplX	J	Translation, ribosomal structure and biogenesis	485	486	0.9979423868312757
OG0000710	COG1959	DNA-binding transcriptional regulator, IscR family	IscR	K	Transcription	486	486	1
OG0000711	COG5319	Uncharacterized conserved protein, DUF1178 domain	NA	S	Function unknown	476	485	0.9814432989690721
OG0000712	COG0350	DNA repair enzyme Ada (O6-methylguanine-DNA--protein-cysteine methyltransferase)	AdaB	L	Replication, recombination and repair	484	485	0.9979381443298969
OG0000713	COG0461	Orotate phosphoribosyltransferase	PyrE	F	Nucleotide transport and metabolism	484	485	0.9979381443298969
OG0000714	COG2928	Uncharacterized membrane protein, DUF502 domain	NA	S	Function unknown	485	485	1
OG0000715	COG0002	N-acetyl-gamma-glutamylphosphate reductase	ArgC	E	Amino acid transport and metabolism	485	485	1
OG0000716	COG0741	Soluble lytic murein transglycosylase or regulatory protein ( may contain LysM/invasin domain), , includes type III secretion system proteins IagB/IpgF/YsaH	MltE	M	Cell wall/membrane/envelope biogenesis	1	485	0.002061855670103093
OG0000716	COG0801	7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (folate biosynthesis)	FolK	H	Coenzyme transport and metabolism	484	485	0.9979381443298969
OG0000717	COG1562	Phytoene/squalene synthetase	ERG9	I	Lipid transport and metabolism	483	485	0.9958762886597938
OG0000718	COG0237	Dephospho-CoA kinase	CoaE	H	Coenzyme transport and metabolism	484	485	0.9979381443298969
OG0000719	COG1132	ABC-type multidrug and LPS transport system, ATPase and permease component MsbA	MdlB	M	Cell wall/membrane/envelope biogenesis	484	484	1
OG0000720	COG0283	Cytidylate kinase	Cmk	F	Nucleotide transport and metabolism	482	484	0.9958677685950413
OG0000721	COG0024	Methionine aminopeptidase	Map	J	Translation, ribosomal structure and biogenesis	484	484	1
OG0000722	COG0712	FoF1-type ATP synthase, delta subunit	AtpH	C	Energy production and conversion	484	484	1
OG0000723	COG0084	3'->5' ssDNA/RNA exonuclease TatD	TatD	N	Cell motility	484	484	1
OG0000724	COG0416	Acyl-ACP:phosphate acyltransferase (fatty acid/phospholipid biosynthesis)	PlsX	I	Lipid transport and metabolism	484	484	1
OG0000725	COG0682	Prolipoprotein diacylglyceryltransferase	Lgt	M	Cell wall/membrane/envelope biogenesis	484	484	1
OG0000726	COG0244	Ribosomal protein L10	RplJ	J	Translation, ribosomal structure and biogenesis	484	484	1
OG0000727	COG0143	Methionyl-tRNA synthetase	MetG	J	Translation, ribosomal structure and biogenesis	482	483	0.9979296066252588
OG0000729	COG0271	DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and biofilm formation	BolA	K	Transcription	479	483	0.9917184265010351
OG0000730	COG0838	NADH:ubiquinone oxidoreductase subunit 3 (chain A)	NuoA	C	Energy production and conversion	483	483	1
OG0000731	COG1008	NADH:ubiquinone oxidoreductase subunit 4 (chain M)	NuoM	C	Energy production and conversion	483	483	1
OG0000732	COG0789	DNA-binding transcriptional regulator, MerR family	SoxR	K	Transcription	479	483	0.9917184265010351
OG0000733	COG2104	Sulfur carrier protein ThiS/TtuB (thiamine biosynthesis, tRNA 2-thiouridylation)	ThiS	H	Coenzyme transport and metabolism	475	483	0.9834368530020704
OG0000734	COG0044	Dihydroorotase or related cyclic amidohydrolase	AllB	F	Nucleotide transport and metabolism	481	483	0.9958592132505176
OG0000734	COG1228	Imidazolonepropionase or related amidohydrolase	HutI	Q	Secondary metabolites biosynthesis, transport and catabolism	2	483	0.004140786749482402
OG0000735	COG0776	DNA-binding chromatin protein HU or IHF, alpha or beta variants	HupA	B	Chromatin structure and dynamics	482	482	1
OG0000736	COG1520	Outer membrane protein assembly factor BamB, contains beta-propeller repeat	BamB	M	Cell wall/membrane/envelope biogenesis	455	482	0.9439834024896265
OG0000736	COG4993	Glucose dehydrogenase, PQQ-dependent	Gcd	G	Carbohydrate transport and metabolism	2	482	0.004149377593360996
OG0000737	COG0568	DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32)	RpoD	K	Transcription	3	482	0.006224066390041493
OG0000737	COG4581	Superfamily II RNA helicase	Dob1	L	Replication, recombination and repair	11	482	0.022821576763485476
OG0000738	COG0329	4-hydroxy-tetrahydrodipicolinate synthase/N-acetylneuraminate lyase	DapA	E	Amino acid transport and metabolism	481	482	0.9979253112033195
OG0000739	COG1521	Pantothenate kinase type III	CoaX	H	Coenzyme transport and metabolism	478	482	0.991701244813278
OG0000740	COG1792	Cell shape-determining protein MreC	MreC	D	Cell cycle control, cell division, chromosome partitioning	481	482	0.9979253112033195
OG0000741	COG0135	Phosphoribosylanthranilate isomerase	TrpF	E	Amino acid transport and metabolism	481	482	0.9979253112033195
OG0000742	COG0216	Protein chain release factor RF1	PrfA	J	Translation, ribosomal structure and biogenesis	482	482	1
OG0000743	COG0683	ABC-type branched-chain amino acid transport system, periplasmic component	LivK	E	Amino acid transport and metabolism	477	482	0.9896265560165975
OG0000743	COG3107	Outer membrane lipoprotein LpoA, binds and activates PBP1a	LpoA	M	Cell wall/membrane/envelope biogenesis	2	482	0.004149377593360996
OG0000744	COG0441	Threonyl-tRNA synthetase	ThrS	J	Translation, ribosomal structure and biogenesis	1	482	0.002074688796680498
OG0000744	COG0544	Trigger factor Tig, ribosome-bound chaperone (peptidyl-prolyl cis-trans isomerase)	Tig	O	Posttranslational modification, protein turnover, chaperones	475	482	0.9854771784232366
OG0000744	COG0620	Methionine synthase II (cobalamin-independent)	MetE	E	Amino acid transport and metabolism	1	482	0.002074688796680498
OG0000745	COG0216	Protein chain release factor RF1	PrfA	J	Translation, ribosomal structure and biogenesis	1	481	0.002079002079002079
OG0000745	COG0542	ATP-dependent Clp protease, ATP-binding subunit ClpA	ClpA	O	Posttranslational modification, protein turnover, chaperones	1	481	0.002079002079002079
OG0000745	COG3883	Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO	CwlO1	S	Function unknown	4	481	0.008316008316008316
OG0000746	COG1452	Lipopolysaccharide export system protein LptD/OstA, potential outer membrane flippase	LptD	M	Cell wall/membrane/envelope biogenesis	480	481	0.997920997920998
OG0000747	COG1176	ABC-type spermidine/putrescine transport system, permease component I	PotB	E	Amino acid transport and metabolism	480	481	0.997920997920998
OG0000748	COG0041	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase	PurE	F	Nucleotide transport and metabolism	481	481	1
OG0000749	COG2204	DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains	AtoC	T	Signal transduction mechanisms	478	481	0.9937629937629938
OG0000749	COG3829	RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains	RocR	K	Transcription	3	481	0.006237006237006237
OG0000750	COG1354	Chromatin segregation and condensation protein Rec8/ScpA/Scc1, kleisin family	ScpA	L	Replication, recombination and repair	481	481	1
OG0000751	COG1386	Chromosome segregation and condensation protein ScpB	ScpB	K	Transcription	481	481	1
OG0000752	COG0617	tRNA nucleotidyltransferase (CCA-adding enzyme)/poly(A) polymerase	PcnB	J	Translation, ribosomal structure and biogenesis	469	481	0.975051975051975
OG0000753	COG1194	Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs	MutY	L	Replication, recombination and repair	474	481	0.9854469854469855
OG0000754	COG1589	Cell division septal protein FtsQ	FtsQ	D	Cell cycle control, cell division, chromosome partitioning	1	481	0.002079002079002079
OG0000754	COG2980	Lipopolysaccharide export system lipoprotein LptE/RlpB	LptE	M	Cell wall/membrane/envelope biogenesis	42	481	0.08731808731808732
OG0000754	COG3889	Extracellular solute-binding protein, contains Ig-fold domain	NA	R	General function prediction only	1	481	0.002079002079002079
OG0000754	COG5468	Predicted lipoprotein involved in lipopolysaccharide assembly	NA	S	Function unknown	34	481	0.07068607068607069
OG0000754	COG5608	Dessication stress tolerance protein, LEA/WHy domain	LEA	V	Defense mechanisms	5	481	0.010395010395010396
OG0000755	COG0697	Amino acid export permease, drug/metabolite transporter (DMT) superfamily	EamA	E	Amino acid transport and metabolism	479	481	0.9958419958419958
OG0000755	COG5006	Threonine/homoserine efflux transporter RhtA, contains EamA domain	RhtA	E	Amino acid transport and metabolism	2	481	0.004158004158004158
OG0000756	COG0484	DnaJ molecular chaperone, contains DnaJ and DnaJ_C  domains	DnaJ	O	Posttranslational modification, protein turnover, chaperones	342	481	0.7110187110187111
OG0000756	COG1287	Asparagine N-glycosylation enzyme, membrane subunit Stt3	Stt3	O	Posttranslational modification, protein turnover, chaperones	1	481	0.002079002079002079
OG0000756	COG1622	Heme/copper-type cytochrome/quinol oxidase, subunit 2	CyoA	C	Energy production and conversion	4	481	0.008316008316008316
OG0000756	COG2214	Curved DNA-binding protein CbpA, contains a DnaJ-like domain	CbpA	K	Transcription	95	481	0.19750519750519752
OG0000756	COG3696	Cu/Ag efflux pump CusA	CusA	P	Inorganic ion transport and metabolism	6	481	0.012474012474012475
OG0000757	COG5360	Uncharacterized conserved protein, heparinase superfamily	NA	R	General function prediction only	477	480	0.99375
OG0000758	COG0760	Periplasmic chaperone SurA (peptidyl-prolyl cis-trans isomerase)	SurA	O	Posttranslational modification, protein turnover, chaperones	417	480	0.86875
OG0000758	COG3883	Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO	CwlO1	S	Function unknown	1	480	0.0020833333333333333
OG0000759	COG0615	Glycerol-3-phosphate cytidylyltransferase, cytidylyltransferase family	TagD	M	Cell wall/membrane/envelope biogenesis	1	480	0.0020833333333333333
OG0000759	COG0669	Phosphopantetheine adenylyltransferase	CoaD	H	Coenzyme transport and metabolism	479	480	0.9979166666666667
OG0000760	COG4696	NTP pyrophosphatase, MazG superfamily	MazG2	F	Nucleotide transport and metabolism	480	480	1
OG0000761	COG0414	Panthothenate synthetase	PanC	H	Coenzyme transport and metabolism	480	480	1
OG0000762	COG0457	Tetratricopeptide (TPR) repeat	TPR	R	General function prediction only	1	480	0.0020833333333333333
OG0000762	COG2956	Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain	LapB	M	Cell wall/membrane/envelope biogenesis	43	480	0.08958333333333333
OG0000762	COG3063	Type IV pilus assembly pilotin PilF, contains TPR repeats	PilF	N	Cell motility	3	480	0.00625
OG0000762	COG3914	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family	Spy	O	Posttranslational modification, protein turnover, chaperones	12	480	0.025
OG0000762	COG4235	Cytochrome c-type biogenesis protein CcmH/NrfG	NrfG	C	Energy production and conversion	306	480	0.6375
OG0000762	COG4783	Periplasmic chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains	BepA	M	Cell wall/membrane/envelope biogenesis	51	480	0.10625
OG0000762	COG4785	Lipoprotein NlpI, contains TPR repeats	NlpI	M	Cell wall/membrane/envelope biogenesis	14	480	0.029166666666666667
OG0000762	COG5010	Flp/Tad pilus assembly pilotin TadD, contains TPR repeats	TadD	W	Extracellular structures	34	480	0.07083333333333333
OG0000762	COG5616	TolB amino-terminal domain (function unknown)	TolBN	T	Signal transduction mechanisms	1	480	0.0020833333333333333
OG0000763	COG0271	DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and biofilm formation	BolA	K	Transcription	4	480	0.008333333333333333
OG0000763	COG5007	Acid stress protein IbaG/YrbA, BolA-like family	IbaG	T	Signal transduction mechanisms	476	480	0.9916666666666667
OG0000764	COG0081	Ribosomal protein L1	RplA	J	Translation, ribosomal structure and biogenesis	480	480	1
OG0000765	COG0735	Fe2+ or Zn2+ uptake regulation protein Fur/Zur	Fur	P	Inorganic ion transport and metabolism	480	480	1
OG0000766	COG2513	2-Methylisocitrate lyase and related enzymes, PEP mutase family	PrpB	G	Carbohydrate transport and metabolism	479	479	1
OG0000767	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	HisJ	E	Amino acid transport and metabolism	479	479	1
OG0000768	COG0359	Ribosomal protein L9	RplI	J	Translation, ribosomal structure and biogenesis	476	479	0.9937369519832986
OG0000769	COG0152	Phosphoribosylaminoimidazole-succinocarboxamide synthase	PurC	F	Nucleotide transport and metabolism	479	479	1
OG0000770	COG1828	Phosphoribosylformylglycinamidine (FGAM) synthase, PurS subunit	PurS	F	Nucleotide transport and metabolism	479	479	1
OG0000771	COG0802	tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE	TsaE	J	Translation, ribosomal structure and biogenesis	476	479	0.9937369519832986
OG0000771	COG2401	ABC-type ATPase fused to a predicted acetyltransferase domain	MK0520	R	General function prediction only	1	479	0.0020876826722338203
OG0000771	COG3267	Type II secretory pathway ATPase component GspA/ExeA/MshM	ExeA	U	Intracellular trafficking, secretion, and vesicular transport	1	479	0.0020876826722338203
OG0000771	COG5635	Predicted NTPase, NACHT family domain	NACHT	T	Signal transduction mechanisms	1	479	0.0020876826722338203
OG0000772	COG0222	Ribosomal protein L7/L12	RplL	J	Translation, ribosomal structure and biogenesis	479	479	1
OG0000773	COG1826	Twin-arginine protein secretion pathway components TatA, TatB, TatE	TatA	U	Intracellular trafficking, secretion, and vesicular transport	469	479	0.9791231732776617
OG0000774	COG4327	Uncharacterized membrane protein, DUF4212 domain	NA	S	Function unknown	479	479	1
OG0000775	COG1073	Fermentation-respiration switch esterase FrsA, DUF1100 family	FrsA	T	Signal transduction mechanisms	478	479	0.9979123173277662
OG0000776	COG0750	Membrane-associated protease RseP, regulator of RpoE activity	RseP	O	Posttranslational modification, protein turnover, chaperones	479	479	1
OG0000777	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	187	478	0.3912133891213389
OG0000777	COG2827	Predicted endonuclease, GIY-YIG superfamily	YhbQ	L	Replication, recombination and repair	1	478	0.0020920502092050207
OG0000777	COG4641	Spore maturation protein CgeB	NA	D	Cell cycle control, cell division, chromosome partitioning	273	478	0.5711297071129707
OG0000778	COG0665	Glycine/D-amino acid oxidase (deaminating)	DadA	E	Amino acid transport and metabolism	477	478	0.997907949790795
OG0000778	COG1232	Protoporphyrinogen oxidase HemY/PPOX	HemY	H	Coenzyme transport and metabolism	1	478	0.0020920502092050207
OG0000779	COG0015	Adenylosuccinate lyase	PurB	F	Nucleotide transport and metabolism	478	478	1
OG0000780	COG1807	PMT family glycosyltransferase ArnT/Agl22, involved in glycosylation of proteins and lipid IVA	ArnT	M	Cell wall/membrane/envelope biogenesis	459	478	0.9602510460251046
OG0000781	COG0785	Cytochrome c biogenesis protein CcdA	CcdA	C	Energy production and conversion	478	478	1
OG0000782	COG0233	Ribosome recycling factor	Frr	J	Translation, ribosomal structure and biogenesis	478	478	1
OG0000783	COG0149	Triosephosphate isomerase	TpiA	G	Carbohydrate transport and metabolism	477	478	0.997907949790795
OG0000784	COG0765	ABC-type amino acid transport system, permease component	HisM	E	Amino acid transport and metabolism	477	478	0.997907949790795
OG0000785	COG1333	Cytochrome c biogenesis protein ResB	ResB	C	Energy production and conversion	2	478	0.0041841004184100415
OG0000785	COG2182	Maltose-binding periplasmic protein MalE	MalE	G	Carbohydrate transport and metabolism	1	478	0.0020920502092050207
OG0000785	COG3015	Uncharacterized lipoprotein NlpE involved in copper resistance	CutF	M	Cell wall/membrane/envelope biogenesis	14	478	0.029288702928870293
OG0000785	COG3018	Flagellar basal body lipoprotein FlgP, LPP20 family	FlgP	N	Cell motility	4	478	0.008368200836820083
OG0000785	COG4105	Outer membrane protein assembly factor BamD, BamD/ComL family	BamD	M	Cell wall/membrane/envelope biogenesis	46	478	0.09623430962343096
OG0000785	COG4259	Uncharacterized conserved protein, DUF4810 domain	NA	S	Function unknown	2	478	0.0041841004184100415
OG0000785	COG5567	Periplasmic lipoprotein LptM/YifL, part of outer membrane beta-barrel assembly machinery	YifL	M	Cell wall/membrane/envelope biogenesis	18	478	0.03765690376569038
OG0000785	COG5633	Uncharacterized conserved protein YcfL	YcfL	S	Function unknown	3	478	0.006276150627615063
OG0000786	COG0566	tRNA G18 (ribose-2'-O)-methylase SpoU	SpoU	J	Translation, ribosomal structure and biogenesis	478	478	1
OG0000787	COG2062	Phosphohistidine phosphatase SixA	SixA	T	Signal transduction mechanisms	475	477	0.9958071278825996
OG0000788	COG1196	Chromosome segregation ATPase Smc	Smc	D	Cell cycle control, cell division, chromosome partitioning	1	477	0.0020964360587002098
OG0000790	COG1472	Periplasmic beta-glucosidase and related glycosidases	BglX	G	Carbohydrate transport and metabolism	472	477	0.989517819706499
OG0000791	COG0679	Predicted permease, AEC (auxin efflux carrier) family	YfdV	R	General function prediction only	476	476	1
OG0000792	COG0238	Ribosomal protein S18	RpsR	J	Translation, ribosomal structure and biogenesis	476	476	1
OG0000793	COG4597	ABC-type amino acid transport system, permease component	BatB	E	Amino acid transport and metabolism	476	476	1
OG0000794	COG0018	Arginyl-tRNA synthetase	ArgS	J	Translation, ribosomal structure and biogenesis	475	476	0.9978991596638656
OG0000795	COG0805	Twin-arginine protein secretion pathway component TatC	TatC	U	Intracellular trafficking, secretion, and vesicular transport	476	476	1
OG0000796	COG0267	Ribosomal protein L33	RpmG	J	Translation, ribosomal structure and biogenesis	172	476	0.36134453781512604
OG0000797	COG3027	Cell division protein ZapA, inhibits GTPase activity of FtsZ	ZapA	D	Cell cycle control, cell division, chromosome partitioning	476	476	1
OG0000798	COG0574	Phosphoenolpyruvate synthase/pyruvate phosphate dikinase	PpsA	G	Carbohydrate transport and metabolism	465	476	0.976890756302521
OG0000798	COG1080	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria)	PtsA	G	Carbohydrate transport and metabolism	11	476	0.023109243697478993
OG0000799	COG0456	Ribosomal protein S18 acetylase RimI and related acetyltransferases	RimI	J	Translation, ribosomal structure and biogenesis	339	476	0.7121848739495799
OG0000799	COG1246	N-acetylglutamate synthase or related acetyltransferase, GNAT family	ArgA	E	Amino acid transport and metabolism	97	476	0.20378151260504201
OG0000799	COG1670	Protein N-acetyltransferase, RimJ/RimL family	RimL	J	Translation, ribosomal structure and biogenesis	10	476	0.02100840336134454
OG0000800	COG0534	Na+-driven multidrug efflux pump, DinF/NorM/MATE family	NorM	V	Defense mechanisms	476	476	1
OG0000801	COG1840	ABC-type transport systems for B6 and hexose phosphate, periplasmic component	AfuA	G	Carbohydrate transport and metabolism	475	475	1
OG0000802	COG1826	Twin-arginine protein secretion pathway components TatA, TatB, TatE	TatA	U	Intracellular trafficking, secretion, and vesicular transport	458	475	0.9642105263157895
OG0000803	COG3748	Uncharacterized membrane protein	NA	S	Function unknown	474	475	0.9978947368421053
OG0000804	COG0333	Ribosomal protein L32	RpmF	J	Translation, ribosomal structure and biogenesis	475	475	1
OG0000805	COG0579	L-2-hydroxyglutarate oxidase LhgO	LhgO	G	Carbohydrate transport and metabolism	465	475	0.9789473684210527
OG0000806	COG0031	Cysteine synthase	CysK	E	Amino acid transport and metabolism	469	474	0.989451476793249
OG0000806	COG0498	Threonine synthase	ThrC	E	Amino acid transport and metabolism	1	474	0.002109704641350211
OG0000806	COG1171	Threonine deaminase	IlvA	E	Amino acid transport and metabolism	4	474	0.008438818565400843
OG0000807	COG1058	ADP-ribose pyrophosphatase domain of DNA damage- and competence-inducible protein CinA	CinA	L	Replication, recombination and repair	471	474	0.9936708860759493
OG0000808	COG0824	Acyl-CoA thioesterase FadM	FadM	I	Lipid transport and metabolism	474	474	1
OG0000811	COG3317	Outer membrane protein assembly factor BamC	BamC	M	Cell wall/membrane/envelope biogenesis	26	474	0.05485232067510549
OG0000811	COG4105	Outer membrane protein assembly factor BamD, BamD/ComL family	BamD	M	Cell wall/membrane/envelope biogenesis	16	474	0.03375527426160337
OG0000811	COG4380	Uncharacterized conserved protein, DUF799 domain	NA	S	Function unknown	2	474	0.004219409282700422
OG0000811	COG5510	Entericidin EcnA/EcnB	EcnA	V	Defense mechanisms	9	474	0.0189873417721519
OG0000811	COG5567	Periplasmic lipoprotein LptM/YifL, part of outer membrane beta-barrel assembly machinery	YifL	M	Cell wall/membrane/envelope biogenesis	36	474	0.0759493670886076
OG0000811	COG5633	Uncharacterized conserved protein YcfL	YcfL	S	Function unknown	1	474	0.002109704641350211
OG0000812	COG0124	Histidyl-tRNA synthetase	HisS	J	Translation, ribosomal structure and biogenesis	474	474	1
OG0000813	COG0352	Thiamine monophosphate synthase	ThiE	H	Coenzyme transport and metabolism	473	474	0.9978902953586498
OG0000814	COG0141	Histidinol dehydrogenase	HisD	E	Amino acid transport and metabolism	471	473	0.9957716701902748
OG0000815	COG0579	L-2-hydroxyglutarate oxidase LhgO	LhgO	G	Carbohydrate transport and metabolism	3	473	0.006342494714587738
OG0000815	COG0665	Glycine/D-amino acid oxidase (deaminating)	DadA	E	Amino acid transport and metabolism	3	473	0.006342494714587738
OG0000815	COG1232	Protoporphyrinogen oxidase HemY/PPOX	HemY	H	Coenzyme transport and metabolism	1	473	0.0021141649048625794
OG0000815	COG2907	Predicted flavin-containing amine oxidase	Ppro0129	R	General function prediction only	466	473	0.985200845665962
OG0000816	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	1	473	0.0021141649048625794
OG0000816	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	BcsA	N	Cell motility	1	473	0.0021141649048625794
OG0000816	COG1216	Glycosyltransferase, GT2 family	WcaE	G	Carbohydrate transport and metabolism	460	473	0.9725158562367865
OG0000817	COG0771	UDP-N-acetylmuramoylalanine-D-glutamate ligase	MurD	M	Cell wall/membrane/envelope biogenesis	473	473	1
OG0000818	COG0071	Small heat shock protein IbpA, HSP20 family	IbpA	O	Posttranslational modification, protein turnover, chaperones	473	473	1
OG0000819	COG1489	DNA-binding protein, stimulates sugar fermentation	SfsA	G	Carbohydrate transport and metabolism	473	473	1
OG0000820	COG1007	NADH:ubiquinone oxidoreductase subunit 2 (chain N)	NuoN	C	Energy production and conversion	473	473	1
OG0000821	COG0571	dsRNA-specific ribonuclease	Rnc	K	Transcription	473	473	1
OG0000822	COG0681	Signal peptidase I	LepB	U	Intracellular trafficking, secretion, and vesicular transport	472	473	0.9978858350951374
OG0000822	COG4959	Type IV secretion/DNA transfer system protease TraF	TraF	U	Intracellular trafficking, secretion, and vesicular transport	1	473	0.0021141649048625794
OG0000823	COG1011	FMN and 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YigB, HAD superfamily (riboflavin biosynthesis)	YigB	H	Coenzyme transport and metabolism	473	473	1
OG0000824	COG0089	Ribosomal protein L23	RplW	J	Translation, ribosomal structure and biogenesis	473	473	1
OG0000825	COG0360	Ribosomal protein S6	RpsF	J	Translation, ribosomal structure and biogenesis	472	472	1
OG0000826	COG1381	Recombinational DNA repair protein RecO (RecF pathway)	RecO	L	Replication, recombination and repair	470	472	0.9957627118644068
OG0000827	COG3242	Uncharacterized conserved protein YjeT, DUF2065 family	YjeT	S	Function unknown	472	472	1
OG0000828	COG0415	Deoxyribodipyrimidine photolyase	PhrB	L	Replication, recombination and repair	467	472	0.989406779661017
OG0000829	COG0508	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component	AceF	C	Energy production and conversion	385	471	0.8174097664543525
OG0000829	COG4845	Chloramphenicol O-acetyltransferase	CatA	V	Defense mechanisms	52	471	0.11040339702760085
OG0000830	COG0483	Archaeal fructose-1,6-bisphosphatase or related enzyme, inositol monophosphatase family	SuhB	G	Carbohydrate transport and metabolism	471	471	1
OG0000831	COG2230	Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases	Cfa	I	Lipid transport and metabolism	1	471	0.0021231422505307855
OG0000831	COG3384	Aromatic ring-opening dioxygenase, catalytic subunit, LigB family	LigB	Q	Secondary metabolites biosynthesis, transport and catabolism	1	471	0.0021231422505307855
OG0000831	COG4380	Uncharacterized conserved protein, DUF799 domain	NA	S	Function unknown	3	471	0.006369426751592357
OG0000831	COG5633	Uncharacterized conserved protein YcfL	YcfL	S	Function unknown	13	471	0.027600849256900213
OG0000832	COG1221	Transcriptional regulators containing sigma54-interacting ATPase domain	PspF	K	Transcription	6	471	0.012738853503184714
OG0000832	COG1729	Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction	CpoB	D	Cell cycle control, cell division, chromosome partitioning	31	471	0.06581740976645435
OG0000832	COG2976	Ancillary subunit YfgM of SecYEG translocon, regulates RcsB-dependent stress response	YfgM	T	Signal transduction mechanisms	66	471	0.14012738853503184
OG0000832	COG2982	Outer membrane assembly factor AsmA	AsmA	M	Cell wall/membrane/envelope biogenesis	1	471	0.0021231422505307855
OG0000832	COG3933	Transcriptional regulator of LevR family, contains sigma54-interacting AAA domain, PTS regulation domain (PRD), and EIIA-type domain	LevR	K	Transcription	1	471	0.0021231422505307855
OG0000832	COG4235	Cytochrome c-type biogenesis protein CcmH/NrfG	NrfG	C	Energy production and conversion	2	471	0.004246284501061571
OG0000832	COG4649	TPR-like repeat domain	TPR1	S	Function unknown	137	471	0.2908704883227176
OG0000833	COG0795	Lipopolysaccharide export LptBFGC system, permease protein LptF	LptF	M	Cell wall/membrane/envelope biogenesis	464	471	0.9851380042462845
OG0000834	COG1208	NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis protein s	GCD1	J	Translation, ribosomal structure and biogenesis	461	470	0.9808510638297873
OG0000834	COG1213	Choline kinase	NA	I	Lipid transport and metabolism	1	470	0.002127659574468085
OG0000835	COG0300	Short-chain dehydrogenase	YqjQ	R	General function prediction only	1	470	0.002127659574468085
OG0000835	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	1	470	0.002127659574468085
OG0000835	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	FabG	I	Lipid transport and metabolism	468	470	0.9957446808510638
OG0000836	COG0568	DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32)	RpoD	K	Transcription	470	470	1
OG0000837	COG0073	tRNA-binding EMAP/Myf domain	EMAP	J	Translation, ribosomal structure and biogenesis	468	470	0.9957446808510638
OG0000838	COG1605	Chorismate mutase	PheA	E	Amino acid transport and metabolism	241	470	0.5127659574468085
OG0000839	COG0736	Phosphopantetheinyl transferase (holo-ACP synthase)	AcpS	I	Lipid transport and metabolism	470	470	1
OG0000840	COG0662	Mannose-6-phosphate isomerase, cupin superfamily	ManC	G	Carbohydrate transport and metabolism	27	469	0.057569296375266525
OG0000840	COG0836	Mannose-1-phosphate guanylyltransferase	CpsB	M	Cell wall/membrane/envelope biogenesis	440	469	0.9381663113006397
OG0000841	COG1589	Cell division septal protein FtsQ	FtsQ	D	Cell cycle control, cell division, chromosome partitioning	464	469	0.9893390191897654
OG0000842	COG0739	Murein endopeptidase or hydrolase activator MepM/NlpD, contains LysM domain	NlpD	M	Cell wall/membrane/envelope biogenesis	467	469	0.9957356076759062
OG0000842	COG3061	Cell division protein YtfB/OapA (opacity-associated protein A)	OapA	D	Cell cycle control, cell division, chromosome partitioning	1	469	0.0021321961620469083
OG0000843	COG1178	ABC-type Fe3+ transport system, permease component	FbpB	P	Inorganic ion transport and metabolism	469	469	1
OG0000844	COG0054	6,7-dimethyl-8-ribityllumazine synthase (Riboflavin synthase beta chain)	RibE	H	Coenzyme transport and metabolism	469	469	1
OG0000845	COG5000	Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation	NtrY	T	Signal transduction mechanisms	466	468	0.9957264957264957
OG0000846	COG0688	Phosphatidylserine decarboxylase	Psd	I	Lipid transport and metabolism	468	468	1
OG0000847	COG0488	ABC cassette proteins with duplicated ATPase domains, Uup/ABCF family	Uup	J	Translation, ribosomal structure and biogenesis	1	467	0.0021413276231263384
OG0000847	COG1123	ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain	GsiA	O	Posttranslational modification, protein turnover, chaperones	1	467	0.0021413276231263384
OG0000847	COG1137	ABC-type lipopolysaccharide export system, ATPase component	LptB	M	Cell wall/membrane/envelope biogenesis	464	467	0.9935760171306209
OG0000848	COG0505	Carbamoylphosphate synthase small subunit	CarA	E	Amino acid transport and metabolism	1	467	0.0021413276231263384
OG0000848	COG0512	Anthranilate/para-aminobenzoate synthase component II (glutamine amidotransferase)	PabA	E	Amino acid transport and metabolism	392	467	0.8394004282655246
OG0000848	COG0518	GMP synthase, glutamine amidotransferase domain/subunit	GuaA1	F	Nucleotide transport and metabolism	10	467	0.021413276231263382
OG0000848	COG2071	Gamma-glutamyl-gamma-aminobutyrate hydrolase PuuD (putrescine degradation), contains GATase1-like domain	PuuD	E	Amino acid transport and metabolism	62	467	0.13276231263383298
OG0000849	COG4626	Phage terminase-like protein, large subunit, contains N-terminal HTH domain	YmfN	X	Mobilome: prophages, transposons	6	467	0.01284796573875803
OG0000849	COG4772	Outer membrane receptor for Fe3+-dicitrate	FecA	P	Inorganic ion transport and metabolism	2	467	0.004282655246252677
OG0000850	COG2271	Sugar phosphate permease	UhpC	G	Carbohydrate transport and metabolism	1	467	0.0021413276231263384
OG0000850	COG2807	Cyanate permease	CynX	P	Inorganic ion transport and metabolism	3	467	0.006423982869379015
OG0000850	COG2814	Predicted arabinose efflux permease AraJ, MFS family	AraJ	G	Carbohydrate transport and metabolism	458	467	0.9807280513918629
OG0000850	COG4177	ABC-type branched-chain amino acid transport system, permease component	LivM	E	Amino acid transport and metabolism	1	467	0.0021413276231263384
OG0000851	COG0683	ABC-type branched-chain amino acid transport system, periplasmic component	LivK	E	Amino acid transport and metabolism	464	467	0.9935760171306209
OG0000852	COG1329	RNA polymerase-interacting regulator, CarD/CdnL/TRCF family	CdnL	K	Transcription	2	467	0.004282655246252677
OG0000852	COG1774	Cell fate regulator YaaT, PSP1 superfamily (controls sporulation, competence, biofilm development)	YaaT	T	Signal transduction mechanisms	4	467	0.008565310492505354
OG0000853	COG0026	Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	PurK	F	Nucleotide transport and metabolism	465	467	0.9957173447537473
OG0000853	COG0027	Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	PurT	F	Nucleotide transport and metabolism	1	467	0.0021413276231263384
OG0000854	COG1981	Protoporphyrinogen oxidase HemJ (unrelated to HemG or HemY)	HemJ	H	Coenzyme transport and metabolism	467	467	1
OG0000855	COG1121	ABC-type Mn2+/Zn2+ transport system, ATPase component	ZnuC	P	Inorganic ion transport and metabolism	1	467	0.0021413276231263384
OG0000855	COG1129	ABC-type sugar transport system, ATPase component	MglA	G	Carbohydrate transport and metabolism	2	467	0.004282655246252677
OG0000855	COG1196	Chromosome segregation ATPase Smc	Smc	D	Cell cycle control, cell division, chromosome partitioning	1	467	0.0021413276231263384
OG0000855	COG3190	Flagellar biogenesis protein FliO	FliO	N	Cell motility	74	467	0.15845824411134904
OG0000855	COG4134	ABC-type uncharacterized transport system YnjBCD, periplasmic component	YnjB	R	General function prediction only	1	467	0.0021413276231263384
OG0000855	COG5373	Uncharacterized membrane protein	NA	S	Function unknown	1	467	0.0021413276231263384
OG0000856	COG0029	Aspartate oxidase	NadB	H	Coenzyme transport and metabolism	11	467	0.023554603854389723
OG0000856	COG1053	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit	SdhA	C	Energy production and conversion	451	467	0.9657387580299786
OG0000857	COG1452	Lipopolysaccharide export system protein LptD/OstA, potential outer membrane flippase	LptD	M	Cell wall/membrane/envelope biogenesis	276	466	0.592274678111588
OG0000857	COG1934	Lipopolysaccharide export system protein LptA	LptA	M	Cell wall/membrane/envelope biogenesis	9	466	0.019313304721030045
OG0000857	COG3117	Lipopolysaccharide export system protein LptC	LptC	M	Cell wall/membrane/envelope biogenesis	68	466	0.1459227467811159
OG0000857	COG5278	Extracytoplasmic sensor domain CHASE3 (specificity unknown)	CHASE3	T	Signal transduction mechanisms	1	466	0.002145922746781116
OG0000857	COG5375	Predicted lipopolysaccharide assembly protein, LptC/YrbK-like family	LptC2	M	Cell wall/membrane/envelope biogenesis	92	466	0.19742489270386265
OG0000858	COG0854	Pyridoxine 5'-phosphate synthase PdxJ	PdxJ	H	Coenzyme transport and metabolism	466	466	1
OG0000859	COG0421	Spermidine synthase (polyamine aminopropyltransferase)	SpeE	E	Amino acid transport and metabolism	20	466	0.04291845493562232
OG0000859	COG0516	IMP dehydrogenase/GMP reductase	GuaB	F	Nucleotide transport and metabolism	1	466	0.002145922746781116
OG0000859	COG1586	S-adenosylmethionine decarboxylase	SpeD	E	Amino acid transport and metabolism	445	466	0.9549356223175965
OG0000860	COG0781	Transcription antitermination protein NusB	NusB	K	Transcription	464	465	0.9978494623655914
OG0000861	COG0108	3,4-dihydroxy-2-butanone 4-phosphate synthase	RibB	H	Coenzyme transport and metabolism	414	465	0.8903225806451613
OG0000861	COG0807	GTP cyclohydrolase II	RibA	H	Coenzyme transport and metabolism	51	465	0.10967741935483871
OG0000862	COG0319	ssRNA-specific RNase YbeY, 16S rRNA maturation enzyme	YbeY	J	Translation, ribosomal structure and biogenesis	464	465	0.9978494623655914
OG0000863	COG0626	Cystathionine beta-lyase/cystathionine gamma-synthase	MetC	E	Amino acid transport and metabolism	465	465	1
OG0000864	COG0316	Fe-S cluster assembly iron-binding protein IscA	IscA	O	Posttranslational modification, protein turnover, chaperones	465	465	1
OG0000865	COG0466	ATP-dependent Lon protease, bacterial type	Lon	O	Posttranslational modification, protein turnover, chaperones	1	465	0.002150537634408602
OG0000865	COG0542	ATP-dependent Clp protease, ATP-binding subunit ClpA	ClpA	O	Posttranslational modification, protein turnover, chaperones	2	465	0.004301075268817204
OG0000865	COG1196	Chromosome segregation ATPase Smc	Smc	D	Cell cycle control, cell division, chromosome partitioning	145	465	0.3118279569892473
OG0000865	COG1579	Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain	DR0291	R	General function prediction only	3	465	0.0064516129032258064
OG0000865	COG2433	Possible nuclease of RNase H fold, RuvC/YqgF family	NA	R	General function prediction only	4	465	0.008602150537634409
OG0000865	COG3206	Tyrosine-protein kinase Wzc involved in exopolysaccharide export, GumC/Wzc1 domain	GumC	M	Cell wall/membrane/envelope biogenesis	1	465	0.002150537634408602
OG0000865	COG3883	Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO	CwlO1	S	Function unknown	187	465	0.4021505376344086
OG0000865	COG4026	Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease	NA	R	General function prediction only	3	465	0.0064516129032258064
OG0000865	COG4913	Uncharacterized conserved protein, contains a C-terminal ATPase domain	NA	S	Function unknown	23	465	0.04946236559139785
OG0000865	COG4942	Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB	EnvC	D	Cell cycle control, cell division, chromosome partitioning	58	465	0.12473118279569892
OG0000866	COG1214	tRNA A37 threonylcarbamoyladenosine modification protein TsaB	TsaB	J	Translation, ribosomal structure and biogenesis	435	465	0.9354838709677419
OG0000866	COG5013	Nitrate reductase alpha subunit	NarG	C	Energy production and conversion	1	465	0.002150537634408602
OG0000867	COG0088	Ribosomal protein L4	RplD	J	Translation, ribosomal structure and biogenesis	465	465	1
OG0000868	COG2938	Succinate dehydrogenase flavin-adding protein, antitoxin component of the CptAB toxin-antitoxin module	SdhE	O	Posttranslational modification, protein turnover, chaperones	460	464	0.9913793103448276
OG0000870	COG0752	Glycyl-tRNA synthetase, alpha subunit	GlyQ	J	Translation, ribosomal structure and biogenesis	464	464	1
OG0000871	COG0069	Glutamate synthase domain 2	GltB2	E	Amino acid transport and metabolism	1	463	0.0021598272138228943
OG0000872	COG2913	Outer membrane protein assembly factor BamE	BamE	M	Cell wall/membrane/envelope biogenesis	395	463	0.8531317494600432
OG0000873	COG2951	Membrane-bound lytic murein transglycosylase B	MltB	M	Cell wall/membrane/envelope biogenesis	460	462	0.9956709956709957
OG0000874	COG0385	Predicted Na+-dependent transporter YfeH	YfeH	R	General function prediction only	461	462	0.9978354978354979
OG0000875	COG1183	Phosphatidylserine synthase	PssA	I	Lipid transport and metabolism	461	461	1
OG0000876	COG0822	Fe-S cluster assembly scaffold protein IscU, NifU family	IscU	O	Posttranslational modification, protein turnover, chaperones	456	461	0.9891540130151844
OG0000877	COG3162	Membrane protein potentially involved in acetate utilization, DUF485 family	YjcH	S	Function unknown	4	461	0.008676789587852495
OG0000878	COG0069	Glutamate synthase domain 2	GltB2	E	Amino acid transport and metabolism	459	461	0.9956616052060737
OG0000879	COG0178	Excinuclease UvrABC ATPase subunit	UvrA	L	Replication, recombination and repair	1	461	0.0021691973969631237
OG0000879	COG0232	dGTP triphosphohydrolase	Dgt	F	Nucleotide transport and metabolism	460	461	0.9978308026030369
OG0000880	COG0797	Peptidoglycan lytic transglycosylase RlpA, contains C-terminal SPOR domain	RlpA	M	Cell wall/membrane/envelope biogenesis	56	461	0.12147505422993492
OG0000880	COG2191	Formylmethanofuran dehydrogenase subunit E	FwdE	C	Energy production and conversion	4	461	0.008676789587852495
OG0000880	COG3087	Cell division protein FtsN	FtsN	D	Cell cycle control, cell division, chromosome partitioning	142	461	0.3080260303687636
OG0000880	COG3147	Cell division protein DedD (periplasmic protein involved in septation)	DedD	D	Cell cycle control, cell division, chromosome partitioning	9	461	0.019522776572668113
OG0000881	COG0307	Riboflavin synthase alpha chain	RibC	H	Coenzyme transport and metabolism	461	461	1
OG0000882	COG0751	Glycyl-tRNA synthetase, beta subunit	GlyS	J	Translation, ribosomal structure and biogenesis	461	461	1
OG0000883	COG4775	Outer membrane protein assembly factor BamA	BamA	M	Cell wall/membrane/envelope biogenesis	460	460	1
OG0000884	COG1686	D-alanyl-D-alanine carboxypeptidase	DacC	M	Cell wall/membrane/envelope biogenesis	458	460	0.9956521739130435
OG0000885	COG2827	Predicted endonuclease, GIY-YIG superfamily	YhbQ	L	Replication, recombination and repair	460	460	1
OG0000886	COG1663	Tetraacyldisaccharide-1-P 4'-kinase (Lipid A 4'-kinase)	LpxK	M	Cell wall/membrane/envelope biogenesis	458	460	0.9956521739130435
OG0000887	COG0525	Valyl-tRNA synthetase	ValS	J	Translation, ribosomal structure and biogenesis	457	459	0.9956427015250545
OG0000888	COG2244	Membrane protein involved in the export of O-antigen and teichoic acid	RfbX	M	Cell wall/membrane/envelope biogenesis	1	459	0.002178649237472767
OG0000888	COG3307	O-antigen ligase	RfaL	M	Cell wall/membrane/envelope biogenesis	433	459	0.9433551198257081
OG0000889	COG0474	Magnesium-transporting ATPase (P-type)	MgtA	P	Inorganic ion transport and metabolism	23	459	0.05010893246187364
OG0000889	COG2606	Cys-tRNA(Pro) deacylase, prolyl-tRNA editing enzyme YbaK/EbsC	EbsC	J	Translation, ribosomal structure and biogenesis	15	459	0.032679738562091505
OG0000890	COG0842	ABC-type multidrug transport system, permease component	YadH	V	Defense mechanisms	458	459	0.9978213507625272
OG0000890	COG1682	ABC-type polysaccharide/teichoic acid/polyol phosphate export permease	TagG	G	Carbohydrate transport and metabolism	1	459	0.002178649237472767
OG0000891	COG1146	NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit	PreA	F	Nucleotide transport and metabolism	458	459	0.9978213507625272
OG0000892	COG1960	Acyl-CoA dehydrogenase related to the alkylation response protein AidB	CaiA	I	Lipid transport and metabolism	457	459	0.9956427015250545
OG0000893	COG1131	Ribosome-associated ATPase or ATPase component of an ABC-type multidrug transport system	RbbA	J	Translation, ribosomal structure and biogenesis	458	458	1
OG0000894	COG2230	Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases	Cfa	I	Lipid transport and metabolism	456	458	0.9956331877729258
OG0000895	COG1304	FMN-dependent dehydrogenase, includes L-lactate dehydrogenase and type II isopentenyl diphosphate isomerase	LldD	C	Energy production and conversion	458	458	1
OG0000896	COG3004	Na+/H+ antiporter NhaA	NhaA	C	Energy production and conversion	458	458	1
OG0000897	COG2898	Bifunctional lysylphosphatidylglycerol synthetase/flippase MprF	MprF	I	Lipid transport and metabolism	7	457	0.015317286652078774
OG0000897	COG4652	Uncharacterized conserved protein, DUF1430 domain	NA	S	Function unknown	1	457	0.002188183807439825
OG0000898	COG3496	Uncharacterized conserved protein, DUF1365 family	NA	S	Function unknown	455	457	0.9956236323851203
OG0000899	COG0500	SAM-dependent methyltransferase SmtA (CmoB moved to COG2228)	SmtA	Q	Secondary metabolites biosynthesis, transport and catabolism	1	456	0.0021929824561403508
OG0000899	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9	UbiE	H	Coenzyme transport and metabolism	1	456	0.0021929824561403508
OG0000899	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	6	456	0.013157894736842105
OG0000899	COG2230	Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases	Cfa	I	Lipid transport and metabolism	445	456	0.9758771929824561
OG0000900	COG1396	Transcriptional regulator, contains XRE-family HTH domain	HipB	K	Transcription	456	456	1
OG0000901	COG0591	Na+/proline symporter	PutP	E	Amino acid transport and metabolism	452	456	0.9912280701754386
OG0000901	COG1007	NADH:ubiquinone oxidoreductase subunit 2 (chain N)	NuoN	C	Energy production and conversion	1	456	0.0021929824561403508
OG0000902	COG0340	Biotin-protein ligase	BirA2	H	Coenzyme transport and metabolism	3	456	0.006578947368421052
OG0000903	COG0492	Thioredoxin reductase	TrxB	O	Posttranslational modification, protein turnover, chaperones	1	455	0.002197802197802198
OG0000903	COG0644	Dehydrogenase (flavoprotein)	FixC	C	Energy production and conversion	447	455	0.9824175824175824
OG0000903	COG2440	Ferredoxin-like protein FixX	FixX	C	Energy production and conversion	7	455	0.015384615384615385
OG0000904	COG0569	Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain	TrkA	P	Inorganic ion transport and metabolism	454	455	0.9978021978021978
OG0000904	COG2985	Uncharacterized membrane protein YbjL, putative transporter	YbjL	R	General function prediction only	1	455	0.002197802197802198
OG0000905	COG0361	Translation initiation factor IF-1	InfA	J	Translation, ribosomal structure and biogenesis	455	455	1
OG0000906	COG0861	Tellurite resistance membrane protein TerC	TerC	P	Inorganic ion transport and metabolism	452	454	0.9955947136563876
OG0000907	COG0342	Preprotein translocase subunit SecD	SecD	U	Intracellular trafficking, secretion, and vesicular transport	6	454	0.013215859030837005
OG0000907	COG0474	Magnesium-transporting ATPase (P-type)	MgtA	P	Inorganic ion transport and metabolism	1	454	0.0022026431718061676
OG0000907	COG1033	Predicted exporter protein, RND superfamily	MMPL	R	General function prediction only	2	454	0.004405286343612335
OG0000907	COG4129	Predicted membrane transporter YgaE, aromatic acid exporter family	YgaE	R	General function prediction only	2	454	0.004405286343612335
OG0000908	COG1235	Phosphoribosyl 1,2-cyclic phosphate phosphodiesterase	PhnP	H	Coenzyme transport and metabolism	454	454	1
OG0000909	COG0697	Amino acid export permease, drug/metabolite transporter (DMT) superfamily	EamA	E	Amino acid transport and metabolism	453	453	1
OG0000910	COG0189	Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily	LysX	E	Amino acid transport and metabolism	452	453	0.9977924944812362
OG0000911	COG0686	Alanine dehydrogenase (includes sporulation protein SpoVN)	Ald	E	Amino acid transport and metabolism	452	453	0.9977924944812362
OG0000911	COG3288	NAD/NADP transhydrogenase alpha subunit	PntA	C	Energy production and conversion	1	453	0.002207505518763797
OG0000912	COG0596	2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH/undecaprenyl monophosphate-sugar esterase UshA/YqjL	MenH	H	Coenzyme transport and metabolism	452	452	1
OG0000913	COG0141	Histidinol dehydrogenase	HisD	E	Amino acid transport and metabolism	449	452	0.9933628318584071
OG0000914	COG1278	Cold shock protein, CspA family	CspC	K	Transcription	452	452	1
OG0000915	COG1884	Methylmalonyl-CoA mutase, N-terminal domain/subunit	Sbm1	I	Lipid transport and metabolism	1	452	0.0022123893805309734
OG0000915	COG2891	Cell shape-determining protein MreD	MreD	M	Cell wall/membrane/envelope biogenesis	297	452	0.6570796460176991
OG0000916	COG1221	Transcriptional regulators containing sigma54-interacting ATPase domain	PspF	K	Transcription	4	452	0.008849557522123894
OG0000916	COG3292	Periplasmic ligand-binding sensor domain	NA	T	Signal transduction mechanisms	1	452	0.0022123893805309734
OG0000917	COG1953	Cytosine/uracil/thiamine/allantoin permease	FUI1	F	Nucleotide transport and metabolism	452	452	1
OG0000918	COG0749	DNA polymerase I, 3'-5' exonuclease and polymerase domains	PolA	L	Replication, recombination and repair	1	452	0.0022123893805309734
OG0000918	COG2177	Cell division protein FtsX	FtsX	D	Cell cycle control, cell division, chromosome partitioning	1	452	0.0022123893805309734
OG0000918	COG4839	Cell division protein FtsL, bacillar variant	FtsL2	D	Cell cycle control, cell division, chromosome partitioning	13	452	0.028761061946902654
OG0000918	COG4942	Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB	EnvC	D	Cell cycle control, cell division, chromosome partitioning	1	452	0.0022123893805309734
OG0000918	COG5462	Cell division protein FtsL, alphaproteobacterial variant	FtsL3	D	Cell cycle control, cell division, chromosome partitioning	2	452	0.004424778761061947
OG0000919	COG3572	Gamma-glutamylcysteine synthetase	Gsh2	H	Coenzyme transport and metabolism	450	451	0.9977827050997783
OG0000920	COG1508	DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog	RpoN	K	Transcription	3	450	0.006666666666666667
OG0000920	COG2982	Outer membrane assembly factor AsmA	AsmA	M	Cell wall/membrane/envelope biogenesis	2	450	0.0044444444444444444
OG0000920	COG3115	Cell division protein ZipA, interacts with FtsZ	ZipA	D	Cell cycle control, cell division, chromosome partitioning	6	450	0.013333333333333334
OG0000921	COG3842	ABC-type Fe3+/spermidine/putrescine transport systems, ATPase component	PotA	E	Amino acid transport and metabolism	449	450	0.9977777777777778
OG0000922	COG0861	Tellurite resistance membrane protein TerC	TerC	P	Inorganic ion transport and metabolism	449	449	1
OG0000923	COG2982	Outer membrane assembly factor AsmA	AsmA	M	Cell wall/membrane/envelope biogenesis	261	448	0.5825892857142857
OG0000923	COG3292	Periplasmic ligand-binding sensor domain	NA	T	Signal transduction mechanisms	2	448	0.004464285714285714
OG0000924	COG1832	Predicted CoA-binding protein	YccU	R	General function prediction only	448	448	1
OG0000925	COG0470	DNA polymerase III, delta prime subunit	HolB	L	Replication, recombination and repair	427	448	0.953125
OG0000926	COG0001	Glutamate-1-semialdehyde aminotransferase	HemL	H	Coenzyme transport and metabolism	1	447	0.0022371364653243847
OG0000926	COG0529	Adenylylsulfate kinase or related kinase	CysC	P	Inorganic ion transport and metabolism	1	447	0.0022371364653243847
OG0000926	COG0645	Predicted kinase, contains AAA domain	AAA	R	General function prediction only	8	447	0.017897091722595078
OG0000926	COG1056	Nicotinamide mononucleotide adenylyltransferase	NadM	H	Coenzyme transport and metabolism	433	447	0.9686800894854586
