Browser-based protein similarity screening
OG Representative Similarity Search Beta
Compare one protein sequence with representative sequences from all 4,577 SAR11 orthogroups. The calculation runs locally in your browser.
This is a rapid exploratory search against one representative sequence per OG. Similarity to a representative is not an OG assignment and no BLAST-equivalent E-value is calculated.
For annotation workflows, SAR11 Genome Atlas Tools (SGAtools)
provides sga-maper, which can be used to annotate sequences against SAR11 orthogroups.
01 · Query
Enter one amino acid sequence
FASTA or plain sequence · 20–5,000 aa · one sequence per search
02 · Local search
Preparing search
03 · Candidate orthogroups
Closest OG candidates
| Rank | OG | Annotation | Score | Identity | Aln. length | Query cov. | Subject cov. | Subject length | Alignment |
|---|
Method & interpretation
About this search
Search scope
The database contains one observed representative protein per OG,
selected from the OG members as the sequence closest to its
multiple-alignment consensus. We used EMBOSS
infoalign to compare each sequence with the
consensus and chose the sequence with the lowest percent change
as the representative. It does not contain every OG member.
Scoring
Smith–Waterman local alignment, BLOSUM62, gap open 11 and gap extension 1. Ranking uses the raw alignment score.
Important limitation
Similarity to a representative does not establish OG membership. No BLAST-equivalent E-value is calculated. For a more sensitive, profile-based sequence similarity search, download the OG HMM profiles and search them with HMMER. Use BLAST, DIAMOND or MMseqs2 for other statistical or comprehensive analyses.
Privacy
Your sequence and results remain in this browser. They are not transmitted, uploaded, logged, retained or saved. The SAR11 Genome Atlas does not collect query sequences, search results or usage data through this search.
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