OG0000927	COG2175	Taurine dioxygenase, alpha-ketoglutarate-dependent	TauD	Q	Secondary metabolites biosynthesis, transport and catabolism	447	447	1
OG0000928	COG0411	ABC-type branched-chain amino acid transport system, ATPase component LivG	LivG	E	Amino acid transport and metabolism	445	446	0.9977578475336323
OG0000928	COG3845	ABC-type guanosine uptake system NupNOPQ, ATPase component NupO	NupO	F	Nucleotide transport and metabolism	1	446	0.002242152466367713
OG0000929	COG2205	K+-sensing histidine kinase KdpD	KdpD	T	Signal transduction mechanisms	199	446	0.4461883408071749
OG0000929	COG3555	Aspartyl/asparaginyl beta-hydroxylase, cupin superfamily,includes lipid A hydroxylase LpxO	LpxO2	O	Posttranslational modification, protein turnover, chaperones	14	446	0.03139013452914798
OG0000930	COG0188	DNA gyrase/topoisomerase IV, subunit A	GyrA	L	Replication, recombination and repair	1	446	0.002242152466367713
OG0000930	COG0760	Periplasmic chaperone SurA (peptidyl-prolyl cis-trans isomerase)	SurA	O	Posttranslational modification, protein turnover, chaperones	17	446	0.03811659192825112
OG0000930	COG1221	Transcriptional regulators containing sigma54-interacting ATPase domain	PspF	K	Transcription	3	446	0.006726457399103139
OG0000930	COG3292	Periplasmic ligand-binding sensor domain	NA	T	Signal transduction mechanisms	1	446	0.002242152466367713
OG0000930	COG5542	Mannosyltransferase related to Gpi18	NA	G	Carbohydrate transport and metabolism	1	446	0.002242152466367713
OG0000931	COG1221	Transcriptional regulators containing sigma54-interacting ATPase domain	PspF	K	Transcription	1	446	0.002242152466367713
OG0000931	COG2433	Possible nuclease of RNase H fold, RuvC/YqgF family	NA	R	General function prediction only	1	446	0.002242152466367713
OG0000931	COG2960	Ubiquinone biosynthesis accessory factor UbiK	UbiK	H	Coenzyme transport and metabolism	94	446	0.21076233183856502
OG0000931	COG3883	Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO	CwlO1	S	Function unknown	8	446	0.017937219730941704
OG0000931	COG3937	Phasin, polyhydroxyalkanoate synthesis regulator	PhaF	Q	Secondary metabolites biosynthesis, transport and catabolism	47	446	0.10538116591928251
OG0000932	COG0795	Lipopolysaccharide export LptBFGC system, permease protein LptF	LptF	M	Cell wall/membrane/envelope biogenesis	434	446	0.9730941704035875
OG0000933	COG0509	Glycine cleavage system protein H (lipoate-binding)	GcvH	E	Amino acid transport and metabolism	445	445	1
OG0000934	COG0697	Amino acid export permease, drug/metabolite transporter (DMT) superfamily	EamA	E	Amino acid transport and metabolism	444	445	0.9977528089887641
OG0000935	COG2759	Formyltetrahydrofolate synthetase	MIS1	F	Nucleotide transport and metabolism	445	445	1
OG0000936	COG2025	Electron transfer flavoprotein, alpha subunit FixB	FixB	C	Energy production and conversion	444	444	1
OG0000937	COG4240	Pantothenate kinase-related protein Tda10 (topoisomerase I damage affected protein)	Tda10	R	General function prediction only	441	443	0.9954853273137697
OG0000938	COG0687	Spermidine/putrescine-binding periplasmic protein	PotD	E	Amino acid transport and metabolism	438	443	0.9887133182844243
OG0000939	COG0575	CDP-diglyceride synthetase	CdsA	I	Lipid transport and metabolism	443	443	1
OG0000940	COG0404	Glycine cleavage system protein T (aminomethyltransferase)	GcvT	E	Amino acid transport and metabolism	443	443	1
OG0000941	COG0020	Undecaprenyl pyrophosphate synthase	UppS	I	Lipid transport and metabolism	442	442	1
OG0000942	COG3175	Cytochrome c oxidase assembly protein Cox11	COX11	C	Energy production and conversion	436	441	0.9886621315192744
OG0000943	COG1834	N-Dimethylarginine dimethylaminohydrolase	DdaH	E	Amino acid transport and metabolism	440	440	1
OG0000944	COG2881	GTPase-interacting Yip1 domain	Yip1	R	General function prediction only	5	440	0.011363636363636364
OG0000945	COG3087	Cell division protein FtsN	FtsN	D	Cell cycle control, cell division, chromosome partitioning	7	440	0.015909090909090907
OG0000946	COG2086	Electron transfer flavoprotein, alpha and beta subunits	FixA	C	Energy production and conversion	440	440	1
OG0000947	COG0685	5,10-methylenetetrahydrofolate reductase	MetF	E	Amino acid transport and metabolism	438	440	0.9954545454545455
OG0000948	COG1221	Transcriptional regulators containing sigma54-interacting ATPase domain	PspF	K	Transcription	32	440	0.07272727272727272
OG0000948	COG5452	Ubiquinol-cytochrome C chaperone Cbp3	Cbp3	C	Energy production and conversion	100	440	0.22727272727272727
OG0000949	COG0117	Riboflavin biosynthesis protein RibD, pyrimidine deaminase domain	RibD1	H	Coenzyme transport and metabolism	432	440	0.9818181818181818
OG0000949	COG1985	Pyrimidine reductase, riboflavin biosynthesis	RibD	H	Coenzyme transport and metabolism	4	440	0.00909090909090909
OG0000950	COG2721	Altronate dehydratase	UxaA	G	Carbohydrate transport and metabolism	440	440	1
OG0000952	COG1540	5-oxoprolinase subunit A	PxpA	E	Amino acid transport and metabolism	437	437	1
OG0000953	COG3781	Predicted membrane chloride channel, bestrophin family	YneE	P	Inorganic ion transport and metabolism	4	437	0.009153318077803204
OG0000953	COG5652	VanZ-like family protein, affects binding of lipoglycopeptide antibiotics to the cell wall	VanZ	S	Function unknown	204	437	0.4668192219679634
OG0000954	COG2364	Membrane protein possibly involved in the transport of sulfur-containing compounds	YczE	R	General function prediction only	436	436	1
OG0000956	COG2218	Formylmethanofuran dehydrogenase subunit C	FwdC	C	Energy production and conversion	432	435	0.993103448275862
OG0000957	COG0403	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain	GcvP1	E	Amino acid transport and metabolism	3	435	0.006896551724137931
OG0000957	COG1003	Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain	GcvP2	E	Amino acid transport and metabolism	432	435	0.993103448275862
OG0000958	COG3473	Maleate cis-trans isomerase	NA	Q	Secondary metabolites biosynthesis, transport and catabolism	434	435	0.9977011494252873
OG0000959	COG0182	5-methylthioribose/5-deoxyribulose 1-phosphate isomerase (methionine salvage pathway), a paralog of eIF-2B alpha subunit	MtnA	E	Amino acid transport and metabolism	435	435	1
OG0000960	COG0125	Thymidylate kinase	Tmk	F	Nucleotide transport and metabolism	433	435	0.9954022988505747
OG0000961	COG0280	Phosphotransacetylase (includes Pta, EutD and phosphobutyryltransferase)	Pta	C	Energy production and conversion	434	435	0.9977011494252873
OG0000962	COG1304	FMN-dependent dehydrogenase, includes L-lactate dehydrogenase and type II isopentenyl diphosphate isomerase	LldD	C	Energy production and conversion	434	434	1
OG0000963	COG4531	ABC-type Zn2+ transport system, periplasmic component/surface adhesin ZnuA	ZnuA	P	Inorganic ion transport and metabolism	434	434	1
OG0000964	COG1108	ABC-type Mn2+/Zn2+ transport system, permease component	ZnuB	P	Inorganic ion transport and metabolism	434	434	1
OG0000966	COG0529	Adenylylsulfate kinase or related kinase	CysC	P	Inorganic ion transport and metabolism	137	433	0.3163972286374134
OG0000966	COG0645	Predicted kinase, contains AAA domain	AAA	R	General function prediction only	292	433	0.674364896073903
OG0000966	COG2895	Sulfate adenylyltransferase subunit 1, EFTu-like GTPase family	CysN	P	Inorganic ion transport and metabolism	2	433	0.004618937644341801
OG0000967	COG1984	5-oxoprolinase subunit C/Allophanate hydrolase subunit 2	PxpC	E	Amino acid transport and metabolism	432	433	0.9976905311778291
OG0000968	COG1917	Cupin domain protein related to quercetin dioxygenase	QdoI	R	General function prediction only	4	433	0.009237875288683603
OG0000969	COG4583	Sarcosine oxidase gamma subunit	SoxG	E	Amino acid transport and metabolism	433	433	1
OG0000970	COG1121	ABC-type Mn2+/Zn2+ transport system, ATPase component	ZnuC	P	Inorganic ion transport and metabolism	432	432	1
OG0000971	COG0006	Xaa-Pro aminopeptidase	PepP	E	Amino acid transport and metabolism	431	431	1
OG0000972	COG0061	NAD kinase	NadK	H	Coenzyme transport and metabolism	431	431	1
OG0000973	COG0168	Trk-type K+ transport system, membrane component	TrkG	P	Inorganic ion transport and metabolism	424	431	0.9837587006960556
OG0000974	COG0579	L-2-hydroxyglutarate oxidase LhgO	LhgO	G	Carbohydrate transport and metabolism	4	430	0.009302325581395349
OG0000974	COG0644	Dehydrogenase (flavoprotein)	FixC	C	Energy production and conversion	1	430	0.002325581395348837
OG0000974	COG0665	Glycine/D-amino acid oxidase (deaminating)	DadA	E	Amino acid transport and metabolism	425	430	0.9883720930232558
OG0000975	COG0161	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	BioA	H	Coenzyme transport and metabolism	1	430	0.002325581395348837
OG0000975	COG0600	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component	TauC	P	Inorganic ion transport and metabolism	424	430	0.986046511627907
OG0000976	COG0312	Zn-dependent protease or N-deacetylase, PmbA/TldD/TldE family	TldD	O	Posttranslational modification, protein turnover, chaperones	429	429	1
OG0000977	COG4948	L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily	RspA	M	Cell wall/membrane/envelope biogenesis	428	429	0.9976689976689976
OG0000978	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	HisJ	E	Amino acid transport and metabolism	428	428	1
OG0000979	COG4215	ABC-type arginine transport system, permease component	ArtQ	E	Amino acid transport and metabolism	427	427	1
OG0000980	COG0403	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain	GcvP1	E	Amino acid transport and metabolism	1	427	0.00234192037470726
OG0000980	COG2049	5-oxoprolinase subunit B/Allophanate hydrolase subunit 1	PxpB	E	Amino acid transport and metabolism	421	427	0.9859484777517564
OG0000981	COG0005	Purine nucleoside phosphorylase	XapA	F	Nucleotide transport and metabolism	426	427	0.9976580796252927
OG0000983	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	422	426	0.9906103286384976
OG0000983	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	BcsA	N	Cell motility	1	426	0.002347417840375587
OG0000984	COG3476	Tryptophan-rich sensory protein TspO/CrtK (mitochondrial benzodiazepine receptor homolog)	TspO	T	Signal transduction mechanisms	426	426	1
OG0000985	COG1217	Predicted membrane GTPase TypA/BipA involved in stress response	TypA	T	Signal transduction mechanisms	424	424	1
OG0000986	COG0228	Ribosomal protein S16	RpsP	J	Translation, ribosomal structure and biogenesis	423	424	0.9976415094339622
OG0000987	COG4664	TRAP-type mannitol/chloroaromatic compound transport system, large permease component	FcbT3	Q	Secondary metabolites biosynthesis, transport and catabolism	423	423	1
OG0000988	COG0147	Anthranilate/para-aminobenzoate synthases component I	TrpE	E	Amino acid transport and metabolism	421	423	0.9952718676122931
OG0000989	COG0743	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Dxr	I	Lipid transport and metabolism	423	423	1
OG0000990	COG3313	Predicted Fe-S protein YdhL, DUF1289 family	YdhL	R	General function prediction only	423	423	1
OG0000991	COG0312	Zn-dependent protease or N-deacetylase, PmbA/TldD/TldE family	TldD	O	Posttranslational modification, protein turnover, chaperones	423	423	1
OG0000992	COG2962	Membrane protein RarD, contains two EamA domains, drug/metabolite transporter family	RarD	R	General function prediction only	423	423	1
OG0000993	COG0715	ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component	TauA	P	Inorganic ion transport and metabolism	1	423	0.002364066193853428
OG0000993	COG4521	ABC-type taurine transport system, periplasmic component	TauA	P	Inorganic ion transport and metabolism	420	423	0.9929078014184397
OG0000994	COG4665	TRAP-type mannitol/chloroaromatic compound transport system, small permease component	FcbT2	Q	Secondary metabolites biosynthesis, transport and catabolism	422	422	1
OG0000995	COG0697	Amino acid export permease, drug/metabolite transporter (DMT) superfamily	EamA	E	Amino acid transport and metabolism	422	422	1
OG0000996	COG0537	Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family	HinT	F	Nucleotide transport and metabolism	422	422	1
OG0000997	COG0624	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase	ArgE	E	Amino acid transport and metabolism	420	422	0.995260663507109
OG0000998	COG0598	Mg2+ and Co2+ transporter CorA	CorA	P	Inorganic ion transport and metabolism	1	422	0.002369668246445498
OG0000999	COG1171	Threonine deaminase	IlvA	E	Amino acid transport and metabolism	419	421	0.995249406175772
OG0001000	COG0432	Thiamin phosphate synthase YjbQ, UPF0047 family	YjbQ	H	Coenzyme transport and metabolism	421	421	1
OG0001001	COG3346	Cytochrome oxidase assembly protein ShyY1	Shy1	O	Posttranslational modification, protein turnover, chaperones	421	421	1
OG0001002	COG0457	Tetratricopeptide (TPR) repeat	TPR	R	General function prediction only	253	420	0.6023809523809524
OG0001002	COG4235	Cytochrome c-type biogenesis protein CcmH/NrfG	NrfG	C	Energy production and conversion	17	420	0.04047619047619048
OG0001002	COG4783	Periplasmic chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains	BepA	M	Cell wall/membrane/envelope biogenesis	1	420	0.002380952380952381
OG0001002	COG4785	Lipoprotein NlpI, contains TPR repeats	NlpI	M	Cell wall/membrane/envelope biogenesis	149	420	0.3547619047619048
OG0001003	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	AdhE	I	Lipid transport and metabolism	419	419	1
OG0001004	COG1322	DNA anti-recombination protein (rearrangement mutator) RmuC	RmuC	L	Replication, recombination and repair	410	419	0.9785202863961814
OG0001006	COG2606	Cys-tRNA(Pro) deacylase, prolyl-tRNA editing enzyme YbaK/EbsC	EbsC	J	Translation, ribosomal structure and biogenesis	416	419	0.9928400954653938
OG0001007	COG3631	Ketosteroid isomerase-related protein	YesE	R	General function prediction only	362	418	0.8660287081339713
OG0001007	COG3723	Recombinational DNA repair protein RecT	RecT	L	Replication, recombination and repair	5	418	0.011961722488038277
OG0001007	COG4922	Predicted SnoaL-like aldol condensation-catalyzing enzyme	NA	R	General function prediction only	25	418	0.05980861244019139
OG0001007	COG4994	Uncharacterized protein CV0675, UCP033623 family	NA	S	Function unknown	7	418	0.01674641148325359
OG0001007	COG5353	Uncharacterized conserved protein YpmB, contains C-terminal PepSY domain	YpmB	S	Function unknown	1	418	0.0023923444976076554
OG0001007	COG5485	Polyketide cyclase, SnoaL/DnrD family	SnoaL	Q	Secondary metabolites biosynthesis, transport and catabolism	4	418	0.009569377990430622
OG0001008	COG1794	Amino acid racemase YgeA	RacX	M	Cell wall/membrane/envelope biogenesis	415	415	1
OG0001009	COG0340	Biotin-protein ligase	BirA2	H	Coenzyme transport and metabolism	415	415	1
OG0001010	COG1074	3'-5' helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V)	RecB	L	Replication, recombination and repair	135	415	0.3253012048192771
OG0001010	COG1468	CRISPR/Cas system-associated exonuclease Cas4, RecB family	Cas4	V	Defense mechanisms	1	415	0.0024096385542168677
OG0001010	COG2887	RecB family exonuclease	Slr0479	L	Replication, recombination and repair	8	415	0.01927710843373494
OG0001011	COG1573	Uracil-DNA glycosylase	Udg4	L	Replication, recombination and repair	414	414	1
OG0001012	COG0230	Ribosomal protein L34	RpmH	J	Translation, ribosomal structure and biogenesis	412	414	0.9951690821256038
OG0001013	COG0652	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family	PpiB	O	Posttranslational modification, protein turnover, chaperones	413	413	1
OG0001015	COG0006	Xaa-Pro aminopeptidase	PepP	E	Amino acid transport and metabolism	407	411	0.9902676399026764
OG0001016	COG4177	ABC-type branched-chain amino acid transport system, permease component	LivM	E	Amino acid transport and metabolism	410	411	0.9975669099756691
OG0001017	COG0704	Phosphate uptake regulator PhoU	PhoU	P	Inorganic ion transport and metabolism	410	411	0.9975669099756691
OG0001017	COG1117	ABC-type phosphate transport system, ATPase component	PstB	P	Inorganic ion transport and metabolism	1	411	0.0024330900243309003
OG0001018	COG0697	Amino acid export permease, drug/metabolite transporter (DMT) superfamily	EamA	E	Amino acid transport and metabolism	410	410	1
OG0001019	COG5454	Uncharacterized alphaproteobacterial protein, DUF1467 family	NA	S	Function unknown	402	410	0.9804878048780488
OG0001020	COG2825	Periplasmic chaperone for outer membrane proteins, Skp/HlpA/OmpH family	Skp	M	Cell wall/membrane/envelope biogenesis	407	410	0.9926829268292683
OG0001021	COG0518	GMP synthase, glutamine amidotransferase domain/subunit	GuaA1	F	Nucleotide transport and metabolism	405	407	0.995085995085995
OG0001022	COG1117	ABC-type phosphate transport system, ATPase component	PstB	P	Inorganic ion transport and metabolism	405	405	1
OG0001023	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	OmpR	T	Signal transduction mechanisms	404	404	1
OG0001024	COG0697	Amino acid export permease, drug/metabolite transporter (DMT) superfamily	EamA	E	Amino acid transport and metabolism	404	404	1
OG0001025	COG0581	ABC-type phosphate transport system, permease component	PstA	P	Inorganic ion transport and metabolism	401	404	0.9925742574257426
OG0001026	COG4664	TRAP-type mannitol/chloroaromatic compound transport system, large permease component	FcbT3	Q	Secondary metabolites biosynthesis, transport and catabolism	403	403	1
OG0001027	COG0226	ABC-type phosphate transport system, periplasmic component	PstS	P	Inorganic ion transport and metabolism	402	402	1
OG0001028	COG0364	Glucose-6-phosphate 1-dehydrogenase	Zwf	G	Carbohydrate transport and metabolism	1	402	0.0024875621890547263
OG0001028	COG2194	Phosphoethanolamine transferase for periplasmic glucans OpgE, AlkP superfamily	OpgE	M	Cell wall/membrane/envelope biogenesis	2	402	0.004975124378109453
OG0001028	COG2985	Uncharacterized membrane protein YbjL, putative transporter	YbjL	R	General function prediction only	1	402	0.0024875621890547263
OG0001029	COG0652	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family	PpiB	O	Posttranslational modification, protein turnover, chaperones	400	400	1
OG0001030	COG1485	Cell division protein ZapE (Z ring-associated ATPase), AFG1 superfamily	ZapE	D	Cell cycle control, cell division, chromosome partitioning	399	400	0.9975
OG0001031	COG1436	Archaeal/vacuolar-type H+-ATPase subunit F/Vma7	NtpF	C	Energy production and conversion	1	399	0.002506265664160401
OG0001031	COG1442	Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase	RfaJ	M	Cell wall/membrane/envelope biogenesis	19	399	0.047619047619047616
OG0001032	COG0573	ABC-type phosphate transport system, permease component	PstC	P	Inorganic ion transport and metabolism	396	399	0.9924812030075187
OG0001033	COG0491	Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II	GloB	R	General function prediction only	397	398	0.9974874371859297
OG0001034	COG0642	Signal transduction histidine kinase	BaeS	T	Signal transduction mechanisms	4	398	0.010050251256281407
OG0001034	COG2205	K+-sensing histidine kinase KdpD	KdpD	T	Signal transduction mechanisms	4	398	0.010050251256281407
OG0001034	COG3829	RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains	RocR	K	Transcription	2	398	0.005025125628140704
OG0001034	COG5002	Sensor histidine kinase WalK	WalK	T	Signal transduction mechanisms	388	398	0.9748743718592965
OG0001035	COG0673	Predicted dehydrogenase	MviM	R	General function prediction only	1	398	0.002512562814070352
OG0001035	COG2105	Predicted gamma-glutamylamine cyclotransferase YtfP, GGCT/AIG2-like family	YtfP	E	Amino acid transport and metabolism	389	398	0.9773869346733668
OG0001037	COG0229	Peptide methionine sulfoxide reductase MsrB	MsrB	O	Posttranslational modification, protein turnover, chaperones	395	395	1
OG0001038	COG2907	Predicted flavin-containing amine oxidase	Ppro0129	R	General function prediction only	2	395	0.005063291139240506
OG0001038	COG3380	Predicted NAD/FAD-dependent oxidoreductase	NA	R	General function prediction only	392	395	0.9924050632911392
OG0001039	COG0352	Thiamine monophosphate synthase	ThiE	H	Coenzyme transport and metabolism	336	394	0.8527918781725888
OG0001040	COG1653	ABC-type glycerol-3-phosphate transport system, periplasmic component	UgpB	G	Carbohydrate transport and metabolism	392	394	0.9949238578680203
OG0001040	COG2182	Maltose-binding periplasmic protein MalE	MalE	G	Carbohydrate transport and metabolism	2	394	0.005076142131979695
OG0001041	COG0115	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase	IlvE	E	Amino acid transport and metabolism	369	393	0.9389312977099237
OG0001042	COG0123	Acetoin utilization deacetylase AcuC or a related deacetylase	AcuC	Q	Secondary metabolites biosynthesis, transport and catabolism	390	392	0.9948979591836735
OG0001043	COG4392	Branched-chain amino acid transport protein	AzlD2	E	Amino acid transport and metabolism	392	392	1
OG0001044	COG1296	Predicted branched-chain amino acid permease (azaleucine resistance)	AzlC	E	Amino acid transport and metabolism	392	392	1
OG0001045	COG0826	23S rRNA C2501 and tRNA U34 5'-hydroxylation protein RlhA/YrrN/YrrO, U32 peptidase family	RlhA	J	Translation, ribosomal structure and biogenesis	1	392	0.002551020408163265
OG0001046	COG1246	N-acetylglutamate synthase or related acetyltransferase, GNAT family	ArgA	E	Amino acid transport and metabolism	392	392	1
OG0001047	COG0824	Acyl-CoA thioesterase FadM	FadM	I	Lipid transport and metabolism	391	391	1
OG0001048	COG2985	Uncharacterized membrane protein YbjL, putative transporter	YbjL	R	General function prediction only	1	390	0.002564102564102564
OG0001049	COG1804	Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases	CaiB	I	Lipid transport and metabolism	388	389	0.9974293059125964
OG0001050	COG2252	Xanthine/guanine/uracil/vitamin C permease GhxP/GhxQ, nucleobase:cation symporter 2 ( NCS2) family	NCS2	F	Nucleotide transport and metabolism	389	389	1
OG0001051	COG0580	Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family)	GlpF	G	Carbohydrate transport and metabolism	387	388	0.9974226804123711
OG0001052	COG0526	Thiol-disulfide isomerase or thioredoxin	TrxA	O	Posttranslational modification, protein turnover, chaperones	338	388	0.8711340206185567
OG0001052	COG3118	Chaperedoxin CnoX, contains thioredoxin-like and TPR-like domains, YbbN/TrxSC family	CnoX	O	Posttranslational modification, protein turnover, chaperones	50	388	0.12886597938144329
OG0001053	COG0010	Arginase/agmatinase family enzyme	SpeB	E	Amino acid transport and metabolism	387	387	1
OG0001054	COG2192	Predicted carbamoyl transferase, NodU family	NA	R	General function prediction only	384	386	0.9948186528497409
OG0001055	COG1396	Transcriptional regulator, contains XRE-family HTH domain	HipB	K	Transcription	6	386	0.015544041450777202
OG0001055	COG3800	Predicted transcriptional regulator	NA	R	General function prediction only	380	386	0.9844559585492227
OG0001056	COG2175	Taurine dioxygenase, alpha-ketoglutarate-dependent	TauD	Q	Secondary metabolites biosynthesis, transport and catabolism	385	385	1
OG0001057	COG0219	tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain	TrmL	J	Translation, ribosomal structure and biogenesis	1	385	0.0025974025974025974
OG0001057	COG2355	Zn-dependent dipeptidase, microsomal dipeptidase homolog	NA	O	Posttranslational modification, protein turnover, chaperones	383	385	0.9948051948051948
OG0001058	COG0611	Thiamine monophosphate kinase	ThiL	H	Coenzyme transport and metabolism	381	383	0.9947780678851175
OG0001058	COG0629	Single-stranded DNA-binding protein	Ssb	L	Replication, recombination and repair	1	383	0.0026109660574412533
OG0001059	COG2224	Isocitrate lyase	AceA	C	Energy production and conversion	382	382	1
OG0001060	COG1491	Predicted nucleic acid-binding OB-fold protein	NA	R	General function prediction only	1	380	0.002631578947368421
OG0001060	COG1614	CO dehydrogenase/acetyl-CoA synthase beta subunit	CdhC	C	Energy production and conversion	3	380	0.007894736842105263
OG0001061	COG2076	Multidrug transporter EmrE and related cation transporters	EmrE	V	Defense mechanisms	379	379	1
OG0001062	COG1360	Flagellar motor protein MotB	MotB	N	Cell motility	1	378	0.0026455026455026454
OG0001062	COG4105	Outer membrane protein assembly factor BamD, BamD/ComL family	BamD	M	Cell wall/membrane/envelope biogenesis	2	378	0.005291005291005291
OG0001062	COG5633	Uncharacterized conserved protein YcfL	YcfL	S	Function unknown	1	378	0.0026455026455026454
OG0001063	COG1083	CMP-N-acetylneuraminic acid synthetase, NeuA/PseF family	NeuA	M	Cell wall/membrane/envelope biogenesis	376	377	0.9973474801061007
OG0001064	COG1132	ABC-type multidrug and LPS transport system, ATPase and permease component MsbA	MdlB	M	Cell wall/membrane/envelope biogenesis	279	376	0.7420212765957447
OG0001064	COG2274	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain	SunT	V	Defense mechanisms	77	376	0.2047872340425532
OG0001064	COG5265	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components	ATM1	O	Posttranslational modification, protein turnover, chaperones	18	376	0.047872340425531915
OG0001065	COG0388	Nitrilase/amidase YafV/Nit2, hydrolyzes deaminated glutathione	Nit1	V	Defense mechanisms	375	375	1
OG0001066	COG0404	Glycine cleavage system protein T (aminomethyltransferase)	GcvT	E	Amino acid transport and metabolism	370	375	0.9866666666666667
OG0001066	COG3665	Uncharacterized conserved protein YcgI, DUF1989 family	YcgI	S	Function unknown	5	375	0.013333333333333334
OG0001067	COG1011	FMN and 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YigB, HAD superfamily (riboflavin biosynthesis)	YigB	H	Coenzyme transport and metabolism	4	375	0.010666666666666666
OG0001068	COG3917	2-hydroxychromene-2-carboxylate isomerase	NahD	Q	Secondary metabolites biosynthesis, transport and catabolism	374	374	1
OG0001069	COG2146	Ferredoxin subunit of nitrite reductase or a ring-hydroxylating dioxygenase	NirD	P	Inorganic ion transport and metabolism	1	374	0.00267379679144385
OG0001069	COG4638	Phenylpropionate dioxygenase or related ring-hydroxylating dioxygenase, large terminal subunit	HcaE	P	Inorganic ion transport and metabolism	347	374	0.9278074866310161
OG0001071	COG0697	Amino acid export permease, drug/metabolite transporter (DMT) superfamily	EamA	E	Amino acid transport and metabolism	365	367	0.9945504087193461
OG0001072	COG0394	Protein-tyrosine-phosphatase	Wzb	T	Signal transduction mechanisms	366	367	0.997275204359673
OG0001073	COG1296	Predicted branched-chain amino acid permease (azaleucine resistance)	AzlC	E	Amino acid transport and metabolism	340	367	0.9264305177111717
OG0001074	COG4583	Sarcosine oxidase gamma subunit	SoxG	E	Amino acid transport and metabolism	365	366	0.9972677595628415
OG0001075	COG5559	Uncharacterized conserved protein, DUF2281 domain	NA	S	Function unknown	25	365	0.0684931506849315
OG0001076	COG4642	Uncharacterized conserved protein, contains MORN repeats	NA	R	General function prediction only	356	363	0.9807162534435262
OG0001077	COG0410	ABC-type branched-chain amino acid transport system, ATPase component LivF	LivF	E	Amino acid transport and metabolism	361	361	1
OG0001078	COG0457	Tetratricopeptide (TPR) repeat	TPR	R	General function prediction only	210	361	0.5817174515235457
OG0001078	COG0863	DNA modification adenine methylase	YhdJ	L	Replication, recombination and repair	1	361	0.002770083102493075
OG0001078	COG2956	Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain	LapB	M	Cell wall/membrane/envelope biogenesis	81	361	0.22437673130193905
OG0001078	COG3551	Uncharacterized conserved protein	NA	S	Function unknown	2	361	0.00554016620498615
OG0001078	COG3914	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family	Spy	O	Posttranslational modification, protein turnover, chaperones	4	361	0.0110803324099723
OG0001078	COG4235	Cytochrome c-type biogenesis protein CcmH/NrfG	NrfG	C	Energy production and conversion	3	361	0.008310249307479225
OG0001078	COG4424	LPS sulfotransferase NodH	LpsS	M	Cell wall/membrane/envelope biogenesis	4	361	0.0110803324099723
OG0001078	COG4783	Periplasmic chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains	BepA	M	Cell wall/membrane/envelope biogenesis	9	361	0.024930747922437674
OG0001078	COG5010	Flp/Tad pilus assembly pilotin TadD, contains TPR repeats	TadD	W	Extracellular structures	1	361	0.002770083102493075
OG0001079	COG0444	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component	DppD	E	Amino acid transport and metabolism	3	361	0.008310249307479225
OG0001079	COG1123	ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain	GsiA	O	Posttranslational modification, protein turnover, chaperones	87	361	0.2409972299168975
OG0001079	COG4107	ABC-type phosphonate transport system, ATPase component PhnK	PhnK	P	Inorganic ion transport and metabolism	52	361	0.1440443213296399
OG0001079	COG4172	ABC-type microcin C transport system, duplicated ATPase component YejF	YejF	Q	Secondary metabolites biosynthesis, transport and catabolism	178	361	0.4930747922437673
OG0001079	COG4608	ABC-type oligopeptide transport system, ATPase component	AppF	E	Amino acid transport and metabolism	41	361	0.11357340720221606
OG0001080	COG1278	Cold shock protein, CspA family	CspC	K	Transcription	359	359	1
OG0001081	COG4677	Pectin methylesterase and related acyl-CoA thioesterases	PemB	G	Carbohydrate transport and metabolism	1	359	0.002785515320334262
OG0001082	COG0841	Multidrug efflux pump subunit AcrB	AcrB	V	Defense mechanisms	1	359	0.002785515320334262
OG0001083	COG4392	Branched-chain amino acid transport protein	AzlD2	E	Amino acid transport and metabolism	339	358	0.946927374301676
OG0001083	COG4541	Uncharacterized membrane protein	NA	S	Function unknown	1	358	0.002793296089385475
OG0001085	COG1608	Isopentenyl phosphate kinase	NA	I	Lipid transport and metabolism	2	355	0.005633802816901409
OG0001085	COG4117	Thiosulfate reductase cytochrome b subunit	YdhU	P	Inorganic ion transport and metabolism	1	355	0.0028169014084507044
OG0001086	COG0004	Ammonia channel protein AmtB	AmtB	P	Inorganic ion transport and metabolism	353	354	0.9971751412429378
OG0001087	COG4758	Membrane protein LiaF, inhibitor of the LiaRS two-component envelope stress sensory system	LiaF	T	Signal transduction mechanisms	1	354	0.002824858757062147
OG0001088	COG2114	Adenylate cyclase, class 3	AcyC	T	Signal transduction mechanisms	7	353	0.019830028328611898
OG0001088	COG2203	GAF domain	GAF	T	Signal transduction mechanisms	1	353	0.0028328611898017
OG0001088	COG2208	Phosphoserine phosphatase RsbU, regulator of sigma subunit	RsbU	T	Signal transduction mechanisms	182	353	0.5155807365439093
OG0001088	COG4252	Extracytoplasmic sensor domain CHASE2 (specificity unknown)	CHASE2	T	Signal transduction mechanisms	162	353	0.45892351274787535
OG0001089	COG1279	Arginine exporter protein ArgO	ArgO	E	Amino acid transport and metabolism	352	352	1
OG0001090	COG2175	Taurine dioxygenase, alpha-ketoglutarate-dependent	TauD	Q	Secondary metabolites biosynthesis, transport and catabolism	10	348	0.028735632183908046
OG0001091	COG1940	Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain	NagC	G	Carbohydrate transport and metabolism	348	348	1
OG0001092	COG0010	Arginase/agmatinase family enzyme	SpeB	E	Amino acid transport and metabolism	344	344	1
OG0001093	COG0431	NAD(P)H-dependent FMN reductase	SsuE	C	Energy production and conversion	1	344	0.0029069767441860465
OG0001093	COG1182	FMN-dependent NADH-azoreductase	AzoR	C	Energy production and conversion	1	344	0.0029069767441860465
OG0001093	COG2249	Putative NADPH-quinone reductase (modulator of drug activity B)	MdaB	R	General function prediction only	341	344	0.9912790697674418
OG0001094	COG0229	Peptide methionine sulfoxide reductase MsrB	MsrB	O	Posttranslational modification, protein turnover, chaperones	343	343	1
OG0001095	COG2133	Glucose/arabinose dehydrogenase, beta-propeller fold	YliI	G	Carbohydrate transport and metabolism	343	343	1
OG0001096	COG0828	Ribosomal protein S21	RpsU	J	Translation, ribosomal structure and biogenesis	329	342	0.9619883040935673
OG0001097	COG1638	TRAP-type C4-dicarboxylate transport system, periplasmic component	DctP	G	Carbohydrate transport and metabolism	339	339	1
OG0001098	COG0397	Protein adenylyltransferase (AMPylase) SelO/YdiU (selenoprotein O)	SelO	O	Posttranslational modification, protein turnover, chaperones	336	338	0.9940828402366864
OG0001099	COG0833	Amino acid permease	LysP	E	Amino acid transport and metabolism	14	338	0.04142011834319527
OG0001099	COG1113	L-asparagine transporter or related permease	AnsP	E	Amino acid transport and metabolism	2	338	0.005917159763313609
OG0001099	COG2976	Ancillary subunit YfgM of SecYEG translocon, regulates RcsB-dependent stress response	YfgM	T	Signal transduction mechanisms	1	338	0.0029585798816568047
OG0001100	COG2755	Lysophospholipase L1 or related esterase. Includes spore coat protein LipC/YcsK	TesA	D	Cell cycle control, cell division, chromosome partitioning	338	338	1
OG0001102	COG2352	Phosphoenolpyruvate carboxylase	Ppc	C	Energy production and conversion	335	335	1
OG0001104	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	321	332	0.9668674698795181
OG0001105	COG5285	Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family	PhyH	Q	Secondary metabolites biosynthesis, transport and catabolism	329	332	0.9909638554216867
OG0001106	COG1232	Protoporphyrinogen oxidase HemY/PPOX	HemY	H	Coenzyme transport and metabolism	1	332	0.0030120481927710845
OG0001106	COG2072	Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD	CzcO	P	Inorganic ion transport and metabolism	327	332	0.9849397590361446
OG0001107	COG3836	2-keto-3-deoxy-L-rhamnonate aldolase RhmA	HpcH	G	Carbohydrate transport and metabolism	327	329	0.993920972644377
OG0001108	COG1366	Anti-anti-sigma factor (antagonist of anti-sigma factor), STAS domain	STAS	T	Signal transduction mechanisms	161	329	0.48936170212765956
OG0001108	COG3113	MlaB (STAS domain) subunit of the ABC-type intermembrane phospholipid transporter Mla	MlaB	M	Cell wall/membrane/envelope biogenesis	167	329	0.5075987841945289
OG0001108	COG5815	Stage II sporulation protein SpoIIAA (anti-anti-sigma F factor), STAS domain	SpoIIAA	D	Cell cycle control, cell division, chromosome partitioning	1	329	0.00303951367781155
OG0001109	COG0559	Branched-chain amino acid ABC-type transport system, permease component	LivH	E	Amino acid transport and metabolism	1	326	0.003067484662576687
OG0001109	COG4177	ABC-type branched-chain amino acid transport system, permease component	LivM	E	Amino acid transport and metabolism	325	326	0.9969325153374233
OG0001110	COG3181	Tripartite-type tricarboxylate transporter, extracytoplasmic receptor component TctC	TctC	C	Energy production and conversion	324	324	1
OG0001111	COG0318	O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming)	MenE	I	Lipid transport and metabolism	1	324	0.0030864197530864196
OG0001111	COG0365	Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase	Acs	I	Lipid transport and metabolism	323	324	0.9969135802469136
OG0001112	COG2135	ssDNA abasic site-binding protein YedK/HMCES, SRAP family	SRAP	L	Replication, recombination and repair	323	323	1
OG0001113	COG0665	Glycine/D-amino acid oxidase (deaminating)	DadA	E	Amino acid transport and metabolism	321	322	0.9968944099378882
OG0001113	COG1233	Phytoene dehydrogenase-related protein	NA	Q	Secondary metabolites biosynthesis, transport and catabolism	1	322	0.003105590062111801
OG0001114	COG3038	Cytochrome b561	CybB	C	Energy production and conversion	320	321	0.9968847352024922
OG0001114	COG3658	Cytochrome b subunit of Ni2+-dependent hydrogenase	CytB	C	Energy production and conversion	1	321	0.003115264797507788
OG0001115	COG3909	Cytochrome c556	CytC556	C	Energy production and conversion	318	318	1
OG0001116	COG3127	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component	YbbP	Q	Secondary metabolites biosynthesis, transport and catabolism	318	318	1
OG0001117	COG0554	Glycerol kinase	GlpK	C	Energy production and conversion	315	316	0.9968354430379747
OG0001117	COG1070	Sugar (pentulose or hexulose) kinase	XylB	G	Carbohydrate transport and metabolism	1	316	0.0031645569620253164
OG0001118	COG0601	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	DppB	E	Amino acid transport and metabolism	315	315	1
OG0001119	COG0747	ABC-type transport system, periplasmic component	DdpA	E	Amino acid transport and metabolism	314	314	1
OG0001120	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	5	314	0.01592356687898089
OG0001120	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	BcsA	N	Cell motility	13	314	0.041401273885350316
OG0001120	COG1216	Glycosyltransferase, GT2 family	WcaE	G	Carbohydrate transport and metabolism	1	314	0.0031847133757961785
OG0001120	COG4640	Uncharacterized protein YvbJ, contains N-terminal Zn ribbon domain	YvbJ	S	Function unknown	1	314	0.0031847133757961785
OG0001121	COG1653	ABC-type glycerol-3-phosphate transport system, periplasmic component	UgpB	G	Carbohydrate transport and metabolism	311	313	0.9936102236421726
OG0001122	COG4649	TPR-like repeat domain	TPR1	S	Function unknown	6	313	0.019169329073482427
OG0001125	COG0500	SAM-dependent methyltransferase SmtA (CmoB moved to COG2228)	SmtA	Q	Secondary metabolites biosynthesis, transport and catabolism	2	308	0.006493506493506494
OG0001125	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9	UbiE	H	Coenzyme transport and metabolism	4	308	0.012987012987012988
OG0001125	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	8	308	0.025974025974025976
OG0001125	COG4976	Predicted methyltransferase, contains TPR repeat	NA	R	General function prediction only	293	308	0.9512987012987013
OG0001127	COG0444	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component	DppD	E	Amino acid transport and metabolism	33	307	0.10749185667752444
OG0001127	COG1173	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	DppC	E	Amino acid transport and metabolism	274	307	0.8925081433224755
OG0001128	COG0500	SAM-dependent methyltransferase SmtA (CmoB moved to COG2228)	SmtA	Q	Secondary metabolites biosynthesis, transport and catabolism	135	306	0.4411764705882353
OG0001128	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9	UbiE	H	Coenzyme transport and metabolism	110	306	0.35947712418300654
OG0001128	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	38	306	0.12418300653594772
OG0001128	COG2230	Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases	Cfa	I	Lipid transport and metabolism	2	306	0.006535947712418301
OG0001128	COG4106	Trans-aconitate methyltransferase	Tam	C	Energy production and conversion	4	306	0.013071895424836602
OG0001128	COG4976	Predicted methyltransferase, contains TPR repeat	NA	R	General function prediction only	4	306	0.013071895424836602
OG0001129	COG0503	Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein	Apt	F	Nucleotide transport and metabolism	1	306	0.0032679738562091504
OG0001129	COG1221	Transcriptional regulators containing sigma54-interacting ATPase domain	PspF	K	Transcription	5	306	0.016339869281045753
OG0001129	COG1368	Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily	MdoB	M	Cell wall/membrane/envelope biogenesis	1	306	0.0032679738562091504
OG0001129	COG2755	Lysophospholipase L1 or related esterase. Includes spore coat protein LipC/YcsK	TesA	D	Cell cycle control, cell division, chromosome partitioning	204	306	0.6666666666666666
OG0001130	COG3180	Uncharacterized membrane protein AbrB, regulator of aidB expression	AbrB	R	General function prediction only	304	306	0.9934640522875817
OG0001131	COG0346	Glyoxalase, catechol 2,3-dioxygenase or related enzyme, vicinal oxygen chelate (VOC) family	GloA	Q	Secondary metabolites biosynthesis, transport and catabolism	304	305	0.9967213114754099
OG0001132	COG3971	2-keto-4-pentenoate hydratase	MhpD	Q	Secondary metabolites biosynthesis, transport and catabolism	301	303	0.9933993399339934
OG0001133	COG2211	Na+/melibiose symporter or related transporter	MelB	G	Carbohydrate transport and metabolism	1	301	0.0033222591362126247
OG0001133	COG4152	ABC-type uncharacterized transport system, ATPase component	YhaQ	R	General function prediction only	3	301	0.009966777408637873
OG0001133	COG4591	ABC-type lipoprotein targeting system transmembrane component LolC/LolE	LolC	M	Cell wall/membrane/envelope biogenesis	8	301	0.026578073089700997
OG0001134	COG0559	Branched-chain amino acid ABC-type transport system, permease component	LivH	E	Amino acid transport and metabolism	299	300	0.9966666666666667
OG0001135	COG2358	TRAP-type uncharacterized transport system, periplasmic component	Imp	R	General function prediction only	297	298	0.9966442953020134
OG0001136	COG3565	Predicted dioxygenase of extradiol dioxygenase family	NA	R	General function prediction only	298	298	1
OG0001137	COG0399	dTDP-4-amino-4,6-dideoxygalactose transaminase	WecE	M	Cell wall/membrane/envelope biogenesis	1	297	0.003367003367003367
OG0001137	COG0500	SAM-dependent methyltransferase SmtA (CmoB moved to COG2228)	SmtA	Q	Secondary metabolites biosynthesis, transport and catabolism	2	297	0.006734006734006734
OG0001137	COG0524	Sugar or nucleoside kinase, ribokinase family	RbsK	G	Carbohydrate transport and metabolism	1	297	0.003367003367003367
OG0001137	COG1221	Transcriptional regulators containing sigma54-interacting ATPase domain	PspF	K	Transcription	1	297	0.003367003367003367
OG0001137	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase or related enzyme	RfbC	M	Cell wall/membrane/envelope biogenesis	1	297	0.003367003367003367
OG0001137	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9	UbiE	H	Coenzyme transport and metabolism	2	297	0.006734006734006734
OG0001137	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	170	297	0.5723905723905723
OG0001137	COG3966	Poly-D-alanine transfer protein DltD, involved in esterification of teichoic acids	DltD	M	Cell wall/membrane/envelope biogenesis	1	297	0.003367003367003367
OG0001137	COG4976	Predicted methyltransferase, contains TPR repeat	NA	R	General function prediction only	80	297	0.26936026936026936
OG0001138	COG0690	Preprotein translocase subunit SecE	SecE	U	Intracellular trafficking, secretion, and vesicular transport	295	295	1
OG0001139	COG0518	GMP synthase, glutamine amidotransferase domain/subunit	GuaA1	F	Nucleotide transport and metabolism	295	295	1
OG0001141	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	287	290	0.9896551724137931
OG0001141	COG1087	UDP-glucose 4-epimerase	GalE	M	Cell wall/membrane/envelope biogenesis	1	290	0.0034482758620689655
OG0001141	COG1089	GDP-D-mannose dehydratase	Gmd	M	Cell wall/membrane/envelope biogenesis	1	290	0.0034482758620689655
OG0001142	COG0474	Magnesium-transporting ATPase (P-type)	MgtA	P	Inorganic ion transport and metabolism	2	290	0.006896551724137931
OG0001142	COG1287	Asparagine N-glycosylation enzyme, membrane subunit Stt3	Stt3	O	Posttranslational modification, protein turnover, chaperones	1	290	0.0034482758620689655
OG0001142	COG1807	PMT family glycosyltransferase ArnT/Agl22, involved in glycosylation of proteins and lipid IVA	ArnT	M	Cell wall/membrane/envelope biogenesis	1	290	0.0034482758620689655
OG0001142	COG4485	Uncharacterized membrane protein YfhO	YfhO	S	Function unknown	1	290	0.0034482758620689655
OG0001142	COG4652	Uncharacterized conserved protein, DUF1430 domain	NA	S	Function unknown	1	290	0.0034482758620689655
OG0001144	COG2133	Glucose/arabinose dehydrogenase, beta-propeller fold	YliI	G	Carbohydrate transport and metabolism	288	289	0.9965397923875432
OG0001145	COG0454	N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2)	PhnO	K	Transcription	18	289	0.06228373702422145
OG0001145	COG1246	N-acetylglutamate synthase or related acetyltransferase, GNAT family	ArgA	E	Amino acid transport and metabolism	3	289	0.010380622837370242
OG0001148	COG0730	Sulfite exporter TauE/SafE/YfcA and related permeases, UPF0721 family	TauE	P	Inorganic ion transport and metabolism	287	287	1
OG0001149	COG3036	Stalled ribosome alternative rescue factor ArfA	ArfA	J	Translation, ribosomal structure and biogenesis	31	287	0.10801393728222997
OG0001150	COG0376	Catalase (peroxidase I)	KatG	P	Inorganic ion transport and metabolism	287	287	1
OG0001151	COG0257	Ribosomal protein L36	RpmJ	J	Translation, ribosomal structure and biogenesis	286	286	1
OG0001152	COG0095	Lipoate-protein ligase A	LplA	H	Coenzyme transport and metabolism	1	284	0.0035211267605633804
OG0001152	COG0252	L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D	AnsA	J	Translation, ribosomal structure and biogenesis	2	284	0.007042253521126761
OG0001152	COG3895	Membrane-bound inhibitor of C-type lysozyme	MliC	M	Cell wall/membrane/envelope biogenesis	1	284	0.0035211267605633804
OG0001152	COG4594	ABC-type Fe3+-citrate transport system, periplasmic component	FecB	P	Inorganic ion transport and metabolism	1	284	0.0035211267605633804
OG0001152	COG4717	Predicted ATPase SbcE/YhaN involved in DNA double-strand break repair, contains AAA domain	YhaN	L	Replication, recombination and repair	1	284	0.0035211267605633804
OG0001152	COG4782	Esterase/lipase superfamily enzyme	NA	R	General function prediction only	2	284	0.007042253521126761
OG0001152	COG5633	Uncharacterized conserved protein YcfL	YcfL	S	Function unknown	19	284	0.06690140845070422
OG0001153	COG4666	TRAP-type uncharacterized transport system, fused permease components	NA	R	General function prediction only	281	284	0.9894366197183099
OG0001154	COG1082	Sugar phosphate isomerase/epimerase	YcjR	G	Carbohydrate transport and metabolism	283	283	1
OG0001155	COG2141	Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase)	SsuD	H	Coenzyme transport and metabolism	279	280	0.9964285714285714
OG0001156	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	274	279	0.982078853046595
OG0001156	COG1087	UDP-glucose 4-epimerase	GalE	M	Cell wall/membrane/envelope biogenesis	2	279	0.007168458781362007
OG0001158	COG2308	Circularly permuted ATP-grasp protein	NA	R	General function prediction only	277	278	0.9964028776978417
OG0001159	COG0225	Peptide methionine sulfoxide reductase MsrA	MsrA	O	Posttranslational modification, protein turnover, chaperones	276	276	1
OG0001160	COG1209	dTDP-glucose pyrophosphorylase	RmlA1	M	Cell wall/membrane/envelope biogenesis	275	275	1
OG0001161	COG3090	TRAP-type C4-dicarboxylate transport system, small permease component YiaM	DctM	G	Carbohydrate transport and metabolism	27	273	0.0989010989010989
OG0001161	COG4665	TRAP-type mannitol/chloroaromatic compound transport system, small permease component	FcbT2	Q	Secondary metabolites biosynthesis, transport and catabolism	242	273	0.8864468864468864
OG0001162	COG1052	Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase	LdhA	C	Energy production and conversion	271	272	0.9963235294117647
OG0001163	COG3181	Tripartite-type tricarboxylate transporter, extracytoplasmic receptor component TctC	TctC	C	Energy production and conversion	270	271	0.996309963099631
OG0001164	COG0424	7-methyl-GTP pyrophosphatase and related NTP pyrophosphatases, Maf/HAM1 superfamily	Maf	Q	Secondary metabolites biosynthesis, transport and catabolism	1	271	0.0036900369003690036
OG0001164	COG0730	Sulfite exporter TauE/SafE/YfcA and related permeases, UPF0721 family	TauE	P	Inorganic ion transport and metabolism	2	271	0.007380073800738007
OG0001164	COG1862	Protein translocase subunit YajC	YajC	U	Intracellular trafficking, secretion, and vesicular transport	9	271	0.033210332103321034
OG0001164	COG3182	Integral membrane siderophore reductase FoxB, contains PepSY domain	PiuB	P	Inorganic ion transport and metabolism	27	271	0.0996309963099631
OG0001164	COG4477	Septation ring formation regulator EzrA	EzrA	D	Cell cycle control, cell division, chromosome partitioning	2	271	0.007380073800738007
OG0001165	COG2175	Taurine dioxygenase, alpha-ketoglutarate-dependent	TauD	Q	Secondary metabolites biosynthesis, transport and catabolism	266	268	0.9925373134328358
OG0001165	COG3536	Putative dioxygenase with GBBH-like_N/DUF971 domain	GBBH	R	General function prediction only	2	268	0.007462686567164179
OG0001166	COG0855	Polyphosphate kinase	Ppk	P	Inorganic ion transport and metabolism	267	267	1
OG0001167	COG0248	Exopolyphosphatase/pppGpp-phosphohydrolase	GppA	F	Nucleotide transport and metabolism	263	267	0.9850187265917603
OG0001169	COG2062	Phosphohistidine phosphatase SixA	SixA	T	Signal transduction mechanisms	264	266	0.9924812030075187
OG0001170	COG0337	3-dehydroquinate synthetase	AroB	E	Amino acid transport and metabolism	261	265	0.9849056603773585
OG0001171	COG2855	Uncharacterized membrane protein YeiH, induced by redox stress, UPF0324 family	YeiH	S	Function unknown	263	265	0.9924528301886792
OG0001172	COG2908	UDP-2,3-diacylglucosamine pyrophosphatase LpxH	LpxH	M	Cell wall/membrane/envelope biogenesis	265	265	1
OG0001173	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component	DctQ	G	Carbohydrate transport and metabolism	264	264	1
OG0001174	COG1182	FMN-dependent NADH-azoreductase	AzoR	C	Energy production and conversion	262	264	0.9924242424242424
OG0001175	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	255	264	0.9659090909090909
OG0001176	COG2113	ABC-type proline/glycine betaine transport system, periplasmic component	ProX	E	Amino acid transport and metabolism	261	264	0.9886363636363636
OG0001177	COG3210	Large exoprotein involved in heme utilization or adhesion	FhaB	U	Intracellular trafficking, secretion, and vesicular transport	1	262	0.003816793893129771
OG0001177	COG4254	Uncharacterized peptidoglycan binding protein, contains LysM and FecR  domains	NA	R	General function prediction only	242	262	0.9236641221374046
OG0001178	COG2211	Na+/melibiose symporter or related transporter	MelB	G	Carbohydrate transport and metabolism	44	262	0.16793893129770993
OG0001179	COG3090	TRAP-type C4-dicarboxylate transport system, small permease component YiaM	DctM	G	Carbohydrate transport and metabolism	257	261	0.9846743295019157
OG0001179	COG4665	TRAP-type mannitol/chloroaromatic compound transport system, small permease component	FcbT2	Q	Secondary metabolites biosynthesis, transport and catabolism	4	261	0.01532567049808429
OG0001180	COG0457	Tetratricopeptide (TPR) repeat	TPR	R	General function prediction only	1	261	0.0038314176245210726
OG0001180	COG2956	Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain	LapB	M	Cell wall/membrane/envelope biogenesis	1	261	0.0038314176245210726
OG0001180	COG3914	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family	Spy	O	Posttranslational modification, protein turnover, chaperones	255	261	0.9770114942528736
OG0001180	COG4783	Periplasmic chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains	BepA	M	Cell wall/membrane/envelope biogenesis	3	261	0.011494252873563218
OG0001181	COG1653	ABC-type glycerol-3-phosphate transport system, periplasmic component	UgpB	G	Carbohydrate transport and metabolism	257	259	0.9922779922779923
OG0001182	COG1459	Type II secretion system/type IV pilus membrane platform protein GspF/PulF/PilC	GspF/PilC	N	Cell motility	258	258	1
OG0001183	COG2030	Acyl-CoA dehydratase PaaZ	MaoC	I	Lipid transport and metabolism	5	257	0.019455252918287938
OG0001183	COG2301	Citrate lyase beta subunit	CitE	G	Carbohydrate transport and metabolism	251	257	0.9766536964980544
OG0001183	COG3836	2-keto-3-deoxy-L-rhamnonate aldolase RhmA	HpcH	G	Carbohydrate transport and metabolism	1	257	0.0038910505836575876
OG0001184	COG0346	Glyoxalase, catechol 2,3-dioxygenase or related enzyme, vicinal oxygen chelate (VOC) family	GloA	Q	Secondary metabolites biosynthesis, transport and catabolism	256	256	1
OG0001185	COG2814	Predicted arabinose efflux permease AraJ, MFS family	AraJ	G	Carbohydrate transport and metabolism	255	256	0.99609375
OG0001186	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	FabG	I	Lipid transport and metabolism	254	255	0.996078431372549
OG0001187	COG1955	Archaellum membrane component ArlJ/FlaJ	ArlJ	N	Cell motility	21	255	0.08235294117647059
OG0001189	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	250	253	0.9881422924901185
OG0001190	COG0337	3-dehydroquinate synthetase	AroB	E	Amino acid transport and metabolism	252	253	0.9960474308300395
OG0001191	COG0584	Glycerophosphoryl diester phosphodiesterase	UgpQ	I	Lipid transport and metabolism	253	253	1
OG0001192	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	AdhE	I	Lipid transport and metabolism	252	252	1
OG0001193	COG0859	ADP-heptose:LPS heptosyltransferase	RfaF	M	Cell wall/membrane/envelope biogenesis	246	250	0.984
OG0001194	COG3564	Uncharacterized conserved protein, DUF779 family	NA	S	Function unknown	250	250	1
OG0001195	COG2805	Type IV pilus retraction ATPase PilT/PilU	PilT/PilU	N	Cell motility	249	250	0.996
OG0001196	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	2	249	0.008032128514056224
OG0001196	COG1083	CMP-N-acetylneuraminic acid synthetase, NeuA/PseF family	NeuA	M	Cell wall/membrane/envelope biogenesis	134	249	0.5381526104417671
OG0001196	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	BcsA	N	Cell motility	1	249	0.004016064257028112
OG0001196	COG1216	Glycosyltransferase, GT2 family	WcaE	G	Carbohydrate transport and metabolism	1	249	0.004016064257028112
OG0001196	COG1861	Spore coat polysaccharide biosynthesis protein SpsF, cytidylyltransferase family	SpsF	M	Cell wall/membrane/envelope biogenesis	102	249	0.40963855421686746
OG0001196	COG3980	Spore coat polysaccharide biosynthesis protein SpsG, predicted glycosyltransferase	SpsG	M	Cell wall/membrane/envelope biogenesis	1	249	0.004016064257028112
OG0001197	COG4795	Type II secretion system protein PulJ/XcpW	PulJ/XcpW	U	Intracellular trafficking, secretion, and vesicular transport	1	249	0.004016064257028112
OG0001197	COG4966	Type IV pilus minor pilin/pseudopilin PilW	PilW	N	Cell motility	244	249	0.9799196787148594
OG0001198	COG1525	Endonuclease YncB, thermonuclease family	YncB	L	Replication, recombination and repair	246	248	0.9919354838709677
OG0001200	COG2804	Type II secretion system/type IV pilus assembly ATPase GspE/PulE/PilB	GspE/PilB	N	Cell motility	248	248	1
OG0001201	COG3156	Type II secretory pathway, component PulK	PulK	U	Intracellular trafficking, secretion, and vesicular transport	9	248	0.036290322580645164
OG0001201	COG4726	Type IV pilus assembly protein PilX	PilX	N	Cell motility	104	248	0.41935483870967744
OG0001202	COG1088	dTDP-D-glucose 4,6-dehydratase	RfbB	M	Cell wall/membrane/envelope biogenesis	246	246	1
OG0001203	COG4565	DNA-binding response regulator DpiB of citrate/malate metabolism	CitB	K	Transcription	1	246	0.0040650406504065045
OG0001203	COG4913	Uncharacterized conserved protein, contains a C-terminal ATPase domain	NA	S	Function unknown	1	246	0.0040650406504065045
OG0001204	COG3484	Predicted proteasome-type protease	NA	O	Posttranslational modification, protein turnover, chaperones	246	246	1
OG0001205	COG0851	Septum formation topological specificity factor MinE	MinE	D	Cell cycle control, cell division, chromosome partitioning	1	246	0.0040650406504065045
OG0001206	COG1450	Type II/type III secretion systems/type IV pilus secretin GspD/PulD/PilQ/YscC/InvG/EscC/HrcC/GspD/SctC family	GspD/PilQ	N	Cell motility	2	245	0.00816326530612245
OG0001206	COG4796	Type II secretion system/DNA uptake membrane channel ComE/HofQ	HofQ	U	Intracellular trafficking, secretion, and vesicular transport	243	245	0.9918367346938776
OG0001207	COG1357	Type IVB secretion/DNA transfer system protein DotG/IcmE, contains pentapeptide repeats	DotG	U	Intracellular trafficking, secretion, and vesicular transport	245	245	1
OG0001208	COG3166	Type II secretion system/type IV pilus alignment protein GspM/PulM/PilN	GspM/PilN	N	Cell motility	6	244	0.02459016393442623
OG0001208	COG4972	Type II secretion system/type IV pilus alignment protein GspL/PulL/PilM	GspL/PilM	N	Cell motility	235	244	0.9631147540983607
OG0001208	COG4974	Site-specific tyrosine recombinase XerD	XerD	L	Replication, recombination and repair	1	244	0.004098360655737705
OG0001210	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	236	243	0.9711934156378601
OG0001210	COG1216	Glycosyltransferase, GT2 family	WcaE	G	Carbohydrate transport and metabolism	3	243	0.012345679012345678
OG0001211	COG0381	UDP-N-acetylglucosamine 2-epimerase	WecB	M	Cell wall/membrane/envelope biogenesis	212	243	0.8724279835390947
OG0001211	COG0859	ADP-heptose:LPS heptosyltransferase	RfaF	M	Cell wall/membrane/envelope biogenesis	1	243	0.00411522633744856
OG0001213	COG1989	Type II secretion system/type IV prepilin peptidase GspO/PulO/PilD	GspO/PilD	N	Cell motility	243	243	1
OG0001214	COG2271	Sugar phosphate permease	UhpC	G	Carbohydrate transport and metabolism	230	243	0.9465020576131687
OG0001214	COG2814	Predicted arabinose efflux permease AraJ, MFS family	AraJ	G	Carbohydrate transport and metabolism	11	243	0.04526748971193416
OG0001215	COG1893	Ketopantoate reductase	PanE	H	Coenzyme transport and metabolism	242	242	1
OG0001216	COG0646	Methionine synthase I (cobalamin-dependent), methyltransferase domain	MetH1	E	Amino acid transport and metabolism	240	241	0.995850622406639
OG0001217	COG3205	Uncharacterized membrane protein, DUF2061 family	NA	S	Function unknown	239	241	0.991701244813278
OG0001217	COG3807	SH3-like domain	SH3	S	Function unknown	1	241	0.004149377593360996
OG0001218	COG0859	ADP-heptose:LPS heptosyltransferase	RfaF	M	Cell wall/membrane/envelope biogenesis	240	240	1
OG0001220	COG1132	ABC-type multidrug and LPS transport system, ATPase and permease component MsbA	MdlB	M	Cell wall/membrane/envelope biogenesis	63	239	0.26359832635983266
OG0001220	COG4332	Uncharacterized conserved protein, DUF1062 domain	NA	S	Function unknown	7	239	0.029288702928870293
OG0001221	COG0279	Phosphoheptose isomerase	GmhA	G	Carbohydrate transport and metabolism	224	238	0.9411764705882353
OG0001221	COG0794	D-arabinose 5-phosphate isomerase GutQ	GutQ	G	Carbohydrate transport and metabolism	1	238	0.004201680672268907
OG0001221	COG1737	DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains	RpiR	K	Transcription	9	238	0.037815126050420166
OG0001223	COG2172	Anti-sigma regulatory factor (Ser/Thr protein kinase)	RsbW	T	Signal transduction mechanisms	235	235	1
OG0001224	COG4177	ABC-type branched-chain amino acid transport system, permease component	LivM	E	Amino acid transport and metabolism	234	234	1
OG0001225	COG0559	Branched-chain amino acid ABC-type transport system, permease component	LivH	E	Amino acid transport and metabolism	233	233	1
OG0001226	COG3164	Phospholipid transporter to the outer membrane, contains AsmA2 domain	YhdP	M	Cell wall/membrane/envelope biogenesis	1	233	0.004291845493562232
OG0001227	COG0474	Magnesium-transporting ATPase (P-type)	MgtA	P	Inorganic ion transport and metabolism	7	231	0.030303030303030304
OG0001228	COG3791	Uncharacterized conserved protein	NA	S	Function unknown	230	230	1
OG0001229	COG0367	Asparagine synthetase B (glutamine-hydrolyzing)	AsnB	E	Amino acid transport and metabolism	226	229	0.9868995633187773
OG0001230	COG1597	Phosphatidylglycerol kinase, diacylglycerol kinase family	LCB5	I	Lipid transport and metabolism	227	229	0.9912663755458515
OG0001231	COG3917	2-hydroxychromene-2-carboxylate isomerase	NahD	Q	Secondary metabolites biosynthesis, transport and catabolism	228	228	1
OG0001232	COG1592	Rubrerythrin	YotD	C	Energy production and conversion	227	227	1
OG0001233	COG0494	8-oxo-dGTP pyrophosphatase MutT and related house-cleaning NTP pyrophosphohydrolases, NUDIX family	MutT	V	Defense mechanisms	223	226	0.9867256637168141
OG0001233	COG0855	Polyphosphate kinase	Ppk	P	Inorganic ion transport and metabolism	1	226	0.004424778761061947
OG0001236	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	224	225	0.9955555555555555
OG0001237	COG1666	Cyclic di-GMP-binding protein YajQ, UPF0234 family	YajQ	T	Signal transduction mechanisms	225	225	1
OG0001238	COG0247	Fe-S cluster-containing oxidoreductase, includes glycolate oxidase subunit GlcF	GlpC	C	Energy production and conversion	225	225	1
OG0001240	COG0765	ABC-type amino acid transport system, permease component	HisM	E	Amino acid transport and metabolism	222	222	1
OG0001241	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	20	222	0.09009009009009009
OG0001241	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	BcsA	N	Cell motility	2	222	0.009009009009009009
OG0001241	COG1216	Glycosyltransferase, GT2 family	WcaE	G	Carbohydrate transport and metabolism	198	222	0.8918918918918919
OG0001242	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	HisJ	E	Amino acid transport and metabolism	222	222	1
OG0001243	COG3246	Uncharacterized conserved protein, DUF849 family	NA	S	Function unknown	222	222	1
OG0001244	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	FabG	I	Lipid transport and metabolism	221	221	1
OG0001246	COG3751	Proline 4-hydroxylase (includes Rps23 Pro-64 3,4-dihydroxylase Tpa1), contains SM-20 domain	EGL9	J	Translation, ribosomal structure and biogenesis	1	219	0.0045662100456621
OG0001248	COG0314	Molybdopterin synthase catalytic subunit MoaE	MoaE	H	Coenzyme transport and metabolism	216	216	1
OG0001249	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	200	215	0.9302325581395349
OG0001249	COG1088	dTDP-D-glucose 4,6-dehydratase	RfbB	M	Cell wall/membrane/envelope biogenesis	12	215	0.05581395348837209
OG0001250	COG0521	Molybdopterin adenylyltransferase MoaB/MogA	MoaB	H	Coenzyme transport and metabolism	214	214	1
OG0001252	COG2258	N-hydroxylaminopurine reductase YiiM, contains MOSC domain	YiiM	F	Nucleotide transport and metabolism	84	213	0.39436619718309857
OG0001252	COG3217	N-hydroxylaminopurine reductase subunit YcbX, contains MOSC domain	YcbX	F	Nucleotide transport and metabolism	127	213	0.596244131455399
OG0001253	COG3492	Uncharacterized conserved protein, DUF1244 family	NA	S	Function unknown	213	213	1
OG0001254	COG1977	Molybdopterin synthase sulfur carrier subunit MoaD	MoaD	H	Coenzyme transport and metabolism	152	212	0.71698113207547165
OG0001255	COG0315	Molybdenum cofactor biosynthesis enzyme MoaC	MoaC	H	Coenzyme transport and metabolism	212	212	1
OG0001257	COG1879	ABC-type sugar transport system, periplasmic component, contains N-terminal xre family HTH domain	RbsB	G	Carbohydrate transport and metabolism	211	211	1
OG0001259	COG0303	Molybdopterin Mo-transferase (molybdopterin biosynthesis)	MoeA	H	Coenzyme transport and metabolism	209	210	0.9952380952380953
OG0001260	COG1030	Membrane-bound serine protease NfeD, ClpP class	NfeD	O	Posttranslational modification, protein turnover, chaperones	2	210	0.009523809523809525
OG0001260	COG2943	Membrane glycosyltransferase	MdoH	M	Cell wall/membrane/envelope biogenesis	1	210	0.004761904761904762
OG0001260	COG5393	Uncharacterized membrane protein YqjE	YqjE	S	Function unknown	8	210	0.0380952380952381
OG0001261	COG0001	Glutamate-1-semialdehyde aminotransferase	HemL	H	Coenzyme transport and metabolism	1	209	0.004784688995215311
OG0001261	COG0189	Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily	LysX	E	Amino acid transport and metabolism	4	209	0.019138755980861243
OG0001261	COG0439	Biotin carboxylase	AccC	I	Lipid transport and metabolism	9	209	0.0430622009569378
OG0001261	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	3	209	0.014354066985645933
OG0001261	COG0456	Ribosomal protein S18 acetylase RimI and related acetyltransferases	RimI	J	Translation, ribosomal structure and biogenesis	2	209	0.009569377990430622
OG0001261	COG0458	Carbamoylphosphate synthase large subunit	CarB	E	Amino acid transport and metabolism	2	209	0.009569377990430622
OG0001261	COG0667	Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family	PdxI	H	Coenzyme transport and metabolism	34	209	0.16267942583732056
OG0001261	COG1453	Predicted oxidoreductase of the aldo/keto reductase family	NA	R	General function prediction only	19	209	0.09090909090909091
OG0001261	COG1670	Protein N-acetyltransferase, RimJ/RimL family	RimL	J	Translation, ribosomal structure and biogenesis	68	209	0.3253588516746411
OG0001261	COG1861	Spore coat polysaccharide biosynthesis protein SpsF, cytidylyltransferase family	SpsF	M	Cell wall/membrane/envelope biogenesis	5	209	0.023923444976076555
OG0001261	COG2232	Pyrrolysine biosynthesis ligase PylC and related enzymes, ATP-grasp superfamily	PylC	E	Amino acid transport and metabolism	1	209	0.004784688995215311
OG0001261	COG3919	Predicted ATP-dependent carboligase, ATP-grasp superfamily	NA	R	General function prediction only	15	209	0.07177033492822966
OG0001262	COG2008	Threonine aldolase	GLY1	E	Amino acid transport and metabolism	209	209	1
OG0001263	COG0730	Sulfite exporter TauE/SafE/YfcA and related permeases, UPF0721 family	TauE	P	Inorganic ion transport and metabolism	207	209	0.9904306220095693
OG0001266	COG3419	Type IV pilus tip-associated adhesin PilY1	PilY1	N	Cell motility	203	206	0.9854368932038835
OG0001267	COG0400	Palmitoyl-CoA esterase	YpfH	R	General function prediction only	30	205	0.14634146341463414
OG0001267	COG0627	S-formylglutathione hydrolase FrmB	FrmB	V	Defense mechanisms	1	205	0.004878048780487805
OG0001267	COG0657	Acetyl esterase/lipase	Aes	I	Lipid transport and metabolism	1	205	0.004878048780487805
OG0001267	COG1506	Dipeptidyl aminopeptidase/acylaminoacyl peptidase	DAP2	E	Amino acid transport and metabolism	96	205	0.4682926829268293
OG0001267	COG1647	Esterase/lipase	YvaK	Q	Secondary metabolites biosynthesis, transport and catabolism	18	205	0.08780487804878048
OG0001267	COG2267	Lysophospholipase, alpha-beta hydrolase superfamily	PldB	I	Lipid transport and metabolism	10	205	0.04878048780487805
OG0001267	COG2382	Enterochelin esterase or related enzyme	Fes	P	Inorganic ion transport and metabolism	1	205	0.004878048780487805
OG0001267	COG4099	Predicted peptidase	NA	R	General function prediction only	3	205	0.014634146341463415
OG0001268	COG0404	Glycine cleavage system protein T (aminomethyltransferase)	GcvT	E	Amino acid transport and metabolism	204	204	1
OG0001269	COG2957	Agmatine/peptidylarginine deiminase	AguA	E	Amino acid transport and metabolism	204	204	1
OG0001270	COG5470	Uncharacterized conserved protein, DUF1330 family	NA	S	Function unknown	14	204	0.06862745098039216
OG0001271	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	1	199	0.005025125628140704
OG0001271	COG2520	tRNA G37 N1-methylase Trm5	Trm5	J	Translation, ribosomal structure and biogenesis	1	199	0.005025125628140704
OG0001271	COG4076	Predicted RNA methylase	NA	R	General function prediction only	1	199	0.005025125628140704
OG0001272	COG0715	ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component	TauA	P	Inorganic ion transport and metabolism	1	199	0.005025125628140704
OG0001272	COG1879	ABC-type sugar transport system, periplasmic component, contains N-terminal xre family HTH domain	RbsB	G	Carbohydrate transport and metabolism	198	199	0.9949748743718593
OG0001275	COG3803	Uncharacterized conserved protein, DUF924 family	NA	S	Function unknown	195	195	1
OG0001276	COG3769	Mannosyl-3-phosphoglycerate phosphatase YedP/MpgP, HAD superfamily	YedP	G	Carbohydrate transport and metabolism	193	194	0.9948453608247423
OG0001277	COG3206	Tyrosine-protein kinase Wzc involved in exopolysaccharide export, GumC/Wzc1 domain	GumC	M	Cell wall/membrane/envelope biogenesis	1	193	0.0051813471502590676
OG0001277	COG3944	Capsular polysaccharide biosynthesis protein YveK	YveK	M	Cell wall/membrane/envelope biogenesis	3	193	0.015544041450777202
OG0001277	COG3966	Poly-D-alanine transfer protein DltD, involved in esterification of teichoic acids	DltD	M	Cell wall/membrane/envelope biogenesis	10	193	0.05181347150259067
OG0001278	COG2259	Uncharacterized membrane protein YphA, DoxX/SURF4 family	DoxX	S	Function unknown	192	193	0.9948186528497409
OG0001280	COG0513	Superfamily II DNA and RNA helicase	SrmB	L	Replication, recombination and repair	176	190	0.9263157894736842
OG0001280	COG0553	Superfamily II DNA or RNA helicase, SNF2 family	HepA	K	Transcription	12	190	0.06315789473684211
OG0001281	COG3408	Glycogen debranching enzyme (alpha-1,6-glucosidase)	GDB1	G	Carbohydrate transport and metabolism	189	190	0.9947368421052631
OG0001282	COG4454	Uncharacterized copper-binding protein, cupredoxin-like subfamily	NA	R	General function prediction only	189	189	1
OG0001283	COG0247	Fe-S cluster-containing oxidoreductase, includes glycolate oxidase subunit GlcF	GlpC	C	Energy production and conversion	189	189	1
OG0001284	COG1629	Outer membrane receptor protein, Fe transport	CirA	P	Inorganic ion transport and metabolism	5	189	0.026455026455026454
OG0001284	COG2956	Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain	LapB	M	Cell wall/membrane/envelope biogenesis	67	189	0.3544973544973545
OG0001284	COG3188	Outer membrane usher protein FimD/PapC	FimD	N	Cell motility	2	189	0.010582010582010581
OG0001284	COG4235	Cytochrome c-type biogenesis protein CcmH/NrfG	NrfG	C	Energy production and conversion	81	189	0.42857142857142855
OG0001284	COG4771	Outer membrane receptor for ferrienterochelin and colicins	FepA	P	Inorganic ion transport and metabolism	2	189	0.010582010582010581
OG0001284	COG4775	Outer membrane protein assembly factor BamA	BamA	M	Cell wall/membrane/envelope biogenesis	3	189	0.015873015873015872
OG0001284	COG4783	Periplasmic chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains	BepA	M	Cell wall/membrane/envelope biogenesis	2	189	0.010582010582010581
OG0001284	COG5338	Uncharacterized conserved protein	NA	S	Function unknown	3	189	0.015873015873015872
OG0001284	COG5571	Secreted esterase EstA, contains T5SS autotransporter beta-barrel domain	EstA	U	Intracellular trafficking, secretion, and vesicular transport	11	189	0.0582010582010582
OG0001285	COG3386	Sugar lactone lactonase YvrE	YvrE	G	Carbohydrate transport and metabolism	187	187	1
OG0001286	COG0277	FAD/FMN-containing lactate dehydrogenase/glycolate oxidase	GlcD	C	Energy production and conversion	186	187	0.9946524064171123
OG0001287	COG3751	Proline 4-hydroxylase (includes Rps23 Pro-64 3,4-dihydroxylase Tpa1), contains SM-20 domain	EGL9	J	Translation, ribosomal structure and biogenesis	31	185	0.16756756756756758
OG0001287	COG5285	Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family	PhyH	Q	Secondary metabolites biosynthesis, transport and catabolism	59	185	0.31891891891891894
OG0001288	COG1526	Formate dehydrogenase assembly factor FdhD, a sulfurtransferase	FdhD	C	Energy production and conversion	185	185	1
OG0001289	COG0746	Molybdopterin-guanine dinucleotide biosynthesis protein A	MobA	H	Coenzyme transport and metabolism	184	185	0.9945945945945946
OG0001290	COG0692	Uracil-DNA glycosylase	Ung	L	Replication, recombination and repair	1	183	0.00546448087431694
OG0001290	COG2205	K+-sensing histidine kinase KdpD	KdpD	T	Signal transduction mechanisms	6	183	0.03278688524590164
OG0001291	COG2717	Heme-binding membrane subunit of periplasmic DMSO/TMAO and protein-methionine-sulfoxide reductases	MsrQ	C	Energy production and conversion	183	183	1
OG0001292	COG3166	Type II secretion system/type IV pilus alignment protein GspM/PulM/PilN	GspM/PilN	N	Cell motility	1	183	0.00546448087431694
OG0001292	COG3167	Type II secretion system/type IV pilus alignment protein PilO	PilO	N	Cell motility	151	183	0.825136612021858
OG0001293	COG2165	Type II secretion system/type IV prepilin peptidase GspO/PulO/PilD	GspO/PilD	N	Cell motility	3	183	0.01639344262295082
OG0001293	COG4967	Type IV pilus minor pilin/pseudopilin PilV	PilV	N	Cell motility	136	183	0.7431693989071039
OG0001293	COG4970	Type IV pilus assembly protein FimT or FimU	FimT	N	Cell motility	6	183	0.03278688524590164
OG0001294	COG2084	3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase	MmsB	I	Lipid transport and metabolism	181	182	0.9945054945054945
OG0001295	COG2041	Molybdopterin-dependent catalytic subunit of periplasmic DMSO/TMAO and protein-methionine-sulfoxide reductases	MsrP	C	Energy production and conversion	182	182	1
OG0001296	COG0037	tRNA-C32 2-thiocytidine or tRNA(Ile)-C34 C2-lysylcytidine synthase TtcA/TilS/MesJ	TtcA	J	Translation, ribosomal structure and biogenesis	40	181	0.22099447513812154
OG0001296	COG0107	Imidazole glycerol phosphate synthase subunit HisF	HisF	E	Amino acid transport and metabolism	1	181	0.0055248618784530384
OG0001296	COG0171	NH3-dependent NAD+ synthetase	NadE	H	Coenzyme transport and metabolism	2	181	0.011049723756906077
OG0001296	COG0175	Phosphoadenylyl sulfate (PAPS) reductase/FAD synthetase or related enzyme	CysH	E	Amino acid transport and metabolism	10	181	0.055248618784530384
OG0001296	COG0301	Adenylyl- and sulfurtransferase ThiI (thiamine and tRNA 4-thiouridine biosynthesis)	ThiI	H	Coenzyme transport and metabolism	1	181	0.0055248618784530384
OG0001296	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	4	181	0.022099447513812154
OG0001296	COG1365	Predicted ATPase, PP-loop superfamily	NA	R	General function prediction only	16	181	0.08839779005524862
OG0001296	COG1606	ATP-utilizing enzyme, PP-loop superfamily	NA	R	General function prediction only	1	181	0.0055248618784530384
OG0001297	COG3665	Uncharacterized conserved protein YcgI, DUF1989 family	YcgI	S	Function unknown	181	181	1
OG0001298	COG0590	tRNA(Arg) A34 adenosine deaminase TadA	TadA	J	Translation, ribosomal structure and biogenesis	178	180	0.9888888888888889
OG0001299	COG3491	Isopenicillin N synthase and related dioxygenases	PcbC	Q	Secondary metabolites biosynthesis, transport and catabolism	179	179	1
OG0001300	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase or related enzyme	RfbC	M	Cell wall/membrane/envelope biogenesis	178	178	1
OG0001301	COG3369	Uncharacterized conserved protein, contains Zn-finger domain of CDGSH type	NA	S	Function unknown	178	178	1
OG0001302	COG0620	Methionine synthase II (cobalamin-independent)	MetE	E	Amino acid transport and metabolism	177	177	1
OG0001303	COG0454	N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2)	PhnO	K	Transcription	67	177	0.3785310734463277
OG0001303	COG0456	Ribosomal protein S18 acetylase RimI and related acetyltransferases	RimI	J	Translation, ribosomal structure and biogenesis	86	177	0.4858757062146893
OG0001303	COG1246	N-acetylglutamate synthase or related acetyltransferase, GNAT family	ArgA	E	Amino acid transport and metabolism	6	177	0.03389830508474576
OG0001304	COG2010	Cytochrome c, mono- and diheme variants	CccA	C	Energy production and conversion	176	177	0.9943502824858758
OG0001304	COG3474	Cytochrome c2	Cyc7	C	Energy production and conversion	1	177	0.005649717514124294
OG0001305	COG0399	dTDP-4-amino-4,6-dideoxygalactose transaminase	WecE	M	Cell wall/membrane/envelope biogenesis	175	175	1
OG0001306	COG0006	Xaa-Pro aminopeptidase	PepP	E	Amino acid transport and metabolism	175	175	1
OG0001307	COG4664	TRAP-type mannitol/chloroaromatic compound transport system, large permease component	FcbT3	Q	Secondary metabolites biosynthesis, transport and catabolism	174	174	1
OG0001308	COG0697	Amino acid export permease, drug/metabolite transporter (DMT) superfamily	EamA	E	Amino acid transport and metabolism	172	174	0.9885057471264368
OG0001310	COG2351	5-hydroxyisourate hydrolase (purine catabolism), transthyretin-related family	HiuH	F	Nucleotide transport and metabolism	113	173	0.653179190751445
OG0001311	COG1397	ADP-ribosylglycohydrolase	DraG	O	Posttranslational modification, protein turnover, chaperones	153	173	0.884393063583815
OG0001311	COG5185	Chromosome segregation protein NDC80, interacts with SMC proteins	HEC1	D	Cell cycle control, cell division, chromosome partitioning	10	173	0.057803468208092484
OG0001312	COG3502	Uncharacterized conserved protein, DUF952 family	NA	S	Function unknown	171	171	1
OG0001313	COG5467	Uncharacterized conserved protein, DUF1476 domain	NA	S	Function unknown	171	171	1
OG0001314	COG1287	Asparagine N-glycosylation enzyme, membrane subunit Stt3	Stt3	O	Posttranslational modification, protein turnover, chaperones	1	170	0.0058823529411764705
OG0001315	COG3031	Type II secretion system/type IV pili GspC/PulC/PilP protein, contains PDZ domain	GspC/PilP	N	Cell motility	8	169	0.047337278106508875
OG0001315	COG3168	Type IV pilus assembly protein PilP	PilP	N	Cell motility	2	169	0.011834319526627219
OG0001316	COG1200	RecG-like helicase	RecG	L	Replication, recombination and repair	1	169	0.005917159763313609
OG0001316	COG1512	Uncharacterized membrane protein YgcG, contains a TPM-fold domain	YgcG	S	Function unknown	2	169	0.011834319526627219
OG0001317	COG3166	Type II secretion system/type IV pilus alignment protein GspM/PulM/PilN	GspM/PilN	N	Cell motility	1	168	0.005952380952380952
OG0001317	COG5373	Uncharacterized membrane protein	NA	S	Function unknown	1	168	0.005952380952380952
OG0001318	COG4968	Type IV pilus minor pilin/pseudopilin PilE	PilE	N	Cell motility	1	168	0.005952380952380952
OG0001319	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	83	164	0.5060975609756098
OG0001319	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9	UbiE	H	Coenzyme transport and metabolism	1	164	0.006097560975609756
OG0001319	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	48	164	0.2926829268292683
OG0001319	COG4976	Predicted methyltransferase, contains TPR repeat	NA	R	General function prediction only	22	164	0.13414634146341464
OG0001320	COG1529	Aldehyde, CO or xanthine dehydrogenase, Mo-binding subunit	CoxL	C	Energy production and conversion	81	164	0.49390243902439024
OG0001320	COG4631	Xanthine dehydrogenase, molybdopterin-binding subunit XdhB	XdhB	F	Nucleotide transport and metabolism	83	164	0.5060975609756098
OG0001322	COG3791	Uncharacterized conserved protein	NA	S	Function unknown	163	163	1
OG0001323	COG3031	Type II secretion system/type IV pili GspC/PulC/PilP protein, contains PDZ domain	GspC/PilP	N	Cell motility	1	163	0.006134969325153374
OG0001324	COG1512	Uncharacterized membrane protein YgcG, contains a TPM-fold domain	YgcG	S	Function unknown	1	162	0.006172839506172839
OG0001324	COG3899	Predicted ATPase	NA	R	General function prediction only	1	162	0.006172839506172839
OG0001324	COG4105	Outer membrane protein assembly factor BamD, BamD/ComL family	BamD	M	Cell wall/membrane/envelope biogenesis	29	162	0.17901234567901234
OG0001325	COG0578	Glycerol-3-phosphate dehydrogenase	GlpA	C	Energy production and conversion	139	162	0.8580246913580247
OG0001325	COG0579	L-2-hydroxyglutarate oxidase LhgO	LhgO	G	Carbohydrate transport and metabolism	20	162	0.12345679012345678
OG0001325	COG0665	Glycine/D-amino acid oxidase (deaminating)	DadA	E	Amino acid transport and metabolism	1	162	0.006172839506172839
OG0001326	COG3239	Fatty acid desaturase	DesA	I	Lipid transport and metabolism	160	160	1
OG0001327	COG3450	Predicted enzyme of the cupin superfamily	NA	R	General function prediction only	130	160	0.8125
OG0001328	COG1960	Acyl-CoA dehydrogenase related to the alkylation response protein AidB	CaiA	I	Lipid transport and metabolism	159	160	0.99375
OG0001330	COG5267	Uncharacterized conserved protein, DUF1800 family	NA	S	Function unknown	159	159	1
OG0001331	COG0457	Tetratricopeptide (TPR) repeat	TPR	R	General function prediction only	86	158	0.5443037974683544
OG0001331	COG0859	ADP-heptose:LPS heptosyltransferase	RfaF	M	Cell wall/membrane/envelope biogenesis	7	158	0.04430379746835443
OG0001331	COG2956	Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain	LapB	M	Cell wall/membrane/envelope biogenesis	61	158	0.3860759493670886
OG0001332	COG3205	Uncharacterized membrane protein, DUF2061 family	NA	S	Function unknown	158	158	1
OG0001333	COG4091	Predicted homoserine dehydrogenase, contains C-terminal SAF domain	NA	E	Amino acid transport and metabolism	158	158	1
OG0001334	COG4154	L-fucose mutarotase/ribose pyranase, RbsD/FucU family	FucU	G	Carbohydrate transport and metabolism	157	157	1
OG0001336	COG1529	Aldehyde, CO or xanthine dehydrogenase, Mo-binding subunit	CoxL	C	Energy production and conversion	6	157	0.03821656050955414
OG0001336	COG2080	Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family	CutS	C	Energy production and conversion	73	157	0.46496815286624205
OG0001336	COG4630	Xanthine dehydrogenase, Fe-S cluster and FAD-binding subunit XdhA	XdhA	F	Nucleotide transport and metabolism	78	157	0.4968152866242038
OG0001337	COG1835	Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains	OafA	M	Cell wall/membrane/envelope biogenesis	148	156	0.9487179487179487
OG0001338	COG1032	Radical SAM superfamily enzyme YgiQ, UPF0313 family	YgiQ	R	General function prediction only	156	156	1
OG0001339	COG1680	CubicO group peptidase, beta-lactamase class C family	AmpC	V	Defense mechanisms	56	156	0.358974358974359
OG0001339	COG3152	Uncharacterized membrane protein YhaH, DUF805 family	YhaH	S	Function unknown	1	156	0.00641025641025641
OG0001339	COG3164	Phospholipid transporter to the outer membrane, contains AsmA2 domain	YhdP	M	Cell wall/membrane/envelope biogenesis	1	156	0.00641025641025641
OG0001340	COG0534	Na+-driven multidrug efflux pump, DinF/NorM/MATE family	NorM	V	Defense mechanisms	156	156	1
OG0001341	COG4102	Uncharacterized conserved protein, DUF1501 family	NA	S	Function unknown	155	155	1
OG0001342	COG3791	Uncharacterized conserved protein	NA	S	Function unknown	153	153	1
OG0001343	COG3631	Ketosteroid isomerase-related protein	YesE	R	General function prediction only	152	153	0.9934640522875817
OG0001344	COG2113	ABC-type proline/glycine betaine transport system, periplasmic component	ProX	E	Amino acid transport and metabolism	151	152	0.993421052631579
OG0001346	COG0153	Galactokinase	GalK	G	Carbohydrate transport and metabolism	24	150	0.16
OG0001346	COG2605	Predicted kinase related to galactokinase and mevalonate kinase	NA	R	General function prediction only	126	150	0.84
OG0001347	COG1331	Uncharacterized conserved protein YyaL, SSP411 family, contains thoiredoxin and six-hairpin glycosidase-like domains	YyaL	R	General function prediction only	148	149	0.9932885906040269
OG0001348	COG0188	DNA gyrase/topoisomerase IV, subunit A	GyrA	L	Replication, recombination and repair	1	148	0.006756756756756757
OG0001348	COG4259	Uncharacterized conserved protein, DUF4810 domain	NA	S	Function unknown	3	148	0.02027027027027027
OG0001349	COG0542	ATP-dependent Clp protease, ATP-binding subunit ClpA	ClpA	O	Posttranslational modification, protein turnover, chaperones	1	147	0.006802721088435374
OG0001349	COG1196	Chromosome segregation ATPase Smc	Smc	D	Cell cycle control, cell division, chromosome partitioning	126	147	0.8571428571428571
OG0001349	COG4942	Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB	EnvC	D	Cell cycle control, cell division, chromosome partitioning	1	147	0.006802721088435374
OG0001350	COG0803	ABC-type Zn uptake system ZnuABC, Zn-binding component ZnuA	ZnuA	P	Inorganic ion transport and metabolism	1	145	0.006896551724137931
OG0001350	COG3417	Outer membrane lipoprotein LpoB, binds and activates PBP1b	LpoB	M	Cell wall/membrane/envelope biogenesis	9	145	0.06206896551724138
OG0001351	COG3639	ABC-type phosphate/phosphonate transport system, permease component	PhnE	P	Inorganic ion transport and metabolism	143	145	0.9862068965517241
OG0001352	COG4664	TRAP-type mannitol/chloroaromatic compound transport system, large permease component	FcbT3	Q	Secondary metabolites biosynthesis, transport and catabolism	144	144	1
OG0001353	COG5485	Polyketide cyclase, SnoaL/DnrD family	SnoaL	Q	Secondary metabolites biosynthesis, transport and catabolism	144	144	1
OG0001354	COG1368	Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily	MdoB	M	Cell wall/membrane/envelope biogenesis	6	143	0.04195804195804196
OG0001354	COG5542	Mannosyltransferase related to Gpi18	NA	G	Carbohydrate transport and metabolism	1	143	0.006993006993006993
OG0001355	COG0524	Sugar or nucleoside kinase, ribokinase family	RbsK	G	Carbohydrate transport and metabolism	4	142	0.028169014084507043
OG0001355	COG0615	Glycerol-3-phosphate cytidylyltransferase, cytidylyltransferase family	TagD	M	Cell wall/membrane/envelope biogenesis	64	142	0.4507042253521127
OG0001355	COG1105	1-phosphofructokinase or 6-phosphofructokinase II	FruK	G	Carbohydrate transport and metabolism	2	142	0.014084507042253521
OG0001355	COG2513	2-Methylisocitrate lyase and related enzymes, PEP mutase family	PrpB	G	Carbohydrate transport and metabolism	3	142	0.02112676056338028
OG0001355	COG2870	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase	RfaE	M	Cell wall/membrane/envelope biogenesis	67	142	0.47183098591549294
OG0001357	COG0399	dTDP-4-amino-4,6-dideoxygalactose transaminase	WecE	M	Cell wall/membrane/envelope biogenesis	140	140	1
OG0001358	COG0236	Acyl carrier protein	AcpP	I	Lipid transport and metabolism	104	140	0.7428571428571429
OG0001358	COG1670	Protein N-acetyltransferase, RimJ/RimL family	RimL	J	Translation, ribosomal structure and biogenesis	1	140	0.007142857142857143
OG0001358	COG3185	4-hydroxyphenylpyruvate dioxygenase and related hemolysins	HppD	E	Amino acid transport and metabolism	1	140	0.007142857142857143
OG0001359	COG0662	Mannose-6-phosphate isomerase, cupin superfamily	ManC	G	Carbohydrate transport and metabolism	4	140	0.02857142857142857
OG0001359	COG1917	Cupin domain protein related to quercetin dioxygenase	QdoI	R	General function prediction only	130	140	0.9285714285714286
OG0001359	COG4101	Uncharacterized conserved protein, RmlC-like cupin domain	RmlC	R	General function prediction only	5	140	0.03571428571428571
OG0001361	COG2067	Long-chain fatty acid transport protein	FadL	I	Lipid transport and metabolism	1	139	0.007194244604316547
OG0001361	COG3121	P pilus assembly protein, chaperone PapD	FimC	W	Extracellular structures	2	139	0.014388489208633094
OG0001361	COG3203	Outer membrane porin OmpC/OmpF/PhoE	OmpC	M	Cell wall/membrane/envelope biogenesis	1	139	0.007194244604316547
OG0001361	COG3637	Opacity protein LomR and related surface antigens	LomR	M	Cell wall/membrane/envelope biogenesis	54	139	0.38848920863309355
OG0001361	COG4571	Outer membrane protease	OmpT	M	Cell wall/membrane/envelope biogenesis	1	139	0.007194244604316547
OG0001363	COG5485	Polyketide cyclase, SnoaL/DnrD family	SnoaL	Q	Secondary metabolites biosynthesis, transport and catabolism	139	139	1
OG0001364	COG5285	Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family	PhyH	Q	Secondary metabolites biosynthesis, transport and catabolism	73	137	0.5328467153284672
OG0001365	COG0241	Histidinol phosphatase/D-glycero-mannoheptose bisphosphatephosphatase, HAD superfamily	HisB1/GmhB	E	Amino acid transport and metabolism	1	136	0.007352941176470588
OG0001365	COG0637	Beta-phosphoglucomutase, HAD superfamily	YcjU	G	Carbohydrate transport and metabolism	135	136	0.9926470588235294
OG0001366	COG1076	DnaJ domain-containing protein	DjlA	O	Posttranslational modification, protein turnover, chaperones	99	135	0.7333333333333333
OG0001366	COG3793	Tellurite resistance protein TerB	TerB	P	Inorganic ion transport and metabolism	3	135	0.022222222222222223
OG0001366	COG4103	Tellurite/oxyanion resistance protein, TerB superfamily	TerB2	P	Inorganic ion transport and metabolism	9	135	0.06666666666666667
OG0001366	COG5407	Preprotein translocase subunit Sec63	SEC63	U	Intracellular trafficking, secretion, and vesicular transport	20	135	0.14814814814814814
OG0001367	COG1196	Chromosome segregation ATPase Smc	Smc	D	Cell cycle control, cell division, chromosome partitioning	130	133	0.9774436090225563
OG0001368	COG3847	Flp/Tad pilus pilin protein Flp	Flp	W	Extracellular structures	1	132	0.007575757575757576
OG0001369	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	132	132	1
OG0001370	COG2217	Cation-transporting P-type ATPase	ZntA	P	Inorganic ion transport and metabolism	3	131	0.022900763358778626
OG0001371	COG1262	Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain	YfmG	O	Posttranslational modification, protein turnover, chaperones	131	131	1
OG0001372	COG1680	CubicO group peptidase, beta-lactamase class C family	AmpC	V	Defense mechanisms	127	130	0.9769230769230769
OG0001373	COG0605	Superoxide dismutase	SodA	P	Inorganic ion transport and metabolism	129	129	1
OG0001375	COG1305	Transglutaminase-like enzyme, putative cysteine protease	YebA	O	Posttranslational modification, protein turnover, chaperones	127	129	0.9844961240310077
OG0001376	COG0270	DNA-cytosine methylase Dcm or eukaryotic tRNA-C38 C5-methylase, Dcm/DNMT2/TRDMT1 family	Dcm	L	Replication, recombination and repair	126	127	0.9921259842519685
OG0001377	COG0608	ssDNA-specific exonuclease RecJ, DHH superfamily, may be involved in archaeal DNA replication intiation	RecJ	L	Replication, recombination and repair	125	127	0.984251968503937
OG0001381	COG4603	ABC-type guanosine uptake system NupNOPQ, permease component NupP	NupP	F	Nucleotide transport and metabolism	125	125	1
OG0001382	COG1744	Lipoprotein Med, regulator of KinD/Spo0A, PBP1-ABC superfamily, includes NupN	Med	T	Signal transduction mechanisms	125	125	1
OG0001383	COG0366	Glycosidase/amylase (phosphorylase)	AmyA	G	Carbohydrate transport and metabolism	119	125	0.952
OG0001384	COG3791	Uncharacterized conserved protein	NA	S	Function unknown	124	124	1
OG0001385	COG0537	Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family	HinT	F	Nucleotide transport and metabolism	123	124	0.9919354838709677
OG0001385	COG2153	Predicted N-acyltransferase, GNAT family	ElaA	R	General function prediction only	1	124	0.008064516129032258
OG0001386	COG2175	Taurine dioxygenase, alpha-ketoglutarate-dependent	TauD	Q	Secondary metabolites biosynthesis, transport and catabolism	123	123	1
OG0001387	COG3469	Chitinase	Chi1	G	Carbohydrate transport and metabolism	1	123	0.008130081300813009
OG0001387	COG4866	N-Acyltransferase, similar to phosphatidylglycerol lysyltransferase	NA	R	General function prediction only	1	123	0.008130081300813009
OG0001388	COG1079	ABC-type guanosine uptake system NupNOPQ, permease subunit NupQ	NupQ	F	Nucleotide transport and metabolism	123	123	1
OG0001389	COG0679	Predicted permease, AEC (auxin efflux carrier) family	YfdV	R	General function prediction only	122	123	0.991869918699187
OG0001390	COG3752	Steroid 5-alpha reductase family enzyme	NA	R	General function prediction only	1	123	0.008130081300813009
OG0001391	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	120	121	0.9917355371900827
OG0001391	COG3967	Short-chain dehydrogenase involved in D-alanine esterification of teichoic acids	DltE	M	Cell wall/membrane/envelope biogenesis	1	121	0.008264462809917356
OG0001392	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	120	121	0.9917355371900827
OG0001393	COG0286	Type I restriction-modification system, DNA methylase subunit	HsdM	V	Defense mechanisms	73	121	0.6033057851239669
OG0001393	COG0732	Restriction endonuclease S subunit	HsdS	V	Defense mechanisms	47	121	0.3884297520661157
OG0001394	COG0859	ADP-heptose:LPS heptosyltransferase	RfaF	M	Cell wall/membrane/envelope biogenesis	74	121	0.6115702479338843
OG0001394	COG3292	Periplasmic ligand-binding sensor domain	NA	T	Signal transduction mechanisms	1	121	0.008264462809917356
OG0001395	COG0599	Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family	YurZ	R	General function prediction only	121	121	1
OG0001396	COG0405	Gamma-glutamyltranspeptidase	Ggt	E	Amino acid transport and metabolism	121	121	1
OG0001397	COG0673	Predicted dehydrogenase	MviM	R	General function prediction only	120	120	1
OG0001398	COG0045	Succinyl-CoA synthetase, beta subunit	SucC	C	Energy production and conversion	1	118	0.00847457627118644
OG0001398	COG0773	UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family	MurC	M	Cell wall/membrane/envelope biogenesis	2	118	0.01694915254237288
OG0001398	COG3510	Rhamnose/hydroxycephalosporin O-methyltransferase, CmcI/Rv2959c family	CmcI	M	Cell wall/membrane/envelope biogenesis	2	118	0.01694915254237288
OG0001398	COG4122	tRNA 5-hydroxyU34 O-methylase TrmR/YrrM	TrmR	J	Translation, ribosomal structure and biogenesis	34	118	0.288135593220339
OG0001399	COG0697	Amino acid export permease, drug/metabolite transporter (DMT) superfamily	EamA	E	Amino acid transport and metabolism	109	118	0.923728813559322
OG0001399	COG2510	Riboflavin transporter RibN, EamA domain	RibN	H	Coenzyme transport and metabolism	9	118	0.07627118644067797
OG0001400	COG3791	Uncharacterized conserved protein	NA	S	Function unknown	117	117	1
OG0001401	COG2608	Copper chaperone CopZ	CopZ	P	Inorganic ion transport and metabolism	116	117	0.9914529914529915
OG0001402	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase or related enzyme	RfbC	M	Cell wall/membrane/envelope biogenesis	69	116	0.5948275862068966
OG0001402	COG1917	Cupin domain protein related to quercetin dioxygenase	QdoI	R	General function prediction only	1	116	0.008620689655172414
OG0001403	COG2010	Cytochrome c, mono- and diheme variants	CccA	C	Energy production and conversion	105	116	0.9051724137931034
OG0001403	COG5677	Cytochrome c6	PetJ	C	Energy production and conversion	11	116	0.09482758620689655
OG0001404	COG1287	Asparagine N-glycosylation enzyme, membrane subunit Stt3	Stt3	O	Posttranslational modification, protein turnover, chaperones	3	115	0.02608695652173913
OG0001404	COG1368	Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily	MdoB	M	Cell wall/membrane/envelope biogenesis	1	115	0.008695652173913044
OG0001404	COG1807	PMT family glycosyltransferase ArnT/Agl22, involved in glycosylation of proteins and lipid IVA	ArnT	M	Cell wall/membrane/envelope biogenesis	36	115	0.3130434782608696
OG0001404	COG4346	Predicted membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase	NA	O	Posttranslational modification, protein turnover, chaperones	1	115	0.008695652173913044
OG0001404	COG4485	Uncharacterized membrane protein YfhO	YfhO	S	Function unknown	2	115	0.017391304347826087
OG0001405	COG1975	Molybdoenzyme maturation factor PaoD (Mo cofactor insertion), XdhC/CoxF family	XdhC	O	Posttranslational modification, protein turnover, chaperones	115	115	1
OG0001407	COG1238	Membrane protein YqaA involved in indium extrusion, DedA family, contains VTT domain	YgaA	P	Inorganic ion transport and metabolism	115	115	1
OG0001408	COG0596	2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH/undecaprenyl monophosphate-sugar esterase UshA/YqjL	MenH	H	Coenzyme transport and metabolism	114	114	1
OG0001409	COG0412	Dienelactone hydrolase	DLH	Q	Secondary metabolites biosynthesis, transport and catabolism	75	113	0.6637168141592921
OG0001409	COG1506	Dipeptidyl aminopeptidase/acylaminoacyl peptidase	DAP2	E	Amino acid transport and metabolism	37	113	0.3274336283185841
OG0001410	COG0714	MoxR-like ATPase, includes components of a predicted archaeal secretion system	MMP0363	R	General function prediction only	113	113	1
OG0001411	COG0110	O-acetyltransferase, isoleucine patch superfamily, LacA/YvoF/WbbJ family	WbbJ	R	General function prediction only	79	112	0.7053571428571429
OG0001411	COG0663	Carbonic anhydrase or acetyltransferase, isoleucine patch superfamily	PaaY	R	General function prediction only	4	112	0.03571428571428571
OG0001411	COG1043	Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase	LpxA	M	Cell wall/membrane/envelope biogenesis	3	112	0.026785714285714284
OG0001411	COG1044	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase	LpxD	M	Cell wall/membrane/envelope biogenesis	21	112	0.1875
OG0001411	COG1045	Serine acetyltransferase	CysE	E	Amino acid transport and metabolism	1	112	0.008928571428571428
OG0001411	COG2171	Tetrahydrodipicolinate N-succinyltransferase	DapD	E	Amino acid transport and metabolism	2	112	0.017857142857142856
OG0001412	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	45	111	0.40540540540540543
OG0001412	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	BcsA	N	Cell motility	48	111	0.43243243243243246
OG0001412	COG1216	Glycosyltransferase, GT2 family	WcaE	G	Carbohydrate transport and metabolism	18	111	0.16216216216216217
OG0001414	COG1975	Molybdoenzyme maturation factor PaoD (Mo cofactor insertion), XdhC/CoxF family	XdhC	O	Posttranslational modification, protein turnover, chaperones	111	111	1
OG0001415	COG1942	Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family	PptA	Q	Secondary metabolites biosynthesis, transport and catabolism	72	111	0.6486486486486487
OG0001416	COG0707	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase	MurG	M	Cell wall/membrane/envelope biogenesis	1	110	0.00909090909090909
OG0001416	COG0763	Lipid A disaccharide synthetase	LpxB	M	Cell wall/membrane/envelope biogenesis	1	110	0.00909090909090909
OG0001416	COG1887	CDP-glycerol glycerophosphotransferase, TagB/SpsB family	TagB	M	Cell wall/membrane/envelope biogenesis	4	110	0.03636363636363636
OG0001418	COG1999	Cytochrome oxidase Cu insertion factor, SCO1/SenC/PrrC family	Sco1	O	Posttranslational modification, protein turnover, chaperones	109	109	1
OG0001419	COG1721	Uncharacterized membrane-anchored protein with extracellular vWFA and Ig-like domains, component of a predicted archaeal secretion system	MMP0362	R	General function prediction only	55	109	0.5045871559633027
OG0001420	COG0535	Radical SAM superfamily maturase, SkfB/NifB/PqqE family	SkfB	D	Cell cycle control, cell division, chromosome partitioning	4	108	0.037037037037037035
OG0001420	COG1497	Predicted transcriptional regulator MJ0558, contains a CRP-type HTH domain	MJ0558	K	Transcription	1	108	0.009259259259259259
OG0001420	COG1522	DNA-binding transcriptional regulator, Lrp family	Lrp	K	Transcription	1	108	0.009259259259259259
OG0001420	COG1733	DNA-binding transcriptional regulator, HxlR family	HxlR	K	Transcription	1	108	0.009259259259259259
OG0001420	COG1777	Predicted transcriptional regulator, ArsR family	NA	K	Transcription	6	108	0.05555555555555555
OG0001420	COG1846	DNA-binding transcriptional regulator, MarR family	MarR	K	Transcription	53	108	0.49074074074074076
OG0001420	COG1974	SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase)	LexA	K	Transcription	7	108	0.06481481481481481
OG0001420	COG2512	Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain	NA	R	General function prediction only	3	108	0.027777777777777776
OG0001420	COG3398	Predicted transcriptional regulator, contains two HTH domains	NA	K	Transcription	14	108	0.12962962962962962
OG0001421	COG0697	Amino acid export permease, drug/metabolite transporter (DMT) superfamily	EamA	E	Amino acid transport and metabolism	60	107	0.5607476635514018
OG0001421	COG2076	Multidrug transporter EmrE and related cation transporters	EmrE	V	Defense mechanisms	1	107	0.009345794392523364
OG0001421	COG2510	Riboflavin transporter RibN, EamA domain	RibN	H	Coenzyme transport and metabolism	45	107	0.4205607476635514
OG0001422	COG1525	Endonuclease YncB, thermonuclease family	YncB	L	Replication, recombination and repair	106	106	1
OG0001423	COG4640	Uncharacterized protein YvbJ, contains N-terminal Zn ribbon domain	YvbJ	S	Function unknown	1	106	0.009433962264150943
OG0001424	COG1082	Sugar phosphate isomerase/epimerase	YcjR	G	Carbohydrate transport and metabolism	2	106	0.018867924528301886
OG0001424	COG3613	Nucleoside 2-deoxyribosyltransferase	RCL	F	Nucleotide transport and metabolism	1	106	0.009433962264150943
OG0001425	COG1525	Endonuclease YncB, thermonuclease family	YncB	L	Replication, recombination and repair	104	104	1
OG0001426	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	95	104	0.9134615384615384
OG0001426	COG1434	Lipid carrier protein ElyC involved in cell wall biogenesis, DUF218 family	ElyC	M	Cell wall/membrane/envelope biogenesis	3	104	0.028846153846153848
OG0001426	COG4641	Spore maturation protein CgeB	NA	D	Cell cycle control, cell division, chromosome partitioning	1	104	0.009615384615384616
OG0001427	COG3851	Signal transduction histidine kinase UhpB, glucose-6-phosphate specific	UhpB	T	Signal transduction mechanisms	1	104	0.009615384615384616
OG0001428	COG0859	ADP-heptose:LPS heptosyltransferase	RfaF	M	Cell wall/membrane/envelope biogenesis	101	104	0.9711538461538461
OG0001429	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	9	103	0.08737864077669903
OG0001429	COG0500	SAM-dependent methyltransferase SmtA (CmoB moved to COG2228)	SmtA	Q	Secondary metabolites biosynthesis, transport and catabolism	29	103	0.2815533980582524
OG0001429	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9	UbiE	H	Coenzyme transport and metabolism	13	103	0.1262135922330097
OG0001429	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	14	103	0.13592233009708737
OG0001429	COG4106	Trans-aconitate methyltransferase	Tam	C	Energy production and conversion	3	103	0.02912621359223301
OG0001430	COG2761	Predicted dithiol-disulfide isomerase, DsbA/YjbH family (virulence, stress resistance)	FrnE	O	Posttranslational modification, protein turnover, chaperones	103	103	1
OG0001431	COG3284	Transcriptional regulator DhaR of acetoin/glycerol metabolism	AcoR	K	Transcription	103	103	1
OG0001432	COG0548	N-acetylglutamate kinase	ArgB	E	Amino acid transport and metabolism	3	102	0.029411764705882353
OG0001432	COG3411	2Fe-2S ferredoxin	2Fe2S	C	Energy production and conversion	1	102	0.00980392156862745
OG0001432	COG4421	Predicted N-acetylglucosamine transferase involved in capsular polysaccharide biosynthesis, GT61 family	NA	M	Cell wall/membrane/envelope biogenesis	1	102	0.00980392156862745
OG0001434	COG0075	Archaeal aspartate aminotransferase or a related aminotransferase, includes purine catabolism protein PucG	PucG	E	Amino acid transport and metabolism	100	100	1
OG0001435	COG0790	Sel1-like repeat, TPR-related	Sel1	R	General function prediction only	100	100	1
OG0001436	COG1653	ABC-type glycerol-3-phosphate transport system, periplasmic component	UgpB	G	Carbohydrate transport and metabolism	1	99	0.010101010101010102
OG0001436	COG5633	Uncharacterized conserved protein YcfL	YcfL	S	Function unknown	2	99	0.020202020202020204
OG0001437	COG2017	Galactose mutarotase or related enzyme	GalM	G	Carbohydrate transport and metabolism	99	99	1
OG0001439	COG3152	Uncharacterized membrane protein YhaH, DUF805 family	YhaH	S	Function unknown	96	97	0.9896907216494846
OG0001440	COG0477	MFS family permease, includes anhydromuropeptide permease AmpG	ProP	G	Carbohydrate transport and metabolism	1	96	0.010416666666666666
OG0001440	COG0730	Sulfite exporter TauE/SafE/YfcA and related permeases, UPF0721 family	TauE	P	Inorganic ion transport and metabolism	1	96	0.010416666666666666
OG0001440	COG1007	NADH:ubiquinone oxidoreductase subunit 2 (chain N)	NuoN	C	Energy production and conversion	1	96	0.010416666666666666
OG0001440	COG1457	Purine-cytosine permease or related protein	CodB	F	Nucleotide transport and metabolism	1	96	0.010416666666666666
OG0001440	COG2035	Undecaprenyl phosphate translocase (flippase), DUF368 family	UndP	M	Cell wall/membrane/envelope biogenesis	2	96	0.020833333333333332
OG0001440	COG2093	RNA polymerase subunit RPABC4/transcription elongation factor Spt4	Spt4	K	Transcription	5	96	0.052083333333333336
OG0001440	COG2223	Nitrate/nitrite transporter NarK	NarK	P	Inorganic ion transport and metabolism	1	96	0.010416666666666666
OG0001440	COG3225	ABC-type uncharacterized transport system involved in gliding motility, auxiliary component	GldG	N	Cell motility	1	96	0.010416666666666666
OG0001440	COG4640	Uncharacterized protein YvbJ, contains N-terminal Zn ribbon domain	YvbJ	S	Function unknown	5	96	0.052083333333333336
OG0001440	COG4642	Uncharacterized conserved protein, contains MORN repeats	NA	R	General function prediction only	2	96	0.020833333333333332
OG0001441	COG2956	Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain	LapB	M	Cell wall/membrane/envelope biogenesis	5	96	0.052083333333333336
OG0001442	COG3090	TRAP-type C4-dicarboxylate transport system, small permease component YiaM	DctM	G	Carbohydrate transport and metabolism	96	96	1
OG0001443	COG5605	Cytochrome c oxidase subunit IV	COX4	C	Energy production and conversion	96	96	1
OG0001444	COG0454	N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2)	PhnO	K	Transcription	1	96	0.010416666666666666
OG0001444	COG0456	Ribosomal protein S18 acetylase RimI and related acetyltransferases	RimI	J	Translation, ribosomal structure and biogenesis	2	96	0.020833333333333332
OG0001444	COG1247	L-amino acid N-acyltransferase MnaT	MnaT	E	Amino acid transport and metabolism	93	96	0.96875
OG0001445	COG0726	Peptidoglycan/xylan/chitin deacetylase, PgdA/NodB/CDA1 family	PgaB	G	Carbohydrate transport and metabolism	94	95	0.9894736842105263
OG0001447	COG1845	Heme/copper-type cytochrome/quinol oxidase, subunit 3	CyoC	C	Energy production and conversion	95	95	1
OG0001448	COG2391	Uncharacterized membrane protein YedE/YeeE, contains two sulfur transport domains	YedE	R	General function prediction only	87	95	0.9157894736842105
OG0001449	COG2391	Uncharacterized membrane protein YedE/YeeE, contains two sulfur transport domains	YedE	R	General function prediction only	93	95	0.9789473684210527
OG0001450	COG4266	Allantoicase	Alc	F	Nucleotide transport and metabolism	94	94	1
OG0001453	COG3194	Ureidoglycolate hydrolase (allantoin degradation)	AllA	F	Nucleotide transport and metabolism	93	93	1
OG0001454	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9	UbiE	H	Coenzyme transport and metabolism	4	93	0.043010752688172046
OG0001454	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	6	93	0.06451612903225806
OG0001454	COG4627	Predicted SAM-depedendent methyltransferase	NA	R	General function prediction only	79	93	0.8494623655913979
OG0001455	COG4397	Mu-like prophage major head subunit gpT	gpT	X	Mobilome: prophages, transposons	1	92	0.010869565217391304
OG0001456	COG4310	Uncharacterized conserved protein, cotains an aminopeptidase-like domain	NA	R	General function prediction only	89	92	0.967391304347826
OG0001457	COG3090	TRAP-type C4-dicarboxylate transport system, small permease component YiaM	DctM	G	Carbohydrate transport and metabolism	92	92	1
OG0001458	COG1622	Heme/copper-type cytochrome/quinol oxidase, subunit 2	CyoA	C	Energy production and conversion	2	91	0.02197802197802198
OG0001460	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	89	91	0.978021978021978
OG0001461	COG1071	TPP-dependent pyruvate or acetoin dehydrogenase subunit alpha	AcoA	C	Energy production and conversion	87	90	0.9666666666666667
OG0001462	COG3340	Peptidase E	PepE	E	Amino acid transport and metabolism	90	90	1
OG0001464	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	60	89	0.6741573033707865
OG0001464	COG1086	NDP-sugar epimerase, includes UDP-N-acetylglucosamine 4,6-dehydratase EpsC	EpsC	M	Cell wall/membrane/envelope biogenesis	28	89	0.3146067415730337
OG0001464	COG1091	dTDP-4-dehydrorhamnose reductase	RfbD	M	Cell wall/membrane/envelope biogenesis	1	89	0.011235955056179775
OG0001465	COG2329	Heme-degrading monooxygenase HmoA and related ABM domain proteins	HmoA	H	Coenzyme transport and metabolism	87	89	0.9775280898876404
OG0001466	COG1322	DNA anti-recombination protein (rearrangement mutator) RmuC	RmuC	L	Replication, recombination and repair	89	89	1
OG0001467	COG4301	Uncharacterized protein, contains predicted SAM-dependent methyltransferase domain	NA	R	General function prediction only	87	88	0.9886363636363636
OG0001468	COG3176	GNAT family N-acetyltransferase domain	Alr0228	R	General function prediction only	88	88	1
OG0001469	COG0399	dTDP-4-amino-4,6-dideoxygalactose transaminase	WecE	M	Cell wall/membrane/envelope biogenesis	87	87	1
OG0001470	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	1	87	0.011494252873563218
OG0001471	COG0373	Glutamyl-tRNA reductase	HemA	H	Coenzyme transport and metabolism	1	87	0.011494252873563218
OG0001471	COG2902	NAD-specific glutamate dehydrogenase	Gdh2	E	Amino acid transport and metabolism	1	87	0.011494252873563218
OG0001472	COG1695	DNA-binding transcriptional regulator, PadR family	PadR	K	Transcription	1	86	0.011627906976744186
OG0001472	COG1846	DNA-binding transcriptional regulator, MarR family	MarR	K	Transcription	22	86	0.2558139534883721
OG0001473	COG1506	Dipeptidyl aminopeptidase/acylaminoacyl peptidase	DAP2	E	Amino acid transport and metabolism	4	85	0.047058823529411764
OG0001473	COG1512	Uncharacterized membrane protein YgcG, contains a TPM-fold domain	YgcG	S	Function unknown	1	85	0.011764705882352941
OG0001473	COG4642	Uncharacterized conserved protein, contains MORN repeats	NA	R	General function prediction only	1	85	0.011764705882352941
OG0001474	COG2120	N-acetylglucosaminyl deacetylase, LmbE family	LmbE	G	Carbohydrate transport and metabolism	83	85	0.9764705882352941
OG0001474	COG3980	Spore coat polysaccharide biosynthesis protein SpsG, predicted glycosyltransferase	SpsG	M	Cell wall/membrane/envelope biogenesis	1	85	0.011764705882352941
OG0001475	COG1733	DNA-binding transcriptional regulator, HxlR family	HxlR	K	Transcription	85	85	1
OG0001477	COG4421	Predicted N-acetylglucosamine transferase involved in capsular polysaccharide biosynthesis, GT61 family	NA	M	Cell wall/membrane/envelope biogenesis	84	84	1
OG0001478	COG0654	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	UbiH	H	Coenzyme transport and metabolism	1	84	0.011904761904761904
OG0001478	COG1249	Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase	Lpd	C	Energy production and conversion	1	84	0.011904761904761904
OG0001478	COG2303	Choline dehydrogenase or related flavoprotein	BetA	I	Lipid transport and metabolism	77	84	0.9166666666666666
OG0001479	COG1368	Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily	MdoB	M	Cell wall/membrane/envelope biogenesis	2	84	0.023809523809523808
OG0001479	COG3119	Arylsulfatase A or related enzyme, AlkP superfamily	AslA	P	Inorganic ion transport and metabolism	82	84	0.9761904761904762
OG0001480	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	AcrA	M	Cell wall/membrane/envelope biogenesis	84	84	1
OG0001481	COG0235	5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation)	AraD	E	Amino acid transport and metabolism	2	83	0.024096385542168676
OG0001481	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	FabG	I	Lipid transport and metabolism	2	83	0.024096385542168676
OG0001481	COG3347	Rhamnose utilisation protein RhaD, predicted bifunctional aldolase and dehydrogenase	RhaD	G	Carbohydrate transport and metabolism	79	83	0.9518072289156626
OG0001482	COG3195	2-oxo-4-hydroxy-4-carboxy--5-ureidoimidazoline (OHCU) decarboxylase (uric acid degradation)	PucL	F	Nucleotide transport and metabolism	83	83	1
OG0001483	COG1840	ABC-type transport systems for B6 and hexose phosphate, periplasmic component	AfuA	G	Carbohydrate transport and metabolism	83	83	1
OG0001484	COG0500	SAM-dependent methyltransferase SmtA (CmoB moved to COG2228)	SmtA	Q	Secondary metabolites biosynthesis, transport and catabolism	5	83	0.060240963855421686
OG0001484	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9	UbiE	H	Coenzyme transport and metabolism	1	83	0.012048192771084338
OG0001485	COG0221	Inorganic pyrophosphatase	Ppa	C	Energy production and conversion	7	83	0.08433734939759036
OG0001485	COG3292	Periplasmic ligand-binding sensor domain	NA	T	Signal transduction mechanisms	1	83	0.012048192771084338
OG0001485	COG3420	Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains	NosD	P	Inorganic ion transport and metabolism	2	83	0.024096385542168676
OG0001485	COG3866	Pectate lyase	PelB	G	Carbohydrate transport and metabolism	1	83	0.012048192771084338
OG0001485	COG5337	Spore coat protein CotH	CotH	M	Cell wall/membrane/envelope biogenesis	24	83	0.2891566265060241
OG0001485	COG5434	Polygalacturonase	Pgu1	G	Carbohydrate transport and metabolism	1	83	0.012048192771084338
OG0001486	COG0654	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	UbiH	H	Coenzyme transport and metabolism	83	83	1
OG0001487	COG3090	TRAP-type C4-dicarboxylate transport system, small permease component YiaM	DctM	G	Carbohydrate transport and metabolism	82	83	0.9879518072289156
OG0001488	COG0711	FoF1-type ATP synthase, membrane subunit b or b'	AtpF	C	Energy production and conversion	1	82	0.012195121951219513
OG0001488	COG1368	Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily	MdoB	M	Cell wall/membrane/envelope biogenesis	1	82	0.012195121951219513
OG0001488	COG5283	Phage-related tail protein	NA	X	Mobilome: prophages, transposons	3	82	0.036585365853658534
OG0001489	COG1178	ABC-type Fe3+ transport system, permease component	FbpB	P	Inorganic ion transport and metabolism	82	82	1
OG0001490	COG2270	MFS-type transporter involved in bile tolerance, Atg22 family	BtlA	R	General function prediction only	82	82	1
OG0001491	COG0488	ABC cassette proteins with duplicated ATPase domains, Uup/ABCF family	Uup	J	Translation, ribosomal structure and biogenesis	1	81	0.012345679012345678
OG0001491	COG1196	Chromosome segregation ATPase Smc	Smc	D	Cell cycle control, cell division, chromosome partitioning	2	81	0.024691358024691357
OG0001491	COG2268	Flotillin family membrane protein YqiK, contains Band7/PHB/SPFH domain	YqiK	R	General function prediction only	1	81	0.012345679012345678
OG0001492	COG3748	Uncharacterized membrane protein	NA	S	Function unknown	81	81	1
OG0001493	COG1033	Predicted exporter protein, RND superfamily	MMPL	R	General function prediction only	32	81	0.3950617283950617
OG0001493	COG4717	Predicted ATPase SbcE/YhaN involved in DNA double-strand break repair, contains AAA domain	YhaN	L	Replication, recombination and repair	1	81	0.012345679012345678
OG0001493	COG5278	Extracytoplasmic sensor domain CHASE3 (specificity unknown)	CHASE3	T	Signal transduction mechanisms	2	81	0.024691358024691357
OG0001494	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	3	81	0.037037037037037035
OG0001494	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	BcsA	N	Cell motility	5	81	0.06172839506172839
OG0001494	COG1216	Glycosyltransferase, GT2 family	WcaE	G	Carbohydrate transport and metabolism	4	81	0.04938271604938271
OG0001494	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	1	81	0.012345679012345678
OG0001495	COG3210	Large exoprotein involved in heme utilization or adhesion	FhaB	U	Intracellular trafficking, secretion, and vesicular transport	63	81	0.7777777777777778
OG0001495	COG3468	Autotransporter adhesin AidA	AidA	M	Cell wall/membrane/envelope biogenesis	2	81	0.024691358024691357
OG0001495	COG4625	Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain	NA	S	Function unknown	13	81	0.16049382716049382
OG0001496	COG1522	DNA-binding transcriptional regulator, Lrp family	Lrp	K	Transcription	81	81	1
OG0001497	COG2148	Sugar transferase involved in LPS biosynthesis (colanic, teichoic acid)	WcaJ	M	Cell wall/membrane/envelope biogenesis	80	80	1
OG0001498	COG2834	Periplasmic chaperone for outer membrane lipoprotein sorting	LolA	M	Cell wall/membrane/envelope biogenesis	1	80	0.0125
OG0001499	COG5285	Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family	PhyH	Q	Secondary metabolites biosynthesis, transport and catabolism	57	80	0.7125
OG0001500	COG2242	Precorrin-6Y C5,15-methylase subunit CbiT	CbiT	H	Coenzyme transport and metabolism	2	79	0.02531645569620253
OG0001500	COG2520	tRNA G37 N1-methylase Trm5	Trm5	J	Translation, ribosomal structure and biogenesis	7	79	0.08860759493670886
OG0001500	COG4076	Predicted RNA methylase	NA	R	General function prediction only	9	79	0.11392405063291139
OG0001500	COG4122	tRNA 5-hydroxyU34 O-methylase TrmR/YrrM	TrmR	J	Translation, ribosomal structure and biogenesis	1	79	0.012658227848101266
OG0001500	COG4123	tRNA1(Val) A37 N6-methylase TrmN6	TrmN6	J	Translation, ribosomal structure and biogenesis	6	79	0.0759493670886076
OG0001501	COG2513	2-Methylisocitrate lyase and related enzymes, PEP mutase family	PrpB	G	Carbohydrate transport and metabolism	79	79	1
OG0001502	COG0457	Tetratricopeptide (TPR) repeat	TPR	R	General function prediction only	70	79	0.8860759493670886
OG0001502	COG2956	Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain	LapB	M	Cell wall/membrane/envelope biogenesis	1	79	0.012658227848101266
OG0001502	COG4783	Periplasmic chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains	BepA	M	Cell wall/membrane/envelope biogenesis	4	79	0.05063291139240506
OG0001502	COG4785	Lipoprotein NlpI, contains TPR repeats	NlpI	M	Cell wall/membrane/envelope biogenesis	2	79	0.02531645569620253
OG0001503	COG5477	Small integral membrane protein, DUF2160 family	NA	S	Function unknown	79	79	1
OG0001505	COG1858	Cytochrome c peroxidase	MauG	O	Posttranslational modification, protein turnover, chaperones	79	79	1
OG0001506	COG1319	Aldehyde, CO, or xanthine dehydrogenase, FAD-binding subunit	CutB	C	Energy production and conversion	78	78	1
OG0001507	COG1287	Asparagine N-glycosylation enzyme, membrane subunit Stt3	Stt3	O	Posttranslational modification, protein turnover, chaperones	8	78	0.10256410256410256
OG0001507	COG1807	PMT family glycosyltransferase ArnT/Agl22, involved in glycosylation of proteins and lipid IVA	ArnT	M	Cell wall/membrane/envelope biogenesis	35	78	0.44871794871794873
OG0001508	COG1629	Outer membrane receptor protein, Fe transport	CirA	P	Inorganic ion transport and metabolism	21	78	0.2692307692307692
OG0001508	COG4206	Outer membrane cobalamin receptor protein BtuB	BtuB	H	Coenzyme transport and metabolism	1	78	0.01282051282051282
OG0001508	COG4771	Outer membrane receptor for ferrienterochelin and colicins	FepA	P	Inorganic ion transport and metabolism	55	78	0.7051282051282052
OG0001508	COG4772	Outer membrane receptor for Fe3+-dicitrate	FecA	P	Inorganic ion transport and metabolism	1	78	0.01282051282051282
OG0001509	COG0859	ADP-heptose:LPS heptosyltransferase	RfaF	M	Cell wall/membrane/envelope biogenesis	2	77	0.025974025974025976
OG0001510	COG1887	CDP-glycerol glycerophosphotransferase, TagB/SpsB family	TagB	M	Cell wall/membrane/envelope biogenesis	6	77	0.07792207792207792
OG0001510	COG2044	Predicted peroxiredoxin, DsrE/DsrF-like family	NA	R	General function prediction only	1	77	0.012987012987012988
OG0001512	COG5285	Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family	PhyH	Q	Secondary metabolites biosynthesis, transport and catabolism	76	77	0.987012987012987
OG0001513	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	2	76	0.02631578947368421
OG0001513	COG0662	Mannose-6-phosphate isomerase, cupin superfamily	ManC	G	Carbohydrate transport and metabolism	8	76	0.10526315789473684
OG0001513	COG1917	Cupin domain protein related to quercetin dioxygenase	QdoI	R	General function prediction only	8	76	0.10526315789473684
OG0001513	COG2140	Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily	OxdD	G	Carbohydrate transport and metabolism	1	76	0.013157894736842105
OG0001514	COG0265	Periplasmic serine protease DegP/DegQ, contain C-terminal PDZ domain	DegQ	O	Posttranslational modification, protein turnover, chaperones	1	76	0.013157894736842105
OG0001515	COG2940	Histone-lysine N-methyltransferase, H3-specific, SET domain	SET	O	Posttranslational modification, protein turnover, chaperones	70	76	0.9210526315789473
OG0001516	COG1280	Threonine/homoserine/homoserine lactone efflux protein	RhtB	E	Amino acid transport and metabolism	1	76	0.013157894736842105
OG0001517	COG0223	Methionyl-tRNA formyltransferase	Fmt	J	Translation, ribosomal structure and biogenesis	4	76	0.05263157894736842
OG0001517	COG0456	Ribosomal protein S18 acetylase RimI and related acetyltransferases	RimI	J	Translation, ribosomal structure and biogenesis	2	76	0.02631578947368421
OG0001517	COG1247	L-amino acid N-acyltransferase MnaT	MnaT	E	Amino acid transport and metabolism	2	76	0.02631578947368421
OG0001517	COG1670	Protein N-acetyltransferase, RimJ/RimL family	RimL	J	Translation, ribosomal structure and biogenesis	9	76	0.11842105263157894
OG0001521	COG0582	Integrase/recombinase, includes phage integrase	FimB	L	Replication, recombination and repair	1	75	0.013333333333333334
OG0001521	COG4974	Site-specific tyrosine recombinase XerD	XerD	L	Replication, recombination and repair	72	75	0.96
OG0001522	COG5036	SPX domain-containing protein involved in vacuolar polyphosphate accumulation	NA	P	Inorganic ion transport and metabolism	67	75	0.8933333333333333
OG0001524	COG3980	Spore coat polysaccharide biosynthesis protein SpsG, predicted glycosyltransferase	SpsG	M	Cell wall/membrane/envelope biogenesis	44	75	0.5866666666666667
OG0001526	COG0469	Pyruvate kinase	PykF	G	Carbohydrate transport and metabolism	73	74	0.9864864864864865
OG0001527	COG3221	ABC-type phosphate/phosphonate transport system, periplasmic component	PhnD	P	Inorganic ion transport and metabolism	74	74	1
OG0001528	COG2376	Dihydroxyacetone kinase	DAK1	G	Carbohydrate transport and metabolism	74	74	1
OG0001529	COG0633	Ferredoxin	Fdx	C	Energy production and conversion	74	74	1
OG0001530	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	59	73	0.8082191780821918
OG0001530	COG1088	dTDP-D-glucose 4,6-dehydratase	RfbB	M	Cell wall/membrane/envelope biogenesis	3	73	0.0410958904109589
OG0001530	COG1091	dTDP-4-dehydrorhamnose reductase	RfbD	M	Cell wall/membrane/envelope biogenesis	2	73	0.0273972602739726
OG0001530	COG3320	Thioester reductase domain of alpha aminoadipate reductase Lys2 and NRPSs	Lys2b	Q	Secondary metabolites biosynthesis, transport and catabolism	1	73	0.0136986301369863
OG0001531	COG1807	PMT family glycosyltransferase ArnT/Agl22, involved in glycosylation of proteins and lipid IVA	ArnT	M	Cell wall/membrane/envelope biogenesis	1	73	0.0136986301369863
OG0001531	COG5305	Uncharacterized membrane protein PF0508, contains N-terminal glycosyltransferase domain of PMT family	NA	R	General function prediction only	63	73	0.863013698630137
OG0001532	COG5276	Uncharacterized secreted protein, contains LVIVD repeats, choice-of-anchor domain	NA	S	Function unknown	73	73	1
OG0001533	COG0415	Deoxyribodipyrimidine photolyase	PhrB	L	Replication, recombination and repair	7	73	0.0958904109589041
OG0001533	COG1035	Coenzyme F420-reducing hydrogenase, beta subunit	FrhB	C	Energy production and conversion	64	73	0.8767123287671232
OG0001534	COG5515	Uncharacterized conserved protein, DUF1737 domain	NA	S	Function unknown	72	73	0.9863013698630136
OG0001536	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	16	72	0.2222222222222222
OG0001536	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	BcsA	N	Cell motility	2	72	0.027777777777777776
OG0001536	COG1216	Glycosyltransferase, GT2 family	WcaE	G	Carbohydrate transport and metabolism	19	72	0.2638888888888889
OG0001537	COG3427	Carbon monoxide dehydrogenase subunit CoxG	CoxG	C	Energy production and conversion	72	72	1
OG0001539	COG1178	ABC-type Fe3+ transport system, permease component	FbpB	P	Inorganic ion transport and metabolism	6	72	0.08333333333333333
OG0001539	COG1221	Transcriptional regulators containing sigma54-interacting ATPase domain	PspF	K	Transcription	1	72	0.013888888888888888
OG0001539	COG1285	Magnesium uptake protein YhiD/SapB, involved in acid resistance	SapB	P	Inorganic ion transport and metabolism	2	72	0.027777777777777776
OG0001540	COG0820	Adenine C2-methylase RlmN of 23S rRNA A2503 and tRNA A37	RlmN	J	Translation, ribosomal structure and biogenesis	72	72	1
OG0001541	COG3127	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component	YbbP	Q	Secondary metabolites biosynthesis, transport and catabolism	1	72	0.013888888888888888
OG0001542	COG1434	Lipid carrier protein ElyC involved in cell wall biogenesis, DUF218 family	ElyC	M	Cell wall/membrane/envelope biogenesis	72	72	1
OG0001543	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	71	71	1
OG0001544	COG2376	Dihydroxyacetone kinase	DAK1	G	Carbohydrate transport and metabolism	71	71	1
OG0001545	COG1253	Mg2+ efflux pump MpfA, contains CBS pair and CorC-HlyC domains, TlyC/UPF0053 family	MpfA	P	Inorganic ion transport and metabolism	33	71	0.4647887323943662
OG0001545	COG4536	Mg2+ and Co2+ transporter CorB, contains DUF21, CBS pair, and CorC-HlyC domains	CorB	P	Inorganic ion transport and metabolism	38	71	0.5352112676056338
OG0001546	COG1887	CDP-glycerol glycerophosphotransferase, TagB/SpsB family	TagB	M	Cell wall/membrane/envelope biogenesis	58	70	0.8285714285714286
OG0001549	COG3794	Plastocyanin	PetE	C	Energy production and conversion	70	70	1
OG0001550	COG5255	Uncharacterized conserved protein	NA	S	Function unknown	70	70	1
OG0001552	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	3	69	0.043478260869565216
OG0001552	COG1091	dTDP-4-dehydrorhamnose reductase	RfbD	M	Cell wall/membrane/envelope biogenesis	1	69	0.014492753623188406
OG0001552	COG1922	UDP-N-acetyl-D-mannosaminuronic acid transferase, WecB/TagA/CpsF family	WecG	M	Cell wall/membrane/envelope biogenesis	57	69	0.8260869565217391
OG0001553	COG3090	TRAP-type C4-dicarboxylate transport system, small permease component YiaM	DctM	G	Carbohydrate transport and metabolism	69	69	1
OG0001555	COG0367	Asparagine synthetase B (glutamine-hydrolyzing)	AsnB	E	Amino acid transport and metabolism	1	69	0.014492753623188406
OG0001555	COG3176	GNAT family N-acetyltransferase domain	Alr0228	R	General function prediction only	36	69	0.5217391304347826
OG0001556	COG4942	Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB	EnvC	D	Cell cycle control, cell division, chromosome partitioning	1	68	0.014705882352941176
OG0001557	COG1664	Cytoskeletal protein CcmA, bactofilin family	CcmA	Z	Cytoskeleton	68	68	1
OG0001558	COG1359	Quinol monooxygenase YgiN	YgiN	C	Energy production and conversion	1	68	0.014705882352941176
OG0001559	COG2723	Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase	BglB	G	Carbohydrate transport and metabolism	68	68	1
OG0001560	COG5342	Invasion protein IalB, involved in pathogenesis	IalB	R	General function prediction only	68	68	1
OG0001561	COG1088	dTDP-D-glucose 4,6-dehydratase	RfbB	M	Cell wall/membrane/envelope biogenesis	67	67	1
OG0001562	COG0241	Histidinol phosphatase/D-glycero-mannoheptose bisphosphatephosphatase, HAD superfamily	HisB1/GmhB	E	Amino acid transport and metabolism	2	67	0.029850746268656716
OG0001562	COG1213	Choline kinase	NA	I	Lipid transport and metabolism	65	67	0.9701492537313433
OG0001563	COG5424	Pyrroloquinoline quinone (PQQ) synthase PqqC, TenA/Thi4/PqqC family	PqqC	H	Coenzyme transport and metabolism	67	67	1
OG0001564	COG1917	Cupin domain protein related to quercetin dioxygenase	QdoI	R	General function prediction only	6	67	0.08955223880597014
OG0001564	COG3806	Anti-sigma factor ChrR, cupin superfamily	ChrR	T	Signal transduction mechanisms	60	67	0.8955223880597015
OG0001564	COG3837	Uncharacterized conserved protein, cupin superfamily	NA	S	Function unknown	1	67	0.014925373134328358
OG0001565	COG2982	Outer membrane assembly factor AsmA	AsmA	M	Cell wall/membrane/envelope biogenesis	57	67	0.8507462686567164
OG0001566	COG0187	DNA gyrase/topoisomerase IV, subunit B	GyrB	L	Replication, recombination and repair	2	67	0.029850746268656716
OG0001566	COG2268	Flotillin family membrane protein YqiK, contains Band7/PHB/SPFH domain	YqiK	R	General function prediction only	1	67	0.014925373134328358
OG0001566	COG3064	Membrane protein TolA involved in colicin uptake	TolA	M	Cell wall/membrane/envelope biogenesis	1	67	0.014925373134328358
OG0001566	COG3292	Periplasmic ligand-binding sensor domain	NA	T	Signal transduction mechanisms	1	67	0.014925373134328358
OG0001566	COG3883	Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO	CwlO1	S	Function unknown	1	67	0.014925373134328358
OG0001568	COG1388	LysM repeat	LysM	M	Cell wall/membrane/envelope biogenesis	59	67	0.8805970149253731
OG0001568	COG3168	Type IV pilus assembly protein PilP	PilP	N	Cell motility	3	67	0.04477611940298507
OG0001571	COG1205	ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain	YprA	L	Replication, recombination and repair	3	66	0.045454545454545456
OG0001572	COG0457	Tetratricopeptide (TPR) repeat	TPR	R	General function prediction only	54	66	0.8181818181818182
OG0001572	COG2956	Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain	LapB	M	Cell wall/membrane/envelope biogenesis	5	66	0.07575757575757576
OG0001572	COG3914	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family	Spy	O	Posttranslational modification, protein turnover, chaperones	2	66	0.030303030303030304
OG0001572	COG4783	Periplasmic chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains	BepA	M	Cell wall/membrane/envelope biogenesis	2	66	0.030303030303030304
OG0001573	COG4940	Competence protein ComGF	ComGF	X	Mobilome: prophages, transposons	1	66	0.015151515151515152
OG0001573	COG4967	Type IV pilus minor pilin/pseudopilin PilV	PilV	N	Cell motility	64	66	0.9696969696969697
OG0001574	COG3751	Proline 4-hydroxylase (includes Rps23 Pro-64 3,4-dihydroxylase Tpa1), contains SM-20 domain	EGL9	J	Translation, ribosomal structure and biogenesis	58	65	0.8923076923076924
OG0001575	COG2072	Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD	CzcO	P	Inorganic ion transport and metabolism	64	65	0.9846153846153847
OG0001576	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9	UbiE	H	Coenzyme transport and metabolism	55	65	0.8461538461538461
OG0001576	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	4	65	0.06153846153846154
OG0001576	COG4106	Trans-aconitate methyltransferase	Tam	C	Energy production and conversion	1	65	0.015384615384615385
OG0001578	COG2259	Uncharacterized membrane protein YphA, DoxX/SURF4 family	DoxX	S	Function unknown	51	65	0.7846153846153846
OG0001579	COG2079	2-methylcitrate dehydratase PrpD	PrpD	G	Carbohydrate transport and metabolism	65	65	1
OG0001580	COG1053	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit	SdhA	C	Energy production and conversion	31	65	0.47692307692307695
OG0001580	COG2081	Predicted flavoprotein YhiN	YhiN	R	General function prediction only	34	65	0.5230769230769231
OG0001582	COG0399	dTDP-4-amino-4,6-dideoxygalactose transaminase	WecE	M	Cell wall/membrane/envelope biogenesis	64	64	1
OG0001583	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	20	64	0.3125
OG0001583	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	1	64	0.015625
OG0001583	COG1793	ATP-dependent DNA ligase	LigC	L	Replication, recombination and repair	1	64	0.015625
OG0001585	COG0119	Isopropylmalate/homocitrate/citramalate synthases	LeuA	E	Amino acid transport and metabolism	59	63	0.9365079365079365
OG0001586	COG4336	YcsI protein, probably involved 5-oxoproline metabolism, UPF0317/DUF1446 family	YcsI	E	Amino acid transport and metabolism	63	63	1
OG0001587	COG1917	Cupin domain protein related to quercetin dioxygenase	QdoI	R	General function prediction only	63	63	1
OG0001588	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	51	62	0.8225806451612904
OG0001588	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	BcsA	N	Cell motility	11	62	0.1774193548387097
OG0001589	COG3210	Large exoprotein involved in heme utilization or adhesion	FhaB	U	Intracellular trafficking, secretion, and vesicular transport	15	62	0.24193548387096775
OG0001589	COG3420	Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains	NosD	P	Inorganic ion transport and metabolism	3	62	0.04838709677419355
OG0001589	COG3468	Autotransporter adhesin AidA	AidA	M	Cell wall/membrane/envelope biogenesis	20	62	0.3225806451612903
OG0001589	COG4625	Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain	NA	S	Function unknown	3	62	0.04838709677419355
OG0001589	COG5295	Type Vc autotransporter adhesin, Ata/Hia family	Hia	U	Intracellular trafficking, secretion, and vesicular transport	1	62	0.016129032258064516
OG0001589	COG5651	PPE-repeat protein	PPE	S	Function unknown	1	62	0.016129032258064516
OG0001590	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	HisJ	E	Amino acid transport and metabolism	62	62	1
OG0001591	COG1221	Transcriptional regulators containing sigma54-interacting ATPase domain	PspF	K	Transcription	1	62	0.016129032258064516
OG0001591	COG3883	Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO	CwlO1	S	Function unknown	2	62	0.03225806451612903
OG0001593	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	AcrA	M	Cell wall/membrane/envelope biogenesis	60	62	0.967741935483871
OG0001593	COG1566	Multidrug resistance efflux pump EmrA	EmrA	V	Defense mechanisms	1	62	0.016129032258064516
OG0001594	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	1	62	0.016129032258064516
OG0001594	COG0637	Beta-phosphoglucomutase, HAD superfamily	YcjU	G	Carbohydrate transport and metabolism	60	62	0.967741935483871
OG0001596	COG2146	Ferredoxin subunit of nitrite reductase or a ring-hydroxylating dioxygenase	NirD	P	Inorganic ion transport and metabolism	2	61	0.03278688524590164
OG0001596	COG2220	L-ascorbate lactonase UlaG, metallo-beta-lactamase superfamily	UlaG	G	Carbohydrate transport and metabolism	58	61	0.9508196721311475
OG0001598	COG1414	DNA-binding transcriptional regulator, IclR family	IclR	K	Transcription	61	61	1
OG0001599	COG0637	Beta-phosphoglucomutase, HAD superfamily	YcjU	G	Carbohydrate transport and metabolism	25	60	0.4166666666666667
OG0001599	COG1208	NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis protein s	GCD1	J	Translation, ribosomal structure and biogenesis	15	60	0.25
OG0001599	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	IspD	I	Lipid transport and metabolism	1	60	0.016666666666666666
OG0001599	COG1213	Choline kinase	NA	I	Lipid transport and metabolism	3	60	0.05
OG0001600	COG2339	Membrane proteinase PrsW, cleaves anti-sigma factor RsiW, M82 family	PrsW	T	Signal transduction mechanisms	60	60	1
OG0001601	COG1359	Quinol monooxygenase YgiN	YgiN	C	Energy production and conversion	5	60	0.08333333333333333
OG0001601	COG2329	Heme-degrading monooxygenase HmoA and related ABM domain proteins	HmoA	H	Coenzyme transport and metabolism	16	60	0.26666666666666666
OG0001602	COG3468	Autotransporter adhesin AidA	AidA	M	Cell wall/membrane/envelope biogenesis	36	60	0.6
OG0001602	COG4625	Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain	NA	S	Function unknown	14	60	0.23333333333333334
OG0001603	COG3000	Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily	ERG3	I	Lipid transport and metabolism	60	60	1
OG0001604	COG1902	NADH:flavin reductase, Old Yellow Enzyme (OYE) family	FadH	C	Energy production and conversion	59	60	0.9833333333333333
OG0001605	COG5395	Uncharacterized membrane protein, DUF2306 domain	NA	S	Function unknown	60	60	1
OG0001606	COG1971	Putative Mn2+ efflux pump MntP	MntP	P	Inorganic ion transport and metabolism	45	60	0.75
OG0001607	COG2755	Lysophospholipase L1 or related esterase. Includes spore coat protein LipC/YcsK	TesA	D	Cell cycle control, cell division, chromosome partitioning	53	59	0.8983050847457628
OG0001608	COG0517	CBS domain	CBS	T	Signal transduction mechanisms	6	59	0.1016949152542373
OG0001608	COG2524	Predicted transcriptional regulator, contains C-terminal CBS domains	NA	K	Transcription	1	59	0.01694915254237288
OG0001608	COG2905	Signal-transduction protein containing cAMP-binding, CBS, and nucleotidyltransferase domains	NA	T	Signal transduction mechanisms	52	59	0.8813559322033898
OG0001609	COG0265	Periplasmic serine protease DegP/DegQ, contain C-terminal PDZ domain	DegQ	O	Posttranslational modification, protein turnover, chaperones	3	59	0.05084745762711865
OG0001609	COG0679	Predicted permease, AEC (auxin efflux carrier) family	YfdV	R	General function prediction only	2	59	0.03389830508474576
OG0001609	COG0750	Membrane-associated protease RseP, regulator of RpoE activity	RseP	O	Posttranslational modification, protein turnover, chaperones	3	59	0.05084745762711865
OG0001609	COG0793	C-terminal processing protease CtpA/Prc, contains a PDZ domain	CtpA	O	Posttranslational modification, protein turnover, chaperones	2	59	0.03389830508474576
OG0001609	COG5817	Stage II sporulation protein SpoIIE/SpoIIH (serine phosphatase - sigma-F activation)	SpoIIE	D	Cell cycle control, cell division, chromosome partitioning	1	59	0.01694915254237288
OG0001610	COG0457	Tetratricopeptide (TPR) repeat	TPR	R	General function prediction only	11	59	0.1864406779661017
OG0001610	COG2956	Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain	LapB	M	Cell wall/membrane/envelope biogenesis	3	59	0.05084745762711865
OG0001610	COG3751	Proline 4-hydroxylase (includes Rps23 Pro-64 3,4-dihydroxylase Tpa1), contains SM-20 domain	EGL9	J	Translation, ribosomal structure and biogenesis	2	59	0.03389830508474576
OG0001610	COG4783	Periplasmic chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains	BepA	M	Cell wall/membrane/envelope biogenesis	3	59	0.05084745762711865
OG0001611	COG1074	3'-5' helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V)	RecB	L	Replication, recombination and repair	7	59	0.11864406779661017
OG0001611	COG1468	CRISPR/Cas system-associated exonuclease Cas4, RecB family	Cas4	V	Defense mechanisms	6	59	0.1016949152542373
OG0001611	COG2887	RecB family exonuclease	Slr0479	L	Replication, recombination and repair	2	59	0.03389830508474576
OG0001611	COG3857	ATP-dependent helicase/DNAse subunit B	AddB	L	Replication, recombination and repair	11	59	0.1864406779661017
OG0001612	COG0662	Mannose-6-phosphate isomerase, cupin superfamily	ManC	G	Carbohydrate transport and metabolism	31	59	0.5254237288135594
OG0001612	COG1917	Cupin domain protein related to quercetin dioxygenase	QdoI	R	General function prediction only	18	59	0.3050847457627119
OG0001612	COG2140	Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily	OxdD	G	Carbohydrate transport and metabolism	10	59	0.1694915254237288
OG0001614	COG0464	AAA+-type ATPase, SpoVK/Ycf46/Vps4 family	SpoVK	M	Cell wall/membrane/envelope biogenesis	59	59	1
OG0001616	COG3167	Type II secretion system/type IV pilus alignment protein PilO	PilO	N	Cell motility	4	59	0.06779661016949153
OG0001617	COG3206	Tyrosine-protein kinase Wzc involved in exopolysaccharide export, GumC/Wzc1 domain	GumC	M	Cell wall/membrane/envelope biogenesis	8	59	0.13559322033898305
OG0001617	COG3883	Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO	CwlO1	S	Function unknown	10	59	0.1694915254237288
OG0001617	COG4717	Predicted ATPase SbcE/YhaN involved in DNA double-strand break repair, contains AAA domain	YhaN	L	Replication, recombination and repair	1	59	0.01694915254237288
OG0001617	COG4913	Uncharacterized conserved protein, contains a C-terminal ATPase domain	NA	S	Function unknown	37	59	0.6271186440677966
OG0001617	COG4942	Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB	EnvC	D	Cell cycle control, cell division, chromosome partitioning	1	59	0.01694915254237288
OG0001617	COG5278	Extracytoplasmic sensor domain CHASE3 (specificity unknown)	CHASE3	T	Signal transduction mechanisms	1	59	0.01694915254237288
OG0001619	COG0075	Archaeal aspartate aminotransferase or a related aminotransferase, includes purine catabolism protein PucG	PucG	E	Amino acid transport and metabolism	1	58	0.017241379310344827
OG0001619	COG1932	Phosphoserine aminotransferase	SerC	H	Coenzyme transport and metabolism	57	58	0.9827586206896551
OG0001620	COG2370	Hydrogenase/urease accessory protein HupE	HupE	O	Posttranslational modification, protein turnover, chaperones	35	58	0.603448275862069
OG0001621	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	AcrA	M	Cell wall/membrane/envelope biogenesis	15	58	0.25862068965517243
OG0001621	COG1566	Multidrug resistance efflux pump EmrA	EmrA	V	Defense mechanisms	23	58	0.39655172413793105
OG0001621	COG1994	Zn-dependent protease (includes sporulation protein SpoIVFB)	SpoIVFB	O	Posttranslational modification, protein turnover, chaperones	19	58	0.3275862068965517
OG0001622	COG2188	DNA-binding transcriptional regulator, GntR family	MngR	K	Transcription	56	58	0.9655172413793104
OG0001622	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	2	58	0.034482758620689655
OG0001623	COG0655	Multimeric flavodoxin WrbA, includes NAD(P)H:quinone oxidoreductase	WrbA	C	Energy production and conversion	1	57	0.017543859649122806
OG0001623	COG1182	FMN-dependent NADH-azoreductase	AzoR	C	Energy production and conversion	56	57	0.9824561403508771
OG0001624	COG1686	D-alanyl-D-alanine carboxypeptidase	DacC	M	Cell wall/membrane/envelope biogenesis	1	57	0.017543859649122806
OG0001624	COG4249	Uncharacterized conserved protein, contains caspase domain	NA	R	General function prediction only	45	57	0.7894736842105263
OG0001624	COG4642	Uncharacterized conserved protein, contains MORN repeats	NA	R	General function prediction only	2	57	0.03508771929824561
OG0001625	COG2230	Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases	Cfa	I	Lipid transport and metabolism	2	57	0.03508771929824561
OG0001625	COG4122	tRNA 5-hydroxyU34 O-methylase TrmR/YrrM	TrmR	J	Translation, ribosomal structure and biogenesis	23	57	0.40350877192982454
OG0001626	COG0457	Tetratricopeptide (TPR) repeat	TPR	R	General function prediction only	41	57	0.7192982456140351
OG0001626	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	2	57	0.03508771929824561
OG0001626	COG2956	Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain	LapB	M	Cell wall/membrane/envelope biogenesis	8	57	0.14035087719298245
OG0001626	COG3914	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family	Spy	O	Posttranslational modification, protein turnover, chaperones	3	57	0.05263157894736842
OG0001626	COG4783	Periplasmic chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains	BepA	M	Cell wall/membrane/envelope biogenesis	1	57	0.017543859649122806
OG0001627	COG0574	Phosphoenolpyruvate synthase/pyruvate phosphate dikinase	PpsA	G	Carbohydrate transport and metabolism	48	56	0.8571428571428571
OG0001627	COG1080	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria)	PtsA	G	Carbohydrate transport and metabolism	2	56	0.03571428571428571
OG0001627	COG1213	Choline kinase	NA	I	Lipid transport and metabolism	1	56	0.017857142857142856
OG0001627	COG3848	Phosphohistidine swiveling domain of PEP-utilizing enzymes	PykA2	T	Signal transduction mechanisms	2	56	0.03571428571428571
OG0001630	COG0778	Nitroreductase	NfnB	C	Energy production and conversion	56	56	1
OG0001633	COG2746	Aminoglycoside N3'-acetyltransferase	YokD	V	Defense mechanisms	29	56	0.5178571428571429
OG0001633	COG3669	Alpha-L-fucosidase	AfuC	G	Carbohydrate transport and metabolism	1	56	0.017857142857142856
OG0001634	COG3883	Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO	CwlO1	S	Function unknown	3	56	0.05357142857142857
OG0001635	COG0662	Mannose-6-phosphate isomerase, cupin superfamily	ManC	G	Carbohydrate transport and metabolism	10	55	0.18181818181818182
OG0001635	COG0664	cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases	Crp	T	Signal transduction mechanisms	2	55	0.03636363636363636
OG0001635	COG1917	Cupin domain protein related to quercetin dioxygenase	QdoI	R	General function prediction only	1	55	0.01818181818181818
OG0001636	COG0562	UDP-galactopyranose mutase	Glf	M	Cell wall/membrane/envelope biogenesis	36	55	0.6545454545454545
OG0001636	COG1232	Protoporphyrinogen oxidase HemY/PPOX	HemY	H	Coenzyme transport and metabolism	16	55	0.2909090909090909
OG0001636	COG3380	Predicted NAD/FAD-dependent oxidoreductase	NA	R	General function prediction only	1	55	0.01818181818181818
OG0001637	COG0683	ABC-type branched-chain amino acid transport system, periplasmic component	LivK	E	Amino acid transport and metabolism	54	55	0.9818181818181818
OG0001638	COG4198	Uncharacterized conserved protein, DUF1015 family	NA	S	Function unknown	55	55	1
OG0001639	COG0030	rRNA adenine N6-methylase, includes 16S rRNA A1518 and A1519 N6-dimethyltransferase  RsmA/KsgA/DIM  and 23S rRNA A2058 N6-methylase ErmO/TlrD (may also have DNA glycosylase/AP lyase activity)	RsmA	J	Translation, ribosomal structure and biogenesis	1	54	0.018518518518518517
OG0001639	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	2	54	0.037037037037037035
OG0001639	COG4076	Predicted RNA methylase	NA	R	General function prediction only	1	54	0.018518518518518517
OG0001639	COG4123	tRNA1(Val) A37 N6-methylase TrmN6	TrmN6	J	Translation, ribosomal structure and biogenesis	1	54	0.018518518518518517
OG0001640	COG0445	tRNA U34 5-carboxymethylaminomethyl modifying enzyme MnmG/GidA	MnmG	J	Translation, ribosomal structure and biogenesis	1	54	0.018518518518518517
OG0001640	COG1221	Transcriptional regulators containing sigma54-interacting ATPase domain	PspF	K	Transcription	2	54	0.037037037037037035
OG0001643	COG1067	Predicted ATP-dependent protease	LonB	O	Posttranslational modification, protein turnover, chaperones	1	54	0.018518518518518517
OG0001644	COG1538	Outer membrane protein TolC	TolC	M	Cell wall/membrane/envelope biogenesis	54	54	1
OG0001645	COG3626	Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnI	PhnI	P	Inorganic ion transport and metabolism	54	54	1
OG0001646	COG1082	Sugar phosphate isomerase/epimerase	YcjR	G	Carbohydrate transport and metabolism	53	53	1
OG0001647	COG0308	Aminopeptidase N, contains DUF3458 domain	PepN	E	Amino acid transport and metabolism	1	53	0.018867924528301886
OG0001647	COG4424	LPS sulfotransferase NodH	LpsS	M	Cell wall/membrane/envelope biogenesis	1	53	0.018867924528301886
OG0001649	COG0220	tRNA G46 N7-methylase TrmB	TrmB	J	Translation, ribosomal structure and biogenesis	48	53	0.9056603773584906
OG0001649	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9	UbiE	H	Coenzyme transport and metabolism	1	53	0.018867924528301886
OG0001649	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	3	53	0.05660377358490566
OG0001650	COG0662	Mannose-6-phosphate isomerase, cupin superfamily	ManC	G	Carbohydrate transport and metabolism	47	53	0.8867924528301887
OG0001650	COG2140	Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily	OxdD	G	Carbohydrate transport and metabolism	1	53	0.018867924528301886
OG0001651	COG0332	3-oxoacyl-[acyl-carrier-protein] synthase III	FabH	I	Lipid transport and metabolism	52	53	0.9811320754716981
OG0001652	COG3624	Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnG	PhnG	P	Inorganic ion transport and metabolism	53	53	1
OG0001653	COG3625	Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnH	PhnH	P	Inorganic ion transport and metabolism	53	53	1
OG0001654	COG3627	Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase PhnJ	PhnJ	P	Inorganic ion transport and metabolism	53	53	1
OG0001655	COG3454	Alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase PhnM	PhnM	P	Inorganic ion transport and metabolism	53	53	1
OG0001656	COG0535	Radical SAM superfamily maturase, SkfB/NifB/PqqE family	SkfB	D	Cell cycle control, cell division, chromosome partitioning	1	52	0.019230769230769232
OG0001656	COG0561	Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases	Cof	H	Coenzyme transport and metabolism	10	52	0.19230769230769232
OG0001656	COG1213	Choline kinase	NA	I	Lipid transport and metabolism	1	52	0.019230769230769232
OG0001656	COG4502	5'(3')-deoxyribonucleotidase	YorC	F	Nucleotide transport and metabolism	1	52	0.019230769230769232
OG0001656	COG5663	Uncharacterized conserved protein YqfW, HAD superfamily	YqfW	R	General function prediction only	4	52	0.07692307692307693
OG0001658	COG0542	ATP-dependent Clp protease, ATP-binding subunit ClpA	ClpA	O	Posttranslational modification, protein turnover, chaperones	30	52	0.5769230769230769
OG0001658	COG0714	MoxR-like ATPase, includes components of a predicted archaeal secretion system	MMP0363	R	General function prediction only	21	52	0.40384615384615385
OG0001658	COG1401	5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB	McrB	V	Defense mechanisms	1	52	0.019230769230769232
OG0001659	COG4032	Sulfopyruvate decarboxylase, TPP-binding subunit (coenzyme M biosynthesis)	NA	H	Coenzyme transport and metabolism	51	51	1
OG0001660	COG0155	Sulfite reductase, beta subunit (hemoprotein)	CysI	P	Inorganic ion transport and metabolism	14	51	0.27450980392156865
OG0001662	COG0062	NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate epimerase (NAXE) domain	NnrE	F	Nucleotide transport and metabolism	10	50	0.2
OG0001662	COG0063	NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase (NAXD) domain	NnrD	F	Nucleotide transport and metabolism	40	50	0.8
OG0001664	COG4993	Glucose dehydrogenase, PQQ-dependent	Gcd	G	Carbohydrate transport and metabolism	50	50	1
OG0001665	COG1061	Superfamily II DNA or RNA helicase	SSL2	K	Transcription	20	50	0.4
OG0001665	COG4096	Type I site-specific restriction endonuclease, part of a restriction-modification system	HsdR	V	Defense mechanisms	30	50	0.6
OG0001666	COG0393	Uncharacterized pentameric protein YbjQ, UPF0145 family	YbjQ	S	Function unknown	1	50	0.02
OG0001666	COG4642	Uncharacterized conserved protein, contains MORN repeats	NA	R	General function prediction only	9	50	0.18
OG0001667	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	44	50	0.88
OG0001669	COG0523	Zinc metallochaperone YeiR/ZagA and related GTPases, G3E family	YejR	R	General function prediction only	50	50	1
OG0001670	COG1670	Protein N-acetyltransferase, RimJ/RimL family	RimL	J	Translation, ribosomal structure and biogenesis	50	50	1
OG0001671	COG0859	ADP-heptose:LPS heptosyltransferase	RfaF	M	Cell wall/membrane/envelope biogenesis	49	49	1
OG0001672	COG2233	Xanthine/uracil permease	UraA	F	Nucleotide transport and metabolism	49	49	1
OG0001674	COG4778	Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnL	PhnL	P	Inorganic ion transport and metabolism	49	49	1
OG0001675	COG0030	rRNA adenine N6-methylase, includes 16S rRNA A1518 and A1519 N6-dimethyltransferase  RsmA/KsgA/DIM  and 23S rRNA A2058 N6-methylase ErmO/TlrD (may also have DNA glycosylase/AP lyase activity)	RsmA	J	Translation, ribosomal structure and biogenesis	4	48	0.08333333333333333
OG0001675	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	2	48	0.041666666666666664
OG0001675	COG2518	Protein-L-isoaspartate O-methyltransferase	Pcm	O	Posttranslational modification, protein turnover, chaperones	32	48	0.6666666666666666
OG0001676	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	1	48	0.020833333333333332
OG0001676	COG3206	Tyrosine-protein kinase Wzc involved in exopolysaccharide export, GumC/Wzc1 domain	GumC	M	Cell wall/membrane/envelope biogenesis	3	48	0.0625
OG0001676	COG3765	LPS O-antigen chain length determinant protein, WzzB/FepE family	WzzB	M	Cell wall/membrane/envelope biogenesis	29	48	0.6041666666666666
OG0001677	COG0300	Short-chain dehydrogenase	YqjQ	R	General function prediction only	1	48	0.020833333333333332
OG0001677	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	3	48	0.0625
OG0001677	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	FabG	I	Lipid transport and metabolism	2	48	0.041666666666666664
OG0001677	COG1091	dTDP-4-dehydrorhamnose reductase	RfbD	M	Cell wall/membrane/envelope biogenesis	1	48	0.020833333333333332
OG0001677	COG2030	Acyl-CoA dehydratase PaaZ	MaoC	I	Lipid transport and metabolism	17	48	0.3541666666666667
OG0001678	COG1368	Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily	MdoB	M	Cell wall/membrane/envelope biogenesis	1	48	0.020833333333333332
OG0001678	COG3292	Periplasmic ligand-binding sensor domain	NA	T	Signal transduction mechanisms	1	48	0.020833333333333332
OG0001679	COG1112	Superfamily I DNA and/or RNA helicase	DNA2	L	Replication, recombination and repair	1	48	0.020833333333333332
OG0001679	COG2251	Predicted nuclease, RecB family	NA	R	General function prediction only	43	48	0.8958333333333334
OG0001680	COG0070	Glutamate synthase domain 3	GltB3	E	Amino acid transport and metabolism	1	48	0.020833333333333332
OG0001683	COG1287	Asparagine N-glycosylation enzyme, membrane subunit Stt3	Stt3	O	Posttranslational modification, protein turnover, chaperones	1	48	0.020833333333333332
OG0001688	COG3971	2-keto-4-pentenoate hydratase	MhpD	Q	Secondary metabolites biosynthesis, transport and catabolism	47	47	1
OG0001689	COG3555	Aspartyl/asparaginyl beta-hydroxylase, cupin superfamily,includes lipid A hydroxylase LpxO	LpxO2	O	Posttranslational modification, protein turnover, chaperones	1	47	0.02127659574468085
OG0001690	COG1221	Transcriptional regulators containing sigma54-interacting ATPase domain	PspF	K	Transcription	1	47	0.02127659574468085
OG0001690	COG1819	UDP:flavonoid glycosyltransferase YjiC, YdhE family	YjiC	G	Carbohydrate transport and metabolism	1	47	0.02127659574468085
OG0001690	COG4641	Spore maturation protein CgeB	NA	D	Cell cycle control, cell division, chromosome partitioning	1	47	0.02127659574468085
OG0001691	COG3618	Predicted metal-dependent hydrolase, TIM-barrel fold	NA	R	General function prediction only	46	47	0.9787234042553191
OG0001692	COG1030	Membrane-bound serine protease NfeD, ClpP class	NfeD	O	Posttranslational modification, protein turnover, chaperones	1	46	0.021739130434782608
OG0001692	COG2755	Lysophospholipase L1 or related esterase. Includes spore coat protein LipC/YcsK	TesA	D	Cell cycle control, cell division, chromosome partitioning	29	46	0.6304347826086957
OG0001694	COG3019	Uncharacterized metal-binding protein, DUF411 family	NA	S	Function unknown	46	46	1
OG0001696	COG0614	ABC-type Fe3+-hydroxamate transport system, periplasmic component	FepB	P	Inorganic ion transport and metabolism	1	46	0.021739130434782608
OG0001696	COG4889	Predicted helicase	NA	R	General function prediction only	20	46	0.43478260869565216
OG0001697	COG3128	Predicted 2-oxoglutarate- and Fe(II)-dependent dioxygenase YbiX	PiuC	R	General function prediction only	41	46	0.8913043478260869
OG0001697	COG3751	Proline 4-hydroxylase (includes Rps23 Pro-64 3,4-dihydroxylase Tpa1), contains SM-20 domain	EGL9	J	Translation, ribosomal structure and biogenesis	3	46	0.06521739130434782
OG0001699	COG1680	CubicO group peptidase, beta-lactamase class C family	AmpC	V	Defense mechanisms	45	46	0.9782608695652174
OG0001700	COG0378	Hydrogenase/urease maturation factor HypB, Ni2+-binding GTPase	HypB	O	Posttranslational modification, protein turnover, chaperones	46	46	1
OG0001701	COG0830	Urease accessory protein UreF	UreF	O	Posttranslational modification, protein turnover, chaperones	46	46	1
OG0001702	COG2371	Urease accessory protein UreE	UreE	O	Posttranslational modification, protein turnover, chaperones	46	46	1
OG0001703	COG3754	Lipopolysaccharide biosynthesis protein	RgpF	M	Cell wall/membrane/envelope biogenesis	3	46	0.06521739130434782
OG0001703	COG4948	L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily	RspA	M	Cell wall/membrane/envelope biogenesis	43	46	0.9347826086956522
OG0001704	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component	MmdA	I	Lipid transport and metabolism	46	46	1
OG0001705	COG0500	SAM-dependent methyltransferase SmtA (CmoB moved to COG2228)	SmtA	Q	Secondary metabolites biosynthesis, transport and catabolism	3	45	0.06666666666666667
OG0001705	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	1	45	0.022222222222222223
OG0001705	COG4976	Predicted methyltransferase, contains TPR repeat	NA	R	General function prediction only	1	45	0.022222222222222223
OG0001707	COG3133	Outer membrane lipoprotein SlyB	SlyB	M	Cell wall/membrane/envelope biogenesis	1	45	0.022222222222222223
OG0001707	COG4717	Predicted ATPase SbcE/YhaN involved in DNA double-strand break repair, contains AAA domain	YhaN	L	Replication, recombination and repair	2	45	0.044444444444444446
OG0001708	COG3664	Beta-xylosidase	XynB	G	Carbohydrate transport and metabolism	30	45	0.6666666666666666
OG0001708	COG3693	Endo-1,4-beta-xylanase, GH35 family	XynA	G	Carbohydrate transport and metabolism	5	45	0.1111111111111111
OG0001709	COG1082	Sugar phosphate isomerase/epimerase	YcjR	G	Carbohydrate transport and metabolism	44	45	0.9777777777777777
OG0001711	COG0664	cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases	Crp	T	Signal transduction mechanisms	3	45	0.06666666666666667
OG0001711	COG2755	Lysophospholipase L1 or related esterase. Includes spore coat protein LipC/YcsK	TesA	D	Cell cycle control, cell division, chromosome partitioning	42	45	0.9333333333333333
OG0001712	COG4530	Uncharacterized conserved protein	NA	S	Function unknown	40	45	0.8888888888888888
OG0001713	COG0804	Urease alpha subunit	UreC	E	Amino acid transport and metabolism	45	45	1
OG0001714	COG1853	FMN reductase RutF, DIM6/NTAB family	RutF	C	Energy production and conversion	45	45	1
OG0001715	COG1570	Exonuclease VII, large subunit	XseA	L	Replication, recombination and repair	45	45	1
OG0001716	COG1324	Divalent cation tolerance protein CutA	CutA1	P	Inorganic ion transport and metabolism	45	45	1
OG0001718	COG2828	2-Methylaconitate cis-trans-isomerase PrpF (2-methyl citrate pathway)	PrpF	C	Energy production and conversion	45	45	1
OG0001719	COG5508	Uncharacterized conserved protein, DUF1674 domain	NA	S	Function unknown	43	45	0.9555555555555556
OG0001720	COG0457	Tetratricopeptide (TPR) repeat	TPR	R	General function prediction only	30	45	0.6666666666666666
OG0001720	COG2956	Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain	LapB	M	Cell wall/membrane/envelope biogenesis	5	45	0.1111111111111111
OG0001720	COG3914	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family	Spy	O	Posttranslational modification, protein turnover, chaperones	1	45	0.022222222222222223
OG0001720	COG4783	Periplasmic chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains	BepA	M	Cell wall/membrane/envelope biogenesis	8	45	0.17777777777777778
OG0001722	COG4775	Outer membrane protein assembly factor BamA	BamA	M	Cell wall/membrane/envelope biogenesis	1	44	0.022727272727272728
OG0001723	COG3933	Transcriptional regulator of LevR family, contains sigma54-interacting AAA domain, PTS regulation domain (PRD), and EIIA-type domain	LevR	K	Transcription	1	44	0.022727272727272728
OG0001724	COG0832	Urease beta subunit	UreB	E	Amino acid transport and metabolism	44	44	1
OG0001725	COG0831	Urease gamma subunit	UreA	E	Amino acid transport and metabolism	44	44	1
OG0001726	COG0829	Urease accessory protein UreD/UreH	UreH	O	Posttranslational modification, protein turnover, chaperones	42	44	0.9545454545454546
OG0001727	COG1187	Pseudouridylate synthase RsuA/RluF, specific for 16S rRNA U516, 23S rRNA U2604/U2605/U2457, and tRNA(Tyr)-35	RsuA	J	Translation, ribosomal structure and biogenesis	44	44	1
OG0001729	COG2319	WD40 repeat	WD40	R	General function prediction only	44	44	1
OG0001730	COG0346	Glyoxalase, catechol 2,3-dioxygenase or related enzyme, vicinal oxygen chelate (VOC) family	GloA	Q	Secondary metabolites biosynthesis, transport and catabolism	30	44	0.6818181818181818
OG0001730	COG2514	Catechol-2,3-dioxygenase	CatE	Q	Secondary metabolites biosynthesis, transport and catabolism	14	44	0.3181818181818182
OG0001731	COG0775	Nucleoside phosphorylase/nucleosidase, includes 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase MtnN and futalosine hydrolase MqnB	MtnN	F	Nucleotide transport and metabolism	44	44	1
OG0001732	COG0088	Ribosomal protein L4	RplD	J	Translation, ribosomal structure and biogenesis	1	44	0.022727272727272728
OG0001732	COG0500	SAM-dependent methyltransferase SmtA (CmoB moved to COG2228)	SmtA	Q	Secondary metabolites biosynthesis, transport and catabolism	2	44	0.045454545454545456
OG0001732	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	8	44	0.18181818181818182
OG0001732	COG2263	Predicted RNA methylase	NA	R	General function prediction only	1	44	0.022727272727272728
OG0001732	COG4123	tRNA1(Val) A37 N6-methylase TrmN6	TrmN6	J	Translation, ribosomal structure and biogenesis	9	44	0.20454545454545456
OG0001732	COG4976	Predicted methyltransferase, contains TPR repeat	NA	R	General function prediction only	8	44	0.18181818181818182
OG0001733	COG5266	Uncharacterized protein, contains GH25 family domain	NA	R	General function prediction only	39	44	0.8863636363636364
OG0001734	COG0399	dTDP-4-amino-4,6-dideoxygalactose transaminase	WecE	M	Cell wall/membrane/envelope biogenesis	43	43	1
OG0001735	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase or related enzyme	RfbC	M	Cell wall/membrane/envelope biogenesis	43	43	1
OG0001737	COG1074	3'-5' helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V)	RecB	L	Replication, recombination and repair	18	43	0.4186046511627907
OG0001737	COG1468	CRISPR/Cas system-associated exonuclease Cas4, RecB family	Cas4	V	Defense mechanisms	3	43	0.06976744186046512
OG0001737	COG2887	RecB family exonuclease	Slr0479	L	Replication, recombination and repair	7	43	0.16279069767441862
OG0001737	COG3857	ATP-dependent helicase/DNAse subunit B	AddB	L	Replication, recombination and repair	4	43	0.09302325581395349
OG0001738	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	BcsA	N	Cell motility	1	43	0.023255813953488372
OG0001738	COG4641	Spore maturation protein CgeB	NA	D	Cell cycle control, cell division, chromosome partitioning	37	43	0.8604651162790697
OG0001739	COG2514	Catechol-2,3-dioxygenase	CatE	Q	Secondary metabolites biosynthesis, transport and catabolism	43	43	1
OG0001740	COG1225	Peroxiredoxin	Bcp	O	Posttranslational modification, protein turnover, chaperones	43	43	1
OG0001742	COG1195	Recombinational DNA repair ATPase RecF	RecF	L	Replication, recombination and repair	43	43	1
OG0001744	COG1576	23S rRNA pseudoU1915 N3-methylase RlmH	RlmH	J	Translation, ribosomal structure and biogenesis	43	43	1
OG0001745	COG0130	tRNA U55 pseudouridine synthase TruB, may also work on U342 of tmRNA	TruB	J	Translation, ribosomal structure and biogenesis	43	43	1
OG0001746	COG0589	Nucleotide-binding universal stress protein,  UspA family	UspA	T	Signal transduction mechanisms	43	43	1
OG0001749	COG0250	Transcription termination/antitermination protein NusG	NusG	K	Transcription	5	42	0.11904761904761904
OG0001750	COG2335	Surface protein containing fasciclin (FAS1) repeats	FAS1	M	Cell wall/membrane/envelope biogenesis	42	42	1
OG0001751	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	2	42	0.047619047619047616
OG0001752	COG3307	O-antigen ligase	RfaL	M	Cell wall/membrane/envelope biogenesis	14	42	0.3333333333333333
OG0001753	COG0545	FKBP-type peptidyl-prolyl cis-trans isomerase	FkpA	O	Posttranslational modification, protein turnover, chaperones	42	42	1
OG0001754	COG1884	Methylmalonyl-CoA mutase, N-terminal domain/subunit	Sbm1	I	Lipid transport and metabolism	42	42	1
OG0001756	COG0689	Ribonuclease PH	Rph	J	Translation, ribosomal structure and biogenesis	42	42	1
OG0001757	COG0625	Glutathione S-transferase or stringent starvation protein SspA	GstA	O	Posttranslational modification, protein turnover, chaperones	42	42	1
OG0001758	COG0239	Fluoride ion exporter CrcB/FEX, affects chromosome condensation	CrcB	D	Cell cycle control, cell division, chromosome partitioning	42	42	1
OG0001759	COG3342	Uncharacterized conserved protein, Ntn-hydrolase superfamily	NA	R	General function prediction only	42	42	1
OG0001760	COG1486	Alpha-galactosidase/6-phospho-beta-glucosidase, family 4 of glycosyl hydrolase	CelF	G	Carbohydrate transport and metabolism	42	42	1
OG0001763	COG0787	Alanine racemase	Alr	M	Cell wall/membrane/envelope biogenesis	41	41	1
OG0001764	COG1664	Cytoskeletal protein CcmA, bactofilin family	CcmA	Z	Cytoskeleton	41	41	1
OG0001765	COG1287	Asparagine N-glycosylation enzyme, membrane subunit Stt3	Stt3	O	Posttranslational modification, protein turnover, chaperones	5	41	0.12195121951219512
OG0001765	COG5617	Predicted membrane glycosyltransferase TK1552, contains 6-pyruvoyl-tetrahydropterin synthase (PTPS)-related domain	PTPS	R	General function prediction only	1	41	0.024390243902439025
OG0001766	COG1208	NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis protein s	GCD1	J	Translation, ribosomal structure and biogenesis	39	40	0.975
OG0001767	COG0225	Peptide methionine sulfoxide reductase MsrA	MsrA	O	Posttranslational modification, protein turnover, chaperones	40	40	1
OG0001768	COG3090	TRAP-type C4-dicarboxylate transport system, small permease component YiaM	DctM	G	Carbohydrate transport and metabolism	39	40	0.975
OG0001769	COG1879	ABC-type sugar transport system, periplasmic component, contains N-terminal xre family HTH domain	RbsB	G	Carbohydrate transport and metabolism	40	40	1
OG0001770	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	39	39	1
OG0001775	COG1221	Transcriptional regulators containing sigma54-interacting ATPase domain	PspF	K	Transcription	1	39	0.02564102564102564
OG0001776	COG1368	Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily	MdoB	M	Cell wall/membrane/envelope biogenesis	1	39	0.02564102564102564
OG0001776	COG1807	PMT family glycosyltransferase ArnT/Agl22, involved in glycosylation of proteins and lipid IVA	ArnT	M	Cell wall/membrane/envelope biogenesis	7	39	0.1794871794871795
OG0001776	COG4485	Uncharacterized membrane protein YfhO	YfhO	S	Function unknown	1	39	0.02564102564102564
OG0001777	COG1757	Na+/H+ antiporter NhaC/MleN	NhaC	C	Energy production and conversion	1	39	0.02564102564102564
OG0001779	COG0657	Acetyl esterase/lipase	Aes	I	Lipid transport and metabolism	39	39	1
OG0001780	COG0846	NAD-dependent protein deacetylase, SIR2 family	SIR2	O	Posttranslational modification, protein turnover, chaperones	1	38	0.02631578947368421
OG0001781	COG0777	Acetyl-CoA carboxylase beta subunit	AccD	I	Lipid transport and metabolism	1	38	0.02631578947368421
OG0001781	COG1439	rRNA maturation endonuclease Nob1	Nob1	J	Translation, ribosomal structure and biogenesis	2	38	0.05263157894736842
OG0001781	COG2913	Outer membrane protein assembly factor BamE	BamE	M	Cell wall/membrane/envelope biogenesis	2	38	0.05263157894736842
OG0001781	COG4640	Uncharacterized protein YvbJ, contains N-terminal Zn ribbon domain	YvbJ	S	Function unknown	3	38	0.07894736842105263
OG0001781	COG5633	Uncharacterized conserved protein YcfL	YcfL	S	Function unknown	3	38	0.07894736842105263
OG0001782	COG4487	Uncharacterized conserved protein, contains DUF2130 domain	NA	S	Function unknown	38	38	1
OG0001783	COG1442	Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase	RfaJ	M	Cell wall/membrane/envelope biogenesis	1	38	0.02631578947368421
OG0001785	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	7	38	0.18421052631578946
OG0001785	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	BcsA	N	Cell motility	5	38	0.13157894736842105
OG0001785	COG1216	Glycosyltransferase, GT2 family	WcaE	G	Carbohydrate transport and metabolism	3	38	0.07894736842105263
OG0001786	COG4635	Protoporphyrinogen IX oxidase, menaquinone-dependent (flavodoxin domain)	HemG	H	Coenzyme transport and metabolism	38	38	1
OG0001787	COG1404	Serine protease, subtilisin family	AprE	O	Posttranslational modification, protein turnover, chaperones	33	38	0.868421052631579
OG0001787	COG3210	Large exoprotein involved in heme utilization or adhesion	FhaB	U	Intracellular trafficking, secretion, and vesicular transport	4	38	0.10526315789473684
OG0001789	COG0596	2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH/undecaprenyl monophosphate-sugar esterase UshA/YqjL	MenH	H	Coenzyme transport and metabolism	38	38	1
OG0001790	COG0347	Nitrogen regulatory protein PII	GlnK	T	Signal transduction mechanisms	38	38	1
OG0001791	COG5269	Ribosome-associated chaperone zuotin, contains DnaJ domain	ZUO1	J	Translation, ribosomal structure and biogenesis	1	38	0.02631578947368421
OG0001792	COG0535	Radical SAM superfamily maturase, SkfB/NifB/PqqE family	SkfB	D	Cell cycle control, cell division, chromosome partitioning	35	38	0.9210526315789473
OG0001792	COG0641	Sulfatase maturation enzyme AslB, radical SAM superfamily	AslB	O	Posttranslational modification, protein turnover, chaperones	2	38	0.05263157894736842
OG0001792	COG0731	Wyosine [tRNA(Phe)-imidazoG37] synthetase, radical SAM superfamily	Tyw1	J	Translation, ribosomal structure and biogenesis	1	38	0.02631578947368421
OG0001794	COG3391	DNA-binding beta-propeller fold protein YncE	YncE	R	General function prediction only	38	38	1
OG0001795	COG0500	SAM-dependent methyltransferase SmtA (CmoB moved to COG2228)	SmtA	Q	Secondary metabolites biosynthesis, transport and catabolism	1	37	0.02702702702702703
OG0001795	COG1221	Transcriptional regulators containing sigma54-interacting ATPase domain	PspF	K	Transcription	1	37	0.02702702702702703
OG0001795	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9	UbiE	H	Coenzyme transport and metabolism	2	37	0.05405405405405406
OG0001798	COG0625	Glutathione S-transferase or stringent starvation protein SspA	GstA	O	Posttranslational modification, protein turnover, chaperones	12	37	0.32432432432432434
OG0001800	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	AdhE	I	Lipid transport and metabolism	36	36	1
OG0001803	COG3542	Predicted sugar epimerase, cupin superfamily	CFF1	R	General function prediction only	36	36	1
OG0001806	COG2520	tRNA G37 N1-methylase Trm5	Trm5	J	Translation, ribosomal structure and biogenesis	2	36	0.05555555555555555
OG0001806	COG4122	tRNA 5-hydroxyU34 O-methylase TrmR/YrrM	TrmR	J	Translation, ribosomal structure and biogenesis	13	36	0.3611111111111111
OG0001807	COG0018	Arginyl-tRNA synthetase	ArgS	J	Translation, ribosomal structure and biogenesis	1	36	0.027777777777777776
OG0001807	COG0584	Glycerophosphoryl diester phosphodiesterase	UgpQ	I	Lipid transport and metabolism	3	36	0.08333333333333333
OG0001808	COG1541	Phenylacetate-coenzyme A ligase PaaK, adenylate-forming domain family	PaaK	H	Coenzyme transport and metabolism	6	36	0.16666666666666666
OG0001809	COG3181	Tripartite-type tricarboxylate transporter, extracytoplasmic receptor component TctC	TctC	C	Energy production and conversion	36	36	1
OG0001810	COG0182	5-methylthioribose/5-deoxyribulose 1-phosphate isomerase (methionine salvage pathway), a paralog of eIF-2B alpha subunit	MtnA	E	Amino acid transport and metabolism	1	36	0.027777777777777776
OG0001810	COG5510	Entericidin EcnA/EcnB	EcnA	V	Defense mechanisms	4	36	0.1111111111111111
OG0001811	COG2095	Small neutral amino acid transporter SnatA, MarC family	MarC	E	Amino acid transport and metabolism	36	36	1
OG0001812	COG2159	5-carboxyvanillate decarboxylase LigW (lignin degradation), amidohydro domain	LigW	G	Carbohydrate transport and metabolism	36	36	1
OG0001813	COG0659	Sulfate permease or related transporter, MFS superfamily, contains STAS domain	SUL1	P	Inorganic ion transport and metabolism	36	36	1
OG0001814	COG0610	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases ...	NA	V	Defense mechanisms	34	35	0.9714285714285714
OG0001815	COG1414	DNA-binding transcriptional regulator, IclR family	IclR	K	Transcription	35	35	1
OG0001816	COG1221	Transcriptional regulators containing sigma54-interacting ATPase domain	PspF	K	Transcription	1	35	0.02857142857142857
OG0001816	COG1401	5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB	McrB	V	Defense mechanisms	3	35	0.08571428571428572
OG0001816	COG3183	5-methylcytosine-specific restriction endonuclease McrA	McrA	V	Defense mechanisms	15	35	0.42857142857142855
OG0001817	COG0531	Serine and glutamate transporter AimA/YbeC, amino acid:H+ symporter family	PotE	E	Amino acid transport and metabolism	2	35	0.05714285714285714
OG0001821	COG2834	Periplasmic chaperone for outer membrane lipoprotein sorting	LolA	M	Cell wall/membrane/envelope biogenesis	34	35	0.9714285714285714
OG0001823	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	26	34	0.7647058823529411
OG0001823	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	BcsA	N	Cell motility	1	34	0.029411764705882353
OG0001823	COG1216	Glycosyltransferase, GT2 family	WcaE	G	Carbohydrate transport and metabolism	2	34	0.058823529411764705
OG0001824	COG0277	FAD/FMN-containing lactate dehydrogenase/glycolate oxidase	GlcD	C	Energy production and conversion	27	34	0.7941176470588235
OG0001827	COG0412	Dienelactone hydrolase	DLH	Q	Secondary metabolites biosynthesis, transport and catabolism	34	34	1
OG0001828	COG0693	Protein/nucleotide deglycase, PfpI/YajL/DJ-1 family (repair of methylglyoxal-glycated proteins and nucleic acids)	YajL	V	Defense mechanisms	34	34	1
OG0001830	COG0530	Ca2+/Na+ antiporter	ECM27	P	Inorganic ion transport and metabolism	34	34	1
OG0001831	COG0624	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase	ArgE	E	Amino acid transport and metabolism	1	34	0.029411764705882353
OG0001834	COG0329	4-hydroxy-tetrahydrodipicolinate synthase/N-acetylneuraminate lyase	DapA	E	Amino acid transport and metabolism	30	34	0.8823529411764706
OG0001835	COG1346	Putative effector of murein hydrolase	LrgB	M	Cell wall/membrane/envelope biogenesis	34	34	1
OG0001837	COG1011	FMN and 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YigB, HAD superfamily (riboflavin biosynthesis)	YigB	H	Coenzyme transport and metabolism	4	33	0.12121212121212122
OG0001838	COG3378	DNA primase, phage- or plasmid-associated	NA	X	Mobilome: prophages, transposons	15	33	0.45454545454545453
OG0001838	COG3598	RecA-family ATPase	RepA	L	Replication, recombination and repair	1	33	0.030303030303030304
OG0001838	COG4951	CRISPR-associated primase-polymerase type A	CAPP_A	V	Defense mechanisms	7	33	0.21212121212121213
OG0001839	COG3292	Periplasmic ligand-binding sensor domain	NA	T	Signal transduction mechanisms	1	33	0.030303030303030304
OG0001839	COG4485	Uncharacterized membrane protein YfhO	YfhO	S	Function unknown	1	33	0.030303030303030304
OG0001840	COG1183	Phosphatidylserine synthase	PssA	I	Lipid transport and metabolism	33	33	1
OG0001841	COG0494	8-oxo-dGTP pyrophosphatase MutT and related house-cleaning NTP pyrophosphohydrolases, NUDIX family	MutT	V	Defense mechanisms	2	33	0.06060606060606061
OG0001841	COG1051	ADP-ribose pyrophosphatase YjhB, NUDIX family	YjhB	F	Nucleotide transport and metabolism	8	33	0.24242424242424243
OG0001841	COG2816	NADH pyrophosphatase NudC, Nudix superfamily	NPY1	F	Nucleotide transport and metabolism	23	33	0.696969696969697
OG0001842	COG4221	NADP-dependent 3-hydroxy acid dehydrogenase YdfG	YdfG	C	Energy production and conversion	33	33	1
OG0001843	COG2041	Molybdopterin-dependent catalytic subunit of periplasmic DMSO/TMAO and protein-methionine-sulfoxide reductases	MsrP	C	Energy production and conversion	33	33	1
OG0001844	COG5485	Polyketide cyclase, SnoaL/DnrD family	SnoaL	Q	Secondary metabolites biosynthesis, transport and catabolism	1	33	0.030303030303030304
OG0001845	COG1380	Putative effector of murein hydrolase LrgA, UPF0299 family	YohJ	R	General function prediction only	33	33	1
OG0001846	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	9	32	0.28125
OG0001846	COG1088	dTDP-D-glucose 4,6-dehydratase	RfbB	M	Cell wall/membrane/envelope biogenesis	23	32	0.71875
OG0001847	COG0652	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family	PpiB	O	Posttranslational modification, protein turnover, chaperones	32	32	1
OG0001848	COG3210	Large exoprotein involved in heme utilization or adhesion	FhaB	U	Intracellular trafficking, secretion, and vesicular transport	17	32	0.53125
OG0001848	COG3468	Autotransporter adhesin AidA	AidA	M	Cell wall/membrane/envelope biogenesis	1	32	0.03125
OG0001848	COG3469	Chitinase	Chi1	G	Carbohydrate transport and metabolism	1	32	0.03125
OG0001848	COG4625	Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain	NA	S	Function unknown	1	32	0.03125
OG0001848	COG5263	Glucan-binding domain (YG repeat)	YG	G	Carbohydrate transport and metabolism	1	32	0.03125
OG0001849	COG3378	DNA primase, phage- or plasmid-associated	NA	X	Mobilome: prophages, transposons	1	32	0.03125
OG0001849	COG3598	RecA-family ATPase	RepA	L	Replication, recombination and repair	27	32	0.84375
OG0001850	COG0205	6-phosphofructokinase	PfkA	G	Carbohydrate transport and metabolism	32	32	1
OG0001851	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	6	32	0.1875
OG0001851	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	BcsA	N	Cell motility	23	32	0.71875
OG0001851	COG1216	Glycosyltransferase, GT2 family	WcaE	G	Carbohydrate transport and metabolism	1	32	0.03125
OG0001852	COG4448	L-asparaginase II	AnsA2	E	Amino acid transport and metabolism	31	32	0.96875
OG0001853	COG0542	ATP-dependent Clp protease, ATP-binding subunit ClpA	ClpA	O	Posttranslational modification, protein turnover, chaperones	1	32	0.03125
OG0001853	COG1196	Chromosome segregation ATPase Smc	Smc	D	Cell cycle control, cell division, chromosome partitioning	6	32	0.1875
OG0001853	COG2433	Possible nuclease of RNase H fold, RuvC/YqgF family	NA	R	General function prediction only	1	32	0.03125
OG0001854	COG0223	Methionyl-tRNA formyltransferase	Fmt	J	Translation, ribosomal structure and biogenesis	13	32	0.40625
OG0001854	COG3507	Beta-xylosidase	XynB2	G	Carbohydrate transport and metabolism	1	32	0.03125
OG0001855	COG1451	UTP pyrophosphatase, metal-dependent hydrolase family	YgjP	R	General function prediction only	32	32	1
OG0001856	COG1647	Esterase/lipase	YvaK	Q	Secondary metabolites biosynthesis, transport and catabolism	32	32	1
OG0001857	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	21	31	0.6774193548387096
OG0001857	COG1216	Glycosyltransferase, GT2 family	WcaE	G	Carbohydrate transport and metabolism	3	31	0.0967741935483871
OG0001859	COG1309	DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA	AcrR	K	Transcription	11	31	0.3548387096774194
OG0001860	COG0771	UDP-N-acetylmuramoylalanine-D-glutamate ligase	MurD	M	Cell wall/membrane/envelope biogenesis	1	31	0.03225806451612903
OG0001860	COG2303	Choline dehydrogenase or related flavoprotein	BetA	I	Lipid transport and metabolism	1	31	0.03225806451612903
OG0001860	COG2907	Predicted flavin-containing amine oxidase	Ppro0129	R	General function prediction only	1	31	0.03225806451612903
OG0001861	COG5002	Sensor histidine kinase WalK	WalK	T	Signal transduction mechanisms	1	31	0.03225806451612903
OG0001863	COG0584	Glycerophosphoryl diester phosphodiesterase	UgpQ	I	Lipid transport and metabolism	4	31	0.12903225806451613
OG0001863	COG1368	Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily	MdoB	M	Cell wall/membrane/envelope biogenesis	26	31	0.8387096774193549
OG0001864	COG1611	Nucleotide monophosphate nucleosidase PpnN/YdgH, Lonely Guy (LOG) family	PpnN	F	Nucleotide transport and metabolism	31	31	1
OG0001865	COG0705	Membrane-associated serine protease, rhomboid family	GlpG	O	Posttranslational modification, protein turnover, chaperones	31	31	1
OG0001868	COG3115	Cell division protein ZipA, interacts with FtsZ	ZipA	D	Cell cycle control, cell division, chromosome partitioning	1	30	0.03333333333333333
OG0001869	COG4520	Surface antigen	LipA17	M	Cell wall/membrane/envelope biogenesis	27	30	0.9
OG0001870	COG1807	PMT family glycosyltransferase ArnT/Agl22, involved in glycosylation of proteins and lipid IVA	ArnT	M	Cell wall/membrane/envelope biogenesis	1	30	0.03333333333333333
OG0001871	COG3882	Predicted enzyme involved in methoxymalonyl-ACP biosynthesis	FkbH	I	Lipid transport and metabolism	30	30	1
OG0001872	COG3203	Outer membrane porin OmpC/OmpF/PhoE	OmpC	M	Cell wall/membrane/envelope biogenesis	11	30	0.36666666666666664
OG0001873	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	9	30	0.3
OG0001873	COG2244	Membrane protein involved in the export of O-antigen and teichoic acid	RfbX	M	Cell wall/membrane/envelope biogenesis	1	30	0.03333333333333333
OG0001873	COG3292	Periplasmic ligand-binding sensor domain	NA	T	Signal transduction mechanisms	1	30	0.03333333333333333
OG0001874	COG0241	Histidinol phosphatase/D-glycero-mannoheptose bisphosphatephosphatase, HAD superfamily	HisB1/GmhB	E	Amino acid transport and metabolism	3	29	0.10344827586206896
OG0001874	COG0517	CBS domain	CBS	T	Signal transduction mechanisms	2	29	0.06896551724137931
OG0001874	COG0637	Beta-phosphoglucomutase, HAD superfamily	YcjU	G	Carbohydrate transport and metabolism	1	29	0.034482758620689655
OG0001874	COG1208	NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis protein s	GCD1	J	Translation, ribosomal structure and biogenesis	8	29	0.27586206896551724
OG0001874	COG1209	dTDP-glucose pyrophosphorylase	RmlA1	M	Cell wall/membrane/envelope biogenesis	1	29	0.034482758620689655
OG0001874	COG1213	Choline kinase	NA	I	Lipid transport and metabolism	8	29	0.27586206896551724
OG0001874	COG3642	tRNA A37 N6-threonylcarbamoyl transferase component Bud32	Bud32	J	Translation, ribosomal structure and biogenesis	1	29	0.034482758620689655
OG0001874	COG5017	UDP-N-acetylglucosamine transferase subunit ALG13	NA	G	Carbohydrate transport and metabolism	1	29	0.034482758620689655
OG0001875	COG1086	NDP-sugar epimerase, includes UDP-N-acetylglucosamine 4,6-dehydratase EpsC	EpsC	M	Cell wall/membrane/envelope biogenesis	1	29	0.034482758620689655
OG0001875	COG3475	Phosphorylcholine metabolism protein LicD	LicD	I	Lipid transport and metabolism	13	29	0.4482758620689655
OG0001876	COG0223	Methionyl-tRNA formyltransferase	Fmt	J	Translation, ribosomal structure and biogenesis	1	29	0.034482758620689655
OG0001876	COG0454	N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2)	PhnO	K	Transcription	2	29	0.06896551724137931
OG0001876	COG0456	Ribosomal protein S18 acetylase RimI and related acetyltransferases	RimI	J	Translation, ribosomal structure and biogenesis	3	29	0.10344827586206896
OG0001876	COG1246	N-acetylglutamate synthase or related acetyltransferase, GNAT family	ArgA	E	Amino acid transport and metabolism	20	29	0.6896551724137931
OG0001876	COG1247	L-amino acid N-acyltransferase MnaT	MnaT	E	Amino acid transport and metabolism	1	29	0.034482758620689655
OG0001877	COG0346	Glyoxalase, catechol 2,3-dioxygenase or related enzyme, vicinal oxygen chelate (VOC) family	GloA	Q	Secondary metabolites biosynthesis, transport and catabolism	1	29	0.034482758620689655
OG0001877	COG0662	Mannose-6-phosphate isomerase, cupin superfamily	ManC	G	Carbohydrate transport and metabolism	2	29	0.06896551724137931
OG0001877	COG1051	ADP-ribose pyrophosphatase YjhB, NUDIX family	YjhB	F	Nucleotide transport and metabolism	1	29	0.034482758620689655
OG0001877	COG1917	Cupin domain protein related to quercetin dioxygenase	QdoI	R	General function prediction only	4	29	0.13793103448275862
OG0001878	COG4391	Uncharacterized protein, contains Zn-finger domain	NA	S	Function unknown	29	29	1
OG0001880	COG5633	Uncharacterized conserved protein YcfL	YcfL	S	Function unknown	1	29	0.034482758620689655
OG0001881	COG0338	DNA-adenine methylase	Dam	L	Replication, recombination and repair	29	29	1
OG0001882	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	1	29	0.034482758620689655
OG0001882	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	BcsA	N	Cell motility	7	29	0.2413793103448276
OG0001882	COG1216	Glycosyltransferase, GT2 family	WcaE	G	Carbohydrate transport and metabolism	1	29	0.034482758620689655
OG0001882	COG3222	Uncharacterized conserved protein, glycosyltransferase A (GT-A) superfamily, DUF2064 family	NA	S	Function unknown	17	29	0.5862068965517241
OG0001883	COG0334	Glutamate dehydrogenase/leucine dehydrogenase	GdhA	E	Amino acid transport and metabolism	29	29	1
OG0001884	COG1070	Sugar (pentulose or hexulose) kinase	XylB	G	Carbohydrate transport and metabolism	29	29	1
OG0001885	COG4704	Uncharacterized conserved protein, DUF2141 family	NA	S	Function unknown	29	29	1
OG0001886	COG1132	ABC-type multidrug and LPS transport system, ATPase and permease component MsbA	MdlB	M	Cell wall/membrane/envelope biogenesis	1	28	0.03571428571428571
OG0001886	COG2274	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain	SunT	V	Defense mechanisms	6	28	0.21428571428571427
OG0001886	COG4133	ABC-type transport system involved in cytochrome c biogenesis, ATPase component	CcmA	O	Posttranslational modification, protein turnover, chaperones	21	28	0.75
OG0001887	COG4714	Uncharacterized membrane-anchored protein	NA	S	Function unknown	18	28	0.6428571428571429
OG0001888	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	10	28	0.35714285714285715
OG0001888	COG1887	CDP-glycerol glycerophosphotransferase, TagB/SpsB family	TagB	M	Cell wall/membrane/envelope biogenesis	1	28	0.03571428571428571
OG0001889	COG1196	Chromosome segregation ATPase Smc	Smc	D	Cell cycle control, cell division, chromosome partitioning	4	28	0.14285714285714285
OG0001889	COG3883	Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO	CwlO1	S	Function unknown	6	28	0.21428571428571427
OG0001889	COG4942	Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB	EnvC	D	Cell cycle control, cell division, chromosome partitioning	4	28	0.14285714285714285
OG0001890	COG1861	Spore coat polysaccharide biosynthesis protein SpsF, cytidylyltransferase family	SpsF	M	Cell wall/membrane/envelope biogenesis	1	28	0.03571428571428571
OG0001890	COG2153	Predicted N-acyltransferase, GNAT family	ElaA	R	General function prediction only	4	28	0.14285714285714285
OG0001890	COG3153	Predicted N-acetyltransferase YhbS	YhbS	R	General function prediction only	3	28	0.10714285714285714
OG0001892	COG1637	Endonuclease NucS, RecB family	NucS	L	Replication, recombination and repair	12	28	0.42857142857142855
OG0001892	COG3183	5-methylcytosine-specific restriction endonuclease McrA	McrA	V	Defense mechanisms	1	28	0.03571428571428571
OG0001892	COG4127	Predicted restriction endonuclease, Mrr-cat superfamily	NA	R	General function prediction only	1	28	0.03571428571428571
OG0001893	COG0500	SAM-dependent methyltransferase SmtA (CmoB moved to COG2228)	SmtA	Q	Secondary metabolites biosynthesis, transport and catabolism	19	28	0.6785714285714286
OG0001893	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9	UbiE	H	Coenzyme transport and metabolism	2	28	0.07142857142857142
OG0001893	COG4106	Trans-aconitate methyltransferase	Tam	C	Energy production and conversion	3	28	0.10714285714285714
OG0001893	COG4123	tRNA1(Val) A37 N6-methylase TrmN6	TrmN6	J	Translation, ribosomal structure and biogenesis	1	28	0.03571428571428571
OG0001893	COG4976	Predicted methyltransferase, contains TPR repeat	NA	R	General function prediction only	3	28	0.10714285714285714
OG0001895	COG1231	Monoamine oxidase	YobN	E	Amino acid transport and metabolism	27	28	0.9642857142857143
OG0001896	COG2307	Uncharacterized conserved protein, Alpha-E superfamily	Alpha-E	S	Function unknown	28	28	1
OG0001897	COG2030	Acyl-CoA dehydratase PaaZ	MaoC	I	Lipid transport and metabolism	28	28	1
OG0001898	COG0500	SAM-dependent methyltransferase SmtA (CmoB moved to COG2228)	SmtA	Q	Secondary metabolites biosynthesis, transport and catabolism	1	28	0.03571428571428571
OG0001898	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9	UbiE	H	Coenzyme transport and metabolism	3	28	0.10714285714285714
OG0001898	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	16	28	0.5714285714285714
OG0001898	COG4627	Predicted SAM-depedendent methyltransferase	NA	R	General function prediction only	1	28	0.03571428571428571
OG0001901	COG5285	Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family	PhyH	Q	Secondary metabolites biosynthesis, transport and catabolism	1	28	0.03571428571428571
OG0001902	COG1072	Pantothenate kinase	CoaA	H	Coenzyme transport and metabolism	28	28	1
OG0001903	COG1368	Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily	MdoB	M	Cell wall/membrane/envelope biogenesis	2	27	0.07407407407407407
OG0001903	COG3083	Periplasmic protein PbgA/YejM, regulator of the LPS biosynthesis, AlkP superfamily	YejM	M	Cell wall/membrane/envelope biogenesis	2	27	0.07407407407407407
OG0001903	COG3119	Arylsulfatase A or related enzyme, AlkP superfamily	AslA	P	Inorganic ion transport and metabolism	6	27	0.2222222222222222
OG0001904	COG1350	Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB)	NA	E	Amino acid transport and metabolism	27	27	1
OG0001905	COG5509	Uncharacterized small protein, DUF1192 family	NA	S	Function unknown	20	27	0.7407407407407407
OG0001907	COG0510	Thiamine kinase or a related kinase	CotS	H	Coenzyme transport and metabolism	1	27	0.037037037037037035
OG0001907	COG3173	Predicted  kinase, aminoglycoside phosphotransferase (APT) family	YcbJ	R	General function prediction only	24	27	0.8888888888888888
OG0001907	COG3642	tRNA A37 N6-threonylcarbamoyl transferase component Bud32	Bud32	J	Translation, ribosomal structure and biogenesis	2	27	0.07407407407407407
OG0001909	COG1553	tRNA U34 sulfur transfer complex TusBCD TusD component, DsrE family	DsrE	J	Translation, ribosomal structure and biogenesis	16	27	0.5925925925925926
OG0001910	COG0346	Glyoxalase, catechol 2,3-dioxygenase or related enzyme, vicinal oxygen chelate (VOC) family	GloA	Q	Secondary metabolites biosynthesis, transport and catabolism	3	27	0.1111111111111111
OG0001910	COG3185	4-hydroxyphenylpyruvate dioxygenase and related hemolysins	HppD	E	Amino acid transport and metabolism	23	27	0.8518518518518519
OG0001911	COG0194	Guanylate kinase	Gmk	F	Nucleotide transport and metabolism	1	27	0.037037037037037035
OG0001911	COG1887	CDP-glycerol glycerophosphotransferase, TagB/SpsB family	TagB	M	Cell wall/membrane/envelope biogenesis	1	27	0.037037037037037035
OG0001911	COG3562	Capsule polysaccharide modification protein KpsS	KpsS	M	Cell wall/membrane/envelope biogenesis	2	27	0.07407407407407407
OG0001911	COG3563	Capsule polysaccharide export protein KpsC/LpsZ	KpsC	M	Cell wall/membrane/envelope biogenesis	5	27	0.18518518518518517
OG0001912	COG2105	Predicted gamma-glutamylamine cyclotransferase YtfP, GGCT/AIG2-like family	YtfP	E	Amino acid transport and metabolism	27	27	1
OG0001913	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase or related enzyme	RfbC	M	Cell wall/membrane/envelope biogenesis	26	26	1
OG0001914	COG1221	Transcriptional regulators containing sigma54-interacting ATPase domain	PspF	K	Transcription	1	26	0.038461538461538464
OG0001914	COG4122	tRNA 5-hydroxyU34 O-methylase TrmR/YrrM	TrmR	J	Translation, ribosomal structure and biogenesis	2	26	0.07692307692307693
OG0001916	COG3206	Tyrosine-protein kinase Wzc involved in exopolysaccharide export, GumC/Wzc1 domain	GumC	M	Cell wall/membrane/envelope biogenesis	26	26	1
OG0001917	COG1807	PMT family glycosyltransferase ArnT/Agl22, involved in glycosylation of proteins and lipid IVA	ArnT	M	Cell wall/membrane/envelope biogenesis	9	26	0.34615384615384615
OG0001917	COG4758	Membrane protein LiaF, inhibitor of the LiaRS two-component envelope stress sensory system	LiaF	T	Signal transduction mechanisms	1	26	0.038461538461538464
OG0001918	COG4591	ABC-type lipoprotein targeting system transmembrane component LolC/LolE	LolC	M	Cell wall/membrane/envelope biogenesis	26	26	1
OG0001919	COG1061	Superfamily II DNA or RNA helicase	SSL2	K	Transcription	2	26	0.07692307692307693
OG0001919	COG1388	LysM repeat	LysM	M	Cell wall/membrane/envelope biogenesis	6	26	0.23076923076923078
OG0001919	COG4096	Type I site-specific restriction endonuclease, part of a restriction-modification system	HsdR	V	Defense mechanisms	1	26	0.038461538461538464
OG0001920	COG3861	Stress response protein YsnF (function unknown)	YsnF	S	Function unknown	1	26	0.038461538461538464
OG0001920	COG3883	Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO	CwlO1	S	Function unknown	1	26	0.038461538461538464
OG0001921	COG3211	Secreted phosphatase, PhoX family	PhoX	R	General function prediction only	26	26	1
OG0001922	COG1134	ABC-type polysaccharide/polyol phosphate transport system, ATPase component	TagH	G	Carbohydrate transport and metabolism	22	26	0.8461538461538461
OG0001922	COG3210	Large exoprotein involved in heme utilization or adhesion	FhaB	U	Intracellular trafficking, secretion, and vesicular transport	2	26	0.07692307692307693
OG0001923	COG2900	Uncharacterized coiled-coil protein SlyX (sensitive to lysis X)	SlyX	S	Function unknown	26	26	1
OG0001924	COG0615	Glycerol-3-phosphate cytidylyltransferase, cytidylyltransferase family	TagD	M	Cell wall/membrane/envelope biogenesis	24	25	0.96
OG0001924	COG2513	2-Methylisocitrate lyase and related enzymes, PEP mutase family	PrpB	G	Carbohydrate transport and metabolism	1	25	0.04
OG0001927	COG4886	Type III secretion system effector YopM, contains leucine-rich repeats	YopM	U	Intracellular trafficking, secretion, and vesicular transport	3	25	0.12
OG0001929	COG3510	Rhamnose/hydroxycephalosporin O-methyltransferase, CmcI/Rv2959c family	CmcI	M	Cell wall/membrane/envelope biogenesis	1	25	0.04
OG0001929	COG4122	tRNA 5-hydroxyU34 O-methylase TrmR/YrrM	TrmR	J	Translation, ribosomal structure and biogenesis	8	25	0.32
OG0001930	COG1596	Periplasmic protein Wza involved in polysaccharide export, contains SLBB domain of the beta-grasp fold	Wza	M	Cell wall/membrane/envelope biogenesis	24	25	0.96
OG0001932	COG0687	Spermidine/putrescine-binding periplasmic protein	PotD	E	Amino acid transport and metabolism	25	25	1
OG0001933	COG1473	Metal-dependent amidase/aminoacylase/carboxypeptidase	AbgB	R	General function prediction only	25	25	1
OG0001934	COG0286	Type I restriction-modification system, DNA methylase subunit	HsdM	V	Defense mechanisms	1	25	0.04
OG0001934	COG1002	Type II restriction/modification system, endonuclease and methylase domains	YeeA	V	Defense mechanisms	21	25	0.84
OG0001938	COG2127	ATP-dependent Clp protease adapter protein ClpS	ClpS	O	Posttranslational modification, protein turnover, chaperones	25	25	1
OG0001939	COG1765	Uncharacterized OsmC-related protein/domain	YhfA	R	General function prediction only	25	25	1
OG0001940	COG3210	Large exoprotein involved in heme utilization or adhesion	FhaB	U	Intracellular trafficking, secretion, and vesicular transport	2	24	0.08333333333333333
OG0001941	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	5	24	0.20833333333333334
OG0001941	COG4106	Trans-aconitate methyltransferase	Tam	C	Energy production and conversion	1	24	0.041666666666666664
OG0001942	COG0558	Phosphatidylglycerophosphate synthase	PgsA	I	Lipid transport and metabolism	20	24	0.8333333333333334
OG0001942	COG5050	sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases	EPT1	I	Lipid transport and metabolism	2	24	0.08333333333333333
OG0001943	COG2105	Predicted gamma-glutamylamine cyclotransferase YtfP, GGCT/AIG2-like family	YtfP	E	Amino acid transport and metabolism	4	24	0.16666666666666666
OG0001944	COG3307	O-antigen ligase	RfaL	M	Cell wall/membrane/envelope biogenesis	21	24	0.875
OG0001945	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	7	24	0.2916666666666667
OG0001945	COG1208	NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis protein s	GCD1	J	Translation, ribosomal structure and biogenesis	1	24	0.041666666666666664
OG0001946	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	3	24	0.125
OG0001946	COG1216	Glycosyltransferase, GT2 family	WcaE	G	Carbohydrate transport and metabolism	2	24	0.08333333333333333
OG0001946	COG1221	Transcriptional regulators containing sigma54-interacting ATPase domain	PspF	K	Transcription	2	24	0.08333333333333333
OG0001948	COG0500	SAM-dependent methyltransferase SmtA (CmoB moved to COG2228)	SmtA	Q	Secondary metabolites biosynthesis, transport and catabolism	1	24	0.041666666666666664
OG0001948	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	15	24	0.625
OG0001948	COG2263	Predicted RNA methylase	NA	R	General function prediction only	2	24	0.08333333333333333
OG0001948	COG4106	Trans-aconitate methyltransferase	Tam	C	Energy production and conversion	1	24	0.041666666666666664
OG0001949	COG0456	Ribosomal protein S18 acetylase RimI and related acetyltransferases	RimI	J	Translation, ribosomal structure and biogenesis	22	24	0.9166666666666666
OG0001949	COG1246	N-acetylglutamate synthase or related acetyltransferase, GNAT family	ArgA	E	Amino acid transport and metabolism	1	24	0.041666666666666664
OG0001949	COG3153	Predicted N-acetyltransferase YhbS	YhbS	R	General function prediction only	1	24	0.041666666666666664
OG0001951	COG3420	Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains	NosD	P	Inorganic ion transport and metabolism	1	24	0.041666666666666664
OG0001951	COG3794	Plastocyanin	PetE	C	Energy production and conversion	22	24	0.9166666666666666
OG0001952	COG4319	SnoaL-fold ligand-binding domain	YybH	T	Signal transduction mechanisms	3	24	0.125
OG0001953	COG2211	Na+/melibiose symporter or related transporter	MelB	G	Carbohydrate transport and metabolism	24	24	1
OG0001954	COG1525	Endonuclease YncB, thermonuclease family	YncB	L	Replication, recombination and repair	21	24	0.875
OG0001954	COG3509	Acetyl xylan esterase AxeA and related esterases, LpqC family	LpqC	G	Carbohydrate transport and metabolism	3	24	0.125
OG0001955	COG0026	Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	PurK	F	Nucleotide transport and metabolism	1	24	0.041666666666666664
OG0001956	COG2847	Copper(I)-binding protein	NA	P	Inorganic ion transport and metabolism	24	24	1
OG0001957	COG3495	Uncharacterized conserved protein, DUF3299 family	NA	S	Function unknown	24	24	1
OG0001958	COG1591	Holliday junction resolvase Hjc, archaeal type	NA	L	Replication, recombination and repair	24	24	1
OG0001960	COG0500	SAM-dependent methyltransferase SmtA (CmoB moved to COG2228)	SmtA	Q	Secondary metabolites biosynthesis, transport and catabolism	5	24	0.20833333333333334
OG0001960	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	12	24	0.5
OG0001960	COG4123	tRNA1(Val) A37 N6-methylase TrmN6	TrmN6	J	Translation, ribosomal structure and biogenesis	1	24	0.041666666666666664
OG0001961	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	FabG	I	Lipid transport and metabolism	23	23	1
OG0001962	COG3008	Intermembrane transporter PqiABC subunit PqiB	PqiB	M	Cell wall/membrane/envelope biogenesis	1	23	0.043478260869565216
OG0001963	COG2230	Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases	Cfa	I	Lipid transport and metabolism	23	23	1
OG0001964	COG0861	Tellurite resistance membrane protein TerC	TerC	P	Inorganic ion transport and metabolism	23	23	1
OG0001966	COG1917	Cupin domain protein related to quercetin dioxygenase	QdoI	R	General function prediction only	23	23	1
OG0001967	COG0726	Peptidoglycan/xylan/chitin deacetylase, PgdA/NodB/CDA1 family	PgaB	G	Carbohydrate transport and metabolism	6	23	0.2608695652173913
OG0001967	COG3233	Predicted deacetylase	NA	R	General function prediction only	15	23	0.6521739130434783
OG0001967	COG5298	Predicted metal-dependent carbohydrate esterase YdaL, contains NodB-like catalytic (CE4) domain	YdaL	R	General function prediction only	2	23	0.08695652173913043
OG0001969	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	2	23	0.08695652173913043
OG0001969	COG1403	HNH family endonuclease, includes 5-methylcytosine-specific restriction endonuclease McrA	McrA	V	Defense mechanisms	1	23	0.043478260869565216
OG0001969	COG4641	Spore maturation protein CgeB	NA	D	Cell cycle control, cell division, chromosome partitioning	6	23	0.2608695652173913
OG0001970	COG5306	Uncharacterized conserved protein MJ1470, contains DUF2341 domain, predicted component of type IV pili-like system	MJ1470	R	General function prediction only	2	23	0.08695652173913043
OG0001971	COG3760	Predicted aminoacyl-tRNA deacylase, YbaK-like aminoacyl-tRNA editing domain	ProX	R	General function prediction only	23	23	1
OG0001972	COG0288	Carbonic anhydrase	CynT	P	Inorganic ion transport and metabolism	23	23	1
OG0001974	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	FabG	I	Lipid transport and metabolism	23	23	1
OG0001977	COG1607	Acyl-CoA hydrolase	YciA	I	Lipid transport and metabolism	23	23	1
OG0001978	COG3686	Uncharacterized conserved protein, MAPEG superfamily	NA	S	Function unknown	1	23	0.043478260869565216
OG0001978	COG5331	Predicted lipid metabolism protein, MAPEG family	MAPEG	I	Lipid transport and metabolism	22	23	0.9565217391304348
OG0001979	COG0318	O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming)	MenE	I	Lipid transport and metabolism	23	23	1
OG0001981	COG0326	Molecular chaperone, HSP90 family	HtpG	O	Posttranslational modification, protein turnover, chaperones	23	23	1
OG0001982	COG1841	Ribosomal protein L30/L7E	RpmD	J	Translation, ribosomal structure and biogenesis	23	23	1
OG0001984	COG3752	Steroid 5-alpha reductase family enzyme	NA	R	General function prediction only	23	23	1
OG0001985	COG2433	Possible nuclease of RNase H fold, RuvC/YqgF family	NA	R	General function prediction only	3	23	0.13043478260869565
OG0001985	COG2919	Cell division protein FtsB	FtsB	D	Cell cycle control, cell division, chromosome partitioning	17	23	0.7391304347826086
OG0001987	COG2366	Acyl-homoserine lactone (AHL) acylase PvdQ	PvdQ	Q	Secondary metabolites biosynthesis, transport and catabolism	23	23	1
OG0001988	COG3488	Uncharacterized conserved protein with two CxxC motifs, DUF1111 family	NA	R	General function prediction only	23	23	1
OG0001989	COG3317	Outer membrane protein assembly factor BamC	BamC	M	Cell wall/membrane/envelope biogenesis	2	23	0.08695652173913043
OG0001990	COG1960	Acyl-CoA dehydrogenase related to the alkylation response protein AidB	CaiA	I	Lipid transport and metabolism	23	23	1
OG0001991	COG1960	Acyl-CoA dehydrogenase related to the alkylation response protein AidB	CaiA	I	Lipid transport and metabolism	23	23	1
OG0001992	COG2046	ATP sulfurylase (sulfate adenylyltransferase)	MET3	P	Inorganic ion transport and metabolism	23	23	1
OG0001993	COG3411	2Fe-2S ferredoxin	2Fe2S	C	Energy production and conversion	23	23	1
OG0001994	COG4447	Photosystem II stability/assembly factor Ycf48	Ycf48	C	Energy production and conversion	23	23	1
OG0001995	COG1682	ABC-type polysaccharide/teichoic acid/polyol phosphate export permease	TagG	G	Carbohydrate transport and metabolism	23	23	1
OG0001998	COG5590	Ubiquinone biosynthesis protein COQ9	NA	H	Coenzyme transport and metabolism	23	23	1
OG0001999	COG5126	Ca2+-binding protein, EF-hand superfamily	FRQ1	T	Signal transduction mechanisms	23	23	1
OG0002001	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	21	22	0.9545454545454546
OG0002002	COG0652	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family	PpiB	O	Posttranslational modification, protein turnover, chaperones	21	22	0.9545454545454546
OG0002004	COG5522	Uncharacterized membrane protein YwaF	YwaF	S	Function unknown	21	22	0.9545454545454546
OG0002006	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9	UbiE	H	Coenzyme transport and metabolism	5	22	0.22727272727272727
OG0002006	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	10	22	0.45454545454545453
OG0002006	COG4627	Predicted SAM-depedendent methyltransferase	NA	R	General function prediction only	7	22	0.3181818181818182
OG0002007	COG2166	Sulfur transfer protein SufE/CsdE, Fe-S cluster assembly	SufE	O	Posttranslational modification, protein turnover, chaperones	22	22	1
OG0002008	COG3510	Rhamnose/hydroxycephalosporin O-methyltransferase, CmcI/Rv2959c family	CmcI	M	Cell wall/membrane/envelope biogenesis	21	22	0.9545454545454546
OG0002008	COG4122	tRNA 5-hydroxyU34 O-methylase TrmR/YrrM	TrmR	J	Translation, ribosomal structure and biogenesis	1	22	0.045454545454545456
OG0002010	COG1359	Quinol monooxygenase YgiN	YgiN	C	Energy production and conversion	22	22	1
OG0002011	COG2244	Membrane protein involved in the export of O-antigen and teichoic acid	RfbX	M	Cell wall/membrane/envelope biogenesis	18	22	0.8181818181818182
OG0002012	COG0730	Sulfite exporter TauE/SafE/YfcA and related permeases, UPF0721 family	TauE	P	Inorganic ion transport and metabolism	9	22	0.4090909090909091
OG0002013	COG0818	Diacylglycerol kinase	DgkA	I	Lipid transport and metabolism	22	22	1
OG0002014	COG0613	5'-3' exoribonuclease/diribonuclease TrpH/YciV (RNase AM), contains PHP domain	YciV	A	RNA processing and modification	20	22	0.9090909090909091
OG0002014	COG5427	Predicted membrane glycosyltransferase AF0583, Arch_YYY/DUF2298 family	NA	S	Function unknown	2	22	0.09090909090909091
OG0002016	COG1934	Lipopolysaccharide export system protein LptA	LptA	M	Cell wall/membrane/envelope biogenesis	22	22	1
OG0002017	COG1452	Lipopolysaccharide export system protein LptD/OstA, potential outer membrane flippase	LptD	M	Cell wall/membrane/envelope biogenesis	2	22	0.09090909090909091
OG0002017	COG3117	Lipopolysaccharide export system protein LptC	LptC	M	Cell wall/membrane/envelope biogenesis	4	22	0.18181818181818182
OG0002017	COG5375	Predicted lipopolysaccharide assembly protein, LptC/YrbK-like family	LptC2	M	Cell wall/membrane/envelope biogenesis	15	22	0.6818181818181818
OG0002018	COG1459	Type II secretion system/type IV pilus membrane platform protein GspF/PulF/PilC	GspF/PilC	N	Cell motility	2	22	0.09090909090909091
OG0002018	COG4700	Uncharacterized conserved protein ECs_4300, contains TPR-like domain	NA	S	Function unknown	15	22	0.6818181818181818
OG0002019	COG1309	DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA	AcrR	K	Transcription	22	22	1
OG0002020	COG2020	Protein-S-isoprenylcysteine O-methyltransferase Ste14	STE14	O	Posttranslational modification, protein turnover, chaperones	22	22	1
OG0002021	COG3367	Uncharacterized conserved protein, NAD-dependent epimerase/dehydratase family	NA	R	General function prediction only	22	22	1
OG0002022	COG5486	Predicted metal-binding membrane protein	NA	S	Function unknown	22	22	1
OG0002023	COG5588	Uncharacterized conserved protein, DUF1326 domain	NA	S	Function unknown	22	22	1
OG0002025	COG4323	Uncharacterized conserved protein, DUF962 domain	NA	S	Function unknown	22	22	1
OG0002026	COG1703	GTPase of the G3E family (not a periplasmic protein kinase)	ArgK	O	Posttranslational modification, protein turnover, chaperones	22	22	1
OG0002027	COG2096	Cob(II)alamin adenosyltransferase	PduO	H	Coenzyme transport and metabolism	22	22	1
OG0002028	COG4093	Uncharacterized conserved protein, DUF2125 domain	NA	S	Function unknown	18	22	0.8181818181818182
OG0002030	COG2386	ABC-type transport system involved in cytochrome c biogenesis, permease component	CcmB	O	Posttranslational modification, protein turnover, chaperones	22	22	1
OG0002032	COG3255	Putative sterol carrier protein, contains SCP2 domain	SCP2	I	Lipid transport and metabolism	22	22	1
OG0002033	COG2050	Acyl-CoA thioesterase PaaI, contains HGG motif	PaaI	Q	Secondary metabolites biosynthesis, transport and catabolism	22	22	1
OG0002034	COG0494	8-oxo-dGTP pyrophosphatase MutT and related house-cleaning NTP pyrophosphohydrolases, NUDIX family	MutT	V	Defense mechanisms	20	22	0.9090909090909091
OG0002034	COG1051	ADP-ribose pyrophosphatase YjhB, NUDIX family	YjhB	F	Nucleotide transport and metabolism	1	22	0.045454545454545456
OG0002036	COG2272	Carboxylesterase type B	PnbA	I	Lipid transport and metabolism	22	22	1
OG0002037	COG0174	Glutamine synthetase	GlnA	E	Amino acid transport and metabolism	22	22	1
OG0002038	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	AdhE	I	Lipid transport and metabolism	22	22	1
OG0002039	COG0496	Broad specificity polyphosphatase and 5'/3'-nucleotidase SurE	SurE	L	Replication, recombination and repair	22	22	1
OG0002040	COG1024	Enoyl-CoA hydratase/carnithine racemase	CaiD	I	Lipid transport and metabolism	22	22	1
OG0002041	COG0494	8-oxo-dGTP pyrophosphatase MutT and related house-cleaning NTP pyrophosphohydrolases, NUDIX family	MutT	V	Defense mechanisms	22	22	1
OG0002042	COG3816	Predicted stress response protein, DUF1285 family	NA	R	General function prediction only	22	22	1
OG0002043	COG2030	Acyl-CoA dehydratase PaaZ	MaoC	I	Lipid transport and metabolism	22	22	1
OG0002045	COG3728	Phage terminase, small subunit	XtmA	X	Mobilome: prophages, transposons	20	22	0.9090909090909091
OG0002048	COG1807	PMT family glycosyltransferase ArnT/Agl22, involved in glycosylation of proteins and lipid IVA	ArnT	M	Cell wall/membrane/envelope biogenesis	14	22	0.6363636363636364
OG0002049	COG0730	Sulfite exporter TauE/SafE/YfcA and related permeases, UPF0721 family	TauE	P	Inorganic ion transport and metabolism	22	22	1
OG0002050	COG5481	Uncharacterized conserved protein, DUF465 domain	NA	S	Function unknown	2	22	0.09090909090909091
OG0002051	COG4766	Ethanolamine utilization protein EutQ, cupin superfamily (function unknown)	EutQ	E	Amino acid transport and metabolism	22	22	1
OG0002053	COG3211	Secreted phosphatase, PhoX family	PhoX	R	General function prediction only	7	22	0.3181818181818182
OG0002055	COG5394	Polyhydroxyalkanoate synthesis regulator, binds DNA and PHA	PhaR	Q	Secondary metabolites biosynthesis, transport and catabolism	22	22	1
OG0002056	COG2814	Predicted arabinose efflux permease AraJ, MFS family	AraJ	G	Carbohydrate transport and metabolism	22	22	1
OG0002057	COG3366	Uncharacterized membrane protein	NA	S	Function unknown	8	22	0.36363636363636365
OG0002058	COG0560	Phosphoserine phosphatase	SerB	E	Amino acid transport and metabolism	22	22	1
OG0002060	COG1181	D-alanine-D-alanine ligase or related ATP-grasp enzyme	DdlA	M	Cell wall/membrane/envelope biogenesis	22	22	1
OG0002063	COG1208	NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis protein s	GCD1	J	Translation, ribosomal structure and biogenesis	21	21	1
OG0002064	COG1961	Site-specific DNA recombinase SpoIVCA/DNA invertase PinE	SpoIVCA	L	Replication, recombination and repair	21	21	1
OG0002065	COG4974	Site-specific tyrosine recombinase XerD	XerD	L	Replication, recombination and repair	19	21	0.9047619047619048
OG0002066	COG1196	Chromosome segregation ATPase Smc	Smc	D	Cell cycle control, cell division, chromosome partitioning	1	21	0.047619047619047616
OG0002066	COG1579	Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain	DR0291	R	General function prediction only	1	21	0.047619047619047616
OG0002066	COG4942	Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB	EnvC	D	Cell cycle control, cell division, chromosome partitioning	1	21	0.047619047619047616
OG0002067	COG1807	PMT family glycosyltransferase ArnT/Agl22, involved in glycosylation of proteins and lipid IVA	ArnT	M	Cell wall/membrane/envelope biogenesis	1	21	0.047619047619047616
OG0002068	COG3313	Predicted Fe-S protein YdhL, DUF1289 family	YdhL	R	General function prediction only	21	21	1
OG0002069	COG4485	Uncharacterized membrane protein YfhO	YfhO	S	Function unknown	2	21	0.09523809523809523
OG0002070	COG0223	Methionyl-tRNA formyltransferase	Fmt	J	Translation, ribosomal structure and biogenesis	3	21	0.14285714285714285
OG0002070	COG0299	Folate-dependent phosphoribosylglycinamide formyltransferase PurN	PurN	F	Nucleotide transport and metabolism	1	21	0.047619047619047616
OG0002071	COG0841	Multidrug efflux pump subunit AcrB	AcrB	V	Defense mechanisms	1	21	0.047619047619047616
OG0002072	COG0322	Excinuclease UvrABC, nuclease subunit	UvrC	L	Replication, recombination and repair	4	21	0.19047619047619047
OG0002072	COG2827	Predicted endonuclease, GIY-YIG superfamily	YhbQ	L	Replication, recombination and repair	1	21	0.047619047619047616
OG0002074	COG1033	Predicted exporter protein, RND superfamily	MMPL	R	General function prediction only	21	21	1
OG0002075	COG1866	Phosphoenolpyruvate carboxykinase, ATP-dependent	PckA	C	Energy production and conversion	21	21	1
OG0002076	COG1651	Protein thiol-disulfide isomerase DsbC	DsbG	O	Posttranslational modification, protein turnover, chaperones	21	21	1
OG0002077	COG2015	Alkyl sulfatase BDS1 and related hydrolases, metallo-beta-lactamase superfamily	BDS1	Q	Secondary metabolites biosynthesis, transport and catabolism	21	21	1
OG0002078	COG1309	DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA	AcrR	K	Transcription	21	21	1
OG0002079	COG1600	Epoxyqueuosine reductase QueG (queuosine biosynthesis)	QueG	J	Translation, ribosomal structure and biogenesis	21	21	1
OG0002080	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component	MmdA	I	Lipid transport and metabolism	21	21	1
OG0002081	COG1234	Ribonuclease BN, tRNA processing enzyme	ElaC	J	Translation, ribosomal structure and biogenesis	21	21	1
OG0002082	COG5470	Uncharacterized conserved protein, DUF1330 family	NA	S	Function unknown	20	21	0.9523809523809523
OG0002083	COG0625	Glutathione S-transferase or stringent starvation protein SspA	GstA	O	Posttranslational modification, protein turnover, chaperones	20	21	0.9523809523809523
OG0002084	COG5361	Uncharacterized conserved protein	NA	X	Mobilome: prophages, transposons	3	21	0.14285714285714285
OG0002084	COG5436	Uncharacterized membrane protein	NA	S	Function unknown	18	21	0.8571428571428571
OG0002085	COG5402	Uncharacterized protein, contains DUF1214 domain	NA	S	Function unknown	21	21	1
OG0002086	COG0671	Membrane-associated phospholipid phosphatase	PgpB	I	Lipid transport and metabolism	21	21	1
OG0002087	COG0778	Nitroreductase	NfnB	C	Energy production and conversion	21	21	1
OG0002088	COG3825	Uncharacterized CoxE-like protein,  contains von Willebrand factor type A (vWA) domain	CoxE2	S	Function unknown	21	21	1
OG0002089	COG1695	DNA-binding transcriptional regulator, PadR family	PadR	K	Transcription	20	21	0.9523809523809523
OG0002090	COG0501	Zn-dependent protease with chaperone function	HtpX	O	Posttranslational modification, protein turnover, chaperones	12	21	0.5714285714285714
OG0002090	COG4783	Periplasmic chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains	BepA	M	Cell wall/membrane/envelope biogenesis	9	21	0.42857142857142855
OG0002092	COG1564	Thiamine pyrophosphokinase	ThiN	H	Coenzyme transport and metabolism	21	21	1
OG0002093	COG2318	Bacillithiol/mycothiol S-transferase BstA/DinB, DinB/YfiT family (unrelated to E. coli DinB)	DinB	Q	Secondary metabolites biosynthesis, transport and catabolism	11	21	0.5238095238095238
OG0002095	COG5331	Predicted lipid metabolism protein, MAPEG family	MAPEG	I	Lipid transport and metabolism	21	21	1
OG0002096	COG1426	Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains	RodZ	D	Cell cycle control, cell division, chromosome partitioning	21	21	1
OG0002097	COG3631	Ketosteroid isomerase-related protein	YesE	R	General function prediction only	3	21	0.14285714285714285
OG0002098	COG0806	Ribosomal 30S subunit maturation factor RimM, required for 16S rRNA processing	RimM	J	Translation, ribosomal structure and biogenesis	21	21	1
OG0002102	COG0423	Glycyl-tRNA synthetase, class II	GRS1	J	Translation, ribosomal structure and biogenesis	21	21	1
OG0002103	COG0204	1-acyl-sn-glycerol-3-phosphate acyltransferase	PlsC	I	Lipid transport and metabolism	21	21	1
OG0002104	COG4321	Predicted DNA-binding protein, contains ribbon-helix-helix (RHH) domain	NA	R	General function prediction only	21	21	1
OG0002105	COG0809	S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase)	QueA	J	Translation, ribosomal structure and biogenesis	21	21	1
OG0002106	COG0599	Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family	YurZ	R	General function prediction only	21	21	1
OG0002107	COG3153	Predicted N-acetyltransferase YhbS	YhbS	R	General function prediction only	20	21	0.9523809523809523
OG0002108	COG2128	Alkylhydroperoxidase family enzyme, contains CxxC motif	YciW	P	Inorganic ion transport and metabolism	21	21	1
OG0002109	COG0348	Polyferredoxin NapH	NapH	C	Energy production and conversion	6	21	0.2857142857142857
OG0002111	COG0607	Rhodanese-related sulfurtransferase	PspE	P	Inorganic ion transport and metabolism	20	21	0.9523809523809523
OG0002112	COG0596	2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH/undecaprenyl monophosphate-sugar esterase UshA/YqjL	MenH	H	Coenzyme transport and metabolism	6	21	0.2857142857142857
OG0002112	COG1506	Dipeptidyl aminopeptidase/acylaminoacyl peptidase	DAP2	E	Amino acid transport and metabolism	10	21	0.47619047619047616
OG0002112	COG2267	Lysophospholipase, alpha-beta hydrolase superfamily	PldB	I	Lipid transport and metabolism	5	21	0.23809523809523808
OG0002113	COG4076	Predicted RNA methylase	NA	R	General function prediction only	1	21	0.047619047619047616
OG0002115	COG0819	Aminopyrimidine aminohydrolase TenA (thiamine salvage pathway)	TenA	H	Coenzyme transport and metabolism	21	21	1
OG0002116	COG2259	Uncharacterized membrane protein YphA, DoxX/SURF4 family	DoxX	S	Function unknown	21	21	1
OG0002119	COG2133	Glucose/arabinose dehydrogenase, beta-propeller fold	YliI	G	Carbohydrate transport and metabolism	20	20	1
OG0002122	COG1216	Glycosyltransferase, GT2 family	WcaE	G	Carbohydrate transport and metabolism	19	20	0.95
OG0002123	COG4583	Sarcosine oxidase gamma subunit	SoxG	E	Amino acid transport and metabolism	20	20	1
OG0002126	COG4095	Sugar transporter, SemiSWEET family, contains PQ motif	SWEET	G	Carbohydrate transport and metabolism	20	20	1
OG0002128	COG0323	DNA mismatch repair ATPase MutL	MutL	L	Replication, recombination and repair	4	20	0.2
OG0002128	COG2972	Sensor histidine kinase YesM	YesM	T	Signal transduction mechanisms	2	20	0.1
OG0002128	COG3290	Sensor histidine kinase DipB regulating citrate/malate metabolism	CitA	T	Signal transduction mechanisms	1	20	0.05
OG0002128	COG5000	Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation	NtrY	T	Signal transduction mechanisms	1	20	0.05
OG0002129	COG1135	ABC-type methionine transport system, ATPase component	AbcC	E	Amino acid transport and metabolism	1	20	0.05
OG0002129	COG4103	Tellurite/oxyanion resistance protein, TerB superfamily	TerB2	P	Inorganic ion transport and metabolism	1	20	0.05
OG0002130	COG0612	Predicted Zn-dependent peptidase, M16 family	PqqL	R	General function prediction only	20	20	1
OG0002136	COG3818	Predicted N-acetyltransferase, GNAT superfamily	NA	R	General function prediction only	20	20	1
OG0002137	COG0824	Acyl-CoA thioesterase FadM	FadM	I	Lipid transport and metabolism	20	20	1
OG0002139	COG1055	Na+/H+ antiporter NhaD or related arsenite permease	ArsB	P	Inorganic ion transport and metabolism	20	20	1
OG0002142	COG3386	Sugar lactone lactonase YvrE	YvrE	G	Carbohydrate transport and metabolism	20	20	1
OG0002143	COG2121	Uncharacterized conserved protein, lysophospholipid acyltransferase (LPLAT) superfamily	NA	S	Function unknown	20	20	1
OG0002144	COG2866	Murein tripeptide amidase MpaA	MpaA	M	Cell wall/membrane/envelope biogenesis	19	20	0.95
OG0002145	COG1816	Adenosine/6-amino-6-deoxyfutalosine deaminase	Add	F	Nucleotide transport and metabolism	20	20	1
OG0002146	COG0439	Biotin carboxylase	AccC	I	Lipid transport and metabolism	18	20	0.9
OG0002146	COG3919	Predicted ATP-dependent carboligase, ATP-grasp superfamily	NA	R	General function prediction only	1	20	0.05
OG0002147	COG3210	Large exoprotein involved in heme utilization or adhesion	FhaB	U	Intracellular trafficking, secretion, and vesicular transport	4	20	0.2
OG0002147	COG3468	Autotransporter adhesin AidA	AidA	M	Cell wall/membrane/envelope biogenesis	3	20	0.15
OG0002147	COG4625	Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain	NA	S	Function unknown	1	20	0.05
OG0002150	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	AdhE	I	Lipid transport and metabolism	20	20	1
OG0002151	COG4642	Uncharacterized conserved protein, contains MORN repeats	NA	R	General function prediction only	12	20	0.6
OG0002153	COG0317	(p)ppGpp synthase/hydrolase, HD superfamily	SpoT	T	Signal transduction mechanisms	19	20	0.95
OG0002154	COG1694	NTP pyrophosphatase, house-cleaning of non-canonical NTPs	MazG	V	Defense mechanisms	20	20	1
OG0002155	COG0156	7-keto-8-aminopelargonate synthetase or related enzyme	BioF	H	Coenzyme transport and metabolism	20	20	1
OG0002156	COG0010	Arginase/agmatinase family enzyme	SpeB	E	Amino acid transport and metabolism	19	19	1
OG0002160	COG2202	PAS domain	PAS	T	Signal transduction mechanisms	1	19	0.05263157894736842
OG0002162	COG2244	Membrane protein involved in the export of O-antigen and teichoic acid	RfbX	M	Cell wall/membrane/envelope biogenesis	19	19	1
OG0002164	COG1196	Chromosome segregation ATPase Smc	Smc	D	Cell cycle control, cell division, chromosome partitioning	3	19	0.15789473684210525
OG0002164	COG1579	Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain	DR0291	R	General function prediction only	3	19	0.15789473684210525
OG0002164	COG4942	Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB	EnvC	D	Cell cycle control, cell division, chromosome partitioning	3	19	0.15789473684210525
OG0002166	COG1887	CDP-glycerol glycerophosphotransferase, TagB/SpsB family	TagB	M	Cell wall/membrane/envelope biogenesis	5	19	0.2631578947368421
OG0002167	COG2755	Lysophospholipase L1 or related esterase. Includes spore coat protein LipC/YcsK	TesA	D	Cell cycle control, cell division, chromosome partitioning	10	19	0.5263157894736842
OG0002169	COG0584	Glycerophosphoryl diester phosphodiesterase	UgpQ	I	Lipid transport and metabolism	1	19	0.05263157894736842
OG0002171	COG0707	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase	MurG	M	Cell wall/membrane/envelope biogenesis	3	19	0.15789473684210525
OG0002171	COG4671	Glycosyl transferase family 28 C-terminal domain	GT28C	G	Carbohydrate transport and metabolism	5	19	0.2631578947368421
OG0002174	COG3063	Type IV pilus assembly pilotin PilF, contains TPR repeats	PilF	N	Cell motility	1	19	0.05263157894736842
OG0002174	COG4235	Cytochrome c-type biogenesis protein CcmH/NrfG	NrfG	C	Energy production and conversion	3	19	0.15789473684210525
OG0002174	COG4783	Periplasmic chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains	BepA	M	Cell wall/membrane/envelope biogenesis	15	19	0.7894736842105263
OG0002175	COG1670	Protein N-acetyltransferase, RimJ/RimL family	RimL	J	Translation, ribosomal structure and biogenesis	12	19	0.631578947368421
OG0002176	COG3391	DNA-binding beta-propeller fold protein YncE	YncE	R	General function prediction only	3	19	0.15789473684210525
OG0002178	COG2514	Catechol-2,3-dioxygenase	CatE	Q	Secondary metabolites biosynthesis, transport and catabolism	19	19	1
OG0002180	COG3332	Uncharacterized stress-responsive protein, TANGO2 (Transport and Golgi organisation 2) family, contains NRDE motif	Tango2	R	General function prediction only	19	19	1
OG0002181	COG3568	Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family	ElsH	R	General function prediction only	19	19	1
OG0002182	COG0859	ADP-heptose:LPS heptosyltransferase	RfaF	M	Cell wall/membrane/envelope biogenesis	3	19	0.15789473684210525
OG0002185	COG2079	2-methylcitrate dehydratase PrpD	PrpD	G	Carbohydrate transport and metabolism	19	19	1
OG0002186	COG0243	Anaerobic selenocysteine-containing dehydrogenase	BisC	C	Energy production and conversion	19	19	1
OG0002189	COG2391	Uncharacterized membrane protein YedE/YeeE, contains two sulfur transport domains	YedE	R	General function prediction only	8	19	0.42105263157894735
OG0002190	COG3481	3'-5' exoribonuclease YhaM, can participate in 23S rRNA maturation,  HD superfamily	YhaM	J	Translation, ribosomal structure and biogenesis	1	19	0.05263157894736842
OG0002192	COG5490	Polyhydroxyalkanoate inclusion-associated protein PhaP/PhaF, phasin family	Phasin	Q	Secondary metabolites biosynthesis, transport and catabolism	19	19	1
OG0002195	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	4	18	0.2222222222222222
OG0002195	COG5322	Predicted acyl-ACP reductase	NA	R	General function prediction only	1	18	0.05555555555555555
OG0002196	COG4664	TRAP-type mannitol/chloroaromatic compound transport system, large permease component	FcbT3	Q	Secondary metabolites biosynthesis, transport and catabolism	18	18	1
OG0002197	COG0399	dTDP-4-amino-4,6-dideoxygalactose transaminase	WecE	M	Cell wall/membrane/envelope biogenesis	18	18	1
OG0002199	COG0559	Branched-chain amino acid ABC-type transport system, permease component	LivH	E	Amino acid transport and metabolism	18	18	1
OG0002200	COG0859	ADP-heptose:LPS heptosyltransferase	RfaF	M	Cell wall/membrane/envelope biogenesis	18	18	1
OG0002201	COG1525	Endonuclease YncB, thermonuclease family	YncB	L	Replication, recombination and repair	18	18	1
OG0002204	COG1904	Glucuronate isomerase	UxaC	G	Carbohydrate transport and metabolism	2	18	0.1111111111111111
OG0002204	COG3883	Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO	CwlO1	S	Function unknown	1	18	0.05555555555555555
OG0002205	COG0793	C-terminal processing protease CtpA/Prc, contains a PDZ domain	CtpA	O	Posttranslational modification, protein turnover, chaperones	1	18	0.05555555555555555
OG0002206	COG0553	Superfamily II DNA or RNA helicase, SNF2 family	HepA	K	Transcription	18	18	1
OG0002207	COG0265	Periplasmic serine protease DegP/DegQ, contain C-terminal PDZ domain	DegQ	O	Posttranslational modification, protein turnover, chaperones	5	18	0.2777777777777778
OG0002207	COG0750	Membrane-associated protease RseP, regulator of RpoE activity	RseP	O	Posttranslational modification, protein turnover, chaperones	1	18	0.05555555555555555
OG0002207	COG4103	Tellurite/oxyanion resistance protein, TerB superfamily	TerB2	P	Inorganic ion transport and metabolism	6	18	0.3333333333333333
OG0002210	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	RpoE	K	Transcription	1	18	0.05555555555555555
OG0002210	COG3311	DNA-binding transcriptional regulator AlpA	AlpA	K	Transcription	3	18	0.16666666666666666
OG0002211	COG2827	Predicted endonuclease, GIY-YIG superfamily	YhbQ	L	Replication, recombination and repair	6	18	0.3333333333333333
OG0002213	COG1014	Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, gamma subunit	PorC	C	Energy production and conversion	18	18	1
OG0002215	COG5349	Uncharacterized conserved protein, DUF983 family	NA	S	Function unknown	18	18	1
OG0002216	COG0300	Short-chain dehydrogenase	YqjQ	R	General function prediction only	4	18	0.2222222222222222
OG0002216	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	FabG	I	Lipid transport and metabolism	14	18	0.7777777777777778
OG0002217	COG1178	ABC-type Fe3+ transport system, permease component	FbpB	P	Inorganic ion transport and metabolism	18	18	1
OG0002219	COG3931	Predicted N-formylglutamate amidohydrolase	HutG2	E	Amino acid transport and metabolism	18	18	1
OG0002221	COG0625	Glutathione S-transferase or stringent starvation protein SspA	GstA	O	Posttranslational modification, protein turnover, chaperones	18	18	1
OG0002222	COG1566	Multidrug resistance efflux pump EmrA	EmrA	V	Defense mechanisms	18	18	1
OG0002223	COG4667	Predicted phospholipase, patatin/cPLA2 family	YjjU	I	Lipid transport and metabolism	18	18	1
OG0002224	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	2	18	0.1111111111111111
OG0002224	COG1887	CDP-glycerol glycerophosphotransferase, TagB/SpsB family	TagB	M	Cell wall/membrane/envelope biogenesis	1	18	0.05555555555555555
OG0002226	COG0737	2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'- or 3'-nucleotidase, 5'-nucleotidase family	UshA	F	Nucleotide transport and metabolism	18	18	1
OG0002227	COG0189	Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily	LysX	E	Amino acid transport and metabolism	18	18	1
OG0002231	COG0726	Peptidoglycan/xylan/chitin deacetylase, PgdA/NodB/CDA1 family	PgaB	G	Carbohydrate transport and metabolism	5	18	0.2777777777777778
OG0002232	COG1196	Chromosome segregation ATPase Smc	Smc	D	Cell cycle control, cell division, chromosome partitioning	2	18	0.1111111111111111
OG0002232	COG1340	Uncharacterized coiled-coil protein, contains DUF342 domain	NA	S	Function unknown	1	18	0.05555555555555555
OG0002232	COG1579	Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain	DR0291	R	General function prediction only	2	18	0.1111111111111111
OG0002232	COG3883	Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO	CwlO1	S	Function unknown	6	18	0.3333333333333333
OG0002232	COG4913	Uncharacterized conserved protein, contains a C-terminal ATPase domain	NA	S	Function unknown	1	18	0.05555555555555555
OG0002232	COG4942	Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB	EnvC	D	Cell cycle control, cell division, chromosome partitioning	5	18	0.2777777777777778
OG0002234	COG0202	DNA-directed RNA polymerase, alpha subunit/40 kD subunit	RpoA	K	Transcription	14	18	0.7777777777777778
OG0002234	COG0568	DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32)	RpoD	K	Transcription	3	18	0.16666666666666666
OG0002235	COG0382	4-hydroxybenzoate polyprenyltransferase	UbiA	H	Coenzyme transport and metabolism	15	18	0.8333333333333334
OG0002237	COG0672	High-affinity Fe2+/Pb2+ permease	FTR1	P	Inorganic ion transport and metabolism	18	18	1
OG0002238	COG3243	Poly-beta-hydroxybutyrate synthase	PhaC	I	Lipid transport and metabolism	18	18	1
OG0002239	COG4227	Antirestriction protein ArdC	ArdC	L	Replication, recombination and repair	1	18	0.05555555555555555
OG0002240	COG0246	Mannitol-1-phosphate/altronate dehydrogenases	MtlD	G	Carbohydrate transport and metabolism	18	18	1
OG0002243	COG4642	Uncharacterized conserved protein, contains MORN repeats	NA	R	General function prediction only	9	17	0.5294117647058824
OG0002244	COG0446	Coenzyme A disulfide reductase or related oxidoreductase, NAD(P)H-disulfide oxidoreductase family	Cdr	H	Coenzyme transport and metabolism	17	17	1
OG0002245	COG0501	Zn-dependent protease with chaperone function	HtpX	O	Posttranslational modification, protein turnover, chaperones	17	17	1
OG0002246	COG0454	N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2)	PhnO	K	Transcription	1	17	0.058823529411764705
OG0002246	COG0456	Ribosomal protein S18 acetylase RimI and related acetyltransferases	RimI	J	Translation, ribosomal structure and biogenesis	13	17	0.7647058823529411
OG0002246	COG1246	N-acetylglutamate synthase or related acetyltransferase, GNAT family	ArgA	E	Amino acid transport and metabolism	1	17	0.058823529411764705
OG0002248	COG3306	Glycosyltransferase involved in LPS biosynthesis, GR25 family	NA	M	Cell wall/membrane/envelope biogenesis	17	17	1
OG0002249	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	1	17	0.058823529411764705
OG0002250	COG4852	Uncharacterized membrane protein	NA	S	Function unknown	17	17	1
OG0002251	COG3268	Uncharacterized conserved protein, related to short-chain dehydrogenases	NA	S	Function unknown	17	17	1
OG0002252	COG4143	ABC-type thiamine transport system, periplasmic component TbpA	TbpA	H	Coenzyme transport and metabolism	17	17	1
OG0002253	COG2262	50S ribosomal subunit-associated GTPase HflX	HflX	J	Translation, ribosomal structure and biogenesis	17	17	1
OG0002254	COG2831	Two-partner (type Vb) secretion system  protein, HlyB/FhaC/ShlB/HecB family	FhaC	U	Intracellular trafficking, secretion, and vesicular transport	17	17	1
OG0002255	COG0210	Superfamily I DNA or RNA helicase	UvrD	L	Replication, recombination and repair	1	17	0.058823529411764705
OG0002255	COG1204	Replicative superfamily II helicase	BRR2	L	Replication, recombination and repair	2	17	0.11764705882352941
OG0002255	COG3972	Superfamily I DNA and RNA helicases	NA	L	Replication, recombination and repair	14	17	0.8235294117647058
OG0002258	COG1178	ABC-type Fe3+ transport system, permease component	FbpB	P	Inorganic ion transport and metabolism	1	17	0.058823529411764705
OG0002258	COG2433	Possible nuclease of RNase H fold, RuvC/YqgF family	NA	R	General function prediction only	1	17	0.058823529411764705
OG0002258	COG3206	Tyrosine-protein kinase Wzc involved in exopolysaccharide export, GumC/Wzc1 domain	GumC	M	Cell wall/membrane/envelope biogenesis	2	17	0.11764705882352941
OG0002258	COG3883	Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO	CwlO1	S	Function unknown	4	17	0.23529411764705882
OG0002264	COG0579	L-2-hydroxyglutarate oxidase LhgO	LhgO	G	Carbohydrate transport and metabolism	12	17	0.7058823529411765
OG0002264	COG0665	Glycine/D-amino acid oxidase (deaminating)	DadA	E	Amino acid transport and metabolism	5	17	0.29411764705882354
OG0002265	COG1637	Endonuclease NucS, RecB family	NucS	L	Replication, recombination and repair	2	17	0.11764705882352941
OG0002269	COG4380	Uncharacterized conserved protein, DUF799 domain	NA	S	Function unknown	2	16	0.125
OG0002270	COG0363	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase	NagB	G	Carbohydrate transport and metabolism	16	16	1
OG0002271	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	HisJ	E	Amino acid transport and metabolism	16	16	1
OG0002275	COG0613	5'-3' exoribonuclease/diribonuclease TrpH/YciV (RNase AM), contains PHP domain	YciV	A	RNA processing and modification	15	16	0.9375
OG0002276	COG2274	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain	SunT	V	Defense mechanisms	15	16	0.9375
OG0002276	COG4618	ABC-type protease/lipase transport system, ATPase and permease components	ArpD	U	Intracellular trafficking, secretion, and vesicular transport	1	16	0.0625
OG0002277	COG0687	Spermidine/putrescine-binding periplasmic protein	PotD	E	Amino acid transport and metabolism	16	16	1
OG0002279	COG0529	Adenylylsulfate kinase or related kinase	CysC	P	Inorganic ion transport and metabolism	1	16	0.0625
OG0002279	COG2755	Lysophospholipase L1 or related esterase. Includes spore coat protein LipC/YcsK	TesA	D	Cell cycle control, cell division, chromosome partitioning	6	16	0.375
OG0002281	COG1426	Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains	RodZ	D	Cell cycle control, cell division, chromosome partitioning	15	16	0.9375
OG0002282	COG0053	Divalent metal cation (Fe/Co/Zn/Cd) efflux pump	FieF	P	Inorganic ion transport and metabolism	16	16	1
OG0002284	COG0142	Geranylgeranyl pyrophosphate synthase	IspA	H	Coenzyme transport and metabolism	1	16	0.0625
OG0002285	COG2453	Protein-tyrosine phosphatase	CDC14	T	Signal transduction mechanisms	16	16	1
OG0002287	COG1011	FMN and 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YigB, HAD superfamily (riboflavin biosynthesis)	YigB	H	Coenzyme transport and metabolism	12	16	0.75
OG0002288	COG4230	Delta 1-pyrroline-5-carboxylate dehydrogenase	PutA2	E	Amino acid transport and metabolism	16	16	1
OG0002289	COG2271	Sugar phosphate permease	UhpC	G	Carbohydrate transport and metabolism	16	16	1
OG0002290	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	15	15	1
OG0002291	COG1887	CDP-glycerol glycerophosphotransferase, TagB/SpsB family	TagB	M	Cell wall/membrane/envelope biogenesis	1	15	0.06666666666666667
OG0002292	COG5829	Stage III sporulation protein SpoIIIAH, component of the engulfment complex	SpoIIIAH	D	Cell cycle control, cell division, chromosome partitioning	1	15	0.06666666666666667
OG0002294	COG0614	ABC-type Fe3+-hydroxamate transport system, periplasmic component	FepB	P	Inorganic ion transport and metabolism	15	15	1
OG0002295	COG1764	Organic hydroperoxide reductase OsmC/OhrA	OsmC	V	Defense mechanisms	15	15	1
OG0002296	COG1696	D-alanyl-lipoteichoic acid acyltransferase DltB, MBOAT superfamily	DltB	M	Cell wall/membrane/envelope biogenesis	15	15	1
OG0002297	COG0433	Crenarchaeal DNA import helicase CedB/HerA or a related bacterial ATPase	CedB	L	Replication, recombination and repair	15	15	1
OG0002299	COG3317	Outer membrane protein assembly factor BamC	BamC	M	Cell wall/membrane/envelope biogenesis	1	15	0.06666666666666667
OG0002299	COG4105	Outer membrane protein assembly factor BamD, BamD/ComL family	BamD	M	Cell wall/membrane/envelope biogenesis	1	15	0.06666666666666667
OG0002299	COG5633	Uncharacterized conserved protein YcfL	YcfL	S	Function unknown	1	15	0.06666666666666667
OG0002300	COG1403	HNH family endonuclease, includes 5-methylcytosine-specific restriction endonuclease McrA	McrA	V	Defense mechanisms	1	15	0.06666666666666667
OG0002302	COG1221	Transcriptional regulators containing sigma54-interacting ATPase domain	PspF	K	Transcription	2	15	0.13333333333333333
OG0002302	COG1368	Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily	MdoB	M	Cell wall/membrane/envelope biogenesis	11	15	0.7333333333333333
OG0002304	COG1280	Threonine/homoserine/homoserine lactone efflux protein	RhtB	E	Amino acid transport and metabolism	1	15	0.06666666666666667
OG0002304	COG1287	Asparagine N-glycosylation enzyme, membrane subunit Stt3	Stt3	O	Posttranslational modification, protein turnover, chaperones	1	15	0.06666666666666667
OG0002304	COG2271	Sugar phosphate permease	UhpC	G	Carbohydrate transport and metabolism	1	15	0.06666666666666667
OG0002307	COG1247	L-amino acid N-acyltransferase MnaT	MnaT	E	Amino acid transport and metabolism	1	15	0.06666666666666667
OG0002310	COG0673	Predicted dehydrogenase	MviM	R	General function prediction only	7	15	0.4666666666666667
OG0002311	COG4485	Uncharacterized membrane protein YfhO	YfhO	S	Function unknown	10	15	0.6666666666666666
OG0002313	COG1112	Superfamily I DNA and/or RNA helicase	DNA2	L	Replication, recombination and repair	11	15	0.7333333333333333
OG0002313	COG2378	Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains	YobV	K	Transcription	4	15	0.26666666666666666
OG0002314	COG1396	Transcriptional regulator, contains XRE-family HTH domain	HipB	K	Transcription	2	15	0.13333333333333333
OG0002314	COG1476	DNA-binding transcriptional regulator, XRE-family HTH domain	XRE	K	Transcription	2	15	0.13333333333333333
OG0002314	COG1813	Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains	aMBF1	J	Translation, ribosomal structure and biogenesis	1	15	0.06666666666666667
OG0002315	COG0369	Flavoprotein (flavin reductase) subunit CysJ of sulfite and N-hydroxylaminopurine reductases	CysJ	F	Nucleotide transport and metabolism	15	15	1
OG0002316	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	11	15	0.7333333333333333
OG0002317	COG1917	Cupin domain protein related to quercetin dioxygenase	QdoI	R	General function prediction only	15	15	1
OG0002319	COG0739	Murein endopeptidase or hydrolase activator MepM/NlpD, contains LysM domain	NlpD	M	Cell wall/membrane/envelope biogenesis	2	15	0.13333333333333333
OG0002320	COG3883	Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO	CwlO1	S	Function unknown	5	15	0.3333333333333333
OG0002322	COG0685	5,10-methylenetetrahydrofolate reductase	MetF	E	Amino acid transport and metabolism	15	15	1
OG0002323	COG2520	tRNA G37 N1-methylase Trm5	Trm5	J	Translation, ribosomal structure and biogenesis	8	14	0.5714285714285714
OG0002323	COG2813	16S rRNA G1207 or 23S rRNA G1835 methylase RsmC/RlmG	RsmC	J	Translation, ribosomal structure and biogenesis	2	14	0.14285714285714285
OG0002323	COG4076	Predicted RNA methylase	NA	R	General function prediction only	1	14	0.07142857142857142
OG0002323	COG4123	tRNA1(Val) A37 N6-methylase TrmN6	TrmN6	J	Translation, ribosomal structure and biogenesis	1	14	0.07142857142857142
OG0002324	COG1525	Endonuclease YncB, thermonuclease family	YncB	L	Replication, recombination and repair	14	14	1
OG0002327	COG2755	Lysophospholipase L1 or related esterase. Includes spore coat protein LipC/YcsK	TesA	D	Cell cycle control, cell division, chromosome partitioning	4	14	0.2857142857142857
OG0002329	COG5653	Acetyltransferase involved in cellulose biosynthesis, CelD/BcsL family	BcsL	N	Cell motility	14	14	1
OG0002330	COG4974	Site-specific tyrosine recombinase XerD	XerD	L	Replication, recombination and repair	11	14	0.7857142857142857
OG0002331	COG0329	4-hydroxy-tetrahydrodipicolinate synthase/N-acetylneuraminate lyase	DapA	E	Amino acid transport and metabolism	13	14	0.9285714285714286
OG0002332	COG5285	Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family	PhyH	Q	Secondary metabolites biosynthesis, transport and catabolism	9	14	0.6428571428571429
OG0002333	COG3440	Predicted restriction endonuclease	NA	V	Defense mechanisms	13	14	0.9285714285714286
OG0002334	COG1082	Sugar phosphate isomerase/epimerase	YcjR	G	Carbohydrate transport and metabolism	14	14	1
OG0002335	COG1442	Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase	RfaJ	M	Cell wall/membrane/envelope biogenesis	1	14	0.07142857142857142
OG0002335	COG3754	Lipopolysaccharide biosynthesis protein	RgpF	M	Cell wall/membrane/envelope biogenesis	1	14	0.07142857142857142
OG0002337	COG2267	Lysophospholipase, alpha-beta hydrolase superfamily	PldB	I	Lipid transport and metabolism	12	14	0.8571428571428571
OG0002337	COG2945	Alpha/beta superfamily hydrolase	NA	R	General function prediction only	2	14	0.14285714285714285
OG0002338	COG1778	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC and related HAD superfamily phosphatases	KdsC	M	Cell wall/membrane/envelope biogenesis	13	14	0.9285714285714286
OG0002339	COG1221	Transcriptional regulators containing sigma54-interacting ATPase domain	PspF	K	Transcription	1	14	0.07142857142857142
OG0002339	COG3292	Periplasmic ligand-binding sensor domain	NA	T	Signal transduction mechanisms	2	14	0.14285714285714285
OG0002341	COG1621	Sucrose-6-phosphate hydrolase SacC, GH32 family	SacC	G	Carbohydrate transport and metabolism	3	14	0.21428571428571427
OG0002341	COG2152	Predicted glycosyl hydrolase, GH43/DUF377 family	NA	G	Carbohydrate transport and metabolism	8	14	0.5714285714285714
OG0002341	COG3507	Beta-xylosidase	XynB2	G	Carbohydrate transport and metabolism	2	14	0.14285714285714285
OG0002342	COG0535	Radical SAM superfamily maturase, SkfB/NifB/PqqE family	SkfB	D	Cell cycle control, cell division, chromosome partitioning	14	14	1
OG0002344	COG2604	Uncharacterized conserved protein	NA	S	Function unknown	2	14	0.14285714285714285
OG0002345	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	1	14	0.07142857142857142
OG0002345	COG1246	N-acetylglutamate synthase or related acetyltransferase, GNAT family	ArgA	E	Amino acid transport and metabolism	1	14	0.07142857142857142
OG0002350	COG1368	Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily	MdoB	M	Cell wall/membrane/envelope biogenesis	1	14	0.07142857142857142
OG0002350	COG4485	Uncharacterized membrane protein YfhO	YfhO	S	Function unknown	1	14	0.07142857142857142
OG0002353	COG0175	Phosphoadenylyl sulfate (PAPS) reductase/FAD synthetase or related enzyme	CysH	E	Amino acid transport and metabolism	14	14	1
OG0002355	COG2164	Uncharacterized protein with cyclophilin fold, contains DUF369 domain	NA	R	General function prediction only	13	14	0.9285714285714286
OG0002356	COG2390	DNA-binding transcriptional regulator LsrR, DeoR family	DeoR	K	Transcription	14	14	1
OG0002358	COG3205	Uncharacterized membrane protein, DUF2061 family	NA	S	Function unknown	1	13	0.07692307692307693
OG0002360	COG2251	Predicted nuclease, RecB family	NA	R	General function prediction only	6	13	0.46153846153846156
OG0002362	COG4938	Predicted ATPase	NA	R	General function prediction only	13	13	1
OG0002363	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	12	13	0.9230769230769231
OG0002366	COG0542	ATP-dependent Clp protease, ATP-binding subunit ClpA	ClpA	O	Posttranslational modification, protein turnover, chaperones	1	13	0.07692307692307693
OG0002366	COG2932	Phage repressor protein C, contains Cro/C1-type HTH and peptidase S24 domains	NA	X	Mobilome: prophages, transposons	7	13	0.5384615384615384
OG0002367	COG1221	Transcriptional regulators containing sigma54-interacting ATPase domain	PspF	K	Transcription	1	13	0.07692307692307693
OG0002369	COG0421	Spermidine synthase (polyamine aminopropyltransferase)	SpeE	E	Amino acid transport and metabolism	4	13	0.3076923076923077
OG0002369	COG4262	Predicted spermidine synthase with an N-terminal membrane domain	NA	R	General function prediction only	9	13	0.6923076923076923
OG0002370	COG0673	Predicted dehydrogenase	MviM	R	General function prediction only	6	13	0.46153846153846156
OG0002371	COG1887	CDP-glycerol glycerophosphotransferase, TagB/SpsB family	TagB	M	Cell wall/membrane/envelope biogenesis	2	13	0.15384615384615385
OG0002372	COG1678	Putative transcriptional regulator, AlgH/UPF0301 family	AlgH	K	Transcription	13	13	1
OG0002374	COG1879	ABC-type sugar transport system, periplasmic component, contains N-terminal xre family HTH domain	RbsB	G	Carbohydrate transport and metabolism	13	13	1
OG0002375	COG5749	Chlorophyllide a oxygenase/letal leaf spot protein	PobA	H	Coenzyme transport and metabolism	12	13	0.9230769230769231
OG0002376	COG0500	SAM-dependent methyltransferase SmtA (CmoB moved to COG2228)	SmtA	Q	Secondary metabolites biosynthesis, transport and catabolism	2	13	0.15384615384615385
OG0002376	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	1	13	0.07692307692307693
OG0002377	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	8	13	0.6153846153846154
OG0002382	COG2862	Uncharacterized membrane protein YqhA related to peroxide resistance, UPF0114 family	YqhA	S	Function unknown	13	13	1
OG0002387	COG3788	Uncharacterized membrane protein YecN, MAPEG domain	YecN	S	Function unknown	13	13	1
OG0002388	COG2825	Periplasmic chaperone for outer membrane proteins, Skp/HlpA/OmpH family	Skp	M	Cell wall/membrane/envelope biogenesis	3	13	0.23076923076923078
OG0002388	COG2833	Uncharacterized protein, contains ferritin-like DUF455 domain	NA	S	Function unknown	1	13	0.07692307692307693
OG0002388	COG3188	Outer membrane usher protein FimD/PapC	FimD	N	Cell motility	1	13	0.07692307692307693
OG0002388	COG3203	Outer membrane porin OmpC/OmpF/PhoE	OmpC	M	Cell wall/membrane/envelope biogenesis	1	13	0.07692307692307693
OG0002389	COG0300	Short-chain dehydrogenase	YqjQ	R	General function prediction only	1	12	0.08333333333333333
OG0002389	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	10	12	0.8333333333333334
OG0002390	COG0399	dTDP-4-amino-4,6-dideoxygalactose transaminase	WecE	M	Cell wall/membrane/envelope biogenesis	12	12	1
OG0002391	COG3056	Uncharacterized lipoprotein YajG	YajG	S	Function unknown	1	12	0.08333333333333333
OG0002392	COG0038	H+/Cl- antiporter ClcA	ClcA	P	Inorganic ion transport and metabolism	3	12	0.25
OG0002392	COG3597	Uncharacterized conserved protein, DUF697 family	NA	S	Function unknown	4	12	0.3333333333333333
OG0002393	COG0569	Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain	TrkA	P	Inorganic ion transport and metabolism	1	12	0.08333333333333333
OG0002397	COG1887	CDP-glycerol glycerophosphotransferase, TagB/SpsB family	TagB	M	Cell wall/membrane/envelope biogenesis	1	12	0.08333333333333333
OG0002399	COG2239	Mg/Co/Ni transporter MgtE (contains CBS domain)	MgtE	P	Inorganic ion transport and metabolism	2	12	0.16666666666666666
OG0002401	COG2755	Lysophospholipase L1 or related esterase. Includes spore coat protein LipC/YcsK	TesA	D	Cell cycle control, cell division, chromosome partitioning	9	12	0.75
OG0002403	COG4529	Uncharacterized NAD(P)/FAD-binding protein YdhS	YdhS	R	General function prediction only	1	12	0.08333333333333333
OG0002404	COG4638	Phenylpropionate dioxygenase or related ring-hydroxylating dioxygenase, large terminal subunit	HcaE	P	Inorganic ion transport and metabolism	1	12	0.08333333333333333
OG0002410	COG1172	Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component	AraH	G	Carbohydrate transport and metabolism	11	12	0.9166666666666666
OG0002412	COG2863	Cytochrome c553	CytC553	C	Energy production and conversion	12	12	1
OG0002414	COG5342	Invasion protein IalB, involved in pathogenesis	IalB	R	General function prediction only	11	12	0.9166666666666666
OG0002419	COG1783	Phage terminase large subunit	XtmB	X	Mobilome: prophages, transposons	10	12	0.8333333333333334
OG0002419	COG4626	Phage terminase-like protein, large subunit, contains N-terminal HTH domain	YmfN	X	Mobilome: prophages, transposons	1	12	0.08333333333333333
OG0002420	COG0579	L-2-hydroxyglutarate oxidase LhgO	LhgO	G	Carbohydrate transport and metabolism	4	12	0.3333333333333333
OG0002421	COG1807	PMT family glycosyltransferase ArnT/Agl22, involved in glycosylation of proteins and lipid IVA	ArnT	M	Cell wall/membrane/envelope biogenesis	2	12	0.16666666666666666
OG0002421	COG2211	Na+/melibiose symporter or related transporter	MelB	G	Carbohydrate transport and metabolism	2	12	0.16666666666666666
OG0002422	COG3133	Outer membrane lipoprotein SlyB	SlyB	M	Cell wall/membrane/envelope biogenesis	12	12	1
OG0002426	COG2244	Membrane protein involved in the export of O-antigen and teichoic acid	RfbX	M	Cell wall/membrane/envelope biogenesis	9	12	0.75
OG0002427	COG2421	Acetamidase/formamidase	FmdA	C	Energy production and conversion	12	12	1
OG0002429	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	2	12	0.16666666666666666
OG0002431	COG0662	Mannose-6-phosphate isomerase, cupin superfamily	ManC	G	Carbohydrate transport and metabolism	4	12	0.3333333333333333
OG0002431	COG1917	Cupin domain protein related to quercetin dioxygenase	QdoI	R	General function prediction only	8	12	0.6666666666666666
OG0002433	COG4391	Uncharacterized protein, contains Zn-finger domain	NA	S	Function unknown	1	12	0.08333333333333333
OG0002435	COG2961	23S rRNA A2030 N6-methylase RlmJ	RlmJ	J	Translation, ribosomal structure and biogenesis	12	12	1
OG0002437	COG2346	Truncated hemoglobin YjbI	YjbI	P	Inorganic ion transport and metabolism	9	12	0.75
OG0002439	COG1011	FMN and 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YigB, HAD superfamily (riboflavin biosynthesis)	YigB	H	Coenzyme transport and metabolism	12	12	1
OG0002444	COG0576	Molecular chaperone GrpE (heat shock protein HSP-70)	GrpE	O	Posttranslational modification, protein turnover, chaperones	2	11	0.18181818181818182
OG0002444	COG3166	Type II secretion system/type IV pilus alignment protein GspM/PulM/PilN	GspM/PilN	N	Cell motility	1	11	0.09090909090909091
OG0002444	COG3883	Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO	CwlO1	S	Function unknown	5	11	0.45454545454545453
OG0002445	COG3440	Predicted restriction endonuclease	NA	V	Defense mechanisms	1	11	0.09090909090909091
OG0002447	COG1442	Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase	RfaJ	M	Cell wall/membrane/envelope biogenesis	3	11	0.2727272727272727
OG0002449	COG4995	Uncharacterized conserved protein, contains CHAT domain	NA	S	Function unknown	10	11	0.9090909090909091
OG0002452	COG1680	CubicO group peptidase, beta-lactamase class C family	AmpC	V	Defense mechanisms	11	11	1
OG0002455	COG0210	Superfamily I DNA or RNA helicase	UvrD	L	Replication, recombination and repair	2	11	0.18181818181818182
OG0002456	COG0635	Coproporphyrinogen-III oxidase HemN  (oxygen-independent) or related Fe-S oxidoreductase	HemN	H	Coenzyme transport and metabolism	11	11	1
OG0002457	COG0500	SAM-dependent methyltransferase SmtA (CmoB moved to COG2228)	SmtA	Q	Secondary metabolites biosynthesis, transport and catabolism	1	11	0.09090909090909091
OG0002457	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9	UbiE	H	Coenzyme transport and metabolism	2	11	0.18181818181818182
OG0002457	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	1	11	0.09090909090909091
OG0002458	COG0491	Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II	GloB	R	General function prediction only	11	11	1
OG0002461	COG3255	Putative sterol carrier protein, contains SCP2 domain	SCP2	I	Lipid transport and metabolism	3	11	0.2727272727272727
OG0002462	COG2268	Flotillin family membrane protein YqiK, contains Band7/PHB/SPFH domain	YqiK	R	General function prediction only	10	11	0.9090909090909091
OG0002463	COG0758	Predicted Rossmann fold nucleotide-binding protein DprA/Smf involved in DNA uptake	Smf	L	Replication, recombination and repair	5	11	0.45454545454545453
OG0002464	COG1403	HNH family endonuclease, includes 5-methylcytosine-specific restriction endonuclease McrA	McrA	V	Defense mechanisms	10	11	0.9090909090909091
OG0002465	COG0537	Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family	HinT	F	Nucleotide transport and metabolism	4	11	0.36363636363636365
OG0002467	COG2515	1-aminocyclopropane-1-carboxylate deaminase/D-cysteine desulfhydrase, PLP-dependent ACC family	Acd	E	Amino acid transport and metabolism	11	11	1
OG0002470	COG0457	Tetratricopeptide (TPR) repeat	TPR	R	General function prediction only	6	11	0.5454545454545454
OG0002470	COG4785	Lipoprotein NlpI, contains TPR repeats	NlpI	M	Cell wall/membrane/envelope biogenesis	5	11	0.45454545454545453
OG0002474	COG1659	Bacteriocin, linocin/CFP29 family	CFP29	V	Defense mechanisms	4	11	0.36363636363636365
OG0002477	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	AdhE	I	Lipid transport and metabolism	11	11	1
OG0002478	COG0749	DNA polymerase I, 3'-5' exonuclease and polymerase domains	PolA	L	Replication, recombination and repair	11	11	1
OG0002479	COG3637	Opacity protein LomR and related surface antigens	LomR	M	Cell wall/membrane/envelope biogenesis	8	11	0.7272727272727273
OG0002481	COG1321	Mn-dependent transcriptional regulator MntR, DtxR family	MntR	K	Transcription	11	11	1
OG0002482	COG5126	Ca2+-binding protein, EF-hand superfamily	FRQ1	T	Signal transduction mechanisms	11	11	1
OG0002484	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9	UbiE	H	Coenzyme transport and metabolism	11	11	1
OG0002486	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	7	10	0.7
OG0002487	COG0861	Tellurite resistance membrane protein TerC	TerC	P	Inorganic ion transport and metabolism	10	10	1
OG0002488	COG0337	3-dehydroquinate synthetase	AroB	E	Amino acid transport and metabolism	10	10	1
OG0002489	COG5410	Uncharacterized domain, often fused with C-terminal phage terminase domain	NA	X	Mobilome: prophages, transposons	10	10	1
OG0002491	COG0358	DNA primase (bacterial type)	DnaG	L	Replication, recombination and repair	3	10	0.3
OG0002491	COG0467	RecA-superfamily ATPase, KaiC/GvpD/RAD55 family	RAD55	T	Signal transduction mechanisms	7	10	0.7
OG0002492	COG0749	DNA polymerase I, 3'-5' exonuclease and polymerase domains	PolA	L	Replication, recombination and repair	10	10	1
OG0002493	COG0258	5'-3' exonuclease Xni/ExoIX (flap endonuclease)	ExoIX	L	Replication, recombination and repair	10	10	1
OG0002494	COG2348	Lipid II:glycine glycyltransferase (Peptidoglycan interpeptide bridge formation enzyme)	FmhB	M	Cell wall/membrane/envelope biogenesis	8	10	0.8
OG0002495	COG0507	ATPase/5'-3' helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V)	RecD	L	Replication, recombination and repair	10	10	1
OG0002496	COG0075	Archaeal aspartate aminotransferase or a related aminotransferase, includes purine catabolism protein PucG	PucG	E	Amino acid transport and metabolism	10	10	1
OG0002498	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	1	10	0.1
OG0002498	COG3836	2-keto-3-deoxy-L-rhamnonate aldolase RhmA	HpcH	G	Carbohydrate transport and metabolism	2	10	0.2
OG0002501	COG2066	Glutaminase	GlsA	E	Amino acid transport and metabolism	10	10	1
OG0002503	COG0749	DNA polymerase I, 3'-5' exonuclease and polymerase domains	PolA	L	Replication, recombination and repair	6	10	0.6
OG0002505	COG0730	Sulfite exporter TauE/SafE/YfcA and related permeases, UPF0721 family	TauE	P	Inorganic ion transport and metabolism	2	10	0.2
OG0002506	COG1100	GTPase SAR1 family domain	Gem1	R	General function prediction only	1	10	0.1
OG0002508	COG1462	Type VIII secretion (curli biogenesis) system outer membrane channel CsgG	CsgG	W	Extracellular structures	10	10	1
OG0002510	COG4338	Uncharacterized conserved protein, DUF2256 family	NA	S	Function unknown	10	10	1
OG0002511	COG1633	Rubrerythrin, includes spore coat protein YhjR	YhjR	P	Inorganic ion transport and metabolism	1	10	0.1
OG0002513	COG3831	WGR domain, predicted DNA-binding domain in MolR	WGR	K	Transcription	10	10	1
OG0002515	COG1221	Transcriptional regulators containing sigma54-interacting ATPase domain	PspF	K	Transcription	1	10	0.1
OG0002518	COG0223	Methionyl-tRNA formyltransferase	Fmt	J	Translation, ribosomal structure and biogenesis	1	10	0.1
OG0002519	COG0622	Mn2+-dependent phosphodiesterase, calcineurin family	YfcE	R	General function prediction only	10	10	1
OG0002523	COG4642	Uncharacterized conserved protein, contains MORN repeats	NA	R	General function prediction only	10	10	1
OG0002526	COG1748	Saccharopine dehydrogenase, NADP-dependent	Lys9	E	Amino acid transport and metabolism	10	10	1
OG0002527	COG3188	Outer membrane usher protein FimD/PapC	FimD	N	Cell motility	1	10	0.1
OG0002528	COG0175	Phosphoadenylyl sulfate (PAPS) reductase/FAD synthetase or related enzyme	CysH	E	Amino acid transport and metabolism	10	10	1
OG0002529	COG0384	Predicted epimerase YddE/YHI9, PhzF superfamily	YHI9	R	General function prediction only	10	10	1
OG0002532	COG0500	SAM-dependent methyltransferase SmtA (CmoB moved to COG2228)	SmtA	Q	Secondary metabolites biosynthesis, transport and catabolism	1	10	0.1
OG0002532	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9	UbiE	H	Coenzyme transport and metabolism	1	10	0.1
OG0002532	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	4	10	0.4
OG0002532	COG4627	Predicted SAM-depedendent methyltransferase	NA	R	General function prediction only	1	10	0.1
OG0002534	COG0792	Predicted endonuclease distantly related to archaeal Holliday junction resolvase, YraN/UPF0102 family	YraN	L	Replication, recombination and repair	3	10	0.3
OG0002535	COG3108	Metallopeptidase MepK/YcbK, cleaves mDAP crosslinks in peptidoglycan, peptidase M15/DUF882 family	YcbK	M	Cell wall/membrane/envelope biogenesis	9	10	0.9
OG0002539	COG1714	Uncharacterized membrane protein YckC, RDD family	YckC	S	Function unknown	10	10	1
OG0002542	COG0251	Enamine deaminase RidA/Endoribonuclease Rid7C, YjgF/YER057c/UK114 family	RidA	V	Defense mechanisms	10	10	1
OG0002544	COG1793	ATP-dependent DNA ligase	LigC	L	Replication, recombination and repair	9	10	0.9
OG0002548	COG1368	Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily	MdoB	M	Cell wall/membrane/envelope biogenesis	1	10	0.1
OG0002548	COG3853	Uncharacterized conserved protein YaaN involved in tellurite resistance	YaaN	V	Defense mechanisms	1	10	0.1
OG0002548	COG4975	Glucose uptake protein GlcU	GlcU	G	Carbohydrate transport and metabolism	1	10	0.1
OG0002549	COG1664	Cytoskeletal protein CcmA, bactofilin family	CcmA	Z	Cytoskeleton	10	10	1
OG0002552	COG3883	Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO	CwlO1	S	Function unknown	3	10	0.3
OG0002554	COG2835	RNA methyltransferase activator Trm112/YbaR	Trm112	J	Translation, ribosomal structure and biogenesis	10	10	1
OG0002555	COG4891	Uncharacterized conserved protein	NA	S	Function unknown	10	10	1
OG0002557	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	6	9	0.6666666666666666
OG0002558	COG1469	GTP cyclohydrolase FolE2	FolE2	H	Coenzyme transport and metabolism	1	9	0.1111111111111111
OG0002560	COG0615	Glycerol-3-phosphate cytidylyltransferase, cytidylyltransferase family	TagD	M	Cell wall/membrane/envelope biogenesis	7	9	0.7777777777777778
OG0002560	COG2513	2-Methylisocitrate lyase and related enzymes, PEP mutase family	PrpB	G	Carbohydrate transport and metabolism	2	9	0.2222222222222222
OG0002562	COG4976	Predicted methyltransferase, contains TPR repeat	NA	R	General function prediction only	1	9	0.1111111111111111
OG0002565	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	1	9	0.1111111111111111
OG0002568	COG0535	Radical SAM superfamily maturase, SkfB/NifB/PqqE family	SkfB	D	Cell cycle control, cell division, chromosome partitioning	9	9	1
OG0002572	COG0582	Integrase/recombinase, includes phage integrase	FimB	L	Replication, recombination and repair	1	9	0.1111111111111111
OG0002572	COG4974	Site-specific tyrosine recombinase XerD	XerD	L	Replication, recombination and repair	8	9	0.8888888888888888
OG0002573	COG3727	G:T-mismatch repair DNA endonuclease Vsr, very short patch repair protein	Vsr	L	Replication, recombination and repair	9	9	1
OG0002575	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	BcsA	N	Cell motility	3	9	0.3333333333333333
OG0002575	COG1216	Glycosyltransferase, GT2 family	WcaE	G	Carbohydrate transport and metabolism	4	9	0.4444444444444444
OG0002578	COG2378	Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains	YobV	K	Transcription	3	9	0.3333333333333333
OG0002580	COG0406	Broad specificity phosphatase PhoE	PhoE	G	Carbohydrate transport and metabolism	9	9	1
OG0002581	COG1809	Phosphosulfolactate synthase, CoM biosynthesis protein A	ComA	H	Coenzyme transport and metabolism	9	9	1
OG0002582	COG1082	Sugar phosphate isomerase/epimerase	YcjR	G	Carbohydrate transport and metabolism	3	9	0.3333333333333333
OG0002584	COG0500	SAM-dependent methyltransferase SmtA (CmoB moved to COG2228)	SmtA	Q	Secondary metabolites biosynthesis, transport and catabolism	7	9	0.7777777777777778
OG0002584	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9	UbiE	H	Coenzyme transport and metabolism	2	9	0.2222222222222222
OG0002585	COG2931	Ca2+-binding protein, RTX toxin-related	NA	Q	Secondary metabolites biosynthesis, transport and catabolism	9	9	1
OG0002589	COG0220	tRNA G46 N7-methylase TrmB	TrmB	J	Translation, ribosomal structure and biogenesis	1	9	0.1111111111111111
OG0002589	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9	UbiE	H	Coenzyme transport and metabolism	1	9	0.1111111111111111
OG0002589	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	2	9	0.2222222222222222
OG0002590	COG2755	Lysophospholipase L1 or related esterase. Includes spore coat protein LipC/YcsK	TesA	D	Cell cycle control, cell division, chromosome partitioning	1	9	0.1111111111111111
OG0002592	COG0367	Asparagine synthetase B (glutamine-hydrolyzing)	AsnB	E	Amino acid transport and metabolism	1	9	0.1111111111111111
OG0002595	COG1881	Uncharacterized protein, putative kinase inhibitor, PEBP/RKIP/YbhB/UPF0098 family	YbhB	R	General function prediction only	1	9	0.1111111111111111
OG0002597	COG1396	Transcriptional regulator, contains XRE-family HTH domain	HipB	K	Transcription	1	9	0.1111111111111111
OG0002597	COG1917	Cupin domain protein related to quercetin dioxygenase	QdoI	R	General function prediction only	1	9	0.1111111111111111
OG0002600	COG4105	Outer membrane protein assembly factor BamD, BamD/ComL family	BamD	M	Cell wall/membrane/envelope biogenesis	1	9	0.1111111111111111
OG0002603	COG1403	HNH family endonuclease, includes 5-methylcytosine-specific restriction endonuclease McrA	McrA	V	Defense mechanisms	9	9	1
OG0002605	COG2225	Malate synthase	AceB	C	Energy production and conversion	9	9	1
OG0002606	COG1622	Heme/copper-type cytochrome/quinol oxidase, subunit 2	CyoA	C	Energy production and conversion	1	9	0.1111111111111111
OG0002607	COG1673	Predicted RNA-binding protein, contains PUA-like EVE domain	NA	R	General function prediction only	6	9	0.6666666666666666
OG0002609	COG1463	Periplasmic subunit MlaD of the ABC-type intermembrane phospholipid transporter Mla	MlaD	M	Cell wall/membrane/envelope biogenesis	1	9	0.1111111111111111
OG0002612	COG0711	FoF1-type ATP synthase, membrane subunit b or b'	AtpF	C	Energy production and conversion	1	9	0.1111111111111111
OG0002612	COG1396	Transcriptional regulator, contains XRE-family HTH domain	HipB	K	Transcription	3	9	0.3333333333333333
OG0002612	COG1579	Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain	DR0291	R	General function prediction only	1	9	0.1111111111111111
OG0002612	COG2825	Periplasmic chaperone for outer membrane proteins, Skp/HlpA/OmpH family	Skp	M	Cell wall/membrane/envelope biogenesis	1	9	0.1111111111111111
OG0002612	COG3398	Predicted transcriptional regulator, contains two HTH domains	NA	K	Transcription	1	9	0.1111111111111111
OG0002616	COG1061	Superfamily II DNA or RNA helicase	SSL2	K	Transcription	9	9	1
OG0002620	COG1359	Quinol monooxygenase YgiN	YgiN	C	Energy production and conversion	9	9	1
OG0002622	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9	UbiE	H	Coenzyme transport and metabolism	1	9	0.1111111111111111
OG0002628	COG4946	Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats	NA	S	Function unknown	1	9	0.1111111111111111
OG0002630	COG5108	Mitochondrial DNA-directed RNA polymerase	RPO41	K	Transcription	8	9	0.8888888888888888
OG0002631	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	8	9	0.8888888888888888
OG0002633	COG2128	Alkylhydroperoxidase family enzyme, contains CxxC motif	YciW	P	Inorganic ion transport and metabolism	9	9	1
OG0002634	COG0582	Integrase/recombinase, includes phage integrase	FimB	L	Replication, recombination and repair	2	9	0.2222222222222222
OG0002634	COG4974	Site-specific tyrosine recombinase XerD	XerD	L	Replication, recombination and repair	7	9	0.7777777777777778
OG0002641	COG0412	Dienelactone hydrolase	DLH	Q	Secondary metabolites biosynthesis, transport and catabolism	7	9	0.7777777777777778
OG0002641	COG1073	Fermentation-respiration switch esterase FrsA, DUF1100 family	FrsA	T	Signal transduction mechanisms	1	9	0.1111111111111111
OG0002641	COG1506	Dipeptidyl aminopeptidase/acylaminoacyl peptidase	DAP2	E	Amino acid transport and metabolism	1	9	0.1111111111111111
OG0002642	COG3081	dsDNA-binding nucleoid-associated protein YejK/NdpA	NdpA	L	Replication, recombination and repair	8	9	0.8888888888888888
OG0002646	COG0419	DNA repair exonuclease SbcCD ATPase subunit	SbcC	L	Replication, recombination and repair	9	9	1
OG0002648	COG5633	Uncharacterized conserved protein YcfL	YcfL	S	Function unknown	1	9	0.1111111111111111
OG0002649	COG0053	Divalent metal cation (Fe/Co/Zn/Cd) efflux pump	FieF	P	Inorganic ion transport and metabolism	9	9	1
OG0002652	COG0337	3-dehydroquinate synthetase	AroB	E	Amino acid transport and metabolism	8	8	1
OG0002653	COG1525	Endonuclease YncB, thermonuclease family	YncB	L	Replication, recombination and repair	8	8	1
OG0002656	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	6	8	0.75
OG0002662	COG5285	Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family	PhyH	Q	Secondary metabolites biosynthesis, transport and catabolism	6	8	0.75
OG0002663	COG2755	Lysophospholipase L1 or related esterase. Includes spore coat protein LipC/YcsK	TesA	D	Cell cycle control, cell division, chromosome partitioning	1	8	0.125
OG0002664	COG3468	Autotransporter adhesin AidA	AidA	M	Cell wall/membrane/envelope biogenesis	1	8	0.125
OG0002664	COG5263	Glucan-binding domain (YG repeat)	YG	G	Carbohydrate transport and metabolism	1	8	0.125
OG0002669	COG0318	O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming)	MenE	I	Lipid transport and metabolism	8	8	1
OG0002671	COG2194	Phosphoethanolamine transferase for periplasmic glucans OpgE, AlkP superfamily	OpgE	M	Cell wall/membrane/envelope biogenesis	8	8	1
OG0002672	COG0673	Predicted dehydrogenase	MviM	R	General function prediction only	4	8	0.5
OG0002673	COG1191	DNA-directed RNA polymerase specialized sigma subunit	FliA	K	Transcription	1	8	0.125
OG0002673	COG3119	Arylsulfatase A or related enzyme, AlkP superfamily	AslA	P	Inorganic ion transport and metabolism	1	8	0.125
OG0002681	COG1221	Transcriptional regulators containing sigma54-interacting ATPase domain	PspF	K	Transcription	1	8	0.125
OG0002682	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	1	8	0.125
OG0002683	COG5617	Predicted membrane glycosyltransferase TK1552, contains 6-pyruvoyl-tetrahydropterin synthase (PTPS)-related domain	PTPS	R	General function prediction only	1	8	0.125
OG0002686	COG0708	Exonuclease III	XthA	L	Replication, recombination and repair	8	8	1
OG0002687	COG2348	Lipid II:glycine glycyltransferase (Peptidoglycan interpeptide bridge formation enzyme)	FmhB	M	Cell wall/membrane/envelope biogenesis	5	8	0.625
OG0002688	COG1464	ABC-type metal ion transport system, periplasmic component/surface antigen	NlpA	P	Inorganic ion transport and metabolism	1	8	0.125
OG0002690	COG2133	Glucose/arabinose dehydrogenase, beta-propeller fold	YliI	G	Carbohydrate transport and metabolism	8	8	1
OG0002692	COG0367	Asparagine synthetase B (glutamine-hydrolyzing)	AsnB	E	Amino acid transport and metabolism	7	8	0.875
OG0002694	COG1807	PMT family glycosyltransferase ArnT/Agl22, involved in glycosylation of proteins and lipid IVA	ArnT	M	Cell wall/membrane/envelope biogenesis	3	8	0.375
OG0002694	COG2972	Sensor histidine kinase YesM	YesM	T	Signal transduction mechanisms	1	8	0.125
OG0002695	COG2175	Taurine dioxygenase, alpha-ketoglutarate-dependent	TauD	Q	Secondary metabolites biosynthesis, transport and catabolism	6	8	0.75
OG0002697	COG4103	Tellurite/oxyanion resistance protein, TerB superfamily	TerB2	P	Inorganic ion transport and metabolism	4	8	0.5
OG0002699	COG1359	Quinol monooxygenase YgiN	YgiN	C	Energy production and conversion	8	8	1
OG0002701	COG5126	Ca2+-binding protein, EF-hand superfamily	FRQ1	T	Signal transduction mechanisms	8	8	1
OG0002702	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	RpoE	K	Transcription	8	8	1
OG0002704	COG5612	Ni/Co/Cd-binding protein CnrX (heavy-metal resistance)	CnrX	P	Inorganic ion transport and metabolism	8	8	1
OG0002709	COG0486	tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE	MnmE	J	Translation, ribosomal structure and biogenesis	1	8	0.125
OG0002713	COG1378	Sugar-specific transcriptional regulator TrmB	YrhO	K	Transcription	1	8	0.125
OG0002714	COG4974	Site-specific tyrosine recombinase XerD	XerD	L	Replication, recombination and repair	8	8	1
OG0002716	COG4642	Uncharacterized conserved protein, contains MORN repeats	NA	R	General function prediction only	6	8	0.75
OG0002721	COG5542	Mannosyltransferase related to Gpi18	NA	G	Carbohydrate transport and metabolism	1	8	0.125
OG0002722	COG5817	Stage II sporulation protein SpoIIE/SpoIIH (serine phosphatase - sigma-F activation)	SpoIIE	D	Cell cycle control, cell division, chromosome partitioning	1	8	0.125
OG0002725	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	1	8	0.125
OG0002726	COG0265	Periplasmic serine protease DegP/DegQ, contain C-terminal PDZ domain	DegQ	O	Posttranslational modification, protein turnover, chaperones	3	8	0.375
OG0002730	COG3111	Predicted periplasmic protein with OB-fold, involved in stress response, YdeI/OmdA family	YdeI	R	General function prediction only	1	8	0.125
OG0002732	COG2433	Possible nuclease of RNase H fold, RuvC/YqgF family	NA	R	General function prediction only	1	8	0.125
OG0002732	COG3074	Cell division protein ZapB, interacts with FtsZ	ZapB	D	Cell cycle control, cell division, chromosome partitioning	1	8	0.125
OG0002732	COG3883	Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO	CwlO1	S	Function unknown	4	8	0.5
OG0002733	COG4547	Cobalamin biosynthesis cobaltochelatase CobT subunit	CobT2	H	Coenzyme transport and metabolism	2	8	0.25
OG0002736	COG3474	Cytochrome c2	Cyc7	C	Energy production and conversion	8	8	1
OG0002739	COG3085	Uncharacterized RNA-binding protein YifE, UPF0438 family	YifE	R	General function prediction only	2	8	0.25
OG0002744	COG2044	Predicted peroxiredoxin, DsrE/DsrF-like family	NA	R	General function prediction only	7	8	0.875
OG0002745	COG3544	Copper/silver metallochaperone CopM, DUF305 family	CopM	P	Inorganic ion transport and metabolism	8	8	1
OG0002748	COG5126	Ca2+-binding protein, EF-hand superfamily	FRQ1	T	Signal transduction mechanisms	7	8	0.875
OG0002750	COG3329	Na+-dependent bicarbonate transporter SbtA	SbtA	C	Energy production and conversion	8	8	1
OG0002752	COG1633	Rubrerythrin, includes spore coat protein YhjR	YhjR	P	Inorganic ion transport and metabolism	8	8	1
OG0002754	COG3158	K+ uptake protein Kup	Kup	P	Inorganic ion transport and metabolism	8	8	1
OG0002755	COG3528	Lipid A deacylase LpxR, DUF2219 family	LpxR	M	Cell wall/membrane/envelope biogenesis	8	8	1
OG0002758	COG1686	D-alanyl-D-alanine carboxypeptidase	DacC	M	Cell wall/membrane/envelope biogenesis	8	8	1
OG0002759	COG1983	Phage shock protein PspC (stress-responsive transcriptional regulator)	PspC	K	Transcription	8	8	1
OG0002764	COG0625	Glutathione S-transferase or stringent starvation protein SspA	GstA	O	Posttranslational modification, protein turnover, chaperones	8	8	1
OG0002766	COG0730	Sulfite exporter TauE/SafE/YfcA and related permeases, UPF0721 family	TauE	P	Inorganic ion transport and metabolism	8	8	1
OG0002769	COG4729	Uncharacterized conserved protein, DUF1850 family	NA	S	Function unknown	8	8	1
OG0002770	COG1430	Uncharacterized conserved membrane protein, UPF0127 family	NA	S	Function unknown	8	8	1
OG0002773	COG0697	Amino acid export permease, drug/metabolite transporter (DMT) superfamily	EamA	E	Amino acid transport and metabolism	8	8	1
OG0002775	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	7	7	1
OG0002776	COG0241	Histidinol phosphatase/D-glycero-mannoheptose bisphosphatephosphatase, HAD superfamily	HisB1/GmhB	E	Amino acid transport and metabolism	4	7	0.5714285714285714
OG0002776	COG1208	NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis protein s	GCD1	J	Translation, ribosomal structure and biogenesis	1	7	0.14285714285714285
OG0002777	COG1638	TRAP-type C4-dicarboxylate transport system, periplasmic component	DctP	G	Carbohydrate transport and metabolism	7	7	1
OG0002778	COG1304	FMN-dependent dehydrogenase, includes L-lactate dehydrogenase and type II isopentenyl diphosphate isomerase	LldD	C	Energy production and conversion	7	7	1
OG0002779	COG0615	Glycerol-3-phosphate cytidylyltransferase, cytidylyltransferase family	TagD	M	Cell wall/membrane/envelope biogenesis	6	7	0.8571428571428571
OG0002779	COG2513	2-Methylisocitrate lyase and related enzymes, PEP mutase family	PrpB	G	Carbohydrate transport and metabolism	1	7	0.14285714285714285
OG0002792	COG4642	Uncharacterized conserved protein, contains MORN repeats	NA	R	General function prediction only	1	7	0.14285714285714285
OG0002793	COG2327	Polysaccharide pyruvyl transferase family protein WcaK (colanic acid biosynthesis)	WcaK	M	Cell wall/membrane/envelope biogenesis	6	7	0.8571428571428571
OG0002794	COG3311	DNA-binding transcriptional regulator AlpA	AlpA	K	Transcription	2	7	0.2857142857142857
OG0002798	COG5285	Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family	PhyH	Q	Secondary metabolites biosynthesis, transport and catabolism	7	7	1
OG0002799	COG5633	Uncharacterized conserved protein YcfL	YcfL	S	Function unknown	1	7	0.14285714285714285
OG0002803	COG1807	PMT family glycosyltransferase ArnT/Agl22, involved in glycosylation of proteins and lipid IVA	ArnT	M	Cell wall/membrane/envelope biogenesis	1	7	0.14285714285714285
OG0002806	COG2852	Very-short-patch-repair endonuclease	YcjD	L	Replication, recombination and repair	4	7	0.5714285714285714
OG0002813	COG0500	SAM-dependent methyltransferase SmtA (CmoB moved to COG2228)	SmtA	Q	Secondary metabolites biosynthesis, transport and catabolism	2	7	0.2857142857142857
OG0002813	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	2	7	0.2857142857142857
OG0002816	COG4725	N6-adenosine-specific RNA methylase, MT-A70 family	IME4	J	Translation, ribosomal structure and biogenesis	7	7	1
OG0002819	COG0625	Glutathione S-transferase or stringent starvation protein SspA	GstA	O	Posttranslational modification, protein turnover, chaperones	7	7	1
OG0002820	COG2755	Lysophospholipase L1 or related esterase. Includes spore coat protein LipC/YcsK	TesA	D	Cell cycle control, cell division, chromosome partitioning	6	7	0.8571428571428571
OG0002821	COG3167	Type II secretion system/type IV pilus alignment protein PilO	PilO	N	Cell motility	1	7	0.14285714285714285
OG0002822	COG0346	Glyoxalase, catechol 2,3-dioxygenase or related enzyme, vicinal oxygen chelate (VOC) family	GloA	Q	Secondary metabolites biosynthesis, transport and catabolism	7	7	1
OG0002826	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9	UbiE	H	Coenzyme transport and metabolism	2	7	0.2857142857142857
OG0002826	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	3	7	0.42857142857142855
OG0002829	COG3203	Outer membrane porin OmpC/OmpF/PhoE	OmpC	M	Cell wall/membrane/envelope biogenesis	2	7	0.2857142857142857
OG0002834	COG1984	5-oxoprolinase subunit C/Allophanate hydrolase subunit 2	PxpC	E	Amino acid transport and metabolism	1	7	0.14285714285714285
OG0002840	COG2223	Nitrate/nitrite transporter NarK	NarK	P	Inorganic ion transport and metabolism	3	7	0.42857142857142855
OG0002843	COG1802	DNA-binding transcriptional regulator, GntR family	GntR	K	Transcription	7	7	1
OG0002844	COG2370	Hydrogenase/urease accessory protein HupE	HupE	O	Posttranslational modification, protein turnover, chaperones	7	7	1
OG0002845	COG0627	S-formylglutathione hydrolase FrmB	FrmB	V	Defense mechanisms	7	7	1
OG0002847	COG2738	Zn-dependent membrane protease YugP	YugP	O	Posttranslational modification, protein turnover, chaperones	7	7	1
OG0002848	COG4974	Site-specific tyrosine recombinase XerD	XerD	L	Replication, recombination and repair	7	7	1
OG0002852	COG1846	DNA-binding transcriptional regulator, MarR family	MarR	K	Transcription	7	7	1
OG0002856	COG1403	HNH family endonuclease, includes 5-methylcytosine-specific restriction endonuclease McrA	McrA	V	Defense mechanisms	6	7	0.8571428571428571
OG0002861	COG3642	tRNA A37 N6-threonylcarbamoyl transferase component Bud32	Bud32	J	Translation, ribosomal structure and biogenesis	1	7	0.14285714285714285
OG0002862	COG1524	c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily	AtaC	T	Signal transduction mechanisms	7	7	1
OG0002865	COG2433	Possible nuclease of RNase H fold, RuvC/YqgF family	NA	R	General function prediction only	4	7	0.5714285714285714
OG0002866	COG4974	Site-specific tyrosine recombinase XerD	XerD	L	Replication, recombination and repair	7	7	1
OG0002867	COG2423	Ornithine cyclodeaminase/archaeal alanine dehydrogenase, mu-crystallin family	OCDMu	E	Amino acid transport and metabolism	7	7	1
OG0002868	COG3883	Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO	CwlO1	S	Function unknown	3	7	0.42857142857142855
OG0002871	COG1266	Membrane protease YdiL, CAAX protease family	YdiL	O	Posttranslational modification, protein turnover, chaperones	7	7	1
OG0002874	COG0010	Arginase/agmatinase family enzyme	SpeB	E	Amino acid transport and metabolism	6	6	1
OG0002875	COG1182	FMN-dependent NADH-azoreductase	AzoR	C	Energy production and conversion	6	6	1
OG0002881	COG3883	Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO	CwlO1	S	Function unknown	4	6	0.6666666666666666
OG0002881	COG4942	Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB	EnvC	D	Cell cycle control, cell division, chromosome partitioning	2	6	0.3333333333333333
OG0002886	COG1403	HNH family endonuclease, includes 5-methylcytosine-specific restriction endonuclease McrA	McrA	V	Defense mechanisms	6	6	1
OG0002888	COG2348	Lipid II:glycine glycyltransferase (Peptidoglycan interpeptide bridge formation enzyme)	FmhB	M	Cell wall/membrane/envelope biogenesis	4	6	0.6666666666666666
OG0002890	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	RpoE	K	Transcription	3	6	0.5
OG0002894	COG0812	UDP-N-acetylenolpyruvoylglucosamine reductase	MurB	M	Cell wall/membrane/envelope biogenesis	5	6	0.8333333333333334
OG0002896	COG1670	Protein N-acetyltransferase, RimJ/RimL family	RimL	J	Translation, ribosomal structure and biogenesis	6	6	1
OG0002897	COG5285	Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family	PhyH	Q	Secondary metabolites biosynthesis, transport and catabolism	6	6	1
OG0002899	COG0392	Predicted membrane flippase AglD2/YbhN, UPF0104 family	AglD2	M	Cell wall/membrane/envelope biogenesis	6	6	1
OG0002900	COG1715	Restriction endonuclease Mrr	Mrr	V	Defense mechanisms	2	6	0.3333333333333333
OG0002900	COG1787	Endonuclease, HJR/Mrr/RecB family	NA	V	Defense mechanisms	4	6	0.6666666666666666
OG0002903	COG1061	Superfamily II DNA or RNA helicase	SSL2	K	Transcription	5	6	0.8333333333333334
OG0002907	COG1300	Stage II sporulation protein SpoIIM, component of the engulfment complex	SpoIIM	D	Cell cycle control, cell division, chromosome partitioning	1	6	0.16666666666666666
OG0002910	COG0600	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component	TauC	P	Inorganic ion transport and metabolism	6	6	1
OG0002911	COG0715	ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component	TauA	P	Inorganic ion transport and metabolism	6	6	1
OG0002912	COG4977	Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain	GlxA	K	Transcription	6	6	1
OG0002914	COG0036	Pentose-5-phosphate-3-epimerase	Rpe	G	Carbohydrate transport and metabolism	1	6	0.16666666666666666
OG0002914	COG0572	Uridine kinase	Udk	F	Nucleotide transport and metabolism	4	6	0.6666666666666666
OG0002915	COG5018	3'-5' exonuclease KapD, inhibitor of KinA-controlled sporulation	KapD	T	Signal transduction mechanisms	5	6	0.8333333333333334
OG0002917	COG0786	Na+/glutamate symporter	GltS	E	Amino acid transport and metabolism	1	6	0.16666666666666666
OG0002918	COG3914	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family	Spy	O	Posttranslational modification, protein turnover, chaperones	1	6	0.16666666666666666
OG0002923	COG0059	Ketol-acid reductoisomerase	IlvC	E	Amino acid transport and metabolism	5	6	0.8333333333333334
OG0002923	COG0673	Predicted dehydrogenase	MviM	R	General function prediction only	1	6	0.16666666666666666
OG0002925	COG4642	Uncharacterized conserved protein, contains MORN repeats	NA	R	General function prediction only	6	6	1
OG0002927	COG0859	ADP-heptose:LPS heptosyltransferase	RfaF	M	Cell wall/membrane/envelope biogenesis	4	6	0.6666666666666666
OG0002928	COG3391	DNA-binding beta-propeller fold protein YncE	YncE	R	General function prediction only	1	6	0.16666666666666666
OG0002930	COG0392	Predicted membrane flippase AglD2/YbhN, UPF0104 family	AglD2	M	Cell wall/membrane/envelope biogenesis	3	6	0.5
OG0002931	COG1878	Kynurenine formamidase	NA	E	Amino acid transport and metabolism	6	6	1
OG0002941	COG3468	Autotransporter adhesin AidA	AidA	M	Cell wall/membrane/envelope biogenesis	1	6	0.16666666666666666
OG0002943	COG1196	Chromosome segregation ATPase Smc	Smc	D	Cell cycle control, cell division, chromosome partitioning	1	6	0.16666666666666666
OG0002943	COG1566	Multidrug resistance efflux pump EmrA	EmrA	V	Defense mechanisms	1	6	0.16666666666666666
OG0002943	COG3679	Cell fate regulator YlbF, YheA/YmcA/DUF963 family (controls sporulation, competence, biofilm development)	YlbF	T	Signal transduction mechanisms	1	6	0.16666666666666666
OG0002947	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9	UbiE	H	Coenzyme transport and metabolism	1	6	0.16666666666666666
OG0002947	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	3	6	0.5
OG0002947	COG4627	Predicted SAM-depedendent methyltransferase	NA	R	General function prediction only	1	6	0.16666666666666666
OG0002951	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	3	6	0.5
OG0002952	COG1647	Esterase/lipase	YvaK	Q	Secondary metabolites biosynthesis, transport and catabolism	2	6	0.3333333333333333
OG0002952	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	1	6	0.16666666666666666
OG0002955	COG5524	Bacteriorhodopsin	NA	C	Energy production and conversion	6	6	1
OG0002959	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	4	6	0.6666666666666666
OG0002961	COG0306	Phosphate/sulfate permease	PitA	P	Inorganic ion transport and metabolism	6	6	1
OG0002962	COG1392	Phosphate transport regulator YkaA, distantly related to PhoU, UPF0111/DUF47 family	YkaA	P	Inorganic ion transport and metabolism	6	6	1
OG0002968	COG1202	Superfamily II helicase, archaea-specific	NA	L	Replication, recombination and repair	3	6	0.5
OG0002969	COG4642	Uncharacterized conserved protein, contains MORN repeats	NA	R	General function prediction only	6	6	1
OG0002973	COG0125	Thymidylate kinase	Tmk	F	Nucleotide transport and metabolism	3	6	0.5
OG0002973	COG1162	Ribosome biogenesis GTPase RsgA	RsgA	J	Translation, ribosomal structure and biogenesis	2	6	0.3333333333333333
OG0002985	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	5	5	1
OG0002987	COG1182	FMN-dependent NADH-azoreductase	AzoR	C	Energy production and conversion	5	5	1
OG0002988	COG4642	Uncharacterized conserved protein, contains MORN repeats	NA	R	General function prediction only	5	5	1
OG0002991	COG1221	Transcriptional regulators containing sigma54-interacting ATPase domain	PspF	K	Transcription	1	5	0.2
OG0002996	COG3311	DNA-binding transcriptional regulator AlpA	AlpA	K	Transcription	1	5	0.2
OG0002998	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	1	5	0.2
OG0002999	COG2956	Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain	LapB	M	Cell wall/membrane/envelope biogenesis	1	5	0.2
OG0002999	COG3063	Type IV pilus assembly pilotin PilF, contains TPR repeats	PilF	N	Cell motility	1	5	0.2
OG0002999	COG4783	Periplasmic chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains	BepA	M	Cell wall/membrane/envelope biogenesis	2	5	0.4
OG0003005	COG3304	Uncharacterized membrane protein YccF, DUF307 family	YccF	S	Function unknown	5	5	1
OG0003006	COG0210	Superfamily I DNA or RNA helicase	UvrD	L	Replication, recombination and repair	5	5	1
OG0003010	COG2050	Acyl-CoA thioesterase PaaI, contains HGG motif	PaaI	Q	Secondary metabolites biosynthesis, transport and catabolism	5	5	1
OG0003012	COG3883	Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO	CwlO1	S	Function unknown	1	5	0.2
OG0003012	COG4942	Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB	EnvC	D	Cell cycle control, cell division, chromosome partitioning	1	5	0.2
OG0003017	COG1834	N-Dimethylarginine dimethylaminohydrolase	DdaH	E	Amino acid transport and metabolism	5	5	1
OG0003018	COG1250	3-hydroxyacyl-CoA dehydrogenase	FadB	I	Lipid transport and metabolism	5	5	1
OG0003021	COG1247	L-amino acid N-acyltransferase MnaT	MnaT	E	Amino acid transport and metabolism	1	5	0.2
OG0003021	COG3153	Predicted N-acetyltransferase YhbS	YhbS	R	General function prediction only	4	5	0.8
OG0003023	COG0738	Fucose permease	FucP	G	Carbohydrate transport and metabolism	1	5	0.2
OG0003027	COG0715	ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component	TauA	P	Inorganic ion transport and metabolism	5	5	1
OG0003029	COG3562	Capsule polysaccharide modification protein KpsS	KpsS	M	Cell wall/membrane/envelope biogenesis	4	5	0.8
OG0003031	COG3210	Large exoprotein involved in heme utilization or adhesion	FhaB	U	Intracellular trafficking, secretion, and vesicular transport	1	5	0.2
OG0003033	COG3055	N-acetylneuraminic acid mutarotase	NanM	M	Cell wall/membrane/envelope biogenesis	5	5	1
OG0003034	COG4573	Tagatose-1,6-bisphosphate aldolase non-catalytic subunit AgaZ/GatZ	GatZ	G	Carbohydrate transport and metabolism	5	5	1
OG0003036	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	1	5	0.2
OG0003036	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	BcsA	N	Cell motility	2	5	0.4
OG0003039	COG0346	Glyoxalase, catechol 2,3-dioxygenase or related enzyme, vicinal oxygen chelate (VOC) family	GloA	Q	Secondary metabolites biosynthesis, transport and catabolism	2	5	0.4
OG0003039	COG3185	4-hydroxyphenylpyruvate dioxygenase and related hemolysins	HppD	E	Amino acid transport and metabolism	2	5	0.4
OG0003042	COG4625	Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain	NA	S	Function unknown	5	5	1
OG0003044	COG1020	EntF, seryl-AMP synthase component  of non-ribosomal peptide synthetase	EntF	Q	Secondary metabolites biosynthesis, transport and catabolism	1	5	0.2
OG0003044	COG1541	Phenylacetate-coenzyme A ligase PaaK, adenylate-forming domain family	PaaK	H	Coenzyme transport and metabolism	4	5	0.8
OG0003046	COG1807	PMT family glycosyltransferase ArnT/Agl22, involved in glycosylation of proteins and lipid IVA	ArnT	M	Cell wall/membrane/envelope biogenesis	1	5	0.2
OG0003048	COG0057	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase	GapA	G	Carbohydrate transport and metabolism	5	5	1
OG0003051	COG2865	Predicted transcriptional regulator, contains HTH domain	NA	K	Transcription	4	5	0.8
OG0003051	COG3472	Uncharacterized conserved protein domain, often C-terminal to DUF262	NA	S	Function unknown	1	5	0.2
OG0003055	COG4569	Acetaldehyde dehydrogenase (acetylating)	MhpF	Q	Secondary metabolites biosynthesis, transport and catabolism	5	5	1
OG0003058	COG3883	Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO	CwlO1	S	Function unknown	1	5	0.2
OG0003060	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9	UbiE	H	Coenzyme transport and metabolism	2	5	0.4
OG0003061	COG0732	Restriction endonuclease S subunit	HsdS	V	Defense mechanisms	5	5	1
OG0003062	COG3210	Large exoprotein involved in heme utilization or adhesion	FhaB	U	Intracellular trafficking, secretion, and vesicular transport	1	5	0.2
OG0003064	COG0234	Co-chaperonin GroES (HSP10)	GroES	O	Posttranslational modification, protein turnover, chaperones	3	5	0.6
OG0003066	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	1	5	0.2
OG0003068	COG1196	Chromosome segregation ATPase Smc	Smc	D	Cell cycle control, cell division, chromosome partitioning	3	5	0.6
OG0003068	COG3206	Tyrosine-protein kinase Wzc involved in exopolysaccharide export, GumC/Wzc1 domain	GumC	M	Cell wall/membrane/envelope biogenesis	2	5	0.4
OG0003069	COG1850	Ribulose 1,5-bisphosphate carboxylase, large subunit, or a RuBisCO-like protein	RbcL	G	Carbohydrate transport and metabolism	5	5	1
OG0003072	COG2852	Very-short-patch-repair endonuclease	YcjD	L	Replication, recombination and repair	1	5	0.2
OG0003077	COG2271	Sugar phosphate permease	UhpC	G	Carbohydrate transport and metabolism	5	5	1
OG0003078	COG1018	Flavodoxin/ferredoxin--NADP reductase	Fpr	C	Energy production and conversion	5	5	1
OG0003079	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9	UbiE	H	Coenzyme transport and metabolism	1	5	0.2
OG0003079	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	4	5	0.8
OG0003080	COG5902	Spore germination receptor GerABC, GerB subunit (amino acid transporter)	GerAB	D	Cell cycle control, cell division, chromosome partitioning	3	5	0.6
OG0003082	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	5	5	1
OG0003086	COG3023	N-acetyl-anhydromuramyl-L-alanine amidase AmpD	AmpD	M	Cell wall/membrane/envelope biogenesis	4	5	0.8
OG0003086	COG5632	N-acetylmuramoyl-L-alanine amidase CwlA	CwlA	M	Cell wall/membrane/envelope biogenesis	1	5	0.2
OG0003092	COG2348	Lipid II:glycine glycyltransferase (Peptidoglycan interpeptide bridge formation enzyme)	FmhB	M	Cell wall/membrane/envelope biogenesis	5	5	1
OG0003100	COG0342	Preprotein translocase subunit SecD	SecD	U	Intracellular trafficking, secretion, and vesicular transport	1	5	0.2
OG0003102	COG1287	Asparagine N-glycosylation enzyme, membrane subunit Stt3	Stt3	O	Posttranslational modification, protein turnover, chaperones	1	5	0.2
OG0003102	COG5185	Chromosome segregation protein NDC80, interacts with SMC proteins	HEC1	D	Cell cycle control, cell division, chromosome partitioning	1	5	0.2
OG0003109	COG0726	Peptidoglycan/xylan/chitin deacetylase, PgdA/NodB/CDA1 family	PgaB	G	Carbohydrate transport and metabolism	1	5	0.2
OG0003110	COG2159	5-carboxyvanillate decarboxylase LigW (lignin degradation), amidohydro domain	LigW	G	Carbohydrate transport and metabolism	5	5	1
OG0003113	COG0500	SAM-dependent methyltransferase SmtA (CmoB moved to COG2228)	SmtA	Q	Secondary metabolites biosynthesis, transport and catabolism	1	5	0.2
OG0003113	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	2	5	0.4
OG0003113	COG4106	Trans-aconitate methyltransferase	Tam	C	Energy production and conversion	1	5	0.2
OG0003113	COG4976	Predicted methyltransferase, contains TPR repeat	NA	R	General function prediction only	1	5	0.2
OG0003116	COG3447	Integral membrane sensor domain MASE1	MASE1	T	Signal transduction mechanisms	2	5	0.4
OG0003121	COG1971	Putative Mn2+ efflux pump MntP	MntP	P	Inorganic ion transport and metabolism	5	5	1
OG0003124	COG0725	ABC-type molybdate transport system, periplasmic Mo-binding protein ModA	ModA	P	Inorganic ion transport and metabolism	4	5	0.8
OG0003134	COG4128	Zona occludens toxin, predicted ATPase	Zot	R	General function prediction only	1	5	0.2
OG0003135	COG1309	DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA	AcrR	K	Transcription	5	5	1
OG0003138	COG0598	Mg2+ and Co2+ transporter CorA	CorA	P	Inorganic ion transport and metabolism	5	5	1
OG0003140	COG4246	Uncharacterized conserved protein, contains a phytase-like domain	NA	S	Function unknown	5	5	1
OG0003141	COG5448	Uncharacterized conserved protein, DUF2460 domain	NA	S	Function unknown	1	5	0.2
OG0003144	COG1088	dTDP-D-glucose 4,6-dehydratase	RfbB	M	Cell wall/membrane/envelope biogenesis	1	4	0.25
OG0003144	COG1089	GDP-D-mannose dehydratase	Gmd	M	Cell wall/membrane/envelope biogenesis	3	4	0.75
OG0003145	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	4	4	1
OG0003146	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	4	4	1
OG0003147	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	2	4	0.5
OG0003147	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	BcsA	N	Cell motility	2	4	0.5
OG0003148	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	3	4	0.75
OG0003149	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	2	4	0.5
OG0003150	COG4664	TRAP-type mannitol/chloroaromatic compound transport system, large permease component	FcbT3	Q	Secondary metabolites biosynthesis, transport and catabolism	4	4	1
OG0003151	COG0615	Glycerol-3-phosphate cytidylyltransferase, cytidylyltransferase family	TagD	M	Cell wall/membrane/envelope biogenesis	4	4	1
OG0003152	COG1182	FMN-dependent NADH-azoreductase	AzoR	C	Energy production and conversion	3	4	0.75
OG0003153	COG0559	Branched-chain amino acid ABC-type transport system, permease component	LivH	E	Amino acid transport and metabolism	4	4	1
OG0003154	COG3791	Uncharacterized conserved protein	NA	S	Function unknown	4	4	1
OG0003155	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	1	4	0.25
OG0003155	COG4976	Predicted methyltransferase, contains TPR repeat	NA	R	General function prediction only	3	4	0.75
OG0003156	COG0500	SAM-dependent methyltransferase SmtA (CmoB moved to COG2228)	SmtA	Q	Secondary metabolites biosynthesis, transport and catabolism	2	4	0.5
OG0003159	COG0348	Polyferredoxin NapH	NapH	C	Energy production and conversion	1	4	0.25
OG0003159	COG2768	Uncharacterized Fe-S cluster protein	NA	S	Function unknown	2	4	0.5
OG0003165	COG0622	Mn2+-dependent phosphodiesterase, calcineurin family	YfcE	R	General function prediction only	4	4	1
OG0003166	COG1196	Chromosome segregation ATPase Smc	Smc	D	Cell cycle control, cell division, chromosome partitioning	1	4	0.25
OG0003167	COG0568	DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32)	RpoD	K	Transcription	4	4	1
OG0003168	COG2186	DNA-binding transcriptional regulator, FadR family	FadR	K	Transcription	1	4	0.25
OG0003171	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	2	4	0.5
OG0003172	COG2852	Very-short-patch-repair endonuclease	YcjD	L	Replication, recombination and repair	2	4	0.5
OG0003173	COG1846	DNA-binding transcriptional regulator, MarR family	MarR	K	Transcription	3	4	0.75
OG0003180	COG2301	Citrate lyase beta subunit	CitE	G	Carbohydrate transport and metabolism	3	4	0.75
OG0003181	COG0144	RNA cytosine C5-methylase, RsmB/RsmF/Trm4/Trm9 family, includes 16S rRNA C967/C1407 and tRNA-C34/C48 C5-methylases	RsmB	J	Translation, ribosomal structure and biogenesis	2	4	0.5
OG0003181	COG0500	SAM-dependent methyltransferase SmtA (CmoB moved to COG2228)	SmtA	Q	Secondary metabolites biosynthesis, transport and catabolism	1	4	0.25
OG0003181	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	1	4	0.25
OG0003183	COG3751	Proline 4-hydroxylase (includes Rps23 Pro-64 3,4-dihydroxylase Tpa1), contains SM-20 domain	EGL9	J	Translation, ribosomal structure and biogenesis	1	4	0.25
OG0003184	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	2	4	0.5
OG0003186	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	4	4	1
OG0003188	COG0716	Flavodoxin	FldA	C	Energy production and conversion	1	4	0.25
OG0003189	COG0248	Exopolyphosphatase/pppGpp-phosphohydrolase	GppA	F	Nucleotide transport and metabolism	1	4	0.25
OG0003189	COG0443	Molecular chaperone DnaK (HSP70)	DnaK	O	Posttranslational modification, protein turnover, chaperones	1	4	0.25
OG0003189	COG0849	Cell division ATPase FtsA	FtsA	D	Cell cycle control, cell division, chromosome partitioning	1	4	0.25
OG0003197	COG1887	CDP-glycerol glycerophosphotransferase, TagB/SpsB family	TagB	M	Cell wall/membrane/envelope biogenesis	1	4	0.25
OG0003207	COG1044	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase	LpxD	M	Cell wall/membrane/envelope biogenesis	4	4	1
OG0003211	COG2982	Outer membrane assembly factor AsmA	AsmA	M	Cell wall/membrane/envelope biogenesis	2	4	0.5
OG0003214	COG4747	ACT domain-containing protein	ACTx2	R	General function prediction only	1	4	0.25
OG0003218	COG0723	Rieske Fe-S protein	QcrA/PetC	C	Energy production and conversion	3	4	0.75
OG0003218	COG2146	Ferredoxin subunit of nitrite reductase or a ring-hydroxylating dioxygenase	NirD	P	Inorganic ion transport and metabolism	1	4	0.25
OG0003222	COG1216	Glycosyltransferase, GT2 family	WcaE	G	Carbohydrate transport and metabolism	4	4	1
OG0003224	COG1512	Uncharacterized membrane protein YgcG, contains a TPM-fold domain	YgcG	S	Function unknown	1	4	0.25
OG0003230	COG1647	Esterase/lipase	YvaK	Q	Secondary metabolites biosynthesis, transport and catabolism	1	4	0.25
OG0003235	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	RpoE	K	Transcription	3	4	0.75
OG0003237	COG5469	Predicted metal-binding protein	NA	S	Function unknown	4	4	1
OG0003238	COG3166	Type II secretion system/type IV pilus alignment protein GspM/PulM/PilN	GspM/PilN	N	Cell motility	2	4	0.5
OG0003240	COG2074	2-phosphoglycerate kinase/Mevalonate-3-phosphate 5-kinase	Pgk2	G	Carbohydrate transport and metabolism	4	4	1
OG0003241	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	BcsA	N	Cell motility	2	4	0.5
OG0003242	COG0286	Type I restriction-modification system, DNA methylase subunit	HsdM	V	Defense mechanisms	4	4	1
OG0003246	COG0863	DNA modification adenine methylase	YhdJ	L	Replication, recombination and repair	2	4	0.5
OG0003246	COG1041	tRNA G10 N-methylase Trm11	Trm11	J	Translation, ribosomal structure and biogenesis	1	4	0.25
OG0003246	COG1743	Adenine-specific DNA methylase, contains a Zn-ribbon domain	NA	L	Replication, recombination and repair	1	4	0.25
OG0003248	COG5306	Uncharacterized conserved protein MJ1470, contains DUF2341 domain, predicted component of type IV pili-like system	MJ1470	R	General function prediction only	1	4	0.25
OG0003249	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	1	4	0.25
OG0003250	COG4974	Site-specific tyrosine recombinase XerD	XerD	L	Replication, recombination and repair	1	4	0.25
OG0003257	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	1	4	0.25
OG0003259	COG0272	NAD-dependent DNA ligase	Lig	L	Replication, recombination and repair	4	4	1
OG0003262	COG3642	tRNA A37 N6-threonylcarbamoyl transferase component Bud32	Bud32	J	Translation, ribosomal structure and biogenesis	2	4	0.5
OG0003262	COG4502	5'(3')-deoxyribonucleotidase	YorC	F	Nucleotide transport and metabolism	2	4	0.5
OG0003263	COG1502	Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthase	Cls	I	Lipid transport and metabolism	4	4	1
OG0003264	COG3307	O-antigen ligase	RfaL	M	Cell wall/membrane/envelope biogenesis	1	4	0.25
OG0003265	COG4733	Phage tail tip protein (host specificity protein J)	NA	X	Mobilome: prophages, transposons	2	4	0.5
OG0003270	COG1064	D-arabinose 1-dehydrogenase, Zn-dependent alcohol dehydrogenase family	AdhP	G	Carbohydrate transport and metabolism	1	4	0.25
OG0003272	COG1309	DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA	AcrR	K	Transcription	4	4	1
OG0003276	COG3751	Proline 4-hydroxylase (includes Rps23 Pro-64 3,4-dihydroxylase Tpa1), contains SM-20 domain	EGL9	J	Translation, ribosomal structure and biogenesis	1	4	0.25
OG0003278	COG0210	Superfamily I DNA or RNA helicase	UvrD	L	Replication, recombination and repair	1	4	0.25
OG0003278	COG3972	Superfamily I DNA and RNA helicases	NA	L	Replication, recombination and repair	3	4	0.75
OG0003279	COG1807	PMT family glycosyltransferase ArnT/Agl22, involved in glycosylation of proteins and lipid IVA	ArnT	M	Cell wall/membrane/envelope biogenesis	1	4	0.25
OG0003280	COG0625	Glutathione S-transferase or stringent starvation protein SspA	GstA	O	Posttranslational modification, protein turnover, chaperones	4	4	1
OG0003283	COG0686	Alanine dehydrogenase (includes sporulation protein SpoVN)	Ald	E	Amino acid transport and metabolism	2	4	0.5
OG0003293	COG0726	Peptidoglycan/xylan/chitin deacetylase, PgdA/NodB/CDA1 family	PgaB	G	Carbohydrate transport and metabolism	4	4	1
OG0003297	COG1442	Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase	RfaJ	M	Cell wall/membrane/envelope biogenesis	1	4	0.25
OG0003298	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	2	4	0.5
OG0003300	COG1061	Superfamily II DNA or RNA helicase	SSL2	K	Transcription	4	4	1
OG0003301	COG0790	Sel1-like repeat, TPR-related	Sel1	R	General function prediction only	4	4	1
OG0003308	COG0524	Sugar or nucleoside kinase, ribokinase family	RbsK	G	Carbohydrate transport and metabolism	3	4	0.75
OG0003312	COG2604	Uncharacterized conserved protein	NA	S	Function unknown	1	4	0.25
OG0003320	COG2120	N-acetylglucosaminyl deacetylase, LmbE family	LmbE	G	Carbohydrate transport and metabolism	4	4	1
OG0003325	COG4717	Predicted ATPase SbcE/YhaN involved in DNA double-strand break repair, contains AAA domain	YhaN	L	Replication, recombination and repair	1	4	0.25
OG0003327	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	RpoE	K	Transcription	4	4	1
OG0003328	COG5662	Transmembrane transcriptional regulator RsiW (anti-sigma-W factor)	RsiW	K	Transcription	4	4	1
OG0003329	COG0456	Ribosomal protein S18 acetylase RimI and related acetyltransferases	RimI	J	Translation, ribosomal structure and biogenesis	4	4	1
OG0003330	COG1228	Imidazolonepropionase or related amidohydrolase	HutI	Q	Secondary metabolites biosynthesis, transport and catabolism	4	4	1
OG0003336	COG3631	Ketosteroid isomerase-related protein	YesE	R	General function prediction only	1	4	0.25
OG0003337	COG1715	Restriction endonuclease Mrr	Mrr	V	Defense mechanisms	4	4	1
OG0003339	COG0560	Phosphoserine phosphatase	SerB	E	Amino acid transport and metabolism	1	4	0.25
OG0003341	COG1807	PMT family glycosyltransferase ArnT/Agl22, involved in glycosylation of proteins and lipid IVA	ArnT	M	Cell wall/membrane/envelope biogenesis	4	4	1
OG0003352	COG2910	Putative NADH-flavin reductase	YwnB	R	General function prediction only	1	4	0.25
OG0003358	COG0501	Zn-dependent protease with chaperone function	HtpX	O	Posttranslational modification, protein turnover, chaperones	4	4	1
OG0003361	COG2246	Putative flippase GtrA (transmembrane translocase of bactoprenol-linked glucose)	GtrA	I	Lipid transport and metabolism	4	4	1
OG0003366	COG1502	Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthase	Cls	I	Lipid transport and metabolism	3	4	0.75
OG0003368	COG3802	Uncharacterized conserved protein GguC, FAA hydrolase family	GguC	S	Function unknown	4	4	1
OG0003369	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	AdhE	I	Lipid transport and metabolism	4	4	1
OG0003372	COG2433	Possible nuclease of RNase H fold, RuvC/YqgF family	NA	R	General function prediction only	1	4	0.25
OG0003373	COG3622	Hydroxypyruvate/dehydroerythronate isomerase, Hyi/OtnI family	Hyi	G	Carbohydrate transport and metabolism	4	4	1
OG0003376	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	3	4	0.75
OG0003379	COG0560	Phosphoserine phosphatase	SerB	E	Amino acid transport and metabolism	4	4	1
OG0003384	COG0634	Hypoxanthine-guanine phosphoribosyltransferase	HptA	F	Nucleotide transport and metabolism	3	4	0.75
OG0003384	COG1040	DNA utilization protein ComFC/GntX, contains phosphoribosyltransferase domain	ComFC	R	General function prediction only	1	4	0.25
OG0003392	COG2211	Na+/melibiose symporter or related transporter	MelB	G	Carbohydrate transport and metabolism	4	4	1
OG0003397	COG2982	Outer membrane assembly factor AsmA	AsmA	M	Cell wall/membrane/envelope biogenesis	1	4	0.25
OG0003398	COG1462	Type VIII secretion (curli biogenesis) system outer membrane channel CsgG	CsgG	W	Extracellular structures	4	4	1
OG0003405	COG3108	Metallopeptidase MepK/YcbK, cleaves mDAP crosslinks in peptidoglycan, peptidase M15/DUF882 family	YcbK	M	Cell wall/membrane/envelope biogenesis	4	4	1
OG0003408	COG3772	Phage-related lysozyme (muramidase), GH24 family	RrrD	M	Cell wall/membrane/envelope biogenesis	4	4	1
OG0003411	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	3	3	1
OG0003412	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	FabG	I	Lipid transport and metabolism	3	3	1
OG0003413	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	2	3	0.6666666666666666
OG0003413	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	BcsA	N	Cell motility	1	3	0.3333333333333333
OG0003415	COG0006	Xaa-Pro aminopeptidase	PepP	E	Amino acid transport and metabolism	3	3	1
OG0003416	COG0615	Glycerol-3-phosphate cytidylyltransferase, cytidylyltransferase family	TagD	M	Cell wall/membrane/envelope biogenesis	2	3	0.6666666666666666
OG0003416	COG2513	2-Methylisocitrate lyase and related enzymes, PEP mutase family	PrpB	G	Carbohydrate transport and metabolism	1	3	0.3333333333333333
OG0003418	COG4974	Site-specific tyrosine recombinase XerD	XerD	L	Replication, recombination and repair	3	3	1
OG0003425	COG1409	3',5'-cyclic AMP phosphodiesterase CpdA	CpdA	T	Signal transduction mechanisms	2	3	0.6666666666666666
OG0003425	COG2129	Predicted phosphoesterase, related to the Icc protein	NA	R	General function prediction only	1	3	0.3333333333333333
OG0003432	COG1734	RNA polymerase-binding transcription factor DksA	DksA	K	Transcription	3	3	1
OG0003433	COG1409	3',5'-cyclic AMP phosphodiesterase CpdA	CpdA	T	Signal transduction mechanisms	3	3	1
OG0003441	COG0392	Predicted membrane flippase AglD2/YbhN, UPF0104 family	AglD2	M	Cell wall/membrane/envelope biogenesis	3	3	1
OG0003455	COG1917	Cupin domain protein related to quercetin dioxygenase	QdoI	R	General function prediction only	2	3	0.6666666666666666
OG0003457	COG1509	L-lysine 2,3-aminomutase EpmB	EpmB	J	Translation, ribosomal structure and biogenesis	3	3	1
OG0003460	COG3883	Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO	CwlO1	S	Function unknown	1	3	0.3333333333333333
OG0003462	COG1221	Transcriptional regulators containing sigma54-interacting ATPase domain	PspF	K	Transcription	1	3	0.3333333333333333
OG0003462	COG1579	Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain	DR0291	R	General function prediction only	1	3	0.3333333333333333
OG0003470	COG0739	Murein endopeptidase or hydrolase activator MepM/NlpD, contains LysM domain	NlpD	M	Cell wall/membrane/envelope biogenesis	3	3	1
OG0003471	COG0392	Predicted membrane flippase AglD2/YbhN, UPF0104 family	AglD2	M	Cell wall/membrane/envelope biogenesis	1	3	0.3333333333333333
OG0003477	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	3	3	1
OG0003482	COG0685	5,10-methylenetetrahydrofolate reductase	MetF	E	Amino acid transport and metabolism	3	3	1
OG0003490	COG0500	SAM-dependent methyltransferase SmtA (CmoB moved to COG2228)	SmtA	Q	Secondary metabolites biosynthesis, transport and catabolism	1	3	0.3333333333333333
OG0003490	COG2230	Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases	Cfa	I	Lipid transport and metabolism	2	3	0.6666666666666666
OG0003499	COG4783	Periplasmic chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains	BepA	M	Cell wall/membrane/envelope biogenesis	2	3	0.6666666666666666
OG0003501	COG1715	Restriction endonuclease Mrr	Mrr	V	Defense mechanisms	2	3	0.6666666666666666
OG0003501	COG1787	Endonuclease, HJR/Mrr/RecB family	NA	V	Defense mechanisms	1	3	0.3333333333333333
OG0003502	COG0574	Phosphoenolpyruvate synthase/pyruvate phosphate dikinase	PpsA	G	Carbohydrate transport and metabolism	3	3	1
OG0003512	COG1807	PMT family glycosyltransferase ArnT/Agl22, involved in glycosylation of proteins and lipid IVA	ArnT	M	Cell wall/membrane/envelope biogenesis	1	3	0.3333333333333333
OG0003518	COG0508	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component	AceF	C	Energy production and conversion	1	3	0.3333333333333333
OG0003519	COG4942	Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB	EnvC	D	Cell cycle control, cell division, chromosome partitioning	1	3	0.3333333333333333
OG0003524	COG2956	Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain	LapB	M	Cell wall/membrane/envelope biogenesis	3	3	1
OG0003528	COG0286	Type I restriction-modification system, DNA methylase subunit	HsdM	V	Defense mechanisms	1	3	0.3333333333333333
OG0003528	COG1002	Type II restriction/modification system, endonuclease and methylase domains	YeeA	V	Defense mechanisms	2	3	0.6666666666666666
OG0003529	COG1061	Superfamily II DNA or RNA helicase	SSL2	K	Transcription	3	3	1
OG0003536	COG5305	Uncharacterized membrane protein PF0508, contains N-terminal glycosyltransferase domain of PMT family	NA	R	General function prediction only	1	3	0.3333333333333333
OG0003541	COG0619	ECF-type transporter transmembrane protein EcfT	EcfT	H	Coenzyme transport and metabolism	1	3	0.3333333333333333
OG0003547	COG0110	O-acetyltransferase, isoleucine patch superfamily, LacA/YvoF/WbbJ family	WbbJ	R	General function prediction only	1	3	0.3333333333333333
OG0003547	COG1043	Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase	LpxA	M	Cell wall/membrane/envelope biogenesis	2	3	0.6666666666666666
OG0003556	COG2141	Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase)	SsuD	H	Coenzyme transport and metabolism	3	3	1
OG0003561	COG3031	Type II secretion system/type IV pili GspC/PulC/PilP protein, contains PDZ domain	GspC/PilP	N	Cell motility	1	3	0.3333333333333333
OG0003564	COG2755	Lysophospholipase L1 or related esterase. Includes spore coat protein LipC/YcsK	TesA	D	Cell cycle control, cell division, chromosome partitioning	1	3	0.3333333333333333
OG0003573	COG2146	Ferredoxin subunit of nitrite reductase or a ring-hydroxylating dioxygenase	NirD	P	Inorganic ion transport and metabolism	3	3	1
OG0003574	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	1	3	0.3333333333333333
OG0003579	COG0730	Sulfite exporter TauE/SafE/YfcA and related permeases, UPF0721 family	TauE	P	Inorganic ion transport and metabolism	3	3	1
OG0003583	COG3166	Type II secretion system/type IV pilus alignment protein GspM/PulM/PilN	GspM/PilN	N	Cell motility	1	3	0.3333333333333333
OG0003584	COG3621	Patatin-like phospholipase/acyl hydrolase, includes sporulation protein CotR	PATA	R	General function prediction only	3	3	1
OG0003585	COG1272	Progestin and AdipoQ receptors (PAQRs) homolog, hemolysin III family	YqfA	U	Intracellular trafficking, secretion, and vesicular transport	3	3	1
OG0003586	COG3898	Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to HemY-type protoporphyrinogen oxidase)	HemYx	S	Function unknown	1	3	0.3333333333333333
OG0003588	COG3602	ACT domain, ACT-3 family	ACT-3	T	Signal transduction mechanisms	3	3	1
OG0003589	COG0204	1-acyl-sn-glycerol-3-phosphate acyltransferase	PlsC	I	Lipid transport and metabolism	3	3	1
OG0003591	COG1586	S-adenosylmethionine decarboxylase	SpeD	E	Amino acid transport and metabolism	3	3	1
OG0003599	COG0454	N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2)	PhnO	K	Transcription	3	3	1
OG0003608	COG1689	Class II terpene cyclase family protein AF1543	AF1543	R	General function prediction only	1	3	0.3333333333333333
OG0003608	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	1	3	0.3333333333333333
OG0003611	COG0662	Mannose-6-phosphate isomerase, cupin superfamily	ManC	G	Carbohydrate transport and metabolism	3	3	1
OG0003612	COG3394	Chitooligosaccharide deacetylase ChbG, YdjC/CelG family	ChbG	G	Carbohydrate transport and metabolism	3	3	1
OG0003613	COG3307	O-antigen ligase	RfaL	M	Cell wall/membrane/envelope biogenesis	1	3	0.3333333333333333
OG0003627	COG4268	5-methylcytosine-specific restriction endonuclease McrBC, regulatory subunit McrC	McrC	V	Defense mechanisms	3	3	1
OG0003628	COG0483	Archaeal fructose-1,6-bisphosphatase or related enzyme, inositol monophosphatase family	SuhB	G	Carbohydrate transport and metabolism	3	3	1
OG0003632	COG0110	O-acetyltransferase, isoleucine patch superfamily, LacA/YvoF/WbbJ family	WbbJ	R	General function prediction only	3	3	1
OG0003635	COG1216	Glycosyltransferase, GT2 family	WcaE	G	Carbohydrate transport and metabolism	1	3	0.3333333333333333
OG0003639	COG5563	Uncharacterized conserved protein CPn0794, contains PKD-like HAF repeats	NA	S	Function unknown	2	3	0.6666666666666666
OG0003639	COG5571	Secreted esterase EstA, contains T5SS autotransporter beta-barrel domain	EstA	U	Intracellular trafficking, secretion, and vesicular transport	1	3	0.3333333333333333
OG0003641	COG0392	Predicted membrane flippase AglD2/YbhN, UPF0104 family	AglD2	M	Cell wall/membrane/envelope biogenesis	2	3	0.6666666666666666
OG0003646	COG3307	O-antigen ligase	RfaL	M	Cell wall/membrane/envelope biogenesis	3	3	1
OG0003647	COG3119	Arylsulfatase A or related enzyme, AlkP superfamily	AslA	P	Inorganic ion transport and metabolism	2	3	0.6666666666666666
OG0003649	COG1061	Superfamily II DNA or RNA helicase	SSL2	K	Transcription	3	3	1
OG0003655	COG1216	Glycosyltransferase, GT2 family	WcaE	G	Carbohydrate transport and metabolism	1	3	0.3333333333333333
OG0003662	COG3193	Formaldehyde-binding sensor protein EfgA, GlcG/HbpS family	EfgA	T	Signal transduction mechanisms	3	3	1
OG0003671	COG1881	Uncharacterized protein, putative kinase inhibitor, PEBP/RKIP/YbhB/UPF0098 family	YbhB	R	General function prediction only	3	3	1
OG0003673	COG1368	Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily	MdoB	M	Cell wall/membrane/envelope biogenesis	1	3	0.3333333333333333
OG0003673	COG3307	O-antigen ligase	RfaL	M	Cell wall/membrane/envelope biogenesis	1	3	0.3333333333333333
OG0003678	COG2433	Possible nuclease of RNase H fold, RuvC/YqgF family	NA	R	General function prediction only	1	3	0.3333333333333333
OG0003678	COG4913	Uncharacterized conserved protein, contains a C-terminal ATPase domain	NA	S	Function unknown	1	3	0.3333333333333333
OG0003682	COG2327	Polysaccharide pyruvyl transferase family protein WcaK (colanic acid biosynthesis)	WcaK	M	Cell wall/membrane/envelope biogenesis	3	3	1
OG0003692	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	1	3	0.3333333333333333
OG0003692	COG4122	tRNA 5-hydroxyU34 O-methylase TrmR/YrrM	TrmR	J	Translation, ribosomal structure and biogenesis	2	3	0.6666666666666666
OG0003694	COG2835	RNA methyltransferase activator Trm112/YbaR	Trm112	J	Translation, ribosomal structure and biogenesis	2	3	0.6666666666666666
OG0003699	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	1	3	0.3333333333333333
OG0003700	COG1638	TRAP-type C4-dicarboxylate transport system, periplasmic component	DctP	G	Carbohydrate transport and metabolism	3	3	1
OG0003701	COG2203	GAF domain	GAF	T	Signal transduction mechanisms	3	3	1
OG0003703	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	UbiG	H	Coenzyme transport and metabolism	1	3	0.3333333333333333
OG0003707	COG2433	Possible nuclease of RNase H fold, RuvC/YqgF family	NA	R	General function prediction only	1	3	0.3333333333333333
OG0003711	COG3265	Gluconate kinase	GntK	G	Carbohydrate transport and metabolism	3	3	1
OG0003722	COG4126	Asp/Glu/hydantoin racemase	Dcg1	E	Amino acid transport and metabolism	1	3	0.3333333333333333
OG0003724	COG0155	Sulfite reductase, beta subunit (hemoprotein)	CysI	P	Inorganic ion transport and metabolism	3	3	1
OG0003725	COG1141	Ferredoxin	Fer	C	Energy production and conversion	3	3	1
OG0003727	COG1140	Nitrate reductase beta subunit	NarY	C	Energy production and conversion	3	3	1
OG0003728	COG2181	Nitrate reductase gamma subunit	NarI	C	Energy production and conversion	3	3	1
OG0003729	COG0695	Glutaredoxin	GrxC	O	Posttranslational modification, protein turnover, chaperones	2	3	0.6666666666666666
OG0003731	COG2981	Sulfate transporter CysZ	CysZ	E	Amino acid transport and metabolism	1	3	0.3333333333333333
OG0003733	COG1216	Glycosyltransferase, GT2 family	WcaE	G	Carbohydrate transport and metabolism	2	3	0.6666666666666666
OG0003734	COG3036	Stalled ribosome alternative rescue factor ArfA	ArfA	J	Translation, ribosomal structure and biogenesis	3	3	1
OG0003738	COG2717	Heme-binding membrane subunit of periplasmic DMSO/TMAO and protein-methionine-sulfoxide reductases	MsrQ	C	Energy production and conversion	3	3	1
OG0003739	COG0789	DNA-binding transcriptional regulator, MerR family	SoxR	K	Transcription	3	3	1
OG0003740	COG2132	Multicopper oxidase with three cupredoxin domains (includes cell division protein FtsP and spore coat protein CotA)	SufI	D	Cell cycle control, cell division, chromosome partitioning	3	3	1
OG0003745	COG2984	ABC-type uncharacterized transport system, periplasmic component	NA	R	General function prediction only	2	3	0.6666666666666666
OG0003747	COG0286	Type I restriction-modification system, DNA methylase subunit	HsdM	V	Defense mechanisms	3	3	1
OG0003758	COG0790	Sel1-like repeat, TPR-related	Sel1	R	General function prediction only	3	3	1
OG0003762	COG4649	TPR-like repeat domain	TPR1	S	Function unknown	1	3	0.3333333333333333
OG0003767	COG2730	Aryl-phospho-beta-D-glucosidase BglC, GH1 family	BglC	G	Carbohydrate transport and metabolism	3	3	1
OG0003769	COG0179	Oxaloacetate decarboxylase and tautomerase, fumarylacetoacetate (FAA) hydrolase family	FAHD1	C	Energy production and conversion	3	3	1
OG0003770	COG4651	Predicted Kef-type K+ transport protein, K+/H+ antiporter domain	RosB	P	Inorganic ion transport and metabolism	3	3	1
OG0003773	COG0679	Predicted permease, AEC (auxin efflux carrier) family	YfdV	R	General function prediction only	3	3	1
OG0003774	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	AcrA	M	Cell wall/membrane/envelope biogenesis	1	3	0.3333333333333333
OG0003785	COG1196	Chromosome segregation ATPase Smc	Smc	D	Cell cycle control, cell division, chromosome partitioning	1	3	0.3333333333333333
OG0003785	COG3941	Phage tail tape-measure protein, controls tail length	HI1514	X	Mobilome: prophages, transposons	1	3	0.3333333333333333
OG0003785	COG4913	Uncharacterized conserved protein, contains a C-terminal ATPase domain	NA	S	Function unknown	1	3	0.3333333333333333
OG0003786	COG3728	Phage terminase, small subunit	XtmA	X	Mobilome: prophages, transposons	1	3	0.3333333333333333
OG0003788	COG1783	Phage terminase large subunit	XtmB	X	Mobilome: prophages, transposons	3	3	1
OG0003791	COG2887	RecB family exonuclease	Slr0479	L	Replication, recombination and repair	1	3	0.3333333333333333
OG0003794	COG1961	Site-specific DNA recombinase SpoIVCA/DNA invertase PinE	SpoIVCA	L	Replication, recombination and repair	3	3	1
OG0003801	COG3473	Maleate cis-trans isomerase	NA	Q	Secondary metabolites biosynthesis, transport and catabolism	3	3	1
OG0003802	COG3292	Periplasmic ligand-binding sensor domain	NA	T	Signal transduction mechanisms	3	3	1
OG0003803	COG1341	Polynucleotide 5'-kinase, involved in rRNA processing	Grc3	J	Translation, ribosomal structure and biogenesis	1	3	0.3333333333333333
OG0003805	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	2	2	1
OG0003806	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	1	2	0.5
OG0003806	COG1088	dTDP-D-glucose 4,6-dehydratase	RfbB	M	Cell wall/membrane/envelope biogenesis	1	2	0.5
OG0003807	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	1	2	0.5
OG0003808	COG0463	Glycosyltransferase involved in cell wall bisynthesis	WcaA	M	Cell wall/membrane/envelope biogenesis	1	2	0.5
OG0003809	COG0006	Xaa-Pro aminopeptidase	PepP	E	Amino acid transport and metabolism	2	2	1
OG0003810	COG0559	Branched-chain amino acid ABC-type transport system, permease component	LivH	E	Amino acid transport and metabolism	2	2	1
OG0003811	COG0559	Branched-chain amino acid ABC-type transport system, permease component	LivH	E	Amino acid transport and metabolism	2	2	1
OG0003815	COG1309	DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA	AcrR	K	Transcription	2	2	1
OG0003816	COG0189	Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily	LysX	E	Amino acid transport and metabolism	2	2	1
OG0003822	COG4734	Antirestriction protein ArdA	ArdA	V	Defense mechanisms	2	2	1
OG0003830	COG0859	ADP-heptose:LPS heptosyltransferase	RfaF	M	Cell wall/membrane/envelope biogenesis	2	2	1
OG0003831	COG3981	Predicted acetyltransferase	NA	R	General function prediction only	1	2	0.5
OG0003847	COG5633	Uncharacterized conserved protein YcfL	YcfL	S	Function unknown	1	2	0.5
OG0003866	COG3156	Type II secretory pathway, component PulK	PulK	U	Intracellular trafficking, secretion, and vesicular transport	2	2	1
OG0003867	COG4795	Type II secretion system protein PulJ/XcpW	PulJ/XcpW	U	Intracellular trafficking, secretion, and vesicular transport	2	2	1
OG0003868	COG2165	Type II secretion system/type IV prepilin peptidase GspO/PulO/PilD	GspO/PilD	N	Cell motility	1	2	0.5
OG0003868	COG4967	Type IV pilus minor pilin/pseudopilin PilV	PilV	N	Cell motility	1	2	0.5
OG0003869	COG3031	Type II secretion system/type IV pili GspC/PulC/PilP protein, contains PDZ domain	GspC/PilP	N	Cell motility	1	2	0.5
OG0003879	COG2110	O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain	YmdB	J	Translation, ribosomal structure and biogenesis	1	2	0.5
OG0003895	COG1541	Phenylacetate-coenzyme A ligase PaaK, adenylate-forming domain family	PaaK	H	Coenzyme transport and metabolism	2	2	1
OG0003916	COG3392	Adenine-specific DNA methylase	NA	L	Replication, recombination and repair	2	2	1
OG0003921	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	1	2	0.5
OG0003933	COG0664	cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases	Crp	T	Signal transduction mechanisms	2	2	1
OG0003942	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	1	2	0.5
OG0003946	COG0574	Phosphoenolpyruvate synthase/pyruvate phosphate dikinase	PpsA	G	Carbohydrate transport and metabolism	2	2	1
OG0003947	COG1173	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	DppC	E	Amino acid transport and metabolism	1	2	0.5
OG0003951	COG3696	Cu/Ag efflux pump CusA	CusA	P	Inorganic ion transport and metabolism	1	2	0.5
OG0003955	COG0417	DNA polymerase B elongation subunit	PolB	L	Replication, recombination and repair	1	2	0.5
OG0003955	COG3359	Uncharacterized conserved protein YprB, contains RNaseH-like and TPR domains	YprB	R	General function prediction only	1	2	0.5
OG0003960	COG3680	Uncharacterized protein, contains GIY-YIG domain	NA	S	Function unknown	2	2	1
OG0003964	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9	UbiE	H	Coenzyme transport and metabolism	1	2	0.5
OG0003969	COG0538	Isocitrate dehydrogenase	Icd	C	Energy production and conversion	2	2	1
OG0003975	COG2112	Predicted Ser/Thr protein kinase	NA	T	Signal transduction mechanisms	1	2	0.5
OG0003975	COG3642	tRNA A37 N6-threonylcarbamoyl transferase component Bud32	Bud32	J	Translation, ribosomal structure and biogenesis	1	2	0.5
OG0003987	COG3555	Aspartyl/asparaginyl beta-hydroxylase, cupin superfamily,includes lipid A hydroxylase LpxO	LpxO2	O	Posttranslational modification, protein turnover, chaperones	2	2	1
OG0003991	COG2020	Protein-S-isoprenylcysteine O-methyltransferase Ste14	STE14	O	Posttranslational modification, protein turnover, chaperones	2	2	1
OG0003994	COG0438	Lipopolysaccharide 1,6-galactosyltransferase, GT1 family	RfaB	M	Cell wall/membrane/envelope biogenesis	1	2	0.5
OG0003995	COG4088	tRNA uridine 5-carbamoylmethylation regulator Kti12	Kti12	J	Translation, ribosomal structure and biogenesis	1	2	0.5
OG0003998	COG2110	O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain	YmdB	J	Translation, ribosomal structure and biogenesis	2	2	1
OG0004008	COG1475	Chromosome segregation protein Spo0J, contains ParB-like CTPase domain	Spo0J	D	Cell cycle control, cell division, chromosome partitioning	2	2	1
OG0004015	COG2994	ACP:protein(Lys) acyltransferase, toxin activator, CyaC/HlyC family	HlyC	O	Posttranslational modification, protein turnover, chaperones	2	2	1
OG0004024	COG5662	Transmembrane transcriptional regulator RsiW (anti-sigma-W factor)	RsiW	K	Transcription	2	2	1
OG0004025	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	RpoE	K	Transcription	2	2	1
OG0004026	COG4520	Surface antigen	LipA17	M	Cell wall/membrane/envelope biogenesis	2	2	1
OG0004028	COG2244	Membrane protein involved in the export of O-antigen and teichoic acid	RfbX	M	Cell wall/membrane/envelope biogenesis	1	2	0.5
OG0004041	COG4642	Uncharacterized conserved protein, contains MORN repeats	NA	R	General function prediction only	2	2	1
OG0004046	COG0859	ADP-heptose:LPS heptosyltransferase	RfaF	M	Cell wall/membrane/envelope biogenesis	2	2	1
OG0004053	COG0625	Glutathione S-transferase or stringent starvation protein SspA	GstA	O	Posttranslational modification, protein turnover, chaperones	2	2	1
OG0004062	COG0793	C-terminal processing protease CtpA/Prc, contains a PDZ domain	CtpA	O	Posttranslational modification, protein turnover, chaperones	1	2	0.5
OG0004063	COG2967	Uncharacterized conserved protein ApaG affecting Mg2+/Co2+ transport	ApaG	P	Inorganic ion transport and metabolism	2	2	1
OG0004064	COG2170	Gamma-glutamyl:cysteine ligase YbdK, ATP-grasp superfamily	YbdK	O	Posttranslational modification, protein turnover, chaperones	2	2	1
OG0004089	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	1	2	0.5
OG0004090	COG1396	Transcriptional regulator, contains XRE-family HTH domain	HipB	K	Transcription	1	2	0.5
OG0004090	COG1813	Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains	aMBF1	J	Translation, ribosomal structure and biogenesis	1	2	0.5
OG0004092	COG3307	O-antigen ligase	RfaL	M	Cell wall/membrane/envelope biogenesis	2	2	1
OG0004100	COG0726	Peptidoglycan/xylan/chitin deacetylase, PgdA/NodB/CDA1 family	PgaB	G	Carbohydrate transport and metabolism	2	2	1
OG0004125	COG5285	Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family	PhyH	Q	Secondary metabolites biosynthesis, transport and catabolism	1	2	0.5
OG0004133	COG3410	Uncharacterized conserved protein, DUF2075 family	BH3996	S	Function unknown	2	2	1
OG0004142	COG4485	Uncharacterized membrane protein YfhO	YfhO	S	Function unknown	1	2	0.5
OG0004154	COG4642	Uncharacterized conserved protein, contains MORN repeats	NA	R	General function prediction only	2	2	1
OG0004160	COG0110	O-acetyltransferase, isoleucine patch superfamily, LacA/YvoF/WbbJ family	WbbJ	R	General function prediction only	2	2	1
OG0004173	COG0572	Uridine kinase	Udk	F	Nucleotide transport and metabolism	2	2	1
OG0004174	COG2246	Putative flippase GtrA (transmembrane translocase of bactoprenol-linked glucose)	GtrA	I	Lipid transport and metabolism	2	2	1
OG0004185	COG1315	Flagellar assembly protein FapA, interacts with EIIAGlc	FapA	N	Cell motility	2	2	1
OG0004188	COG1807	PMT family glycosyltransferase ArnT/Agl22, involved in glycosylation of proteins and lipid IVA	ArnT	M	Cell wall/membrane/envelope biogenesis	2	2	1
OG0004203	COG2382	Enterochelin esterase or related enzyme	Fes	P	Inorganic ion transport and metabolism	1	2	0.5
OG0004210	COG3153	Predicted N-acetyltransferase YhbS	YhbS	R	General function prediction only	1	2	0.5
OG0004218	COG1109	Phosphomannomutase	ManB	G	Carbohydrate transport and metabolism	1	2	0.5
OG0004225	COG0172	Seryl-tRNA synthetase	SerS	J	Translation, ribosomal structure and biogenesis	1	2	0.5
OG0004226	COG1045	Serine acetyltransferase	CysE	E	Amino acid transport and metabolism	1	2	0.5
OG0004230	COG0205	6-phosphofructokinase	PfkA	G	Carbohydrate transport and metabolism	2	2	1
OG0004232	COG2309	Leucyl aminopeptidase (aminopeptidase T)	AmpS	E	Amino acid transport and metabolism	2	2	1
OG0004236	COG2205	K+-sensing histidine kinase KdpD	KdpD	T	Signal transduction mechanisms	2	2	1
OG0004240	COG2159	5-carboxyvanillate decarboxylase LigW (lignin degradation), amidohydro domain	LigW	G	Carbohydrate transport and metabolism	1	2	0.5
OG0004240	COG4753	Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains	YesN	T	Signal transduction mechanisms	1	2	0.5
OG0004250	COG3392	Adenine-specific DNA methylase	NA	L	Replication, recombination and repair	2	2	1
OG0004253	COG0551	DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains	YrdD	L	Replication, recombination and repair	1	2	0.5
OG0004253	COG2191	Formylmethanofuran dehydrogenase subunit E	FwdE	C	Energy production and conversion	1	2	0.5
OG0004258	COG4713	Uncharacterized membrane protein, DUF2142 domain	NA	S	Function unknown	1	2	0.5
OG0004260	COG3653	N-acyl-D-aspartate/D-glutamate deacylase	NA	Q	Secondary metabolites biosynthesis, transport and catabolism	2	2	1
OG0004264	COG5633	Uncharacterized conserved protein YcfL	YcfL	S	Function unknown	1	2	0.5
OG0004271	COG0451	Nucleoside-diphosphate-sugar epimerase	WcaG	M	Cell wall/membrane/envelope biogenesis	1	2	0.5
OG0004273	COG3011	Predicted thiol-disulfide oxidoreductase YuxK, DCC family	YuxK	R	General function prediction only	2	2	1
OG0004277	COG2246	Putative flippase GtrA (transmembrane translocase of bactoprenol-linked glucose)	GtrA	I	Lipid transport and metabolism	2	2	1
OG0004283	COG4974	Site-specific tyrosine recombinase XerD	XerD	L	Replication, recombination and repair	2	2	1
OG0004300	COG0826	23S rRNA C2501 and tRNA U34 5'-hydroxylation protein RlhA/YrrN/YrrO, U32 peptidase family	RlhA	J	Translation, ribosomal structure and biogenesis	2	2	1
OG0004304	COG1013	Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, beta subunit	PorB	C	Energy production and conversion	2	2	1
OG0004305	COG0007	Uroporphyrinogen-III methylase (siroheme synthase)	CysG	H	Coenzyme transport and metabolism	2	2	1
OG0004308	COG0826	23S rRNA C2501 and tRNA U34 5'-hydroxylation protein RlhA/YrrN/YrrO, U32 peptidase family	RlhA	J	Translation, ribosomal structure and biogenesis	2	2	1
OG0004309	COG2606	Cys-tRNA(Pro) deacylase, prolyl-tRNA editing enzyme YbaK/EbsC	EbsC	J	Translation, ribosomal structure and biogenesis	2	2	1
OG0004310	COG1960	Acyl-CoA dehydrogenase related to the alkylation response protein AidB	CaiA	I	Lipid transport and metabolism	2	2	1
OG0004311	COG2180	Nitrate reductase assembly protein NarJ, required for insertion of molybdenum cofactor	NarJ	C	Energy production and conversion	2	2	1
OG0004312	COG3904	Predicted periplasmic protein	NA	S	Function unknown	1	2	0.5
OG0004323	COG3090	TRAP-type C4-dicarboxylate transport system, small permease component YiaM	DctM	G	Carbohydrate transport and metabolism	1	2	0.5
OG0004327	COG0009	tRNA A37 threonylcarbamoyladenosine synthetase subunit TsaC/SUA5/YrdC	TsaC	J	Translation, ribosomal structure and biogenesis	2	2	1
OG0004332	COG0515	Serine/threonine protein kinase, uncludes type III secretion system effector YopO	SPS1	T	Signal transduction mechanisms	2	2	1
OG0004334	COG1538	Outer membrane protein TolC	TolC	M	Cell wall/membrane/envelope biogenesis	2	2	1
OG0004335	COG3384	Aromatic ring-opening dioxygenase, catalytic subunit, LigB family	LigB	Q	Secondary metabolites biosynthesis, transport and catabolism	2	2	1
OG0004336	COG0730	Sulfite exporter TauE/SafE/YfcA and related permeases, UPF0721 family	TauE	P	Inorganic ion transport and metabolism	2	2	1
OG0004339	COG3886	HKD family nuclease	NA	L	Replication, recombination and repair	2	2	1
OG0004349	COG0597	Lipoprotein signal peptidase	LspA	M	Cell wall/membrane/envelope biogenesis	1	2	0.5
OG0004349	COG1230	Co/Zn/Cd efflux system component	CzcD	P	Inorganic ion transport and metabolism	1	2	0.5
OG0004350	COG0640	DNA-binding transcriptional regulator, ArsR family	ArsR	K	Transcription	2	2	1
OG0004371	COG0726	Peptidoglycan/xylan/chitin deacetylase, PgdA/NodB/CDA1 family	PgaB	G	Carbohydrate transport and metabolism	2	2	1
OG0004373	COG2244	Membrane protein involved in the export of O-antigen and teichoic acid	RfbX	M	Cell wall/membrane/envelope biogenesis	2	2	1
OG0004376	COG3667	Uncharacterized conserved protein involved in copper resistance	PcoB	P	Inorganic ion transport and metabolism	2	2	1
OG0004392	COG2128	Alkylhydroperoxidase family enzyme, contains CxxC motif	YciW	P	Inorganic ion transport and metabolism	2	2	1
OG0004395	COG3239	Fatty acid desaturase	DesA	I	Lipid transport and metabolism	2	2	1
OG0004403	COG0394	Protein-tyrosine-phosphatase	Wzb	T	Signal transduction mechanisms	1	2	0.5
OG0004404	COG1846	DNA-binding transcriptional regulator, MarR family	MarR	K	Transcription	2	2	1
OG0004405	COG1271	Cytochrome bd-type quinol oxidase, subunit 1	AppC	C	Energy production and conversion	2	2	1
OG0004406	COG1294	Cytochrome bd-type quinol oxidase, subunit 2	AppB	C	Energy production and conversion	2	2	1
OG0004412	COG3898	Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to HemY-type protoporphyrinogen oxidase)	HemYx	S	Function unknown	1	2	0.5
OG0004415	COG2433	Possible nuclease of RNase H fold, RuvC/YqgF family	NA	R	General function prediction only	1	2	0.5
OG0004415	COG4942	Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB	EnvC	D	Cell cycle control, cell division, chromosome partitioning	1	2	0.5
OG0004416	COG3765	LPS O-antigen chain length determinant protein, WzzB/FepE family	WzzB	M	Cell wall/membrane/envelope biogenesis	1	2	0.5
OG0004417	COG3307	O-antigen ligase	RfaL	M	Cell wall/membrane/envelope biogenesis	1	2	0.5
OG0004443	COG2244	Membrane protein involved in the export of O-antigen and teichoic acid	RfbX	M	Cell wall/membrane/envelope biogenesis	2	2	1
OG0004446	COG1254	Acylphosphatase	AcyP	C	Energy production and conversion	2	2	1
OG0004449	COG4235	Cytochrome c-type biogenesis protein CcmH/NrfG	NrfG	C	Energy production and conversion	1	2	0.5
OG0004450	COG1034	NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G)	NuoG	C	Energy production and conversion	1	2	0.5
OG0004461	COG4315	Predicted lipoprotein with conserved Yx(FWY)xxD motif (function unknown)	NA	S	Function unknown	2	2	1
OG0004462	COG0258	5'-3' exonuclease Xni/ExoIX (flap endonuclease)	ExoIX	L	Replication, recombination and repair	2	2	1
OG0004475	COG3864	Predicted metal-dependent peptidase	NA	R	General function prediction only	2	2	1
OG0004477	COG0714	MoxR-like ATPase, includes components of a predicted archaeal secretion system	MMP0363	R	General function prediction only	2	2	1
OG0004481	COG4913	Uncharacterized conserved protein, contains a C-terminal ATPase domain	NA	S	Function unknown	1	2	0.5
OG0004482	COG4625	Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain	NA	S	Function unknown	1	2	0.5
OG0004482	COG5651	PPE-repeat protein	PPE	S	Function unknown	1	2	0.5
OG0004488	COG1196	Chromosome segregation ATPase Smc	Smc	D	Cell cycle control, cell division, chromosome partitioning	1	2	0.5
OG0004490	COG3926	Type X secretion system component, combines lysozyme-like N-acetylmuramidase GH108 and peptidoglycan hydrolase domains	ZliS	U	Intracellular trafficking, secretion, and vesicular transport	2	2	1
OG0004491	COG0825	Acetyl-CoA carboxylase alpha subunit	AccA	I	Lipid transport and metabolism	1	2	0.5
OG0004494	COG4913	Uncharacterized conserved protein, contains a C-terminal ATPase domain	NA	S	Function unknown	1	2	0.5
OG0004512	COG3378	DNA primase, phage- or plasmid-associated	NA	X	Mobilome: prophages, transposons	2	2	1
OG0004516	COG0420	DNA repair exonuclease SbcCD nuclease subunit	SbcD	L	Replication, recombination and repair	2	2	1
OG0004517	COG0419	DNA repair exonuclease SbcCD ATPase subunit	SbcC	L	Replication, recombination and repair	2	2	1
OG0004529	COG3672	Predicted transglutaminase-like protein	NA	O	Posttranslational modification, protein turnover, chaperones	2	2	1
OG0004534	COG3774	Mannosyltransferase OCH1 or related enzyme	OCH1	M	Cell wall/membrane/envelope biogenesis	2	2	1
OG0004541	COG3740	Phage head maturation protease	NA	X	Mobilome: prophages, transposons	1	2	0.5
OG0004543	COG5410	Uncharacterized domain, often fused with C-terminal phage terminase domain	NA	X	Mobilome: prophages, transposons	2	2	1
OG0004548	COG0760	Periplasmic chaperone SurA (peptidyl-prolyl cis-trans isomerase)	SurA	O	Posttranslational modification, protein turnover, chaperones	2	2	1
OG0004549	COG1246	N-acetylglutamate synthase or related acetyltransferase, GNAT family	ArgA	E	Amino acid transport and metabolism	1	2	0.5
OG0004549	COG3153	Predicted N-acetyltransferase YhbS	YhbS	R	General function prediction only	1	2	0.5
OG0004550	COG2887	RecB family exonuclease	Slr0479	L	Replication, recombination and repair	2	2	1
OG0004552	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	BcsA	N	Cell motility	1	2	0.5
OG0004558	COG2850	Ribosomal protein L16 Arg81 hydroxylase, contains JmjC domain	RoxA	J	Translation, ribosomal structure and biogenesis	2	2	1
OG0004566	COG1974	SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase)	LexA	K	Transcription	1	2	0.5
OG0004567	COG1835	Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains	OafA	M	Cell wall/membrane/envelope biogenesis	2	2	1
OG0004568	COG3307	O-antigen ligase	RfaL	M	Cell wall/membrane/envelope biogenesis	1	2	0.5
OG0004571	COG1668	ABC-type Na+ efflux pump, permease component NatB	NatB	C	Energy production and conversion	1	2	0.5
OG0004571	COG3115	Cell division protein ZipA, interacts with FtsZ	ZipA	D	Cell cycle control, cell division, chromosome partitioning	1	2	0.5
OG0004572	COG2825	Periplasmic chaperone for outer membrane proteins, Skp/HlpA/OmpH family	Skp	M	Cell wall/membrane/envelope biogenesis	2	2	1